CN113577144A - A composition with effect in improving respiratory system inflammation and its preparation method - Google Patents
A composition with effect in improving respiratory system inflammation and its preparation method Download PDFInfo
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- CN113577144A CN113577144A CN202110955644.6A CN202110955644A CN113577144A CN 113577144 A CN113577144 A CN 113577144A CN 202110955644 A CN202110955644 A CN 202110955644A CN 113577144 A CN113577144 A CN 113577144A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Microbiology (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition with the function of improving respiratory inflammation, which is an inhalation preparation prepared by taking water or organic solvent extracts of any two or three of Chinese pulsatilla root, honeysuckle flower and baical skullcap root as active ingredients and adding auxiliary materials acceptable in medicines/foods. The composition can obviously reduce and slowly desorb the throat inflammation of smokers, plays a role in obvious synergy, can reduce the harm of smoking to the bodies of the smokers, and has practical popularization and application values.
Description
Technical Field
The invention belongs to the field of electronic cigarettes, and particularly relates to a composition with a function of improving respiratory system inflammation and a preparation method thereof.
Background
With the development of the times, the electronic cigarette becomes one of the well-known products, can simulate the appearance and the smoke taste of the cigarette, has a remarkably reduced hazard index compared with the cigarette, and as a healthy substitute product, the electronic cigarette continuously climbs in sales and rapidly expands in market scale.
The tobacco tar of the electronic cigarette is the core part of the electronic cigarette, the traditional tobacco tar is generally formed by mixing nicotine, propylene glycol, glycerin, essence and the like, and because the tobacco tar of the electronic cigarette can avoid harmful substances such as carbon monoxide and tar generated by combustion, but part of the electronic cigarette is a real simulated cigarette taste, and the tobacco leaf extract is added into the electronic cigarette, certain harm is still generated.
The electronic cigarette tobacco tar is prepared from basic raw materials and different additives, such as cooling agents, throat wetting agents, flavoring agents, 2-acetylpyrazine, sweetening agents and the like, and the additives are used for improving the taste or mouthfeel.
Disclosure of Invention
The invention aims to provide a composition with the effect of improving respiratory inflammation, which is characterized in that: the inhalation preparation is prepared by taking water or organic solvent extracts of any two or three of Chinese pulsatilla root, honeysuckle flower and baical skullcap root as active ingredients and adding auxiliary materials acceptable in medicines/foods.
Further, the feed additive is prepared from the following raw materials in parts by weight:
20-40 parts of pulsatilla chinensis extract and 10-20 parts of scutellaria baicalensis extract.
Furthermore, the medicine is prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract and 15 parts of scutellaria baicalensis extract.
Further, the feed additive is prepared from the following raw materials in parts by weight:
20-40 parts of Chinese pulsatilla root extract and 10-20 parts of honeysuckle extract.
Further, the feed additive is prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract and 15 parts of honeysuckle extract.
Further, the feed additive is prepared from the following raw materials in parts by weight:
10-20 parts of honeysuckle extract and 10-20 parts of scutellaria extract.
Furthermore, the medicine is prepared from the following raw materials in parts by weight:
15 parts of honeysuckle extract and 15 parts of scutellaria extract.
Further, the feed additive is prepared from the following raw materials in parts by weight:
20-40 parts of Chinese pulsatilla root extract, 3-7 parts of honeysuckle extract and 7-13 parts of scutellaria baicalensis extract.
Furthermore, the medicine is prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract, 5 parts of honeysuckle extract and 10 parts of scutellaria baicalensis extract.
Further, the Chinese pulsatilla root extract is a Chinese pulsatilla root alcohol extract, the honeysuckle extract is a honeysuckle aqueous extract, and the scutellaria baicalensis extract is a scutellaria baicalensis aqueous extract.
Furthermore, the inhalant is inhalant powder, aerosol, spray or tobacco tar additive.
Further, the tobacco tar additive is an inhalant prepared from the following raw materials in parts by weight:
20-40 parts of Chinese pulsatilla root extract, 3-7 parts of honeysuckle extract, 7-13 parts of scutellaria baicalensis extract, 50-70 parts of propylene glycol, 10-30 parts of glycerol and 1-3 parts of spice.
Further, the tobacco tar additive is an inhalant prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract, 5 parts of honeysuckle extract, 10 parts of scutellaria baicalensis extract, 60 parts of propylene glycol, 20 parts of glycerol and 2 parts of spice.
The invention also provides a method for preparing the composition, which is characterized by comprising the following steps: it comprises the following steps:
1) weighing the raw materials according to the proportion;
2) mixing radix Pulsatillae extract, flos Lonicerae extract and Scutellariae radix extract, dissolving with 30% ethanol, and stirring to obtain Chinese medicinal extract mixture; mixing propylene glycol and glycerol at 30 deg.C under stirring to obtain base solution;
3) adding the mixture of the spice and the Chinese medicinal extract obtained in the step 2) into the base solution obtained in the step 2), uniformly stirring at 30 ℃, and cooling to 25 ℃ to obtain the Chinese medicinal composition.
The invention also provides tobacco tar which comprises the composition.
The invention finally provides application of the tobacco tar in preparation of tobacco or electronic cigarettes with the function of clearing heat from throat.
The Chinese pulsatilla root in the composition is bitter and cold in nature; entering stomach and large intestine meridians, has the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery, and is used for treating heat-toxin bloody dysentery, pruritus vulvae and leukorrhagia. The chemical components of the Chinese pulsatilla root mainly comprise triterpenoid saponin, triterpenic acid, lignan, daucosterol, glycoprotein and the like, and the Chinese pulsatilla root has pharmacological activities of resisting inflammation, oxidation, tumors, schistosomiasis and the like, can enhance the immune function, and has the effects of clearing heat and removing toxicity by using the Chinese pulsatilla root.
Honeysuckle flower is sweet in nature and taste and cold; it enters lung, heart and stomach meridians. Has the effects of clearing away heat and toxic materials, and dispelling pathogenic wind and heat, and can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, toxic heat, dysentery with bloody stool, wind-heat type common cold, epidemic febrile disease, and fever. The effective components in flos Lonicerae mainly comprise organic acids, flavonoids, volatile oils and triterpenoid saponins, and have various physiological activities such as antibacterial, antiinflammatory, antivirus, fever relieving and immunity regulating effects. Modern pharmacological studies show that the honeysuckle can be used for treating pertussis, infantile pneumonia, paranasal sinusitis and the like.
Baical skullcap root, radix Scutellariae is bitter and cold in nature; enters lung, gallbladder, spleen, large intestine and small intestine meridians, and has effects of clearing heat and eliminating dampness, purging fire and removing toxic substance, stopping bleeding, and preventing miscarriage. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion. The scutellaria baicalensis has various and very complex chemical components, mainly contains different components such as flavonoid, phenol glycoside, alcohol glycoside, volatile oil, trace elements, amino acid and the like, and has better treatment effect on inflammation, bacterial infection, oxidation, allergy, tumor, cardiovascular disease, pain, liver disease and the like.
The test proves that: the composition provided by the invention combines extracts of the Chinese pulsatilla root, the honeysuckle and the scutellaria baicalensis to be used for the electronic cigarette oil, can obviously reduce and relieve the throat inflammation of smokers, plays an obvious synergistic effect, reduces the harm of smoking to the body of the smokers, and has practical popularization and application values.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
Example 1 preparation of the extract of the present invention
Chinese pulsatilla root extract: reflux-extracting radix Pulsatillae with 10 times of v/w, ml/g 70% ethanol for 3 times, each for 2 hr, mixing extractive solutions, filtering, concentrating the filtrate to relative density of 1.05-1.10 at 60 deg.C, dissolving the filtrate with water, passing through AB-8 resin, eluting with 50% ethanol, concentrating the eluate under reduced pressure to obtain soft extract, and oven drying the soft extract;
and (3) honeysuckle extract: decocting flos Lonicerae with 10 times of v/w water, ml/g for 2 times, each for 1.5 hr, mixing decoctions, filtering, concentrating the filtrate under reduced pressure to obtain fluid extract with relative density of 1.15-1.20(60 deg.C), adding ethanol to make ethanol content reach 85%, standing for 24 hr, filtering, adding ethanol to residue to make ethanol content reach 85%, standing for 24 hr, filtering, mixing the filtrates, recovering ethanol, concentrating under reduced pressure to relative density of 1.20-1.24(60 deg.C) to obtain flos Lonicerae extract;
and (3) extracting scutellaria baicalensis: taking scutellaria baicalensis, adding 10 times of v/w of water and decocting with ml/g of water for 2 times, each time for 1.5 hours, combining decoction liquids, concentrating to 60 ℃ relative density of 1.10-1.20, adjusting pH value to 1.0-2.0 by hydrochloric acid, keeping the temperature at 80 ℃, standing for 24 hours, filtering, adding 10 times of v/w of water and ml/g of precipitate, stirring uniformly, adjusting pH value to 7.0 by 40% sodium hydroxide solution, adding equivalent ethanol, stirring to dissolve, filtering, adjusting pH value of filtrate to 1.0-2.0 by hydrochloric acid, keeping the temperature at 60 ℃, standing for 24 hours, filtering, washing precipitate to 7.0 by using appropriate water and ethanol in sequence, volatilizing the ethanol completely, and drying under reduced pressure to obtain the traditional Chinese medicine.
Example 2 preparation of tobacco tar according to the invention
1) Dissolving 3g of the pulsatilla chinensis extract prepared in the example 1 and 1.5g of the honeysuckle extract in 4 times of 30% ethanol (v/w, ml/g), mixing and stirring uniformly to obtain a Chinese medicinal extract mixture solution;
2) stirring and mixing 6g of propylene glycol and 2g of glycerol uniformly at 30 ℃ to obtain a base solution;
3) and (3) pouring the solution of the mixture of the traditional Chinese medicine extracts and 0.2g of mint essence into the base solution, keeping the temperature at 30 ℃, uniformly stirring, and cooling to room temperature to obtain the electronic cigarette oil.
EXAMPLE 3 preparation of tobacco tar according to the invention
1) Dissolving 3g of the pulsatilla chinensis extract prepared in example 1 and 1.5g of the scutellaria baicalensis extract in 4 times of 30% ethanol (v/w, ml/g), mixing and stirring uniformly to obtain a Chinese medicinal extraction mixture solution;
2) stirring and mixing 6g of propylene glycol and 2g of glycerol uniformly at 30 ℃ to obtain a base solution;
3) and (3) pouring the solution of the mixture of the traditional Chinese medicine extracts and 0.2g of mint essence into the base solution, keeping the temperature at 30 ℃, uniformly stirring, and cooling to room temperature to obtain the electronic cigarette oil.
EXAMPLE 4 preparation of tobacco tar according to the invention
1) 2.25g of the honeysuckle extract prepared in the embodiment 1 and 2.25g of the scutellaria baicalensis extract are taken, and the two extracts are dissolved and mixed by 30 percent ethanol with 4 times of volume, volume/w and ml/g and are stirred uniformly;
2) stirring and mixing 6g of propylene glycol and 2g of glycerol uniformly at 30 ℃ to obtain a base solution;
3) and (3) pouring the solution of the mixture of the traditional Chinese medicine extracts and 0.2g of mint essence into the base liquid according to the proportion, keeping the temperature at 30 ℃, uniformly stirring, and cooling to room temperature to obtain the electronic cigarette oil.
EXAMPLE 5 preparation of tobacco tar according to the invention
1) Dissolving 3g of the pulsatilla chinensis extract prepared in the example 1, 0.5g of the honeysuckle extract and 1g of the scutellaria baicalensis extract in 4 times of 30% ethanol (v/w, ml/g), mixing and stirring uniformly;
2) stirring and mixing 6g of propylene glycol and 2g of glycerol uniformly at 30 ℃ to obtain a base solution;
3) and (3) pouring the solution of the mixture of the traditional Chinese medicine extracts and 0.2g of mint essence into the base solution, keeping the temperature at 30 ℃, uniformly stirring, and cooling to room temperature to obtain the electronic cigarette oil.
The beneficial effects of the invention are illustrated by way of test examples below:
test example 1 Effect of electronic cigarette oil on cough and asthma caused by throat inflammation
1 test object
100 cough and asthma people with more than three years of tobacco age and obvious throat inflammation are selected in the test and divided into 4 groups of 25 people.
2 test sample
The electronic cigarette oils prepared in examples 2 to 5 of the present invention.
3 method of administration
Each person consumes 5ml of tobacco tar with electronic cigarette every day for 3 days.
4 observation index
Refer to the standard for determining therapeutic effect of cough and asthma in "standard for therapeutic effect of diagnosis of traditional Chinese medicine". And (3) curing: the clinical signs of cough and asthma of the patient are completely disappeared, and the patient does not relapse after continuously observing for more than 2 weeks; improvement: the times of cough and asthma and the amount of phlegm are obviously reduced, and the degree of cough and asthma is obviously reduced; and (4) invalidation: cough and asthma, etc. have no obvious improvement or even aggravation of clinical signs. The total effective rate is the combination of cure and improvement. SPSS 23.0 statistical software was used to analyze experimental data and to measure data "
"indicates, column t test, count data column χ2And (6) checking. P < 0.05 is statistically significant for the differences.
5 results of the test
The specific results are shown in Table 1, and the results show that the comparative differences of the treatment effects among the groups have statistical significance (P is less than 0.05). The treatment effect of the electronic cigarette oil prepared from the extracts of the pulsatilla chinensis, the honeysuckle and the scutellaria baicalensis in the example 5 is obviously better than that in the examples 2-4, namely the combined treatment effect of the three medicines is better than that of the two medicines.
TABLE 1 comparison of therapeutic Effect
| Group of | Number of examples | Cure of disease | Improvement of life | Invalidation | Total effective rate (%) |
| Example 2 | 25 | 13 | 6 | 6 | 76.0 |
| Example 3 | 25 | 11 | 9 | 5 | 80.0 |
| Example 4 | 25 | 6 | 8 | 11 | 56.0 |
| Example 5 | 25 | 18 | 5 | 2 | 92.0 |
In conclusion, the electronic cigarette liquid prepared by combining the extracts of the Chinese pulsatilla root, the honeysuckle and the scutellaria baicalensis can obviously reduce and relieve the throat inflammation of smokers, plays an obvious synergistic effect, can reduce the damage of smoking to the bodies of the smokers, and has practical popularization and application values.
Claims (16)
1. A composition having an effect of ameliorating respiratory inflammation, comprising: the inhalation preparation is prepared by taking water or organic solvent extracts of any two or three of Chinese pulsatilla root, honeysuckle flower and baical skullcap root as active ingredients and adding auxiliary materials acceptable in medicines/foods.
2. The composition of claim 1, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
20-40 parts of pulsatilla chinensis extract and 10-20 parts of scutellaria baicalensis extract.
3. The composition of claim 2, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract and 15 parts of scutellaria baicalensis extract.
4. The composition of claim 1, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
20-40 parts of Chinese pulsatilla root extract and 10-20 parts of honeysuckle extract.
5. The composition of claim 4, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract and 15 parts of honeysuckle extract.
6. The composition of claim 1, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
10-20 parts of honeysuckle extract and 10-20 parts of scutellaria extract.
7. The composition of claim 6, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
15 parts of honeysuckle extract and 15 parts of scutellaria extract.
8. The composition of claim 1, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
20-40 parts of Chinese pulsatilla root extract, 3-7 parts of honeysuckle extract and 7-13 parts of scutellaria baicalensis extract.
9. The composition of claim 8, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract, 5 parts of honeysuckle extract and 10 parts of scutellaria baicalensis extract.
10. The composition according to any one of claims 1 to 9, characterized in that: the Chinese pulsatilla root extract is a Chinese pulsatilla root alcohol extract, the honeysuckle extract is a honeysuckle aqueous extract, and the scutellaria baicalensis extract is a scutellaria baicalensis aqueous extract.
11. The composition according to any of claims 1-9, characterized in that: the inhalant is inhalant powder, aerosol, spray or tobacco tar additive.
12. The composition of claim 11, wherein: the tobacco tar additive is an inhalant prepared from the following raw materials in parts by weight:
20-40 parts of Chinese pulsatilla root extract, 3-7 parts of honeysuckle extract, 7-13 parts of scutellaria baicalensis extract, 50-70 parts of propylene glycol, 10-30 parts of glycerol and 1-3 parts of spice.
13. The composition of claim 12, wherein: the tobacco tar additive is an inhalant prepared from the following raw materials in parts by weight:
30 parts of Chinese pulsatilla root extract, 5 parts of honeysuckle extract, 10 parts of scutellaria baicalensis extract, 60 parts of propylene glycol, 20 parts of glycerol and 2 parts of spice.
14. A process for preparing a composition according to any one of claims 11 to 13, characterized in that: it comprises the following steps:
1) weighing the raw materials according to the proportion;
2) mixing radix Pulsatillae extract, flos Lonicerae extract and Scutellariae radix extract, dissolving with 30% ethanol, and stirring to obtain Chinese medicinal extract mixture; mixing propylene glycol and glycerol at 30 deg.C under stirring to obtain base solution;
3) adding the mixture of the spice and the Chinese medicinal extract obtained in the step 2) into the base solution obtained in the step 2), uniformly stirring at 30 ℃, and cooling to 25 ℃ to obtain the Chinese medicinal composition.
15. A tobacco tar comprising the composition of any one of claims 1-13.
16. Use of the tobacco tar of claim 15 in the preparation of tobacco or electronic cigarettes with throat clearing function.
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| CN107773581A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of silver yellow Neulized inhalation pharmaceutical solutions and preparation method thereof |
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Application publication date: 20211102 |