CN111973499A - 用于护肤的试剂组合 - Google Patents
用于护肤的试剂组合 Download PDFInfo
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- CN111973499A CN111973499A CN201910437646.9A CN201910437646A CN111973499A CN 111973499 A CN111973499 A CN 111973499A CN 201910437646 A CN201910437646 A CN 201910437646A CN 111973499 A CN111973499 A CN 111973499A
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- oil
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Abstract
本发明提供一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,所述第一试剂包含尿囊素和甘草酸二钾;所述第二试剂包含羟乙磺酸己氧苯脒、吡哆素、吡硫鎓锌和北美金缕梅提取物;所述第三试剂包含二裂酵母发酵产物溶胞物和蔓荆果提取物。本发明用于护肤的试剂组合不仅能够祛痘消除痘印而且能够从内部抗炎修复皮肤,能够更好的改善皮肤状态。
Description
技术领域
本发明涉及护肤品领域,具体涉及一种用于护肤的试剂组合及其应用。
背景技术
随着生活压力、生活不规律、食品安全、环境影响等原因的加剧,痘痘成为困扰众多年轻人的皮肤问题之一。
痘痘,常见于青春发育期的青年男女,主要发生在面部、前胸肌肩胛部位,形成丘疹,中医称“粉刺”,西医称为“痤疮”,常表现为粉刺、丘疹、脓疱、结节、囊肿及瘢痕,是一种发生在毛囊皮脂腺及其周围组织的炎症病变。
痘痘发病原因,一般可分为以下几种:
1)内分泌失调:内分泌失调促使皮脂分泌过盛,无法排出而将毛囊阻塞,为青春痘的产生营造了先决条件。
2)毛囊角化异常:正常毛囊口上部的角质层较薄,易脱落,从而保证毛囊口畅通无阻,皮脂顺利流出。反之,角质层变厚不易脱落,来不及流出的皮脂就会堵塞在毛囊口,形成粉刺。
3)神经系统:过于紧张或忧虑,会刺激肾脏腺素的产生。肾脏腺素本身即可进行雄性荷尔蒙素的正常生长,进而刺激油脂的 分泌。
4)性荷尔蒙:有些女性在成人期,会出现油性皮肤,大部分是由于她们的皮脂腺容易 吸收雄性荷尔蒙,并刺激皮脂的分泌。
5)食物:吃得过饱,未经充分消化道的食物积存于体内,消化不良、废物毒素排泄不畅,以及对高糖分饮料、油炸类、海鲜类的嗜好,均会为青春痘的产生埋下祸根。
6)气候:皮下脂肪的分泌会随着外在气温的升高而自然地增加,于是冬季为混合性的肌肤却在夏季转变为油性肌肤。
7)不适当的保养品:较为油性的保养品,只适用于干性肌肤的保养。反之,则会将毛囊阻塞,使皮肤油脂分泌难以排泄。
8)睡眠不足:睡眠不足会引起新陈代谢失调,皮肤也由健康的弱酸性变成碱性,失去杀菌作用。
9)发育期间:青春期雄性激素急剧增加,皮脂腺过度发育,毛囊角质化严重,不能顺利排除皮脂,引发青春痘。
10)紫外线:某些高防晒系数产品,经太阳辐射后,防晒品的分子极易渗入皮肤,从而堵塞毛孔,影响油脂的正常分泌,增加了青春痘形成的机会。
11)药物:不适宜的药物及某些抗生素,可能会扰乱荷尔蒙的平衡系统,而产生过度皮脂溢出。
研究证实,痘痘的发生主要与皮脂分泌过多、毛囊皮脂腺导管阻塞、细菌感染和炎症反应等诸多因素密切相关。其中,油脂及皮脂堵塞毛孔是诱发痘痘的根本原因,而细菌感染则加剧痘痘的并发症状。
目前市场上许多祛痘产品,这类产品对消除痘痘、粉刺等有一定效果,但是长期使用会刺激皮肤,引起接触性皮炎,表现为红斑、水肿、糜烂、瘙痒等,而且大多数祛痘产品在祛痘、消除痘印方面有一定的效果,但不能从内部抗炎修复皮肤。
专利CN108969429A公开了一种祛痘精华液,包含祛痘组合物A;所述祛痘组合物A包含丹参根提取物、丁香花蕾提取物、黄芩根提取物、当归根提取物、甘草根提取物和积雪草提取物。该专利通过添加温和的植物萃取成分,配合基础原料,制成祛痘精华液,能调节皮肤的水油平衡,去除痘痘,淡化痘印,修复受损肌肤,恢复肌肤自然健康状态;该专利搭配大量中药提取物,致使产品起效慢、治疗周期长,可能有难闻的气味和难看的颜色,不受消费者的欢迎。
因此,有必要开发一种控油祛痘、抗炎、修复的护肤产品,不仅能够祛痘消除痘印而且能够从内部抗炎修复皮肤,能够更好的改善皮肤状态。
发明内容
有鉴于此,本发明的目的在于提供一种控油祛痘、抗炎、修复的护肤产品,不仅能够祛痘消除痘印而且能够从内部抗炎修复皮肤,能够更好的改善皮肤状态。
为此,本发明提供了以下技术方案。
第一方面,本发明提供了一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,
所述第一试剂包含尿囊素和甘草酸二钾;
所述第二试剂包含羟乙磺酸己氧苯脒、吡哆素、吡硫鎓锌和北美金缕梅提取物;
所述第三试剂包含二裂酵母发酵产物溶胞物和蔓荆果提取物。
其中,所述二裂酵母发酵产物溶胞物可以商购获得,例如本发明购自CLRChemisches Laboratorium Dr. Kurt Richter GmbH,批号为3191570;所述蔓荆果提取物可以商购获得,例如,本发明购自广东大山化工科技有限公司,批号为20190414;所述北美金缕梅提取物可以商购获得,例如,本发明购自大韩民国丹鼎生物科技有限公司,批号为DBA1820007。
在优选的实施方式中,所述组合物可以包含水。
在优选的实施方式中,按照重量份数,
所述第一试剂包含0.01-0.2份尿囊素和0.2-0.5份甘草酸二钾。例如,所述尿囊素的重量份数可以为0.01-0.15、0.01-0.1、0.01-0.05、0.05-0.2、0.1-0.2或0.15-0.2;例如,所述甘草酸二钾的重量份数可以为0.2-0.45、0.2-0.4、0.2-0.35、0.2-0.3、0.25-0.5、0.3-0.5、0.35-0.5或0.4-0.5。
在优选的实施方式中,按照重量份数,
所述第二试剂包含0.01-0.1份羟乙磺酸己氧苯脒、0.1-2份吡哆素、0.01-0.5份吡硫鎓锌和0.1-3份北美金缕梅提取物。例如,所述羟乙磺酸己氧苯脒的重量份数可以为0.01-0.08、0.01-0.05、0.02-0.1、0.03-0.1、0.04-0.1、0.05-0.1、0.06-0.1或0.07-0.1;例如,所述吡哆素的重量份数可以为0.1-1.5、0.1-1、0.1-0.8、0.1-0.5、0.2-2、0.3-2、0.4-2、0.5-2、0.6-2、0.7-2、1-2、1.2-2、1.5-2或1.7-2;例如,所述北美金缕梅提取物的重量份数可以为0.08-0.1、0.09-0.1、0.07-0.09或0.07-0.08。
在优选的实施方式中,按照重量份数,
所述第三试剂包含0.5-3份二裂酵母发酵产物溶胞物和0.5-3份蔓荆果提取物。例如,所述二裂酵母发酵产物溶胞物的重量份数可以为0.5-2.5、0.5-2、0.5-1.5、0.5-1、0.7-3、0.9-3、1.2-3、1.5-3、1.8-3、2-3或2.5-3;例如,所述蔓荆果提取物的重量份数可以为0.5-2.5、0.5-2、0.5-1.5、0.5-1、0.7-3、0.9-3、1.2-3、1.5-3、1.8-3、2-3或2.5-3。
第二方面,本发明提供了一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含0.01-0.2份尿囊素和0.2-0.5份甘草酸二钾;
所述第二试剂包含0.01-0.1份羟乙磺酸己氧苯脒、0.1-2份吡哆素、0.01-0.5份吡硫鎓锌和0.1-3份北美金缕梅提取物;
所述第三试剂包含0.5-3份二裂酵母发酵产物溶胞物和0.5-3份蔓荆果提取物。
第三方面,本发明提供了一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含0.1份尿囊素和0.3份甘草酸二钾;
所述第二试剂包含0.05份羟乙磺酸己氧苯脒、1份吡哆素、0.3份吡硫鎓锌和2份北美金缕梅提取物;
所述第三试剂包含1.5份二裂酵母发酵产物溶胞物和1.5份蔓荆果提取物。
在优选的实施方式中,所述第一试剂还包含增稠剂、乳化剂、表面活性剂、皮肤调理剂、pH调节剂、螯合剂、油脂、香料和防腐剂中的一种或多种,其中,
所述增稠剂选自卡波姆、黄原胶、角叉菜胶钠、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素和羟丙基甲基纤维素中的一种或多种;
所述乳化剂选自鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、聚山梨醇酯-85、甲基葡糖倍半硬脂酸酯、硬脂醇聚醚-2、硬脂醇聚醚-21、鲸蜡硬脂基葡糖苷、鲸蜡醇聚醚-20、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖二硬脂酸酯和蔗糖多硬脂酸酯中的一种或多种;
所述表面活性剂选自月桂酸聚乙二醇甘油酯、阴离子烷基多苷、聚甘油-3甲基葡糖二硬脂酸酯、鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷和十二烷基二甲基甜菜碱中的一种或几种;
所述皮肤调理剂选自曲酸、抗坏血酸、抗坏血酸葡糖苷、透明质酸钠、熊果苷、传明酸、烟酰胺、植物甾醇、苯乙基间苯二酚、姜黄根提取物、白桦树皮提取物、神经酰胺2、神经酰胺3、泛醇、乙酰植物鞘氨醇、甘草酸二钾、羧甲基脱乙酰壳多糖、海藻糖、甘油、羟乙基脲、丙二醇、β-葡聚糖、甘油聚醚-26、尿囊素、乙醇、白藜芦醇、花榈木树皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物、甘油聚丙烯酸酯、温泉水、银耳子实体提取物、泛醌、胆甾醇、胆甾醇硬脂酸酯、抗坏血酸二棕榈酸酯、生育酚、生育酚乙酸酯、红没药醇、抗坏血酸四异棕榈酸酯、吡哆素二辛酸酯、吡哆素二棕榈酸酯、视黄醇棕榈酸酯和植物甾醇澳洲坚果油酸酯中的一种或多种;
所述pH值调节剂选自磷酸缓冲液、柠檬酸缓冲液、醋酸缓冲液、三乙醇胺缓冲液、三羟甲基氨基甲烷缓冲液和羟乙基哌嗪乙硫磺酸缓冲液中的一种或多种;
所述螯合剂可以选自醋酸钙、氯化钙、乙二胺四乙酸二钠、酸式焦磷酸钠、硫酸钠钙和氧化硬脂精中的一种或多种;
所述油脂选自油橄榄果油、澳洲坚果油、甜杏仁油、矿油、葡萄籽油、鳄梨油、玉米油、芝麻油、大豆油、花生油、白池花籽油、红花籽油、狗牙蔷薇果油、茴香油、刺阿干树仁油、霍霍巴籽油、向日葵籽油、毛瑞榈果油、角鲨烷、棕榈酸乙基己酯、肉豆蔻酸异丙酯、氢化聚异丁烯、异十六烷、霍霍巴酯、聚二甲基硅氧烷、二异硬脂醇苹果酸酯、异十二烷、碳酸二乙基己酯、碳酸二辛酯、月桂酰肌氨酸异丙酯、异壬酸异壬酯、氢化聚癸烯、鲸蜡醇乙基己酸酯、双-二乙氧基二甘醇环己烷1,4-二羧酸酯、油醇芥酸酯、辛基十二醇肉豆蔻酸酯、辛基十二醇、聚二甲基硅氧烷、辛基聚甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、鲸蜡硬脂醇乙基己酸酯、鳄梨甾醇、环五聚二甲基硅氧烷、鲸蜡醇、硬脂醇、鲸蜡硬脂醇、山嵛醇、鲨肝醇、月桂酸、牛油果树果脂、肉豆蔻酸、棕榈酸、硬脂酸、蜂蜡、小烛树蜡、巴西棕榈蜡、羊毛脂、地蜡、霍霍巴籽蜡、石蜡、矿脂、微晶蜡、氢化米糠蜡、氢化椰油甘油酯、肉豆蔻醇肉豆蔻酸酯、双-二甘油多酰基己二酸酯-2、牛油果树果脂和木鲁星果棕籽脂中的一种或多种;
所述香料选自鼠尾草油、春黄菊油、丁香油、香脂油、薄荷油、肉桂叶油、椴树花油、杜松子果油、岩兰草油、 乳香油、波斯树脂油、岩蔷薇油和杂熏衣草油中的一种或多种;
所述防腐剂选自羟苯甲酯、羟苯丙酯、苯氧乙醇、甘油辛酸酯、乙基己基甘油、苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、辛酰羟肟酸和甘油辛酸酯中的一种或多种。
在优选的实施方式中,所述第二试剂还包含增稠剂、乳化剂、表面活性剂、皮肤调理剂、pH调节剂、螯合剂、油脂、香料和防腐剂中的一种或多种,其中,
所述增稠剂选自卡波姆、黄原胶、角叉菜胶钠、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素和羟丙基甲基纤维素中的一种或多种;
所述乳化剂选自鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、聚山梨醇酯-85、甲基葡糖倍半硬脂酸酯、硬脂醇聚醚-2、硬脂醇聚醚-21、鲸蜡硬脂基葡糖苷、鲸蜡醇聚醚-20、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖二硬脂酸酯和蔗糖多硬脂酸酯中的一种或多种;
所述表面活性剂选自月桂酸聚乙二醇甘油酯、阴离子烷基多苷、聚甘油-3甲基葡糖二硬脂酸酯、鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷和十二烷基二甲基甜菜碱中的一种或几种;
所述皮肤调理剂选自曲酸、抗坏血酸、抗坏血酸葡糖苷、透明质酸钠、熊果苷、传明酸、烟酰胺、植物甾醇、苯乙基间苯二酚、姜黄根提取物、白桦树皮提取物、神经酰胺2、神经酰胺3、泛醇、乙酰植物鞘氨醇、甘草酸二钾、羧甲基脱乙酰壳多糖、海藻糖、甘油、羟乙基脲、丙二醇、β-葡聚糖、甘油聚醚-26、尿囊素、乙醇、白藜芦醇、花榈木树皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物、甘油聚丙烯酸酯、温泉水、银耳子实体提取物、泛醌、胆甾醇、胆甾醇硬脂酸酯、抗坏血酸二棕榈酸酯、生育酚、生育酚乙酸酯、红没药醇、抗坏血酸四异棕榈酸酯、吡哆素二辛酸酯、吡哆素二棕榈酸酯、视黄醇棕榈酸酯和植物甾醇澳洲坚果油酸酯中的一种或多种;
所述pH值调节剂选自磷酸缓冲液、柠檬酸缓冲液、醋酸缓冲液、三乙醇胺缓冲液、三羟甲基氨基甲烷缓冲液和羟乙基哌嗪乙硫磺酸缓冲液中的一种或多种;
所述螯合剂可以选自醋酸钙、氯化钙、乙二胺四乙酸二钠、酸式焦磷酸钠、硫酸钠钙和氧化硬脂精中的一种或多种;
所述油脂选自油橄榄果油、澳洲坚果油、甜杏仁油、矿油、葡萄籽油、鳄梨油、玉米油、芝麻油、大豆油、花生油、白池花籽油、红花籽油、狗牙蔷薇果油、茴香油、刺阿干树仁油、霍霍巴籽油、向日葵籽油、毛瑞榈果油、角鲨烷、棕榈酸乙基己酯、肉豆蔻酸异丙酯、氢化聚异丁烯、异十六烷、霍霍巴酯、聚二甲基硅氧烷、二异硬脂醇苹果酸酯、异十二烷、碳酸二乙基己酯、碳酸二辛酯、月桂酰肌氨酸异丙酯、异壬酸异壬酯、氢化聚癸烯、鲸蜡醇乙基己酸酯、双-二乙氧基二甘醇环己烷1,4-二羧酸酯、油醇芥酸酯、辛基十二醇肉豆蔻酸酯、辛基十二醇、聚二甲基硅氧烷、辛基聚甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、鲸蜡硬脂醇乙基己酸酯、鳄梨甾醇、环五聚二甲基硅氧烷、鲸蜡醇、硬脂醇、鲸蜡硬脂醇、山嵛醇、鲨肝醇、月桂酸、牛油果树果脂、肉豆蔻酸、棕榈酸、硬脂酸、蜂蜡、小烛树蜡、巴西棕榈蜡、羊毛脂、地蜡、霍霍巴籽蜡、石蜡、矿脂、微晶蜡、氢化米糠蜡、氢化椰油甘油酯、肉豆蔻醇肉豆蔻酸酯、双-二甘油多酰基己二酸酯-2、牛油果树果脂和木鲁星果棕籽脂中的一种或多种;
所述香料选自鼠尾草油、春黄菊油、丁香油、香脂油、薄荷油、肉桂叶油、椴树花油、杜松子果油、岩兰草油、 乳香油、波斯树脂油、岩蔷薇油和杂熏衣草油中的一种或多种;
所述防腐剂选自羟苯甲酯、羟苯丙酯、苯氧乙醇、甘油辛酸酯、乙基己基甘油、苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、辛酰羟肟酸和甘油辛酸酯中的一种或多种。
在优选的实施方式中,所述第三试剂还包含增稠剂、乳化剂、表面活性剂、皮肤调理剂、pH调节剂、螯合剂、油脂、香料和防腐剂中的一种或多种,其中,
所述增稠剂选自卡波姆、黄原胶、角叉菜胶钠、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素和羟丙基甲基纤维素中的一种或多种;
所述乳化剂选自鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、聚山梨醇酯-85、甲基葡糖倍半硬脂酸酯、硬脂醇聚醚-2、硬脂醇聚醚-21、鲸蜡硬脂基葡糖苷、鲸蜡醇聚醚-20、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖二硬脂酸酯和蔗糖多硬脂酸酯中的一种或多种;
所述表面活性剂选自月桂酸聚乙二醇甘油酯、阴离子烷基多苷、聚甘油-3甲基葡糖二硬脂酸酯、鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷和十二烷基二甲基甜菜碱中的一种或几种;
所述皮肤调理剂选自曲酸、抗坏血酸、抗坏血酸葡糖苷、透明质酸钠、熊果苷、传明酸、烟酰胺、植物甾醇、苯乙基间苯二酚、姜黄根提取物、白桦树皮提取物、神经酰胺2、神经酰胺3、泛醇、乙酰植物鞘氨醇、甘草酸二钾、羧甲基脱乙酰壳多糖、海藻糖、甘油、羟乙基脲、丙二醇、β-葡聚糖、甘油聚醚-26、尿囊素、乙醇、白藜芦醇、花榈木树皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物、甘油聚丙烯酸酯、温泉水、银耳子实体提取物、泛醌、胆甾醇、胆甾醇硬脂酸酯、抗坏血酸二棕榈酸酯、生育酚、生育酚乙酸酯、红没药醇、抗坏血酸四异棕榈酸酯、吡哆素二辛酸酯、吡哆素二棕榈酸酯、视黄醇棕榈酸酯和植物甾醇澳洲坚果油酸酯中的一种或多种;
所述pH值调节剂选自磷酸缓冲液、柠檬酸缓冲液、醋酸缓冲液、三乙醇胺缓冲液、三羟甲基氨基甲烷缓冲液和羟乙基哌嗪乙硫磺酸缓冲液中的一种或多种;
所述螯合剂可以选自醋酸钙、氯化钙、乙二胺四乙酸二钠、酸式焦磷酸钠、硫酸钠钙和氧化硬脂精中的一种或多种;
所述油脂选自油橄榄果油、澳洲坚果油、甜杏仁油、矿油、葡萄籽油、鳄梨油、玉米油、芝麻油、大豆油、花生油、白池花籽油、红花籽油、狗牙蔷薇果油、茴香油、刺阿干树仁油、霍霍巴籽油、向日葵籽油、毛瑞榈果油、角鲨烷、棕榈酸乙基己酯、肉豆蔻酸异丙酯、氢化聚异丁烯、异十六烷、霍霍巴酯、聚二甲基硅氧烷、二异硬脂醇苹果酸酯、异十二烷、碳酸二乙基己酯、碳酸二辛酯、月桂酰肌氨酸异丙酯、异壬酸异壬酯、氢化聚癸烯、鲸蜡醇乙基己酸酯、双-二乙氧基二甘醇环己烷1,4-二羧酸酯、油醇芥酸酯、辛基十二醇肉豆蔻酸酯、辛基十二醇、聚二甲基硅氧烷、辛基聚甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、鲸蜡硬脂醇乙基己酸酯、鳄梨甾醇、环五聚二甲基硅氧烷、鲸蜡醇、硬脂醇、鲸蜡硬脂醇、山嵛醇、鲨肝醇、月桂酸、牛油果树果脂、肉豆蔻酸、棕榈酸、硬脂酸、蜂蜡、小烛树蜡、巴西棕榈蜡、羊毛脂、地蜡、霍霍巴籽蜡、石蜡、矿脂、微晶蜡、氢化米糠蜡、氢化椰油甘油酯、肉豆蔻醇肉豆蔻酸酯、双-二甘油多酰基己二酸酯-2、牛油果树果脂和木鲁星果棕籽脂中的一种或多种;
所述香料选自鼠尾草油、春黄菊油、丁香油、香脂油、薄荷油、肉桂叶油、椴树花油、杜松子果油、岩兰草油、 乳香油、波斯树脂油、岩蔷薇油和杂熏衣草油中的一种或多种;
所述防腐剂选自羟苯甲酯、羟苯丙酯、苯氧乙醇、甘油辛酸酯、乙基己基甘油、苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、辛酰羟肟酸和甘油辛酸酯中的一种或多种。
第四方面,提供了一种护肤产品,所述护肤产品包含本发明所述的试剂组合。
第五方面,提供了一种药物组合物,所述药物组合物包含安全有效量的如本发明所述的试剂组合。
此外,还提供了本发明所述的试剂组合在制备护肤产品中的用途。
另外,提供了本发明所述的试剂组合在制备药物组合物中的用途。
现对于现有技术,本发明的有益效果在于:
本发明提供的用于护肤的试剂组合,该试剂组合包含的羟乙磺酸己氧苯脒和吡硫鎓锌能够减少痤疮丙酸杆菌的过度增长;吡哆素能够调控皮脂5-α还原酶能力,抑制皮肤分泌太多油脂,增强皮肤抵抗力;北美金缕梅提取物能够提高皮层局部雌激素水平,增强皮肤细胞新陈代谢,达到抗炎收敛的作用,含量过高,会加重皮肤负担。
本发明提供的用于护肤的试剂组合,该试剂组合包含的尿囊素和甘草酸二钾能够促进组织生长,细胞新陈代谢,软化角质层蛋白,加快伤口愈合速度,具有抗氧化作用。
本发明提供的用于护肤的试剂组合,该试剂组合包含的二裂酵母发酵产物溶胞物、蔓荆果提取物和细胞营养液能够促进紫外线照射后皮肤自我修复能力,保护皮肤,促进皮肤自我修复;二裂酵母发酵产物溶胞物含量不能太高,过高去角质能力过大,会使皮肤变得敏感。
本发明提供的用于护肤的试剂组合,能够减少痘痘的生成、控制油脂分泌、减少皮肤炎症,提高皮肤自身的修复自愈能力。
再一方面,通过筛选用于护肤的试剂组合中组分的种类及调整用于护肤的试剂组合中组分的重量份数,本发明用于护肤的试剂组合能够更好的减少痘痘的生成、更好的控制油脂分泌、更好的减少皮肤炎症,更好的提高皮肤自身的修复自愈能力。
具体实施方式
下文将结合具体实施方式和实施例,具体阐述本发明,本发明的优点和各种效果将由此更加清楚的呈现。本领域技术人员应理解,这些具体实施方式和实施例是用于说明本发明,而非限制本发明。
在整个说明书中,除非另有特别说明,本文使用的术语应理解为如本领域中通常所使用的含义。由此,除非另有定义,本文使用的所有技术和科学术语具有与本发明所属领域技术人员的一般理解相同的含义。若存在矛盾,本说明书优先。
增稠剂
增稠剂会对产品的外观形态产生重要的影响。增稠剂通过与表面活性剂形成的棒状胶束、与水作用形成的三维水化网络结构,或利用自身的大分子长链结构等,使体系达到增稠的目的。
对于增稠剂的种类,本发明选自卡波姆、黄原胶、角叉菜胶钠、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素和羟丙基甲基纤维素中的一种或多种。
对于增稠剂的用量,本领域技术人员可以根据增稠剂的种类进行选择,比如,在使用黄原胶时可以采用例如小于等于0.5的重量份数,在使用卡波姆时可以采用例如小于等于0.5的重量份数,在使用羟乙基纤维素时可以采用例如小于等于0.3的重量份数。
乳化剂
在本发明中,乳化剂是指能够改善乳浊液中各种构成相之间的表面张力,使之形成均匀稳定的分散体系或乳浊液的物质。
对于乳化剂的种类,本发明选自鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、聚山梨醇酯-85、甲基葡糖倍半硬脂酸酯、硬脂醇聚醚-2、硬脂醇聚醚-21、鲸蜡硬脂基葡糖苷、鲸蜡醇聚醚-20、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖二硬脂酸酯和蔗糖多硬脂酸酯中的一种或多种。
对于乳化剂的用量,本领域技术人员可以根据乳化剂的种类进行选择。
表面活性剂
在本发明中,表面活性剂是指加入少量能够使其溶液体系的界面状态发生明显变化的物质;其具有固定的亲水亲油集团且在溶液的表面能够定向排列。
对于表面活性剂的种类,本发明选自月桂酸聚乙二醇甘油酯、阴离子烷基多苷、聚甘油-3甲基葡糖二硬脂酸酯、鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷和十二烷基二甲基甜菜碱中的一种或几种。
对于表面活性剂的用量,本领域技术人员能够根据表面活性剂的种类进行选择,比如,在使用聚甘油-3甲基葡糖二硬脂酸酯时可以采用例如0.1-1的重量份数,在使用鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷时可以采用1-3的重量份数。
皮肤调理剂
在本发明中,皮肤调理剂是指能够改善干燥/受损皮肤的外观,减少脱皮和恢复皮肤柔软,还具有抗刺激、消炎和舒缓皮肤的功效的试剂。
对于皮肤调理剂的种类,本发明选自多元醇、曲酸、抗坏血酸、抗坏血酸葡糖苷、透明质酸钠、熊果苷、传明酸、烟酰胺、植物甾醇、苯乙基间苯二酚、姜黄根提取物、白桦树皮提取物、神经酰胺2、神经酰胺3、泛醇、乙酰植物鞘氨醇、甘草酸二钾、羧甲基脱乙酰壳多糖、海藻糖、甘油、羟乙基脲、丙二醇、β-葡聚糖、甘油聚醚-26、尿囊素、乙醇、白藜芦醇、花榈木树皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物、甘油聚丙烯酸酯、温泉水、银耳子实体提取物、泛醌、胆甾醇、胆甾醇硬脂酸酯、抗坏血酸二棕榈酸酯、生育酚、生育酚乙酸酯、红没药醇、抗坏血酸四异棕榈酸酯、吡哆素二辛酸酯、吡哆素二棕榈酸酯、视黄醇棕榈酸酯和植物甾醇澳洲坚果油酸酯中的一种或多种。
对于皮肤调理剂的用量,本领域技术人员可以根据皮肤调理剂的种类进行选择,比如,在使用多元醇时可以采用例如5-12的重量份数,在使用透明质酸钠时可以采用例如0.1-0.3的重量份数,在采用生育酚时可以采用例如0-0.4的重量份数,在使用甘油聚醚-26时可以采用例如3-8的重量份数。
pH调节剂
在本发明中,pH调节剂是指是用以维持或改变护肤产品酸碱度的物质。
对于pH值调节剂的种类,本发明选自磷酸缓冲液、柠檬酸缓冲液、醋酸缓冲液、TEA缓冲液、Tris缓冲液和HEPES缓冲液中的一种或多种。
对于pH调节剂的用量,本领域技术人员可以根据pH调节剂的种类进行选择,比如,在使用三乙醇胺缓冲液时可以采用例如0.08-05的重量份数。
螯合剂
在本发明中,螯合剂在护肤产品中的作用主要在于软化硬水和减少离子对整个系统的氧化作用。
对于螯合剂的种类,本发明选自醋酸钙、氯化钙、乙二胺四乙酸二钠、酸式焦磷酸钠、硫酸钠钙和氧化硬脂精中的一种或多种
对于螯合剂的用量,本领域技术人员可以根据螯合剂的种类进行选择,比如,在使用乙二胺四乙酸二钠时可以采用例如0.01-0.1的重量份数。
油脂
在本发明中,使用的油脂原料主要包括油脂和蜡,是油相原料的总称,也是一种基质原料,常温下呈流体形态的称为油,呈半固体形态的称谓蜡,其主要成分都是高级脂肪酸酯。主要起到护肤、润滑、固化赋型等作用。
按照来源不同,油性原料可大致分为动物油脂、植物油脂、矿物油脂、半合成油脂以及相关的蜡。一般来说皮肤对动物油脂吸收最好,其次是植物油脂。
对于油脂的种类,所述油脂选自油橄榄果油、澳洲坚果油、甜杏仁油、矿油、葡萄籽油、鳄梨油、玉米油、芝麻油、大豆油、花生油、白池花籽油、红花籽油、狗牙蔷薇果油、茴香油、刺阿干树仁油、霍霍巴籽油、向日葵籽油、毛瑞榈果油、角鲨烷、棕榈酸乙基己酯、肉豆蔻酸异丙酯、氢化聚异丁烯、异十六烷、霍霍巴酯、聚二甲基硅氧烷、二异硬脂醇苹果酸酯、异十二烷、碳酸二乙基己酯、碳酸二辛酯、月桂酰肌氨酸异丙酯、异壬酸异壬酯、氢化聚癸烯、鲸蜡醇乙基己酸酯、双-二乙氧基二甘醇环己烷1,4-二羧酸酯、油醇芥酸酯、辛基十二醇肉豆蔻酸酯、辛基十二醇、聚二甲基硅氧烷、辛基聚甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、鲸蜡硬脂醇乙基己酸酯、鳄梨甾醇、环五聚二甲基硅氧烷、鲸蜡醇、硬脂醇、鲸蜡硬脂醇、山嵛醇、鲨肝醇、月桂酸、牛油果树果脂、肉豆蔻酸、棕榈酸、硬脂酸、蜂蜡、小烛树蜡、巴西棕榈蜡、羊毛脂、地蜡、霍霍巴籽蜡、石蜡、矿脂、微晶蜡、氢化米糠蜡、氢化椰油甘油酯、肉豆蔻醇肉豆蔻酸酯、双-二甘油多酰基己二酸酯-2、牛油果树果脂和木鲁星果棕籽脂中的一种或多种。
对于油脂的用量,本领域技术人员可以根据油脂的种类进行选择,比如,在使用聚二甲基硅氧烷时可以采用例如0.2-0.9的重量份数。
香料
在本发明中,香料主要起着使护肤产品赋香的作用,具有审美的价值。
对于香料的种类,本发明选自鼠尾草油、春黄菊油、丁香油、香脂油、薄荷油、肉桂叶油、椴树花油、杜松子果油、岩兰草油、 乳香油、波斯树脂油、岩蔷薇油和杂熏衣草油中的一种或多种。
对于香料的使用剂量,本领域技术人员能够根据香料的种类进行选择。
防腐剂
在本发明中,防腐剂是指以抑制微生物在用于护肤的试剂组合中的生长和繁殖为目的而在用于护肤的试剂组合中加入的物质,用来延长用于护肤的试剂组合的保存时间。
用于护肤的试剂组合中的防腐剂有不同的分类方式。常见的用于护肤的试剂组合中的防腐剂有羟苯甲酯、羟苯丙酯、苯氧乙醇、甘油辛酸酯、乙基己基甘油、苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、辛酰羟肟酸和甘油辛酸酯中的一种或多种。
对于防腐剂的使用剂量,本领域技术人员能够根据防腐剂的种类进行选择,比如,在使用苯氧乙醇时可以采用例如0.1-2的重量份数,在使用羟苯甲酯时候可以采用例如0.1-1的重量份数。
护肤产品
除非特殊说明,本发明中的用语“第一”、“第二”、“第三”仅用于区分多个相似的要素,而不意在表示要素之间重要性或次序等方面的任何差异。
在优选的实施方式中,本发明的试剂组合包含于护肤产品中。
本发明的护肤产品根据需要可包括容器、使用说明书、使用助剂、第四试剂、第五试剂和/或用于进行性能测试所需的其他结构和/或试剂。
本发明的护肤产品中用于进行性能测试所需的其他结构包括但不限于,用于取样结构、用于进行对照结构和/或用于观察测定过程或结果的结构。
本发明的效果验证护肤品中用于进行性能测试所需的其他试剂包括但不限于,培养基、洗涤剂、显色剂和/或终止剂,以及除本发明的增稠剂、乳化剂、表面活性剂、皮肤调理剂、油脂、香料和防腐剂外的其他增稠剂、乳化剂、表面活性剂、皮肤调理剂、油脂、香料和防腐剂。
当然,本领域技术人员应该可以理解,除了上述组分以外,本发明试剂组合中还可以包含其它附属组分,比如自由基清除剂、抗氧化剂、成膜剂、稳定剂。这些附属组分根据它们在第一试剂、第二试剂和第三试剂中的溶解性而包含在第一试剂、第二试剂和/或第三试剂中。
在本发明中,药物组合物包含本发明所述的试剂组合以及药物上可接受的辅料。
在本发明中,安全有效量是指一定量的化合物或组合物,所述量足以显著诱发积极的有益效果,优选积极的皮肤组织外观或感觉有益效果,以独立或组合的形式包括本文所公开的有益效果,但所述量又足够低以避免严重的副作用,即在技术人员合理判断的范围内提供合理的效险比。
以下通过实施例更详细地说明本发明,但本发明不限于这些实施例。
实施例1
本实施例提供一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含:0.01份尿囊素和0.2份甘草酸二钾;
所述第二试剂包含:0.01份羟乙磺酸己氧苯脒、0.1份吡哆素、0.01份吡硫鎓锌和0.1份北美金缕梅提取物;
所述第三试剂包含:0.5份二裂酵母发酵产物溶胞物和0.5份蔓荆果提取物。
本实施例用于护肤的试剂组合的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.01份尿囊素、0.2份甘草酸二钾、0.5份蔓荆果提取物、0.5份二裂酵母发酵产物溶胞物、0.1份吡哆素、0.1份北美金缕梅提取物、0.01份羟乙磺酸己氧苯脒、0.01份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
实施例2
本实施例提供一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含:0.2份尿囊素和0.5份甘草酸二钾;
所述第二试剂包含:0.1份羟乙磺酸己氧苯脒、2份吡哆素、0.5份吡硫鎓锌和0.1-3份北美金缕梅提取物;
所述第三试剂包含:3份二裂酵母发酵产物溶胞物和3份蔓荆果提取物。
本实施例用于护肤的试剂组合的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.2份尿囊素、0.5份甘草酸二钾、3份蔓荆果提取物、3份二裂酵母发酵产物溶胞物、2份吡哆素、3份北美金缕梅提取物、0.1份羟乙磺酸己氧苯脒、0.5份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
实施例3
本实施例提供一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含:0.1份尿囊素和0.3份甘草酸二钾;
所述第二试剂包含:0.05份羟乙磺酸己氧苯脒、1份吡哆素、0.3份吡硫鎓锌和2份北美金缕梅提取物;
所述第三试剂包含:1.5份二裂酵母发酵产物溶胞物和1.5份蔓荆果提取物。
本实施例用于护肤的试剂组合的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.1份尿囊素、0.3份甘草酸二钾、1.5份蔓荆果提取物、1.5份二裂酵母发酵产物溶胞物、1份吡哆素、2份北美金缕梅提取物、0.05份羟乙磺酸己氧苯脒、0.3份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
实施例4
本实施例提供一种护肤产品,所述护肤产品包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含:0.01份尿囊素和0.2份甘草酸二钾;
所述第二试剂包含:0.01份羟乙磺酸己氧苯脒、0.1份吡哆素、0.01份吡硫鎓锌和0.1份北美金缕梅提取物;
所述第三试剂包含:0.5份二裂酵母发酵产物溶胞物和0.5份蔓荆果提取物。
本实施例护肤产品的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.01份尿囊素、0.2份甘草酸二钾、0.5份蔓荆果提取物、0.5份二裂酵母发酵产物溶胞物、0.1份吡哆素、0.1份北美金缕梅提取物、0.01份羟乙磺酸己氧苯脒、0.01份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
实施例5
本实施例提供一种护肤产品,所述护肤产品包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含:0.2份尿囊素和0.5份甘草酸二钾;
所述第二试剂包含:0.1份羟乙磺酸己氧苯脒、2份吡哆素、0.5份吡硫鎓锌和0.1-3份北美金缕梅提取物;
所述第三试剂包含:3份二裂酵母发酵产物溶胞物和3份蔓荆果提取物。
本实施例护肤产品的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.2份尿囊素、0.5份甘草酸二钾、3份蔓荆果提取物、3份二裂酵母发酵产物溶胞物、2份吡哆素、3份北美金缕梅提取物、0.1份羟乙磺酸己氧苯脒、0.5份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
实施例6
本实施例提供一种护肤产品,所述护肤产品包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含:0.1份尿囊素和0.3份甘草酸二钾;
所述第二试剂包含:0.05份羟乙磺酸己氧苯脒、1份吡哆素、0.3份吡硫鎓锌和2份北美金缕梅提取物;
所述第三试剂包含:1.5份二裂酵母发酵产物溶胞物和1.5份蔓荆果提取物。
本实施例护肤产品的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.1份尿囊素、0.3份甘草酸二钾、1.5份蔓荆果提取物、1.5份二裂酵母发酵产物溶胞物、1份吡哆素、2份北美金缕梅提取物、0.05份羟乙磺酸己氧苯脒、0.3份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
对比例1
为了进一步说明本发明的有益效果,提供一种祛痘精华液,该祛痘精华液是采用专利CN108969429A中的方法制备的。
对比例2
为了进一步说明本发明的有益效果,提供对比例2,和实施例3相比,该对比例2的区别在于:将本发明的甘草酸二钾替换为18β-甘草次酸。
对比例2用于护肤的试剂组合的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.1份尿囊素、0.3份18β-甘草次酸、1.5份蔓荆果提取物、1.5份二裂酵母发酵产物溶胞物、1份吡哆素、2份北美金缕梅提取物、0.05份羟乙磺酸己氧苯脒、0.3份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
对比例3
为了进一步说明本发明的有益效果,提供对比例3,和实施例6相比,该对比例3的区别在于:将本发明的吡哆素替换为盐酸吡哆素。
对比例2护肤产品的制备方法如下:
步骤一:将5份多元醇、3份甘油聚醚-26、0.1份透明质酸钠、0.1份黄原胶、0.5份鲸蜡硬脂醇橄榄油酸酯混合加热至80℃,搅拌使其溶解;
步骤二:将0.2份聚二甲基硅氧烷和0.1份生育酚加入步骤一的物料中,混合加热至80℃,搅拌使其溶解;
步骤三:将步骤二得到的物料在容器中混合乳化,当温度降为45℃时,加入0.08份三乙醇胺缓冲液调节pH,加入0.1份尿囊素、0.3份甘草酸二钾、1.5份蔓荆果提取物、1.5份二裂酵母发酵产物溶胞物、1份盐酸吡哆素、2份北美金缕梅提取物、0.05份羟乙磺酸己氧苯脒、0.3份吡硫鎓锌和0.01份乙二胺四乙酸二钠,搅拌均匀即可。
实验1:效果验证
选择180例面部有痤疮的志愿者,其中年龄分布为15-30岁,随机分成A、B、C、D、E、F、G、H、I九组,每组20人。其中,
A组敷用由本发明上述实施例1制备的用于护肤的试剂组合,
B组敷用由本发明上述实施例2制备的用于护肤的试剂组合,
C组敷用由本发明上述实施例3制备的用于护肤的试剂组合,
D组敷用由本发明上述实施例4制备的护肤产品,
E组敷用由本发明上述实施例5制备的护肤产品,
F组敷用由本发明上述实施例6制备的护肤产品,
G组敷用由对比例1制备的祛痘精华液,
H组敷用由对比例2制备的用于护肤的试剂组合,
I组敷用由对比例3制备的护肤产品,
每日早晚各使用一次,10天后进行对比。评价分数为10分制,评分结果如下表1所示。
表1
评价项目 | 控油祛痘效果 | 抗炎效果 | 皮肤光滑、修复效果 | 祛痘时间效果 |
实施例1 | 8.5 | 8.7 | 8.2 | 8.1 |
实施例2 | 8.1 | 8.1 | 8.5 | 8.5 |
实施例3 | 9.1 | 9.5 | 9.3 | 9.8 |
实施例4 | 8.3 | 8.2 | 8.5 | 8.6 |
实施例5 | 8.4 | 8.7 | 8.3 | 8.2 |
实施例6 | 9.4 | 9.2 | 9.1 | 9.7 |
对比例1 | 4.2 | 5.5 | 5.9 | 5.2 |
对比例2 | 4.1 | 5.2 | 5.5 | 4.7 |
对比例3 | 4.1 | 5.1 | 5.3 | 4.9 |
由以上结果可知:
使用本发明提供的用于护肤的试剂组合,能够达到很好的控油祛痘效果、抗炎效果、修复效果,其效果均可达8分以上,而且祛痘所用时间更短。通过筛选本发明用于护肤的试剂组合中组分的种类或调整本发明用于护肤的试剂组合中组分的重量份数,能够显著控油祛痘、抗炎和修复肌肤,且皮肤变得更加光滑,其结果均达到9分以上,而且显著缩短了祛痘所需时间,说明本发明提供的用于护肤的试剂组合不仅能够解决祛痘问题,同时具有修复皮肤损伤的作用,具有较好的肌肤修复效果。而未使用本发明的用于护肤的试剂组合,其控油祛痘效果、抗炎效果和修复效果的分数均在6分以下,而且祛痘时间更长。
同样的,使用本发明提供的护肤产品,能够达到很好的控油祛痘效果、抗炎效果、修复效果,其效果均可达8分以上,而且祛痘所用时间更短。通过筛选本发明护肤产品中组分的种类或调整本发明护肤产品组分的重量份数,能够显著控油祛痘、抗炎和修复肌肤,且皮肤变得更加光滑,其结果均达到9分以上,而且显著缩短了祛痘所需时间,说明本发明提供的护肤产品不仅能够解决祛痘问题,同时具有修复皮肤损伤的作用,具有较好的肌肤修复效果。
应该理解到披露的本发明不仅仅限于描述的特定的方法、方案和物质,因为这些均可变化。还应理解这里所用的术语仅仅是为了描述特定的实施方式方案的目的,而不是意欲限制本发明的范围,本发明的范围仅受限于所附的权利要求。
本领域的技术人员还将认识到,或者能够确认使用不超过常规实验,在本文中所述的本发明的具体的实施方案的许多等价物。这些等价物也包含在所附的权利要求中。
Claims (10)
1.一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,
所述第一试剂包含尿囊素和甘草酸二钾;
所述第二试剂包含羟乙磺酸己氧苯脒、吡哆素、吡硫鎓锌和北美金缕梅提取物;
所述第三试剂包含二裂酵母发酵产物溶胞物和蔓荆果提取物。
2.根据权利要求1所述的试剂组合,其中,按照重量份数,
所述第一试剂包含0.01-0.2份尿囊素和0.2-0.5份甘草酸二钾。
3.根据权利要求1所述的试剂组合,其中,按照重量份数,
所述第二试剂包含0.01-0.1份羟乙磺酸己氧苯脒、0.1-2份吡哆素、0.01-0.5份吡硫鎓锌和0.1-3份北美金缕梅提取物。
4.根据权利要求1所述的试剂组合,其中,按照重量份数,
所述第三试剂包含0.5-3份二裂酵母发酵产物溶胞物和0.5-3份蔓荆果提取物。
5.一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含0.01-0.2份尿囊素和0.2-0.5份甘草酸二钾;
所述第二试剂包含0.01-0.1份羟乙磺酸己氧苯脒、0.1-2份吡哆素、0.01-0.5份吡硫鎓锌和0.1-3份北美金缕梅提取物;
所述第三试剂包含0.5-3份二裂酵母发酵产物溶胞物和0.5-3份蔓荆果提取物。
6.一种用于护肤的试剂组合,所述试剂组合包含第一试剂、第二试剂和第三试剂,其中,按照重量份数,
所述第一试剂包含0.1份尿囊素和0.3份甘草酸二钾;
所述第二试剂包含0.05份羟乙磺酸己氧苯脒、1份吡哆素、0.3份吡硫鎓锌和2份北美金缕梅提取物;
所述第三试剂包含1.5份二裂酵母发酵产物溶胞物和1.5份蔓荆果提取物。
7.根据权利要求1所述的试剂组合,所述第一试剂、第二试剂和/或第三试剂还包含增稠剂、乳化剂、表面活性剂、皮肤调理剂、pH调节剂、螯合剂、油脂、香料和防腐剂中的一种或多种,其中,
所述增稠剂选自卡波姆、黄原胶、角叉菜胶钠、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素和羟丙基甲基纤维素中的一种或多种;
所述乳化剂选自鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、聚山梨醇酯-85、甲基葡糖倍半硬脂酸酯、硬脂醇聚醚-2、硬脂醇聚醚-21、鲸蜡硬脂基葡糖苷、鲸蜡醇聚醚-20、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖二硬脂酸酯和蔗糖多硬脂酸酯中的一种或多种;
所述表面活性剂选自月桂酸聚乙二醇甘油酯、阴离子烷基多苷、聚甘油-3甲基葡糖二硬脂酸酯、鲸蜡硬脂醇和鲸蜡硬脂基葡糖苷和十二烷基二甲基甜菜碱中的一种或几种;
所述皮肤调理剂选自多元醇、曲酸、抗坏血酸、抗坏血酸葡糖苷、透明质酸钠、熊果苷、传明酸、烟酰胺、植物甾醇、苯乙基间苯二酚、姜黄根提取物、白桦树皮提取物、神经酰胺2、神经酰胺3、泛醇、乙酰植物鞘氨醇、甘草酸二钾、羧甲基脱乙酰壳多糖、海藻糖、甘油、羟乙基脲、丙二醇、β-葡聚糖、甘油聚醚-26、尿囊素、乙醇、白藜芦醇、花榈木树皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物、甘油聚丙烯酸酯、温泉水、银耳子实体提取物、泛醌、胆甾醇、胆甾醇硬脂酸酯、抗坏血酸二棕榈酸酯、生育酚、生育酚乙酸酯、红没药醇、抗坏血酸四异棕榈酸酯、吡哆素二辛酸酯、吡哆素二棕榈酸酯、视黄醇棕榈酸酯和植物甾醇澳洲坚果油酸酯中的一种或多种;
所述pH值调节剂选自磷酸缓冲液、柠檬酸缓冲液、醋酸缓冲液、三乙醇胺缓冲液、三羟甲基氨基甲烷缓冲液和羟乙基哌嗪乙硫磺酸缓冲液中的一种或多种;
所述螯合剂选自醋酸钙、氯化钙、乙二胺四乙酸二钠、酸式焦磷酸钠、硫酸钠钙和氧化硬脂精中的一种或多种;
所述油脂选自油橄榄果油、澳洲坚果油、甜杏仁油、矿油、葡萄籽油、鳄梨油、玉米油、芝麻油、大豆油、花生油、白池花籽油、红花籽油、狗牙蔷薇果油、茴香油、刺阿干树仁油、霍霍巴籽油、向日葵籽油、毛瑞榈果油、角鲨烷、棕榈酸乙基己酯、肉豆蔻酸异丙酯、氢化聚异丁烯、异十六烷、霍霍巴酯、聚二甲基硅氧烷、二异硬脂醇苹果酸酯、异十二烷、碳酸二乙基己酯、碳酸二辛酯、月桂酰肌氨酸异丙酯、异壬酸异壬酯、氢化聚癸烯、鲸蜡醇乙基己酸酯、双-二乙氧基二甘醇环己烷1,4-二羧酸酯、油醇芥酸酯、辛基十二醇肉豆蔻酸酯、辛基十二醇、聚二甲基硅氧烷、辛基聚甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、鲸蜡硬脂醇乙基己酸酯、鳄梨甾醇、环五聚二甲基硅氧烷、鲸蜡醇、硬脂醇、鲸蜡硬脂醇、山嵛醇、鲨肝醇、月桂酸、牛油果树果脂、肉豆蔻酸、棕榈酸、硬脂酸、蜂蜡、小烛树蜡、巴西棕榈蜡、羊毛脂、地蜡、霍霍巴籽蜡、石蜡、矿脂、微晶蜡、氢化米糠蜡、氢化椰油甘油酯、肉豆蔻醇肉豆蔻酸酯、双-二甘油多酰基己二酸酯-2、牛油果树果脂和木鲁星果棕籽脂中的一种或多种;
所述香料选自鼠尾草油、春黄菊油、丁香油、香脂油、薄荷油、肉桂叶油、椴树花油、杜松子果油、岩兰草油、 乳香油、波斯树脂油、岩蔷薇油和杂熏衣草油中的一种或多种;
所述防腐剂选自羟苯甲酯、羟苯丙酯、苯氧乙醇、甘油辛酸酯、乙基己基甘油、苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、辛酰羟肟酸和甘油辛酸酯中的一种或多种。
8.一种护肤产品,其中,所述护肤产品包含权利要求1-7任一项所述的试剂组合。
9.一种药物组合物,其中,所述药物组合物包含安全有效量的如权利要求1-7任一项所述的试剂组合。
10.权利要求1-7任一项所述的试剂组合在制备护肤产品或药物组合物中的用途。
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