CN113576435A - Preparation method of nano chip integrating pulse wave, blood oxygen, heat metabolism and spectrum - Google Patents
Preparation method of nano chip integrating pulse wave, blood oxygen, heat metabolism and spectrum Download PDFInfo
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- 239000008280 blood Substances 0.000 title claims abstract description 36
- 210000004369 blood Anatomy 0.000 title claims abstract description 36
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 23
- 239000001301 oxygen Substances 0.000 title claims abstract description 23
- 230000004060 metabolic process Effects 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 17
- 239000008103 glucose Substances 0.000 claims abstract description 17
- 238000004364 calculation method Methods 0.000 claims abstract description 6
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- 238000000034 method Methods 0.000 claims description 32
- 239000000758 substrate Substances 0.000 claims description 16
- 230000003287 optical effect Effects 0.000 claims description 12
- 230000031700 light absorption Effects 0.000 claims description 9
- 238000007639 printing Methods 0.000 claims description 9
- 238000004528 spin coating Methods 0.000 claims description 9
- 238000007641 inkjet printing Methods 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000003595 spectral effect Effects 0.000 claims description 4
- 238000010241 blood sampling Methods 0.000 claims description 3
- 108010025899 gelatin film Proteins 0.000 claims description 3
- 239000011241 protective layer Substances 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 239000002210 silicon-based material Substances 0.000 claims description 3
- 210000000707 wrist Anatomy 0.000 claims description 3
- -1 polytetrafluoroethylene Polymers 0.000 claims description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 7
- 238000005259 measurement Methods 0.000 abstract description 6
- 238000012544 monitoring process Methods 0.000 abstract description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
- A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02438—Detecting, measuring or recording pulse rate or heart rate with portable devices, e.g. worn by the patient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4866—Evaluating metabolism
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Abstract
The invention discloses a preparation method of a nanometer chip integrating pulse wave, blood oxygen, heat metabolism and spectrum, which comprises the steps of preparing a pulse wave sensor; step two, preparing a blood oxygen sensor; step three, preparing a temperature sensor; step four, preparing a spectrum sensor; step five, detecting a chip; the blood sugar measuring device obtains the electronic signals of body surface temperature, volume pulse wave, heart rate, impedance and spectrum through the pulse wave sensor, the blood oxygen sensor, the temperature sensor and the spectrum sensor on the nano integrated chip, then measures the concentration of glucose on the surface of the skin of a human body through an edge calculation method, improves the accuracy of glucose concentration measurement, realizes a blood sugar continuous monitoring mode which does not cause external detection wound on the human body, can avoid physiological pain of a user, does not need consumables, realizes multiple continuous detections, is convenient for daily health examination, and has compact structure and simple operation.
Description
Technical Field
The invention relates to the technical field of medical accessories, in particular to a preparation method of a nano chip for collecting pulse waves, blood oxygen, heat metabolism and spectra.
Background
Because people pay attention to body health, in order to prevent diabetes, the blood sugar needs to be measured regularly, so that certain requirements are made on the preparation method of some nano chips for measuring the blood sugar in the market; however, most of the existing blood sugar measurement methods adopt a sampling measurement method, and although the sampling measurement is more accurate, the method has the defects of physiological pain, material consumption and inconvenience for continuous and repeated detection of a user; the existing blood sugar measuring equipment is complex in operation and large in structure, and the use is influenced; therefore, it is necessary to invent a method for preparing a pulse wave, blood oxygen, thermal metabolism and spectrum-integrated nano-chip for measuring the blood sugar concentration in a human body.
Disclosure of Invention
The invention aims to provide a preparation method of a nanometer chip integrating pulse wave, blood oxygen, heat metabolism and spectrum, and aims to solve the problems that a sampling type blood sugar measurement mode provided in the background art causes physiological pain to a user, consumables and inconvenience are caused to continuously detect for multiple times, and blood sugar measurement equipment is complex to operate.
In order to achieve the purpose, the invention provides the following technical scheme: the preparation method of the nanometer chip integrating pulse wave, blood oxygen, heat metabolism and spectrum comprises the steps of preparing a pulse wave sensor; step two, preparing a blood oxygen sensor; step three, preparing a temperature sensor; step four, preparing a spectrum sensor; step five, detecting a chip;
firstly, spin-coating an ionic gel film on a larger flexible substrate through a spin coating process to form a flexible medium layer, then printing a drain-source electrode, a gate electrode and an electrocardio measuring electrode on the flexible medium layer through an ink-jet printing method, and then printing an active layer on an interdigital area of the drain-source electrode through the ink-jet printing method to prepare a sensor capable of measuring pulse waves;
in the second step, the film layers of the infrared light emitter, the red light emitter and the photoelectric detector are sequentially formed on the flexible substrate on one side of the pulse wave sensor through a printing process to form the blood oxygen sensor;
in the third step, a plurality of NTC resistors are arranged on the flexible substrate in the first step, then the NTC resistors for measuring the body surface temperature are isolated from the radiation source through a filter, a lens and an optical shutter, and the rest NTC resistors are used for measuring air to form a reference to manufacture a temperature sensor;
in the fourth step, a light receiving element is formed on the flexible substrate in the first step, and then a light shielding layer, an angle limiting filter and a spectrum filter are formed to manufacture the spectrum sensor;
and in the fifth step, the quality of the manufactured nanometer integrated chip is detected, electronic signals of body surface temperature, volume pulse wave, heart rate, impedance and spectrum are obtained through the nanometer integrated chip, then the concentration of glucose on the surface of the skin of the wrist is determined through an edge calculation method, then the accurate glucose concentration is collected and measured through a blood sampling pen, the concentration of the glucose measured by the nanometer integrated chip is compared, and the accuracy of the nanometer integrated chip is determined.
Preferably, in the first step, after the active layer is printed out, teflon is spin-coated on the active layer and the region not covered with the active layer through a spin coating process to form the protective layer.
Preferably, in the second step, the photodetector is composed of a light absorption layer and two metal electrode layers, the light absorption layer is fixed on the flexible substrate, and the two metal electrode layers are arranged on the light absorption layer at intervals.
Preferably, in the third step, the optical filter, the lens and the optical shutter are all made of silicon material.
Preferably, in the fourth step, the spectral filter is located above the angle limiting filter, the spectral filter has a first light-transmitting film and a second light-transmitting film, the first light-transmitting film is formed by a peeling method, and the second light-transmitting film is formed at a position shifted from the first light-transmitting film by the peeling method.
Compared with the prior art, the invention has the beneficial effects that: the invention is safe and reliable, obtains the electronic signals of the body surface temperature, the volume pulse wave, the heart rate, the impedance and the spectrum through the pulse wave sensor, the blood oxygen sensor, the temperature sensor and the spectrum sensor on the nanometer integrated chip, then determines the concentration of the glucose on the surface of the skin of the human body through the edge calculation method, improves the accuracy of the glucose concentration measurement, realizes the continuous monitoring mode of the blood sugar which does not cause the external detection wound to the human body, can avoid the physiological pain of the user, does not use consumables, realizes the repeated continuous detection, and is convenient for the daily health examination, and the blood sugar measuring equipment made of the nanometer integrated chip has compact structure, simple operation and convenient use.
Drawings
FIG. 1 is a flow chart of the method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, an embodiment of the present invention: the preparation method of the nanometer chip integrating pulse wave, blood oxygen, heat metabolism and spectrum comprises the steps of preparing a pulse wave sensor; step two, preparing a blood oxygen sensor; step three, preparing a temperature sensor; step four, preparing a spectrum sensor; step five, detecting a chip;
in the first step, firstly, spin-coating an ionic gel film on a larger flexible substrate through a spin coating process to form a flexible medium layer, then printing a drain-source electrode, a gate electrode and an electrocardio measuring electrode on the flexible medium layer through an ink-jet printing method, then printing an active layer on an interdigital area of the drain-source electrode through the ink-jet printing method, and then spin-coating polytetrafluoroethylene on the active layer and an area which is not covered by the active layer through the spin coating process to form a protective layer to prepare the sensor capable of measuring pulse waves;
in the second step, the infrared light emitter, the red light emitter and the photoelectric detector are sequentially formed on the flexible substrate on one side of the pulse wave sensor through a printing process to form the blood oxygen sensor, the photoelectric detector consists of a light absorption layer and two metal electrode layers, the light absorption layer is fixed on the flexible substrate, and the two metal electrode layers are arranged on the light absorption layer at intervals;
in the third step, a plurality of NTC resistors are arranged on the flexible substrate in the first step, then the flexible substrate passes through a filter lens, a lens and an optical shutter, the filter lens, the lens and the optical shutter are all made of silicon materials, the NTC resistors used for measuring the body surface temperature are isolated from a radiation source, the NTC resistors are left for measuring air, a reference is formed, and a temperature sensor is manufactured;
in the fourth step, a light receiving element is formed on the flexible substrate in the first step, then a light shielding layer, an angle limiting filter and a spectrum filter are formed to manufacture the spectrum sensor, the spectrum filter is positioned on the angle limiting filter, a first light-transmitting film and a second light-transmitting film are arranged on the spectrum filter, the first light-transmitting film is formed through a stripping method, and the second light-transmitting film is formed at a position staggered with the first light-transmitting film through the stripping method;
and in the fifth step, the quality of the manufactured nanometer integrated chip is detected, electronic signals of body surface temperature, volume pulse wave, heart rate, impedance and spectrum are obtained through the nanometer integrated chip, then the concentration of glucose on the surface of the skin of the wrist is determined through an edge calculation method, then the accurate glucose concentration is collected and measured through a blood sampling pen, the concentration of the glucose measured by the nanometer integrated chip is compared, and the accuracy of the nanometer integrated chip is determined.
Based on the above, the invention has the advantages that the pulse wave sensor, the blood oxygen sensor, the temperature sensor and the spectrum sensor are integrated into the nanometer integrated chip, the electronic signals of the body surface temperature, the volume pulse wave, the heart rate, the impedance and the spectrum are obtained through various sensors, then the concentration of glucose on the surface of the skin of the human body is measured through the edge calculation method, the accuracy of glucose concentration measurement is improved, the purpose of continuously monitoring the blood glucose under the condition of not causing external detection trauma to the human body is realized, the physiological pain of a user is avoided, no consumable material is used, the continuous detection for a plurality of times is facilitated, the daily health examination is facilitated, and the blood glucose measuring equipment made of the nanometer integrated chip has a compact structure, is simple to operate and is convenient to use.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (5)
1. The preparation method of the nanometer chip integrating pulse wave, blood oxygen, heat metabolism and spectrum comprises the steps of preparing a pulse wave sensor; step two, preparing a blood oxygen sensor; step three, preparing a temperature sensor; step four, preparing a spectrum sensor; step five, detecting a chip; the method is characterized in that:
firstly, spin-coating an ionic gel film on a larger flexible substrate through a spin coating process to form a flexible medium layer, then printing a drain-source electrode, a gate electrode and an electrocardio measuring electrode on the flexible medium layer through an ink-jet printing method, and then printing an active layer on an interdigital area of the drain-source electrode through the ink-jet printing method to prepare a sensor capable of measuring pulse waves;
in the second step, the film layers of the infrared light emitter, the red light emitter and the photoelectric detector are sequentially formed on the flexible substrate on one side of the pulse wave sensor through a printing process to form the blood oxygen sensor;
in the third step, a plurality of NTC resistors are arranged on the flexible substrate in the first step, then the NTC resistors for measuring the body surface temperature are isolated from the radiation source through a filter, a lens and an optical shutter, and the rest NTC resistors are used for measuring air to form a reference to manufacture a temperature sensor;
in the fourth step, a light receiving element is formed on the flexible substrate in the first step, and then a light shielding layer, an angle limiting filter and a spectrum filter are formed to manufacture the spectrum sensor;
and in the fifth step, the quality of the manufactured nanometer integrated chip is detected, electronic signals of body surface temperature, volume pulse wave, heart rate, impedance and spectrum are obtained through the nanometer integrated chip, then the concentration of glucose on the surface of the skin of the wrist is determined through an edge calculation method, then the accurate glucose concentration is collected and measured through a blood sampling pen, the concentration of the glucose measured by the nanometer integrated chip is compared, and the accuracy of the nanometer integrated chip is determined.
2. The method for preparing a nano-chip for collecting pulse wave, blood oxygen, thermal metabolism and optical spectrum according to claim 1, wherein the method comprises the following steps: in the first step, after the active layer is printed, polytetrafluoroethylene is spin-coated on the active layer and the region which is not covered with the active layer through a whirl coating process to form a protective layer.
3. The method for preparing a nano-chip for collecting pulse wave, blood oxygen, thermal metabolism and optical spectrum according to claim 1, wherein the method comprises the following steps: in the second step, the photoelectric detector consists of a light absorption layer and two metal electrode layers, the light absorption layer is fixed on the flexible substrate, and the two metal electrode layers are arranged on the light absorption layer at intervals.
4. The method for preparing a nano-chip for collecting pulse wave, blood oxygen, thermal metabolism and optical spectrum according to claim 1, wherein the method comprises the following steps: in the third step, the optical filter, the lens and the optical shutter are all made of silicon materials.
5. The method for preparing a nano-chip for collecting pulse wave, blood oxygen, thermal metabolism and optical spectrum according to claim 1, wherein the method comprises the following steps: in the fourth step, the spectral filter is located above the angle limiting filter, the spectral filter is provided with a first light-transmitting film and a second light-transmitting film, the first light-transmitting film is formed by a stripping method, and the second light-transmitting film is formed at a position staggered with the first light-transmitting film by the stripping method.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385711A (en) * | 2013-08-02 | 2013-11-13 | 临沂市拓普网络股份有限公司 | MEMS -based human body physiological parameter detection device |
| CN107714021A (en) * | 2017-09-08 | 2018-02-23 | 深圳大学 | Monitoring of blood pressure sensor chip based on PPG pulse waves and preparation method thereof |
| CN109730662A (en) * | 2019-03-20 | 2019-05-10 | 复旦大学附属中山医院 | Physiology physical sign monitoring system based on multispectral pulse wave |
| CN111870236A (en) * | 2020-09-01 | 2020-11-03 | 广州中金育能教育科技有限公司 | Body sign data monitoring and analyzing system and analyzing method |
| CN113180618A (en) * | 2021-04-20 | 2021-07-30 | 华中科技大学 | Skin-attached health detection system and preparation method thereof |
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- 2021-09-10 CN CN202111059413.3A patent/CN113576435A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385711A (en) * | 2013-08-02 | 2013-11-13 | 临沂市拓普网络股份有限公司 | MEMS -based human body physiological parameter detection device |
| CN107714021A (en) * | 2017-09-08 | 2018-02-23 | 深圳大学 | Monitoring of blood pressure sensor chip based on PPG pulse waves and preparation method thereof |
| CN109730662A (en) * | 2019-03-20 | 2019-05-10 | 复旦大学附属中山医院 | Physiology physical sign monitoring system based on multispectral pulse wave |
| CN111870236A (en) * | 2020-09-01 | 2020-11-03 | 广州中金育能教育科技有限公司 | Body sign data monitoring and analyzing system and analyzing method |
| CN113180618A (en) * | 2021-04-20 | 2021-07-30 | 华中科技大学 | Skin-attached health detection system and preparation method thereof |
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