CN113576981A - Multi-effect natural no-clean hand sanitizer and preparation method thereof - Google Patents

Abstract

The invention discloses a multi-effect natural skin-care type no-wash hand sanitizer, which relates to the technical field of cleaning and care and is prepared from the following components: water, a gleditsia sinensis extract, a sophora flavescens root extract, an aloe barbadensis leaf extract, a sanguisorba root extract, a citrus peel extract, a lysimachia christinae root bark extract, a biota orientalis extract, tamarind seed polysaccharide, 1, 2-pentanediol, trehalose, sodium cocoyl malate, p-hydroxyacetophenone, 1, 2-hexanediol, and aminomethyl propanol. The skin-care product has a mild formula, contains various plant extracts such as a gleditsia sinensis extract, a picrasma quassioides root extract, an aloe barbadensis leaf extract, a sanguisorba officinalis root extract, a citrus peel extract and a loosestrife root bark extract, and effectively cleans and moisturizes the skin. The hand-washing-free hand-washing machine is convenient for a user to clean hands anytime and anywhere, and is fresh and cool without being sticky. When in use, a proper amount of the product is applied to the palm of the hand, and the hands are kneaded to be dry and comfortable without washing.

Description

Multi-effect natural no-clean hand sanitizer and preparation method thereof

Technical Field

The invention relates to the technical field of chemical industry, in particular to a multi-effect natural no-clean hand sanitizer and a preparation method thereof.

Background

The hand determined by the human body structure has good flexibility, so that the hands have a lot of situations in daily life, a great deal of opportunities are objectively provided for the hands to contact bacteria, viruses and stains outside, the hands are easily polluted in the process of using the hands, and if people do not pay attention to washing the hands, a great amount of foreign substances which can further influence the human health are left on the hands, so that daily hand cleaning is very necessary. In addition, as the potential harmful agents in the environment increase, such as infectious virus particles. And the scenes that the availability of clean water resources is possibly limited are increased, higher requirements are put forward for the hand washing process, and the no-clean hand sanitizer can well meet the use requirements of the situations. Most of the hand washing solutions mainly prepared from petrochemical raw materials can irritate the skin of hands when being frequently used, are not suitable for people with skin allergy, easily cause the skin dryness and other conditions of users, and cause the skin itch and other symptoms of serious people. Therefore, in order to solve the above problems, it is necessary to develop a natural skin-care type no-clean hand sanitizer which can clean and sterilize skin.

Disclosure of Invention

The invention aims to provide a multi-effect natural no-clean hand sanitizer and a preparation method thereof, and aims to solve the problems in the background technology.

In order to realize the purpose, the invention provides the following technical scheme:

a multi-effect natural no-clean hand sanitizer comprises a first mixture, a second mixture, a third component and a fourth component; the first mixture comprises water, trehalose, sodium cocoyl malate, p-hydroxyacetophenone, and 1, 2-hexanediol; said second mixture comprises water, Gleditsia sinensis extract, radix Sophorae Flavescentis extract, Aloe barbadensis leaf extract, radix Sanguisorbae extract, Mandarin orange pericarp extract, Pseudolarix loosestrife root bark extract, and Platycladus orientalis extract; the third component is acid soybean seed polysaccharide; the fourth component is aminomethyl propanol.

As a further technical scheme of the invention: the composition comprises the following components in percentage by mass: 70-90% of the first mixture and 10-30% of the second mixture.

As a further technical scheme of the invention: the first mixture comprises the following components in percentage by mass: 60-95% of water, 1-10% of trehalose, 1-10% of sodium cocoyl malate, 1-10% of p-hydroxyacetophenone and 1-10% of 1, 2-hexanediol.

As a further technical scheme of the invention: the second mixture comprises the following components in percentage by mass: 50-95% of water, 1-10% of gleditsia sinensis extract, 1-10% of sophora flavescens root extract, 1-10% of aloe barbadensis leaf extract, 1-10% of sanguisorba officinalis root extract, 1-10% of citrus peel extract, 1-10% of loosestrife root bark extract and 1-10% of platycladus orientalis extract.

A preparation method of a multi-effect natural no-clean hand sanitizer comprises the following steps:

step one, adding water, trehalose, sodium cocoyl malate, p-hydroxyacetophenone and 1, 2-hexanediol into a water kettle, heating to 55-65 ℃, and stirring for 10-20 minutes to dissolve and transparent;

step two, adding water, a gleditsia sinensis extract, a picrasma quassioides root extract, an aloe barbadensis leaf extract, a sanguisorba officinalis root extract, a citrus peel extract, a loosestrife root bark extract, a platycladus orientalis extract and tamarind seed polysaccharide in sequence, stirring to dissolve and transparent, and cooling to below 45 ℃;

step three, adding aminomethyl propanol to adjust the pH value of the system;

step four, sampling and detecting the semi-finished product;

and fifthly, filtering and discharging the materials by a 300-mesh filter screen after the materials are detected to be qualified, and filling.

Compared with the prior art, the invention has the beneficial effects that: the skin-care product has a mild formula, contains various plant extracts such as a gleditsia sinensis extract, a picrasma quassioides root extract, an aloe barbadensis leaf extract, a sanguisorba officinalis root extract, a citrus peel extract and a loosestrife root bark extract, and effectively cleans and moisturizes the skin. The hand-washing-free hand-washing machine is convenient for a user to clean hands anytime and anywhere, and is fresh and cool without being sticky. When in use, a proper amount of the product is applied to the palm of the hand, and the hands are kneaded to be dry and comfortable without washing.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1: a multi-effect natural no-clean hand sanitizer comprises a first mixture, a second mixture, a third component and a fourth component; the first mixture comprises water, trehalose, sodium cocoyl malate, p-hydroxyacetophenone, and 1, 2-hexanediol; said second mixture comprises water, Gleditsia sinensis extract, radix Sophorae Flavescentis extract, Aloe barbadensis leaf extract, radix Sanguisorbae extract, Mandarin orange pericarp extract, Pseudolarix loosestrife root bark extract, and Platycladus orientalis extract; the third component is acid soybean seed polysaccharide; the fourth component is aminomethyl propanol.

Wherein the composition comprises the following components in percentage by mass: 70-90% of the first mixture and 10-30% of the second mixture. The natural skin care hand sanitizer composition comprises the following components in percentage by mass in the first mixture: 60-95% of water, 1-10% of trehalose, 1-10% of sodium cocoyl malate, 1-10% of p-hydroxyacetophenone and 1-10% of 1, 2-hexanediol. The natural skin care hand sanitizer composition comprises the following components in percentage by mass in the second mixture: 50-95% of water, 1-10% of gleditsia sinensis extract, 1-10% of sophora flavescens root extract, 1-10% of aloe barbadensis leaf extract, 1-10% of sanguisorba officinalis root extract, 1-10% of citrus peel extract, 1-10% of loosestrife root bark extract and 1-10% of platycladus orientalis extract.

The main active ingredients in the composition are as follows: trehalose has strong moisturizing effect and physiological effects in various aspects such as sun protection, ultraviolet protection and the like.

The natural active ingredients in the gleditsia sinensis extract are neutral, have rich foam, are easy to biodegrade, have no stimulation to skin, have better surface activity and washing and decontaminating capacity, and are rare natural and safe cleaning agents. The extract of the root of the Sophora flavescens is mainly from the root of the Sophora flavescens, and the active ingredient of the extract is mainly matrine, which is a traditional herbal medicine. It can be used for treating eczema and dermatitis, and has antibacterial and anti-inflammatory effects; has effects in promoting collagen production, promoting fibroblast proliferation, and resisting skin aging; meanwhile, the product has the efficacy of moisturizing. The Aloe Barbadensis leaf extract has various biological activities, and is important additive in cosmetic. It has effects of promoting fibrin growth, inhibiting elastin, synthesizing collagen, and scavenging free radicals, and has good skin-activating and antiaging effects; promoting cholesterol synthesis, changing sebum composition, reducing gloss, and improving skin softness; it also has antibacterial, antiinflammatory and moisture keeping effects. The sanguisorba officinalis root extract has effective antiallergic and antioxidant effects, and strong oxygen free radical scavenging effect. The citrus peel extract is a volatile aromatic oil and can be used as a flavor. Has strong broad-spectrum antibacterial property and good inhibition effect on acne-causing bacteria; has effects in scavenging free radicals, resisting aging, and promoting proliferation of fibroblast. A Pseudolarix amabilis root bark extract is derived from root bark and near-root bark of Pseudolarix amabilis of Pinaceae. Mainly contains diterpenoid compounds such as pseudolaric acid, pseudolaric acetic acid, glucoroniside and the like, has the effects of killing parasites, relieving itching, dispelling wind and removing dampness, has activities of resisting fungi, tumors, angiogenesis and the like on various chemical components in the pseudolaric, and can be used for treating tinea manus and pedis, eczema and dermatitis. The sour bean seed polysaccharide is extracted from sour bean seeds, is known as green hyaluronic acid as a novel healthy skin care raw material, is also known as a natural plant water locking molecular nail, has a reticular water locking molecular structure similar to hyaluronic acid, and is a novel green multi-effect repair component with natural sources for moisturizing, anti-inflammation, antibiosis, skin elasticity increasing and skin density reducing. The tamarind seed polysaccharide has the moisturizing effect equivalent to that of sodium hyaluronate, activates skin silk fibroin synthesis, increases the self moisturizing capability of skin, improves roughness, can increase skin elasticity and density, reduces wrinkles and resists skin aging. In addition, the tamarind seed polysaccharide has excellent anti-inflammatory and antibacterial effects, and can promote repair of skin with damaged barrier, relieve inflammation and improve the resistance of skin to external flora stimulation.

Example 2, on the basis of example 1, a preparation method of a multi-effect natural no-clean hand sanitizer comprises the following steps:

step one, adding water, trehalose, sodium cocoyl malate, p-hydroxyacetophenone and 1, 2-hexanediol into a water kettle, heating to 55-65 ℃, and stirring for 10-20 minutes to dissolve and transparent;

step two, adding water, a gleditsia sinensis extract, a picrasma quassioides root extract, an aloe barbadensis leaf extract, a sanguisorba officinalis root extract, a citrus peel extract, a loosestrife root bark extract, a platycladus orientalis extract and tamarind seed polysaccharide in sequence, stirring to dissolve and transparent, and cooling to below 45 ℃;

step three, adding aminomethyl propanol to adjust the pH value of the system;

step four, sampling and detecting the semi-finished product;

and fifthly, filtering and discharging the materials by a 300-mesh filter screen after the materials are detected to be qualified, and filling.

The hand sanitizer prepared by the embodiment of the invention is subjected to a bacteriostatic performance test: according to the test of the bacteriostatic performance of the dissoluble antibacterial product (Escherichia coli, staphylococcus aureus and candida albicans) in the national standard GB15979-2002 hygienic Standard for Disposable sanitary articles.

Table 1: the data table of the bacteriostatic effect of the antibacterial agent on staphylococcus aureus after 2min, 5min, 10min and 20 min:

through the inspection: the antibacterial rate of staphylococcus aureus is more than 90% after 2min, 5min, 10min and 20min of action, and the antibacterial effect is strong.

Table 2: the data table of the bacteriostatic effect of the liquid medicine on escherichia coli for 2min, 5min, 10min and 20min comprises the following steps:

the antibacterial rate of Escherichia coli is more than 90% after 2min, 5min, 10min and 20min of action, and has strong antibacterial effect.

Table 3: the data table of the bacteriostatic effect of the candida albicans on 2min, 5min, 10min and 20 min:

the antibacterial rate of Escherichia coli is more than 90% after 2min, 5min, 10min and 20min of action, and has strong antibacterial effect.

As can be seen from the table, the hand sanitizer prepared by the embodiment of the invention has a certain bacteriostasis effect on escherichia coli, and has a good bacteriostasis effect on staphylococcus aureus and candida albicans.

This design also performed multiple complete skin irritation tests:

the inspection basis is as follows: the technical code for disinfection 2002 is as follows,

1. materials: experimental animals: 3 common-grade New Zealand white rabbits, body weight: 2-3 kg.

2. The experimental environment is as follows: the ambient temperature is 18-23 ℃, and the relative humidity is 45-65%.

3. The test steps are as follows: and (3) removing hairs at two sides of the spinal column of the experimental animal 24h before the experiment to avoid damaging the skin, wherein the hair removing range is 3cm x 10 cm. 0.5mL of the test substance was applied to the skin of the test site on one side and physiological saline was applied to the other side as a control, and after 4 hours, the residual sample was removed and the contact site was washed with water. Applied once daily for 14 consecutive days.

4. As a result:

table 4: integrating the response of the cleaning solution to the rabbit skin irritation;

the cumulative sexual stimulation integral of the sample to the skin was 0.

Table 5: grading the stimulation intensity of the rabbits;

skin irritation integration	Intensity of stimulus
		0～＜0.5	Has no irritation
0.5～＜2.0	Light irritation
		2.0～＜6.0	Middle irritation
6.0～＜8.0	Strong irritation

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (5)

1. A multi-effect natural no-clean hand sanitizer is characterized by comprising a first mixture, a second mixture, a third component and a fourth component; the first mixture comprises water, trehalose, sodium cocoyl malate, p-hydroxyacetophenone, and 1, 2-hexanediol; the second mixture comprises water, Gleditsia sinensis extract, radix Sophorae Flavescentis extract, Aloe barbadensis leaf extract, radix Sanguisorbae extract, Mandarin orange pericarp extract, Pseudolarix loosestrife root bark extract, and Platycladus orientalis extract; the third component is acid soybean seed polysaccharide; the fourth component is aminomethyl propanol.

2. The multi-effect natural no-clean hand sanitizer according to claim 1, wherein the composition comprises, by mass: 70-90% of the first mixture and 10-30% of the second mixture.

3. The multi-effect natural no-clean hand sanitizer according to claim 1, wherein the first mixture comprises, by mass: 60-95% of water, 1-10% of trehalose, 1-10% of sodium cocoyl malate, 1-10% of p-hydroxyacetophenone and 1-10% of 1, 2-hexanediol.

4. The multi-effect natural no-clean hand sanitizer according to claim 1, wherein the second mixture comprises, by mass: 50-95% of water, 1-10% of gleditsia sinensis extract, 1-10% of sophora flavescens root extract, 1-10% of aloe barbadensis leaf extract, 1-10% of sanguisorba officinalis root extract, 1-10% of citrus peel extract, 1-10% of loosestrife root bark extract and 1-10% of platycladus orientalis extract.

5. A preparation method of a multi-effect natural no-clean hand sanitizer is characterized by comprising the following steps:

step one, adding water, trehalose, sodium cocoyl malate, p-hydroxyacetophenone and 1, 2-hexanediol into a water kettle, heating to 55-65 ℃, and stirring for 10-20 minutes to dissolve and transparent;

step two, adding water, a gleditsia sinensis extract, a picrasma quassioides root extract, an aloe barbadensis leaf extract, a sanguisorba officinalis root extract, a citrus peel extract, a loosestrife root bark extract, a platycladus orientalis extract and tamarind seed polysaccharide in sequence, stirring to dissolve and transparent, and cooling to below 45 ℃;

step three, adding aminomethyl propanol to adjust the pH value of the system;

step four, sampling and detecting the semi-finished product;

and fifthly, filtering and discharging the materials by a 300-mesh filter screen after the materials are detected to be qualified, and filling.