CN107064048A - A kind of quick Noninvasive Blood Glucose Detection Methods and device - Google Patents
A kind of quick Noninvasive Blood Glucose Detection Methods and device Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
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- G—PHYSICS
- G08—SIGNALLING
- G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
- G08C17/00—Arrangements for transmitting signals characterised by the use of a wireless electrical link
- G08C17/02—Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
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Abstract
The invention provides a kind of quick Noninvasive Blood Glucose Detection Methods and device.By the way of the collection of minimally invasive blood glucose, the blood-sugar content of human body middle finger is detected；And quick noninvasive dynamics monitoring device is utilized, gather the corresponding near infrared spectrum data of human body；By the blood-sugar content of collection and blood glucose near infrared spectrum data, with reference to multiple linear regression analysis method, the forecast model of blood sugar for human body content is set up；By Bluetooth Low Energy module, spectroscopic data is wirelessly transmitted to Android development board；To spectral data analysis on Android development board, blood-sugar content is shown in real time.Methods and apparatus of the present invention, based near infrared spectrum Bluetooth Low Energy technology, quick noninvasive quantitative detection can be carried out to single individual blood-sugar content, the function of optimizing with software model, there is invasive method compared to tradition, the pain of patient is not only reduced, wound infection is it also avoid, available for the consumption for instructing diabetic to adjust oral hypoglycaemic medicine and insulin.
Description
Technical field
It is specifically low using near-infrared spectrum technique, bluetooth the present invention relates to the quick Non-invasive detection technology of blood glucose and equipment
Power consumption wireless transmission technology, the method and device of quick Non-invasive detection blood sugar for human body content.
Background technology
As the mankind are continuously increased to the attention degree of health, routine physical examination and preventive treatment of disease and obtained the extensive of people
Accreditation, but work and rhythm of life quickening due to modern society people, cause blood sugar for human body class disease.Diabetes are allusion quotations
The chronic disease that long term frequent is monitored the need for type, can cause a series of metabolic disorder in human body, modern diseases of being known as
In the second killer.
The Main Means of monitoring diabetes are by continually detecting blood sugar concentration and adjusting on this basis accurately, in time
Give sb. a hard time the consumption of body oral hypoglycemic drug and insulin, effectively control blood sugar concentration.Popular widely used blood sugar test is that have
(micro-) to create the mode for bleeding or referring to blood additional examination paper, generally test needs are daily tests multiple, though belonging to minimally invasive takes blood, user
Still generally reflect that this kind test is pestered beyond endurance, in the market is badly in need of a kind of non-invasive blood sugar measuring instrument to solve these problems.
Chinese Patent Application No. is that the blood glucose meter in CN201520880188.3 contains, it is necessary to be acquired blood sample and carry out blood glucose
Amount analysis, while instrumentation interface does not have good man-machine interaction.Because finger acupuncture treatment takes blood, caused for tester
Pain, and there is the danger of infection.If things go on like this, the enthusiasm that the shouting pain of blood sampling can also cause patient blood glucose to detect declines, such as
Fruit blood sugar test can not adhere to that detection data are very little, it is impossible to reflect the control situation and variation tendency of blood glucose for a long time.
Near infrared spectrum is a kind of comprising near infrared light（near-infrared,NIR）Electromagnetic wave, respective wavelength scope
For 900-1700nm, the quick detection for the internal component being widely used in solid, liquid belongs in optical means and more may be used
A kind of capable Noninvasive Blood Glucose Detection Methods.
Chinese Patent Application No. is the noninvasive system for detecting blood sugar in CN200920205457.0, though using near infrared spectrum
Technology carries out noninvasive dynamics monitoring, but its light conduction module and light detection module must design swelling via light transmission fiber modal data
It is swollen, not readily portable；Its function is single, does not possess the function of being detected suitable for individual difference, software self-optimizing model function, nothing
Method effectively analyzes the variation tendency of blood sugar for human body.
Therefore a kind of high portable quick noninvasive blood sugar for human body detection method and device of reasonable in design, degree of integration are found,
There are extensive clinical practice and dissemination.The present invention uses highly integrated portable near infrared spectrometer, obtains to be measured
The diffusing reflection spectrum of person's finger, the real blood-sugar content of human body is obtained with reference to the conventional minimally invasive method of bleeding；It is near red by what is obtained
External spectrum information and blood-sugar content, by corresponding chemometrics method, set up corresponding blood sugar concentration forecast model；It is based on
Bluetooth Low Energy Radio Transmission Technology, blood sugar for human body fast quantitative analysis can be realized in cell-phone customer terminal；In later stage blood glucose level data
After the increase of storehouse, the function of software optimization model can improve the precision of blood sugar for human body detection.
The content of the invention
It is an object of the invention to provide a kind of quick Woundless blood sugar inspection based near infrared spectrum-Bluetooth Low Energy technology
Method and device is surveyed, to realize the quick non-invasive quantitative analysis to blood sugar for human body, and instructs diabetic's adjustment oral with this
The consumption of hypoglycemic drug and insulin.
For the method and device of the present invention, the technical scheme specifically used is as follows：
A kind of quick Noninvasive Blood Glucose Detection Methods, it is characterised in that comprise the following steps：
Step one, the minimally invasive acquisition testing of blood-sugar content：According to daily morning before the meal, before lunch, sleep before timing node, continue
One week, using conventional minimally invasive blood glucose meter, sample blood-sugar content is determined in the way of aculeus blood-taking, conventional minimally invasive blood glucose meter is obtained and surveys
Fixed blood glucose value；
Step 2, the collection of blood glucose near infrared spectrum data：Using light source module as signal source, portable near infrared spectrum mould
Block receives the diffusing reflection spectrum of blood glucose, carries out quick noninvasive blood glucose spectra collection, obtains blood glucose near infrared spectrum data；
Step 3, the optimization analysis of blood sugar test model：The blood glucose near infrared spectrum data collected and routine is minimally invasive
The blood glucose value that blood glucose meter is determined, with reference to multiple linear regression analysis method, sets up blood sugar test model；.
Step 4, the Non-invasive detection of blood-sugar content：Being connected to by Bluetooth Low Energy module supports the Android of bluetooth 4.0 to open
Plate is sent out, blood glucose near infrared spectrum data is wirelessly transferred；The blood sugar test model write with reference to exploitation software, pointedly
Noninvasive dynamics monitoring is carried out to single individual.
Early timing node before the meal, before lunch, before sleep in the step one, with crowd's universality, meets popular day
Normal work and rest rule；It is described to continue one week, 21 blood-sugar content numerical value are specially gathered, for subsequently setting up blood sugar test model；
The mode of the aculeus blood-taking is specially that middle finger blood is dripped in collection one, and human body is without obvious pain.
The light source module is integrated in one near infrared spectrum module and Bluetooth Low Energy module；It is described portable,
In light source module and near infrared spectrum module and the integrated small volume of Bluetooth Low Energy module, light weight, it is easy to carry；It is described fast
Speed be scanning the used time be 2.88s/ times.
The light source module has two halogen tungsten lamps；The operating power of the halogen tungsten lamp is 1.4W, is put in 40 ° of angles of level
Put；The scanning window size of the light source module is 5mm*5mm, can effectively gather the blood glucose of normal adult middle finger.
The wave-length coverage of the near infrared spectrum module is 900nm ~ 1700nm, can effectively cover near infrared spectrum region；
The signal to noise ratio of the near infrared spectrum module is 6000:1, optical resolution is 10nm, and scanning optical spectrum information is good.
Without using auto sleep is then carried out in the Bluetooth Low Energy module 10s, to save electricity；It is described to be wirelessly transferred
For the commercially available Android development board with supporting bluetooth 4.0（Or Android mobile phone）Carry out data transmission；The software write-in supports many
Individual blood sugar test model；The analysis prediction carries out blood sugar test using particular individual blood sugar test model；The individual
Blood sugar test model, with the increase of detection data, individual blood sugar test model can voluntarily optimize.
A kind of quick noninvasive dynamics monitoring device, it is characterised in that：Described quick Noninvasive Blood Glucose Detection Methods can be realized,
Blood sugar detection apparatus and blood glucose display device are specifically included, via 4 screw phases for being located at blood glucose display device diagonal positions
Even；
In the blood sugar detection apparatus, light source module（1）With near-infrared module（2）Front end is connected；The near-infrared module（2）End
End connection Bluetooth Low Energy module（3）；The light source module（1）, near-infrared module（2）With Bluetooth Low Energy module（3）, put
It is placed in housing（4）It is internal；The housing（4）Leave detection window in front end（5）；The housing（4）Upper end is provided with Android exploitation
Plate（7）；The housing（4）Lower end and handle（6）It is connected；The handle（6）Inside is equipped with portable power source；
The blood glucose display device, is Android development board（7）；The Android development board（7）Contain curve of spectrum viewing area
（8）, quantitative detection zone（9）.
The detection window（5）Size is 1.0cm*1.0cm, positioned at housing（4）The center of front end, can be effectively matched
The scanning window of light source module；The housing（4）With handle（6）It is connected via 4 screws；The handle（6）For height and bottom
A certain size cylinder of face circular diameter；The portable power source that the cylinder is built-in with；
In the blood glucose display device, the first half is curve of spectrum viewing area（8）, lower half is quantitative detection zone（9）.
Beneficial effects of the present invention, it is specific as follows：
First, for the collection of blood glucose near infrared spectrum：The present invention uses portable near infrared spectrometer, obtains blood sugar for human body
Spectrum can accomplish quick non-invasive blood glucose measurement, have the advantages that no shouting pain, without infecting, have no side effect, the testing time it is short；
Second, for the transmission of blood glucose spectroscopic data：The present invention uses Bluetooth Low Energy（BLE）Radio Transmission Technology, supports to work as
The preceding Android mobile phone peace end application transmitted with bluetooth 4.0, meets the demand trend of popular information age；
Third, for the Non-invasive detection of blood-sugar content：The present invention is directed to particular individual, sets up corresponding forecast model, is different from
The non-invasive methods of the multifactor consideration of tradition, detection method is more easy, and operability is higher；Support that multiple individual blood glucose are pre-
Survey, and with data storage function, the optimization available for later stage forecast model is analyzed, and improves the accuracy of blood sugar test.
Fourth, for the quick noninvasive detection device of blood glucose：The present invention is used halogen tungsten lamp light source module, Bluetooth Low Energy mould
The near infrared spectrometer that block and near-infrared module are integrated, non-invasive glucose monitoring apparatus structure design is simple, is easy to operation；
Android development board or mobile phone of the matching with bluetooth 4.0 are supported, blood glucose level data is transferred to mobile device end in real time, can be whole right
The blood glucose situation of patient is detected, so as to improve the monitoring to patient and protective capability.
Brief description of the drawings
Fig. 1 is experimental provision structure chart of the invention；
Fig. 2 is experimental provision top view of the invention；
In figure：1 light source module, 2 near-infrared modules, 3 Bluetooth Low Energy modules, 4 housings, 5 scanning windows, 6 handles, 7 Androids are opened
Send out plate, 8 curve of spectrum regions, 9 quantitative display regions, 10 qualitative viewing areas.
Embodiment
Below in conjunction with the drawings and specific embodiments, the technical scheme in the embodiment of the present invention is carried out clearly and completely
Description.
Embodiments of the invention are described below in detail, the example of the embodiment is shown in the drawings, wherein from beginning to end
Same or similar label represents same or similar element or the element with same or like function.Below with reference to attached
The embodiment of figure description is exemplary, is only used for explaining the present invention, and is not considered as limiting the invention.
The experimental provision structure chart of Fig. 1 present invention, according to Fig. 1, in the blood sugar detection apparatus, light source module and near-infrared
Module front end is connected；The near-infrared end of module connects Bluetooth Low Energy module；The light source module, near-infrared module and indigo plant
Tooth low-power consumption module, is placed in enclosure interior；The housing forward end, leaves detection window；The housing upper end, is provided with
Tall and erect development board；The housing lower end, is connected with handle；The handle, inside is equipped with portable power source.
Fig. 2 is the experimental provision top view of the present invention, and according to Fig. 2, the blood glucose display device is Android development board；Institute
Android development board is stated, contains curve of spectrum viewing area, quantitative detection zone.
One hand holds the handle of blood sugar detection apparatus, by the detection window of blood sugar detection apparatus, is directed at human body middle finger, clicks on
After " scanning " button at blood glucose display device interface, the 2.88s that waits, in curve of spectrum viewing area, the near of blood glucose can be observed
Infrared spectrum curve image；" prediction " button at blood glucose display device interface is clicked on, blood-sugar content can be checked.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " illustrative examples ",
The description of " example ", " specific example " or " some examples " etc. means to combine specific features, the knot that the embodiment or example are described
Structure, material or feature are contained at least one embodiment of the present invention or example.In this manual, to above-mentioned term
Schematic representation is not necessarily referring to identical embodiment or example.Moreover, specific features, structure, material or the spy of description
Point can in an appropriate manner be combined in any one or more embodiments or example.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The scope of invention is limited by claim and its equivalent.
Claims (8)
1. a kind of quick Noninvasive Blood Glucose Detection Methods, it is characterised in that comprise the following steps：
Step one, the minimally invasive acquisition testing of blood-sugar content：According to daily morning before the meal, before lunch, sleep before timing node, continue
One week, using conventional minimally invasive blood glucose meter, sample blood-sugar content is determined in the way of aculeus blood-taking, conventional minimally invasive blood glucose meter is obtained and surveys
Fixed blood glucose value；
Step 2, the collection of blood glucose near infrared spectrum data：Using light source module as signal source, portable near infrared spectrum mould
Block receives the diffusing reflection spectrum of blood glucose, carries out quick noninvasive blood glucose spectra collection, obtains blood glucose near infrared spectrum data；
Step 3, the optimization analysis of blood sugar test model：The blood glucose near infrared spectrum data collected and routine is minimally invasive
The blood glucose value that blood glucose meter is determined, with reference to multiple linear regression analysis method, sets up blood sugar test model；
Step 4, the Non-invasive detection of blood-sugar content：It is connected to by Bluetooth Low Energy module and supports the Android of bluetooth 4.0 to develop
Plate, is wirelessly transferred to blood glucose near infrared spectrum data；The blood sugar test model write with reference to exploitation software, it is pointedly right
Single individual carries out noninvasive dynamics monitoring.
2. a kind of quick Noninvasive Blood Glucose Detection Methods according to claim 1, it is characterised in that breakfast in the step one
Before, before lunch, sleep before timing node, with crowd's universality, meet popular daily work and rest rule；It is described to continue one week,
21 blood-sugar content numerical value are specially gathered, for subsequently setting up blood sugar test model；The mode of the aculeus blood-taking is specially
Middle finger blood is dripped in collection one, and human body is without obvious pain.
3. a kind of quick Noninvasive Blood Glucose Detection Methods according to claim 1, it is characterised in that：The light source module with it is near
Infrared spectrum module and Bluetooth Low Energy module are integrated in one；It is described portable, it is light source module and near infrared spectrum mould
Block and the integrated small volume of Bluetooth Low Energy module, light weight, it is easy to carry；It is described it is quick be the scanning used time be 2.88s/ times.
4. a kind of quick Noninvasive Blood Glucose Detection Methods according to claim 1, it is characterised in that：The light source module has
Two halogen tungsten lamps；The operating power of the halogen tungsten lamp is 1.4W, is placed in 40 ° of angles of level；The scanning window of the light source module
Mouth size is 5mm*5mm, can effectively gather the blood glucose of normal adult middle finger.
5. a kind of quick Noninvasive Blood Glucose Detection Methods according to claim 1, it is characterised in that：The near infrared spectrum mould
The wave-length coverage of block is 900nm ~ 1700nm, can effectively cover near infrared spectrum region；The noise of the near infrared spectrum module
Than for 6000:1, optical resolution is 10nm, and scanning optical spectrum information is good.
6. a kind of quick Noninvasive Blood Glucose Detection Methods according to claim 1, it is characterised in that：The Bluetooth Low Energy mould
Without using auto sleep is then carried out in block 10s, to save electricity；It is described to be wirelessly transferred for supporting the commercially available of bluetooth 4.0
Android development board or Android mobile phone carry out data transmission；Multiple individual blood sugar test models are supported in the software write-in；Described point
Analysis prediction carries out blood sugar test using particular individual blood sugar test model；The individual blood sugar test model, with detection data
Increase, individual blood sugar test model can voluntarily optimize.
7. a kind of quick noninvasive dynamics monitoring device, it is characterised in that：The quick Woundless blood sugar inspection described in claim 1 can be realized
Survey method, specifically includes blood sugar detection apparatus and blood glucose display device, is located at blood glucose display device diagonal positions via 4
Screw is connected；
In the blood sugar detection apparatus, light source module（1）With near-infrared module（2）Front end is connected；The near-infrared module（2）End
End connection Bluetooth Low Energy module（3）；The light source module（1）, near-infrared module（2）With Bluetooth Low Energy module（3）, put
It is placed in housing（4）It is internal；The housing（4）Leave detection window in front end（5）；The housing（4）Upper end is provided with Android exploitation
Plate（7）；The housing（4）Lower end and handle（6）It is connected；The handle（6）Inside is equipped with portable power source；
The blood glucose display device, is Android development board（7）；The Android development board（7）Contain curve of spectrum viewing area
（8）, quantitative detection zone（9）.
8. a kind of quick noninvasive dynamics monitoring device according to claim 7, it is characterised in that：The detection window（5）
Size is 1.0cm*1.0cm, positioned at housing（4）The center of front end, can be effectively matched the scanning window of light source module；It is described
Housing（4）With handle（6）It is connected via 4 screws；The handle（6）For height and a certain size cylinder of bottom surface circular diameter
Body；The portable power source that the cylinder is built-in with；
In the blood glucose display device, the first half is curve of spectrum viewing area（8）, lower half is quantitative detection zone（9）.
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| CN201710120020.6A CN107064048A (en) | 2017-03-02 | 2017-03-02 | A kind of quick Noninvasive Blood Glucose Detection Methods and device |
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| CN201710120020.6A CN107064048A (en) | 2017-03-02 | 2017-03-02 | A kind of quick Noninvasive Blood Glucose Detection Methods and device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111326255A (en) * | 2020-01-19 | 2020-06-23 | 湖南盈赛缇思人工智能公共数据平台有限公司 | Blood glucose concentration correction method based on big data, storage medium and system |
| CN111599470A (en) * | 2020-04-23 | 2020-08-28 | 中国科学院上海技术物理研究所 | Method for improving near-infrared noninvasive blood glucose detection precision |
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