CN101968450B - Embedded porphyrin sensor array-based saliva sugar and urine sugar detector - Google Patents
Embedded porphyrin sensor array-based saliva sugar and urine sugar detector Download PDFInfo
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- CN101968450B CN101968450B CN2010102966920A CN201010296692A CN101968450B CN 101968450 B CN101968450 B CN 101968450B CN 2010102966920 A CN2010102966920 A CN 2010102966920A CN 201010296692 A CN201010296692 A CN 201010296692A CN 101968450 B CN101968450 B CN 101968450B
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Abstract
The invention discloses an embedded porphyrin sensor array-based saliva sugar and urine sugar detector. The detector comprises a porphyrin sensor array, an image acquisition instrument, an illumination device and an embedded processing controller, wherein the image acquisition instrument and the illumination device are connected with the embedded processing controller respectively; the porphyrin sensor array comprises an organic glass plate and porphyrin units; a plurality of porphyrin unit installation holes are formed on the organic glass plate; and the porphyrin unit is installed on the top of each porphyrin unit installation hole in a sealed mode. The acquired saliva or urine is input into the porphyrin sensor array, the color images of the porphyrin units subjected to reaction are acquired, the acquired digital images are input into the embedded processing controller by the image acquisition instrument, and the embedded processing controller analyzes the digital images and directly detects the sugar content of the saliva and the urine. Therefore, the detector can provide non-invasive, continuous and direct detection means, and the detected sugar content of the saliva and the urine of persons with diabetes are more accurate.
Description
Technical field
The present invention relates to a kind of saliva glycosuria sugar detector, be specifically related to a kind of saliva glycosuria sugar detector based on embedded porphyrin array sensor.
Background technology
Diabetes (diabetes) are to act on body by inherent cause, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, mental element or the like various virulence factors to cause hypoinsulinism, insulin resistance (Insulin Resistance; And a series of metabolic disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi IR) etc.; Be principal feature clinically with the hyperglycaemia; Diuresis can appear in model case, performance, i.e. " three-many-one-little " symptom such as drink more, eat more, become thin.
Under the overall situation that current global diabetes form worsens, the incidence of disease of Chinese diabetes also presents the development trend of growth at full speed, and China has become the second in the world diabetes big country that is only second to India at present.And not only the onset diabetes situation is very severe, and the control of the diabetes state of an illness is also allowed of no optimist.Diabetes are known as noiseless killer, are because hyperglycaemia is harmful, normal insentience.Therefore, monitoring blood sugar in time, exactly is to guarantee to treat important means up to standard.But it is very dissatisfied that the blood sugar monitoring present situation is also made us.In the U.S., the diabetic of 15%-20% carries out the blood sugar self-monitoring; Be about 10% in area, China Hong Kong, and the area, continent is merely 1%.Average monitored frequency every diabetic of the U.S. is 30.1 times/month, and area, Hong Kong is 8-10 time/month, and the China mainland area is merely 2.5 times/month.China only has 1% patient to carry out self-blood sugar monitoring.
The method of traditional detection blood sugar concentration needs blood extracting assay, and sense cycle is long, causes the wound and the pain of injury to human body, has increased the approach of infection and cross infection simultaneously.
Existing electronics blood-sugar detecting instrument (like the U.S. Johnson & Johnson blood glucose meter in the 4th generation: " surveying conveniently ") still belongs to diminish and detects or the medical supply of indirect detection, also has some electronics blood-sugar detecting instruments that adopt direct measurement means (to authorize publication number: CN201233368Y; Authorize publication number: CN1300025A), directly adopt and detect as the sugar content of blood glucose sensor, convert the current signal that records to computing machine manageable digital signal to saliva with glucolase; Analysis through digital machine; Handle, directly record the content of blood sugar, though this blood glucose meter can obtain needed data fast; But data acquisition is complicated; The hardware Acquisition Circuit is complicated: at first will convert the bio signal that detects through glucose sensor to electric signal, become digital signal to analog signal conversion through digital-to-analog conversion again, send into computing machine at last and carry out Treatment Analysis.Complicated data acquisition has like this reduced the validity of original signal, has increased the probability of external interference signal to the pollution of original signal, and then has reduced the accuracy and the precision of signal.If signal is directly gathered; Promptly can directly import the digital signal that computing machine is analyzed and handled; Will reduce the loaded down with trivial details and simplification acquisition hardware circuit of the process of signals collecting so greatly; Most importantly the level that has reduced conversion of signals is inferior, has reduced the loss of the validity of signal in transfer process and has disturbed probability.
The test paper of traditional glucolase is owing to the influence of operating ambient temperature, and precision is not too high, and is difficult for storing, and is prone to oxidation takes place in air, causes the inefficacy of test paper; Existing blood sugar enzyme electrode probe needs to insert human epidermal, causes the wound and the pain of injury to human body.
Summary of the invention
To weak point of the prior art; The invention provides a kind of no wound, continuous, directly detection; And can measure the saliva of diabetes and the sugar content of urine accurately, be convenient to the obligation personnel's of household person and community the saliva glycosuria sugar detector that uses and operate based on embedded porphyrin array sensor.This instrument detecting is quick, accurate, portable, simple and convenient.
A kind of saliva glycosuria sugar detector based on embedded porphyrin array sensor provided by the invention comprises porphyrin array sensor, image capture instrument, lighting device, embedded processing controller and LCD touch-control display screen; Said lighting device is arranged on the below of porphyrin array sensor, and said image capture instrument is arranged on the top of porphyrin array sensor; Shown in image capture instrument, lighting device be connected with the embedded processing controller respectively with LCD touch-control display screen; Said porphyrin array sensor comprises poly (methyl methacrylate) plate and porphyrin unit, and the top of said poly (methyl methacrylate) plate is array and is provided with several porphyrin unit mounting holes, and the bottom of adjacent porphyrin unit mounting hole is communicated with through raceway groove; The top of each porphyrin unit mounting hole all is equipped with the porphyrin unit, and said porphyrin unit cooperates with the top seal of porphyrin unit mounting hole; Also be provided with on the said poly (methyl methacrylate) plate with porphyrin unit mounting hole in the feed tube and the drain pipe that are used to carry saliva sugar or glucose in urine that are communicated with.
Further, also comprise airtight container, said porphyrin array sensor is arranged on the middle part of airtight container, and said lighting device is arranged on the bottom of airtight container, and said image capture instrument is provided with the top of airtight container.
Further again, also comprise printer, said printer is connected with the embedded processing controller.
Compared with prior art, a kind of saliva glycosuria sugar detector based on embedded porphyrin array sensor of the present invention has following advantage:
1, the photosensitive property of porphyrin array sensor of the present invention's employing is good, and stable performance is easy to modify, and adopts ultraviolet, and is infrared, fluorescence, and phosphorescence waits spectral technique and electrochemical method can detect its subtle change; The porphyrin array sensor can reach 5.0 * 10 to the detection lower limit of glucose
-7Mol/L compares with traditional glucose oxidase and to have higher sensitivity, stability and antijamming capability.
2, the present invention only needs saliva of gathering or urine are got into the porphyrin array sensor through feed tube; And with the porphyrin unit process; Through the color image after the unit process of image capture instrument collection porphyrin and with the digital picture input embedded processing controller of gathering; The embedded processing controller carries out analyzing and processing to the digital picture before and after the reaction, directly detects the saliva of diabetes and the sugar content of urine.Therefore, detector of the present invention can provide no wound, continuous, direct detection means, and the saliva of detected diabetes and the sugar content of urine are more accurate.
3, LCD touch-control display screen has friendly human-computer interaction interface, and easy operating is easy to use, is convenient to using and operating of the obligation personnel of household person and community.
Description of drawings
Fig. 1 is the structural representation based on the saliva glycosuria sugar detector of embedded porphyrin array sensor;
Fig. 2 is the structural representation of porphyrin array sensor.
In the accompanying drawing, 1-porphyrin array sensor; 2-image capture instrument; 3-lighting device; 4-embedded processing controller; 5-poly (methyl methacrylate) plate; 6-porphyrin unit; 7-porphyrin unit mounting hole; 8-raceway groove; 9-feed tube; 10-drain pipe; 11-airtight container; 12-LCD touch-control display screen; 13-printer; 14-USB interface; 15-interface circuit; 16-VGA interface; 17-serial port drive circuit.
Embodiment
Below in conjunction with accompanying drawing and embodiment the present invention is done explanation in further detail.
Fig. 1 is that Fig. 2 is the structural representation of porphyrin array sensor, and is as shown in the figure based on the structural representation of the saliva glycosuria sugar detector of embedded porphyrin array sensor.Saliva glycosuria sugar detector based on embedded porphyrin array sensor comprises airtight container 11, porphyrin array sensor 1, image capture instrument 2, lighting device 3, embedded processing controller 4 and LCD touch-control display screen 12.
Porphyrin array sensor 1 is arranged on the middle part of airtight container 11, and said lighting device 3 is arranged on the bottom of airtight container 11, and said image capture instrument 2 is provided with the top of airtight container 11.In the present embodiment, image capture instrument 2 adopts ccd image sensor, and the quality of ccd image sensor imaging is high; Highly sensitive; The image color good resolution can well be accomplished image signal's collection, obtains view data; Image capture instrument 2 is electrically connected with embedded processing controller 4 through usb 14, and the digital picture of image capture instrument 2 being gathered through usb 14 sends to embedded processing controller 4.Lighting device 3 is electrically connected with embedded processing controller 4 through interface circuit 15; In the present embodiment; Lighting device 3 adopts the LED lamp, and embedded processing controller 4 control lighting devices 3 are to improve light source in airtight container 11; Be convenient to the camera collection porphyrin array sensor 1 reacted data image of ccd image sensor, under the coordination of embedded processing controller 4, synchronous working with ccd image sensor; Simultaneously can be according to the requirement of image definition, the illumination intensity of lighting device 3 can be adjusted through 4 controls of embedded processing controller, thereby can adopt different intensity irradiation images according to the requirement of image.
LCD touch-control display screen 12 is connected with embedded processing controller 4 through VGA interface 16, and LCD touch-control display screen 12 has friendly human-computer interaction interface, and easy operating is easy to use, is convenient to using and operating of the obligation personnel of household person and community.Also be connected with printer 13 through serial port drive circuit 17 at embedded processing controller 4, in the present embodiment, printer 13 adopts the temperature-sensitive mini-printer, is used to print last data measured.
When using detector of the present invention, at first, gather the initial number images, and store in the reservoir in the input embedded processing controller 4 through image capture instrument 2 to being placed on the porphyrin array sensor 1 in the airtight container 11 in advance.Operate and control through 12 pairs of these detectors of LCD touch-control display screen; Start lighting device 3 and image capture instrument 2 through embedded processing controller 4; The saliva or the urine of gathering are sent into porphyrin array sensor 1 through feed tube 9; Saliva or urine react with the porphyrin unit 6 that is provided with in advance during through porphyrin unit mounting hole 7; Image capture instrument 2 is gathered porphyrin unit 6 reacted images, and will be processed into and can be embedded into the digital picture that formula processing controller 4 is handled, and is transferred in the storer of embedded processing controller 4 to store.Digital picture before and after 4 pairs of reactions of embedded processing controller is subsequently carried out analyzing and processing, detects the saliva of diabetes and the sugar content of urine at last, and shows through LCD touch-control display screen 12, can also print through the result that printer 13 will detect.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although with reference to preferred embodiment the present invention is specified, those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention; And not breaking away from the aim and the scope of technical scheme of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (3)
1. the saliva glycosuria sugar detector based on embedded porphyrin array sensor is characterized in that: comprise porphyrin array sensor (1), image capture instrument (2), lighting device (3), embedded processing controller (4) and LCD touch-control display screen (12); Said lighting device (3) is arranged on the below of porphyrin array sensor (1), and said image capture instrument (2) is arranged on the top of porphyrin array sensor (1); Shown in image capture instrument (2), lighting device (3) be connected with embedded processing controller (4) respectively with LCD touch-control display screen (12);
Said porphyrin array sensor (1) comprises poly (methyl methacrylate) plate (5) and porphyrin unit (6); The top of said poly (methyl methacrylate) plate (5) is array and is provided with several porphyrin unit mounting holes (7), and the bottom of adjacent porphyrin unit mounting hole (7) is communicated with through raceway groove (8); The top of each porphyrin unit mounting hole (7) all is equipped with porphyrin unit (6), and said porphyrin unit (6) cooperates with the top seal of porphyrin unit mounting hole (7); Also be provided with on the said poly (methyl methacrylate) plate (5) and interior feed tube that is used to carry saliva or urine (9) and the drain pipe (10) that is communicated with of porphyrin unit mounting hole (7).
2. a kind of saliva glycosuria sugar detector according to claim 1 based on embedded porphyrin array sensor; It is characterized in that: also comprise airtight container (11); Said porphyrin array sensor (1) is arranged on the middle part of airtight container (11); Said lighting device (3) is arranged on the bottom of airtight container (11), and said image capture instrument (2) is provided with the top of airtight container (11).
3. a kind of saliva glycosuria sugar detector based on embedded porphyrin array sensor according to claim 1 and 2, it is characterized in that: also comprise printer (13), said printer (13) is connected with embedded processing controller (4).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102966920A CN101968450B (en) | 2010-09-29 | 2010-09-29 | Embedded porphyrin sensor array-based saliva sugar and urine sugar detector |
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| CN2010102966920A CN101968450B (en) | 2010-09-29 | 2010-09-29 | Embedded porphyrin sensor array-based saliva sugar and urine sugar detector |
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| CN101968450A CN101968450A (en) | 2011-02-09 |
| CN101968450B true CN101968450B (en) | 2012-07-04 |
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| CN2010102966920A Expired - Fee Related CN101968450B (en) | 2010-09-29 | 2010-09-29 | Embedded porphyrin sensor array-based saliva sugar and urine sugar detector |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102680531A (en) * | 2012-05-21 | 2012-09-19 | 江阴美英特生物仪器科技有限公司 | Biosensor for rapidly detecting microorganisms |
| CN103472043B (en) * | 2013-09-11 | 2016-03-02 | 上海移宇科技有限公司 | A kind of fluorescent glucose sensor |
| CN107632145A (en) * | 2017-08-17 | 2018-01-26 | 四川康码科技有限公司 | Based on the medical detection system just to struggle against |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007136390A1 (en) * | 2004-07-13 | 2007-11-29 | Dexcom, Inc. | Analyte sensor |
| CN101738372A (en) * | 2009-12-03 | 2010-06-16 | 重庆大学 | Optical detection device of liquid porphyrin array and method thereof for detecting amino acid |
| CN201803954U (en) * | 2010-09-29 | 2011-04-20 | 重庆大学 | Diabetes detection device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2001247660A1 (en) * | 2000-03-21 | 2001-10-03 | The Board Of Trustees Of The University Of Illinois | Colorimetric artificial nose having an array of dyes and method for artificial olfaction |
| CN2715150Y (en) * | 2004-07-08 | 2005-08-03 | 华东师范大学 | A nanometer decorated biologic array sensor |
| CN100567952C (en) * | 2007-05-31 | 2009-12-09 | 重庆大学 | The metal porphyrin langmuir blodgett film optical fiber gas sensor |
| CN100567965C (en) * | 2007-05-31 | 2009-12-09 | 重庆大学 | A kind of fiber gas sensor |
| CN101074931B (en) * | 2007-06-27 | 2010-05-19 | 江苏大学 | Production of color-sensitive gas sensor array |
| CN100585382C (en) * | 2007-09-26 | 2010-01-27 | 重庆大学 | Method for detecting micro-trace amount methyl-phosphoric acid dimethyl ester |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007136390A1 (en) * | 2004-07-13 | 2007-11-29 | Dexcom, Inc. | Analyte sensor |
| CN101738372A (en) * | 2009-12-03 | 2010-06-16 | 重庆大学 | Optical detection device of liquid porphyrin array and method thereof for detecting amino acid |
| CN201803954U (en) * | 2010-09-29 | 2011-04-20 | 重庆大学 | Diabetes detection device |
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