CN113180618A - Skin-attached health detection system and preparation method thereof - Google Patents
Skin-attached health detection system and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
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- A—HUMAN NECESSITIES
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- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
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Abstract
The invention discloses a skin-attached health detection system and a preparation method thereof, belonging to the technical field of medical health detection instruments, wherein the system comprises a front-end flexible physiological signal detection module and a rear-end signal processing output module which are mutually connected, wherein the front-end flexible physiological signal detection module takes a flexible packaging material as a packaging layer, and the surface of the front-end flexible physiological signal detection module is provided with a functional layer for directly adhering to the skin of a user; the front-end flexible physiological signal detection module comprises a blood oxygen detection circuit, a body temperature detection circuit and an epidermal electrode, and is used for respectively collecting pulse, body temperature signals and myoelectric signals; and the rear-end signal processing output module sends the processed health information to the mobile terminal. The detection system can be closely attached to the skin of a human body and has conformal capability, the back-end signal processing and outputting module is used for receiving, processing and sending front-end sensing data through a designed circuit, and the real-time transmission and display of the information of the blood oxygen saturation, the body temperature, the pulse and the muscle fatigue degree can be realized.
Description
Technical Field
The invention belongs to the technical field of medical health detection instruments, and particularly relates to a skin-attached health detection system and a preparation method thereof.
Background
With the continuous development of electronic information technology, plastic electronics, organic electronics and printed electronics are equivalent to the emerging electronic field related to the flexible electronic field in recent years, and the flexible electronics have the advantages of unique ductility, good wearability, large-scale manufacturing, low cost and the like, so that the flexible electronics are widely applied to the fields of medical treatment, energy, military, education and the like. At present, flexible electronic products on the market comprise printed RFID, flexible displays, Organic Light Emitting Diodes (OLED) and the like. The product is different from the traditional hard circuit, can realize the functions of bending, stretching, extending and the like, and is widely applied to real life.
The physical principle of non-invasive blood oxygen detection is a photoplethysmography, which calculates the blood oxygen saturation of a human body by detecting the change of light absorption amount of blood when a blood vessel of the human body beats. The blood oxygen sensor mainly comprises a photoelectric converter and a light source. The light source employs two pairs of light emitting diodes of different specific wavelengths with selectivity for oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (Hb). And the photoelectric converter receives the reflected optical fiber, converts and amplifies the photoelectric signal, outputs the amplified signal, and calculates the output signal based on the Lambor's law to obtain the blood oxygen saturation at the corresponding moment.
The body temperature of a human body is an important index for reflecting the health degree of the human body, so that the real-time detection of the body temperature is of great significance. Temperature sensors based on different physical principles are very diverse, for example: temperature indicating paint, thermistors, platinum temperature measuring resistors, semiconductor diodes, and the like. The semiconductor diode-based digital temperature sensor has the advantages of high measurement precision, low power consumption, small and flexible package, and wide application in medical electronic equipment.
The muscle fibers have high excitability like nerve cells, and action potentials appear firstly when the muscle fibers are excited, so that weak current can be generated when the muscle contracts, and the muscle current on the surface of a body can be measured by attaching electrodes at proper positions of the skin. And when the muscle is in a fatigue state, its electromyographic signal is changed compared to a normal state. The electromyographic signals can be analyzed to assess the fatigue state of the muscle.
Today, industrial machines are more and more popular, and a lot of high-risk industries still need exhibition workers to directly participate in first-line work, such as special equipment operation, petrochemical industry and the like. In general, these post operations have a complex environment and require a lot of protective equipment to be worn by the personnel, such as: safety helmets, ear shields, protective clothing, etc., which hinder the agility of the worker's movements to some extent and cause serious accidents with a little carelessness. In this case, therefore, there are high demands on the physical health and psychological health of the practitioner. Commercial health status monitoring system in the existing market adopts the stereoplasm circuit mostly, and its convenience and travelling comfort are not high, are not fit for above-mentioned crowd. Therefore, the development of the mobile wearable device which is flexible, light and convenient and can simultaneously detect multiple physiological indexes has a very wide application prospect.
Disclosure of Invention
Aiming at the defects or improvement requirements of the prior art, the invention provides a skin-attached health detection system and a preparation method thereof, wherein the front-end flexible physiological signal detection module is endowed with the capability of being tightly attached to the skin of a human body and conforming to the skin through structural design and flexible materials, the front-end sensing data can be received, processed and sent by the rear-end signal processing module through a designed circuit, the data sent by the rear-end signal processing output module is received by a mobile terminal, and the pulse information, the blood oxygen saturation information, the body temperature information and the muscle fatigue degree information are further displayed. The system can realize real-time transmission and display of physiological signals. In addition, the preparation method can directly adopt a screen printing process, and compared with the traditional micro-nano processing processes such as photoetching, electron beam river ion etching and the like, the preparation method has the advantages of simpler process and lower manufacturing cost, and is more beneficial to large-area and batch industrial production.
To achieve the above objects, according to one aspect of the present invention, there is provided a skin-attached health detection system, comprising a front-end flexible physiological signal detection module and a rear-end signal processing output module, wherein,
the front-end flexible physiological signal detection module takes a flexible packaging material as a packaging layer, and the surface of the front-end flexible physiological signal detection module is provided with a viscous functional layer which is used for directly adhering to the skin of a user, so that the whole skin-attached health detection system is adhered to the skin epidermis of the user; the front-end flexible physiological signal detection module comprises a blood oxygen detection circuit, a body temperature detection circuit and an epidermal electrode and is used for respectively acquiring a pulse signal, a body temperature signal and an electromyographic signal;
the rear-end signal processing and outputting module is connected with the front-end flexible physiological signal detecting module and receives the pulse signal, the body temperature signal and the myoelectric signal; the rear-end signal processing and outputting module is used for converting the pulse signals into the blood oxygen saturation of the user according to the Lamborbit theorem, analyzing the time domain and the frequency domain of the electromyographic signals to judge the muscle fatigue degree of the user, and then sending the pulse information, the blood oxygen saturation information, the body temperature information and the muscle fatigue degree information of the user to the mobile terminal.
As a further preferred aspect of the present invention, the rear-end signal processing and outputting module processes and analyzes the signal detected by the front-end flexible physiological signal detecting module, wherein the digital body temperature signal is accurate enough and does not need to be processed and analyzed, the pulse signals include two kinds, which are light intensity signals reflected by infrared light and red light, the two kinds of pulse signals are firstly filtered, and then the blood oxygen saturation of the user can be calculated according to the lambert-bor theorem.
Preferably, the front-end flexible physiological signal detection module comprises a flexible substrate layer, a wire layer, a chip layer and a flexible packaging layer, wherein the flexible substrate layer and the flexible packaging layer are used for being matched to construct a flexible frame body forming the front-end flexible physiological signal detection module, the wire layer and the chip layer are both positioned in the flexible frame body, the chip layer is provided with the blood oxygen detection circuit and the body temperature detection circuit, and the wire layer is used for conducting an electric signal of the chip layer;
the blood oxygen detection circuit and the body temperature detection circuit are respectively used for acquiring pulse signals and body temperature signals.
Preferably, the chip layer is a MAX30102 chip and a TMP117 chip, so as to realize the collection of the blood oxygen volume waveform and the body temperature of the user by the blood oxygen detection circuit and the body temperature detection circuit; the lead layer comprises the skin electrode and a lead, the skin electrode is used for collecting myoelectric signals, the lead is used for transmitting electric signals, and the lead layer is made of cured conductive silver paste with tensile property.
Preferably, the conductive silver paste is prepared by mixing and grinding silver powder and polydimethylsiloxane according to the mass ratio of 3.5: 1;
the flexible substrate layer and the flexible packaging layer are made of Polydimethylsiloxane (PDMS);
the material of the viscous functional layer is polypropylene, polyvinyl alcohol or silica gel Silbaine RT 4717.
Preferably, the rear-end signal processing output module includes a CC2640R2F core processing module, an AD8232 electromyographic signal processing module, a clock crystal oscillator module, a program programming module, a bluetooth antenna transmitting module, and a front-end communication module;
the ports X32KQ1, X32KQ2, X24MP and X24MN of the CC2640R2F core processing module are respectively connected with the input end of the clock crystal oscillator module; TMSC, TCKC, TDI, TDO and RESET ports of the CC2640R2F core processing module are respectively connected with the input end of the program programming module to realize program programming; an MCU AD port of the CC2640R2F core processing module is connected with an input end of the AD8232 electromyographic signal processing module; the SCL, SDA and INT ports of the CC2640R2F core processing module are respectively connected with the input end of the communication port of the front-end communication module; the RFN and RFP ports of the CC2640R2F core processing module are respectively connected with the signal input end of the Bluetooth antenna emission module;
and the ports of IN +, IN-, RLD, RLDFB and RLD of the AD8232 electromyographic signal processing module are connected with the input end of the communication port of the front-end communication module, wherein the ports of RLD and RLDFB are connected with the same input port.
Preferably, the rear-end signal processing output module further comprises a power supply module, and the power supply module comprises a CR2032 button cell and a TPS63001 boosting module; the CR2032 button cell is used for providing fixed voltage, and the TPS63001 boosting module is used for boosting the fixed voltage provided by the CR2032 button cell power supply module to reach the required voltage of circuit operation;
the 3.3V voltage output end of the TPS63001 boosting module is connected with the voltage input ports of the CC2640R2F core processing module and the AD8232 electromyographic signal processing module; the 3.3V voltage output end of the TPS63001 boosting module is further connected with the communication port of the front-end communication module, and stable voltage input is provided for the front-end flexible physiological signal detection module.
Preferably, the rear-end signal processing output module is connected with the front-end flexible physiological signal detection module through an FPC (flexible printed circuit) connecting flexible flat cable;
the front-end flexible physiological signal detection module transmits detected pulse, body temperature and myoelectric signals to the rear-end signal processing and outputting module for analysis and processing through the FPC connecting flexible flat cable; the rear-end signal processing output module supplies power to the front-end flexible physiological signal detection module through the FPC connecting flexible flat cable and provides ground potential at the same time.
Preferably, the volume of the front-end flexible physiological signal detection module is not more than 35mm × 20mm × 2 mm; the rear end signal processing output module is a multilayer hard circuit, and the area of the rear end signal processing output module is not more than 28mm multiplied by 28 mm.
Preferably, the mobile terminal is a mobile phone.
According to another aspect of the present invention, there is provided a method of manufacturing a skin-attached health detection system, the method comprising the steps of:
(1) firstly, solidifying polydimethylsiloxane on a hard substrate through spin coating to obtain a flexible substrate layer; then, a mask of a circuit to be printed is attached to the flexible substrate, and conductive silver paste is uniformly coated on the mask by a blade coating method; taking down the mask, and placing in a drying oven at 160 ℃ for 1 hour to obtain a wire layer on the first surface;
(2) a TMP117 chip, an XC6206 buck chip, a pull-up resistor and a decoupling capacitor are pasted on the lead layer on the first surface; the pins of each chip are adhered to the conductive layer in a mode of light touch pressing after being coated with conductive silver paste, the pins are fixedly connected after being cured for 1 hour in a drying oven at 160 ℃, and a chip layer of the first surface is prepared;
(3) aiming at seven connecting ports of VIN, SCL, SDA, INT, GND, RA, LA and RL of the FPC flexible flat cable, the seven connecting ports are adhered to a lead layer of a first surface through conductive silver paste, after the seven connecting ports are cured in an oven at 160 ℃ for 1 hour, polydimethylsiloxane is poured on a chip layer of the first surface to be used as a flexible packaging layer, after the polydimethylsiloxane is cured, a flexible substrate layer is taken down from a hard substrate, and a through hole is processed on the flexible substrate layer by using a laser engraving machine;
(4) preparing a second surface lead layer on the first surface by using the same process in the step (3), wherein the second surface lead layer comprises a skin electrode; mounting a MAX30102 chip to prepare a second surface chip layer, and pouring polydimethylsiloxane to prepare a flexible packaging layer, wherein the flexible packaging layer on the second surface is not required to cover the surface electrode;
(5) and preparing an organic polymer layer on the flexible packaging layer of the second surface as a viscous functional layer to obtain the front-end flexible physiological signal detection module.
Preferably, the step (1) of uniformly coating the mask with the conductive silver paste by using a blade coating method specifically comprises the following steps of blade-coating the conductive silver paste by using a flat scraper, and extruding the conductive silver paste through the mask printed with the circuit pattern by using the scraper, so as to form a conductor layer with a pre-designed circuit pattern on the flexible substrate layer.
As a further preferred aspect of the present invention, in the step (1), the mask may be prepared by using a relatively thin paper material, and the desired circuit pattern is processed on the paper material by laser engraving.
In general, compared with the prior art, the above technical solution contemplated by the present invention can achieve the following beneficial effects:
1. the skin-attached health detection system provided by the invention can realize the detection of the blood oxygen saturation, the pulse, the body temperature and the myoelectric signals of a human body, transmit the pulse information, the blood oxygen saturation information, the body temperature information and the muscle fatigue degree information to the mobile terminal and feed back the data of the blood oxygen, the pulse, the body temperature and the myoelectric signals in real time.
2. According to the front-end flexible physiological signal detection module in the skin-attached health detection system, polydimethylsiloxane is used as a substrate of the flexible circuit, self-made conductive silver paste is used as a wire layer, and the flexible circuit has good stretchability, ductility and small volume. An adhesive layer, i.e. a sticky functional layer, is added on the flexible packaging layer. Taking polypropylene, polyvinyl alcohol and silica gel Silbeine RT4717 as an example for preparing an adhesive layer, the stripping capability of the adhesive layer is 10 times of that of a common polydimethylsiloxane material (Sylgard184), so that the prepared system can be well attached to a part to be detected of a human body by iron and has strong anti-interference performance; these adhesive functional materials, on the one hand, are flexible and, on the other hand, have good biocompatibility and do not react with polydimethylsiloxane.
3. According to the front-end flexible physiological signal detection circuit, the flexible high polymer material polydimethylsiloxane is used as the packaging layer and the viscous high polymer material is used as the viscous functional layer, and the used electronic element is packaged by the flexible material in a coating mode. The flexible material is used as the packaging material of the circuit, so that the whole circuit can bear the capability of a certain range of deformation, and the circuit can deform synchronously with the skin of a human body. The adhesive polymer material further endows the adhesive polymer material with the capability of being tightly attached to the skin. By preparing a layer of organic polymer thin layer with good viscosity as a viscosity functional layer, the device can be adhered and fixed on the skin, and long-time good contact between the device and the skin is realized.
4. The wearable performance of the system is improved by using the rear-end signal processing output module as a communication mode of the system and the mobile terminal. The back-end signal processing output circuit can preferably adopt a CC2640R2F core processor, the CC2640R2F core processor chip is provided with a 2.4GHz antenna, supports a Bluetooth 5.0 protocol, has low required power consumption, and adopts a 3VCR2032 button battery to supply power, thereby enabling the physiological signals of the user to be collected for a long time.
5. The volume of the front-end flexible physiological signal detection module in the invention can preferably not exceed 35mm multiplied by 20mm multiplied by 2 mm; the rear-end signal processing output module is a multilayer circuit, the area size of the rear-end signal processing output module can be preferably not more than 30mm multiplied by 30mm, and the whole system is small, exquisite, light, good in stability and high in measurement precision.
In conclusion, the invention adopts a special mask printing mode, and can realize large-area and batch preparation of the flexible circuit due to simple mask material taking and processing. According to the invention, the solidified stretchable conductive silver paste with a specific composition ratio is adopted, and the silver powder and the polydimethylsiloxane are mixed and ground according to the mass ratio of 3.5:1 to prepare the conductive silver paste with the specific composition ratio, so that the yield of the front-end flexible physiological signal detection module can be further ensured.
The design of the circuit substrate of the front-end flexible physiological signal detection module is different from the existing commercialized hard substrate or the bendable non-stretchable substrate, such as polyimide, polyethylene terephthalate and the like, a detection circuit prepared based on the substrate material cannot keep conformal contact with the skin, the wearability is poor, and signals are easily interfered by motion artifacts and other factors in the measurement process. The invention adopts flexible conductive material and special mask printing process to realize the preparation of the flexible circuit patterned lead. The present invention employs a front-end circuit composed of a combination of soft and hard materials, wherein the substrate and lead materials are stretchable and the electronic components are hard. The overall system is stretch crimpable and remains operational in both the stretched and crimped states. In the aspect of attaching the sensor to the skin, the invention adopts adhesive functional materials (such as polypropylene, polyvinyl alcohol, silica gel Silbaine RT4717 and the like) to realize close attachment with the skin without external fixation such as bandages, wrist bands and the like. In addition, on the integration of the signal processing and transmitting system, the invention selects the master control chip integrated with the Bluetooth generation function, supports the Bluetooth 5.0, has low power consumption, reduces the whole volume of the system and simplifies the wiring among different modules.
Drawings
FIG. 1 is a schematic circuit diagram of a skin-attached health detection system according to the present invention;
FIG. 2 is a schematic structural diagram of a first side and a second side of a front end flexible physiological signal detection module of the skin-attached health detection system of the present invention;
FIG. 3 is a process flow diagram of a method for manufacturing the skin-attached health detection system of the present invention.
The same reference numbers will be used throughout the drawings to refer to the same or like elements or structures, wherein: the flexible physiological signal detection module comprises a flexible substrate layer 1, a hard substrate layer 2, a mask 3, a wire layer 4, a first surface wire layer 401, a second surface wire layer 402, an epidermal electrode 403, a chip layer 5, a first decoupling capacitor 501, a TMP117 chip 502, an XC6206 buck chip 503, a second decoupling capacitor 504, a first pull-up resistor 505, a second pull-up resistor 506, a third pull-up resistor 507, a third decoupling capacitor 508, an MAX30102 chip 509, an oven 6, a flexible packaging layer 7, a box mold 8, a viscous functional layer 9, a CC2640R2F core processing module 10, an AD8232 electromyographic signal processing module 11, a program programming module 12, a clock crystal oscillator module 13, a Bluetooth antenna transmitting module 14, a CR2032 button cell 15, a TPS63001 boost module 16, a front-end communication module 17, a flexible physiological signal detection module 18, a FPC (flexible printed circuit board) connection, and a front-end flexible physiological signal detection module 19.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The invention provides a wearable skin-attached health detection system based on blood oxygen, body temperature and myoelectric signals, which is used for detecting the blood oxygen saturation, pulse, body temperature and myoelectric signals of a human body in real time and transmitting the detected data information to a remote mobile terminal through a Bluetooth antenna transmitting module to feed back the data information.
The health detection system comprises a front-end flexible physiological signal detection module and a rear-end signal processing output module, wherein the front-end flexible physiological signal detection module takes a flexible packaging material as a packaging layer, and the surface of the front-end flexible physiological signal detection module is provided with a viscous functional layer which is used for directly adhering to the skin of a user, so that the skin adhesion is that the whole health detection system is adhered to the skin of the user; the front-end flexible physiological signal detection module comprises a blood oxygen detection circuit, a body temperature detection circuit and an epidermal electrode and is used for respectively acquiring a pulse signal, a body temperature signal and an electromyographic signal;
the rear-end signal processing and outputting module is connected with the front-end flexible physiological signal detecting module and receives the pulse signal, the body temperature signal and the myoelectric signal; the rear end signal processing and outputting module processes and analyzes signals obtained by detection of the front end flexible physiological signal detection module, wherein the body temperature digital signals are accurate enough and do not need to be processed and analyzed, the pulse signals are two light intensity signals respectively reflected by infrared light and red light, the two pulse signals are firstly filtered, and then the blood oxygen saturation of a user can be calculated according to the Lamborbor theorem. And finally, sending the pulse information, the blood oxygen saturation information, the body temperature information and the muscle fatigue degree information of the user to the mobile terminal.
The technical solution of the present invention is further explained below with reference to specific examples, as shown in fig. 1 to 3.
The Sylgard184 polydimethylsiloxane can be used, wherein the mass ratio of the prepolymer to the curing agent can be 10:1, the prepolymer and the curing agent are uniformly mixed and stirred for 5-8 minutes, then the mixture is placed in a vacuum box drying box and stands for 40-60 minutes, and the mixture can be taken out after all bubbles generated by stirring are eliminated. The air pressure of the vacuum box is 0-0.1 atmosphere.
Then, uniformly coating the static polydimethylsiloxane on a common hard substrate 2, then placing the substrate on a platform of a spin coater, setting the spin coater into a single-step spin coating mode, and selecting the rotation speed of 300rpm/min and the acceleration of 300rpm2Min, spin coatingThe time is 45s, and the polydimethylsiloxane on the common hard substrate 2 is uniform and consistent in thickness; and after the spin coating is finished, standing the common hard substrate 2 coated with the polydimethylsiloxane in a spin mode for 1-2 minutes at normal temperature, putting the common hard substrate on the hot plate, adjusting the temperature to 90 ℃, and curing for 1 hour to obtain the flexible substrate layer 1 manufactured on the common hard substrate 2.
Then, the mask 3 engraved with the circuit pattern is attached to the flexible substrate layer 1, conductive silver paste is uniformly coated on the mask 3 of the circuit pattern part, a flat scraper can be adopted to scrape the mask 3 at a constant speed, the speed is kept at 1cm/s, the conductive silver paste is ensured to be uniformly coated on the flexible substrate layer 1, and the mask 3 is peeled off to form the conductive silver paste layer. The conductive silver paste is prepared by mixing and grinding commercial silver powder (such as AgF-3C silver powder) and polydimethylsiloxane according to the mass ratio of 3.5: 1.
Then, the flexible substrate layer 1 coated with the conductive silver paste layer and the hard substrate 2 are placed in an oven at 160 ℃, heated for 1 hour, and then the conductive silver paste layer is taken out to be cured and have excellent conductivity, so that the A-side conductive wire layer 401 is prepared.
Next, after the TMP117 chip 501, the XC6206 buck chip 503, the first pull-up resistor 505, the second pull-up resistor 506, the third pull-up resistor 507, the first decoupling capacitor 501, the second decoupling capacitor 504, the third decoupling capacitor 508, and the fourth decoupling capacitor are coated with conductive silver paste on the pins, the pins are clamped by tweezers and are lightly put down at positions aligned with the corresponding pin connections on the a-plane conductor layer 401, and then the chips are lightly pressed by the tweezers, thereby ensuring stable connections.
Conductive silver paste is coated on seven welding points exposed at one end of the FPC connecting flexible flat cable 18, and then the seven welding points are aligned to the SCL, SDA, INT, GND, VIN, RA, LA and RL ports on the A-side conducting wire layer 401, so that the FPC connecting flexible flat cable is connected with the A-side conducting wire layer 401.
And putting the device in the current stage into the oven at 160 ℃ again, heating for 1h, and taking out to realize the fixed connection of the chip and the FPC connecting flexible flat cable 18 and the A-surface conducting wire layer 401.
Then, placing a square frame mold 8 on the flexible substrate layer 1 with the cured FPC connected with the flexible flat cables 18 and the chips, fixing the square frame mold 8 by using a PI (polyimide) adhesive tape, slowly injecting the static polydimethylsiloxane into the square frame mold 8, uniformly covering the whole circuit after the static polydimethylsiloxane, then placing the circuit in an oven 6 for curing at 90 ℃ for 1 hour, taking out the circuit, manufacturing a flexible packaging layer 7 above the A-side chip layer 401, and then slowly taking off the square frame mold by using a blade.
And peeling off the device at the present stage from the hard substrate 2, turning over the device, placing the device on the hard substrate 2 again, and engraving a through hole for connecting the B-surface wire guide layer 402 and the A-surface wire guide layer 401 to be prepared on the other surface of the flexible substrate layer 1 by using a laser engraving machine.
And preparing a B-surface wire guide layer 402 by adopting the same process, attaching the MAX30102 chip on the wire guide layer of the cover surface by using the same method, finally attaching a square frame mold, pouring polydimethylsiloxane for packaging treatment, further coating a layer of adhesive functional layer material as an adhesive functional layer 9, standing for reaction for 25min, placing in an oven 8, curing at 60 ℃ for 3h, and taking out to obtain the B-surface flexible packaging layer 7 and the adhesive functional layer 9. Note that the flexible encapsulation layer 7 of the B-side may not cover the skin electrode 403 of the B-side.
Therefore, the front-end flexible physiological signal detection module is manufactured.
In this example, the back-end signal processing output module is a multi-layer rigid circuit, and can be manufactured by using a commercial PCB manufacturing process and an SMT mounting process.
As shown in fig. 2, in the present example, the front end flexible physiological signal detection module 19 comprises a flexible substrate layer 1, a wire layer 4, a chip layer 5, a flexible packaging layer 7 and an adhesive functional layer 9; the flexible substrate layer 1 is prepared by spin-coating polydimethylsiloxane on the hard substrate 2 and heating and curing at 90 ℃ for 1 h; the lead layer 4 comprises a front layer and a back layer of a surface A and a surface B, the lead layer 402 of the surface B comprises a surface electrode 403, the lead layer 4 is provided with a conductive silver paste layer with a circuit pattern by a special mask printing method, and then the conductive silver paste layer is put into a 160 ℃ oven to be heated for 1h for curing; the chip layer comprises a TMP117 chip on the A surface, an XC6206 voltage-reducing chip, a first pull-up resistor, a second pull-up resistor, a third pull-up resistor, a first decoupling capacitor, a second decoupling capacitor, a third decoupling capacitor, a fourth decoupling capacitor and a MAX30102 chip on the B surface, wherein pins of the lead layer 4 are connected at pin connection positions after conductive silver paste is coated on pins of the chip, and then the device is put into an oven to be heated for 1h at 160 ℃, and the full and fixed connection can be realized after the conductive silver paste is cured; the flexible packaging layer 7 is formed by pouring polydimethylsiloxane in a square frame mold, heating at 90 ℃ for 1h and then curing to protect the chip layer and the lead layer; the adhesive functional layer 9 is prepared by preparing a layer of organic polymer thin layer (such as polypropylene, polyvinyl alcohol, silica gel Silbaine RT4717 and the like) with good adhesiveness, and can adhere and fix the device on the skin to realize long-time good contact between the device and the skin.
As shown in fig. 3, in the present embodiment, the front end flexible physiological signal detection module passes the blood oxygen optical volume waveform signal and the body temperature signal acquired by the blood oxygen detection circuit and the body temperature detection circuit through I2The protocol C is transmitted to a rear-end signal processing output module through SCL, SDA and INT ports of the FPC 18; the front end flexible physiological signal detection module transmits weak current generated when the muscle of the user is contracted and collected by the skin electrode to the rear end signal processing output module through RA, LA and RL ports of the FPC connection flexible flat cable 18.
The body temperature and blood oxygen light volume waveform signals transmitted to the rear end signal processing output module by the front end flexible physiological signal detection module are directly transmitted to the CC2640R2F core processing module. The body temperature signal is directly transmitted to the mobile terminal through the Bluetooth antenna transmitting module 14 without any processing and displayed in real time. After the blood oxygen light volume waveform is processed by digital filtering, the ratio between the amplitude and the peak value of the projected light intensity in the same pulse process is found by a specially designed peak searching algorithm, and then a calculation formula is used
Calculating to obtain the value of the blood oxygen saturation of the user, wherein D1And D2The ratios of the absorption amplitude and the peak value of the light intensity respectively representing different wavelengths, A, B, C is a constantThe specific value can be determined by experimental calibration. And finally, sending the calculated blood oxygen saturation to a mobile terminal and displaying the blood oxygen saturation in real time. The front-end flexible physiological signal detection module 19 transmits the weak current collected by the skin electrode 403 when the muscle of the user contracts to the AD8232 electromyographic signal processing module of the rear-end signal processing output module, and then transmits the weak current to the CC2640R2F core processing module, and the fatigue state of the muscle of the user is judged by analyzing the electromyographic signal.
The skin-attached health detection system based on blood oxygen, body temperature and myoelectric signals can be used in cooperation with a specially designed APP in the mobile terminal. Through the wireless bluetooth communication of bluetooth antenna emission module and cell-phone terminal APP realization of rear end signal processing output module, transmission blood oxygen, body temperature and flesh electrical signal data. Can develop a supporting APP of section, the cell phone terminal can receive user's health data, APP operating procedure is simple and convenient, and the professional knowledge level requires lowly, and human-computer interaction interface is friendly, can be adapted to the crowd of different age brackets.
Each of the components employed in the present invention is commercially available; the connections of the pins of the functional module, the chip, and the like are not described in detail with reference to the relevant description.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. A skin-attached health detection system is characterized by comprising a front-end flexible physiological signal detection module (19) and a rear-end signal processing output module, wherein,
the front-end flexible physiological signal detection module (19) takes a flexible packaging material as a packaging layer, and the surface of the packaging layer is provided with an adhesive functional layer (9), and the adhesive functional layer (9) is used for directly adhering to the skin of a user; the front-end flexible physiological signal detection module (19) is used for collecting pulse signals, body temperature signals and myoelectric signals when being adhered to the skin epidermis of a user;
the rear-end signal processing and outputting module is connected with the front-end flexible physiological signal detecting module (19) and receives the pulse signal, the body temperature signal and the electromyographic signal; the rear-end signal processing and outputting module is used for converting the pulse signals into the blood oxygen saturation of the user, analyzing the time domain and the frequency domain of the electromyographic signals to judge the muscle fatigue degree of the user, and then sending the pulse information, the blood oxygen saturation information, the body temperature information and the muscle fatigue degree information of the user to the mobile terminal.
2. The skin-attached health detection system according to claim 1, wherein the front-end flexible physiological signal detection module (19) comprises a flexible substrate layer (1), a wire layer (4), a chip layer (5) and a flexible packaging layer (7), wherein the flexible substrate layer (1) and the flexible packaging layer (7) are used for cooperatively constructing a flexible frame body forming the front-end flexible physiological signal detection module (19), the wire layer (4) and the chip layer (5) are both located in the flexible frame body, the chip layer (5) is provided with a blood oxygen detection circuit and a body temperature detection circuit, and the wire layer (4) is used for conducting an electrical signal of the chip layer (5);
the blood oxygen detection circuit and the body temperature detection circuit are respectively used for acquiring pulse signals and body temperature signals.
3. The skin-attached health detection system of claim 2, wherein the chip layer (5) is a MAX30102 chip (509) and a TMP117 chip (502) to realize the blood oxygen detection circuit and the body temperature detection circuit to acquire the blood oxygen volume waveform and the body temperature of the user; the lead layer (4) comprises a skin electrode (403) and a lead, the skin electrode (403) is used for collecting myoelectric signals, the lead is used for transmitting electric signals, and the lead layer (4) is made of cured conductive silver paste with stretchable performance.
4. The skin-attached health detection system of claim 3, wherein the conductive silver paste is prepared by mixing and grinding silver powder and polydimethylsiloxane in a mass ratio of 3.5: 1;
the flexible substrate layer (1) and the flexible packaging layer (7) are made of polydimethylsiloxane;
the material of the viscous functional layer (9) is polypropylene, polyvinyl alcohol or silica gel Silbaine RT 4717.
5. The skin-attached health detection system according to claim 1 or 4, wherein the rear-end signal processing output module comprises a CC2640R2F core processing module (10), an AD8232 electromyographic signal processing module (11), a clock crystal oscillator module (13), a program programming module (12), a Bluetooth antenna emission module (14) and a front-end communication module (17);
the ports X32KQ1, X32KQ2, X24MP and X24MN of the CC2640R2F core processing module (10) are respectively connected with the input end of the clock crystal oscillator module (13); TMSC, TCKC, TDI, TDO and RESET ports of the CC2640R2F core processing module (10) are respectively connected with the input end of the program programming module (12) to realize program programming; the MCU AD port of the CC2640R2F core processing module (10) is connected with the input end of the AD8232 electromyographic signal processing module (11); the SCL, SDA and INT ports of the CC2640R2F core processing module (10) are respectively connected with the input end of the communication port of the front-end communication module (17); the RFN and RFP ports of the CC2640R2F core processing module (10) are respectively connected with the signal input end of the Bluetooth antenna emission module (14);
the ports IN +, IN-, RLD, RLDFB and RLD of the AD8232 electromyographic signal processing module (11) are connected with the input end of the communication port of the front-end communication module (17), wherein the ports RLD and RLDFB are connected to the same input port.
6. The skin-attached health detection system of claim 5, wherein the rear-end signal processing output module further comprises a power supply module, the power supply module comprises a CR2032 button cell (15) and a TPS63001 boost module (16); the CR2032 button cell (15) is used for providing fixed voltage, and the TPS63001 boosting module (16) is used for boosting the fixed voltage provided by the CR2032 button cell power supply module (15) to reach the required voltage of circuit operation;
the 3.3V voltage output end of the TPS63001 boosting module (16) is connected with the voltage input ends of the CC2640R2F core processing module (10) and the AD8232 electromyographic signal processing module (11); the 3.3V voltage output end of the TPS63001 boosting module (16) is also connected with the communication port of the front-end communication module (17) to provide stable voltage input for the front-end flexible physiological signal detection module (19).
7. The skin-attached health detection system according to claim 1, wherein the rear-end signal processing output module is connected to the front-end flexible physiological signal detection module (19) through an FPC connection flexible flat cable;
the front-end flexible physiological signal detection module (19) is connected with a flexible flat cable through the FPC and transmits detected pulse, body temperature and myoelectric signals to the rear-end signal processing output module for analysis and processing; the rear-end signal processing output module supplies power to the front-end flexible physiological signal detection module (19) through the FPC connecting flexible flat cable and provides ground potential at the same time.
8. The skin-attachable health detection system according to any one of claims 1 to 7, wherein the volume of the front-end flexible physiological signal detection module (19) is not more than 35mm x 20mm x2 mm; the rear end signal processing output module is a multilayer hard circuit, and the area of the rear end signal processing output module is not more than 28mm multiplied by 28 mm.
9. Method for preparing a skin-attachable health-detection system according to any of claims 1 to 8, comprising the steps of:
(1) firstly, solidifying polydimethylsiloxane on a hard substrate through spin coating to obtain a flexible substrate layer; then, a mask of a circuit to be printed is attached to the flexible substrate, and conductive silver paste is uniformly coated on the mask by a blade coating method; taking down the mask, and placing in a drying oven at 160 ℃ for 1 hour to obtain a wire layer on the first surface;
(2) a TMP117 chip, an XC6206 buck chip, a pull-up resistor and a decoupling capacitor are pasted on the lead layer on the first surface; the pins of each chip are adhered to the conductive layer in a mode of light touch pressing after being coated with conductive silver paste, the pins are fixedly connected after being cured for 1 hour in a drying oven at 160 ℃, and a chip layer of the first surface is prepared;
(3) adhering the port of the FPC flexible flat cable and the lead layer of the first surface through conductive silver paste, curing for 1 hour in a 160 ℃ oven, pouring polydimethylsiloxane on the chip layer of the first surface to serve as a flexible packaging layer, taking the flexible substrate layer down from the hard substrate after the polydimethylsiloxane is cured, and processing a through hole on the flexible substrate layer by using a laser engraving machine;
(4) preparing a second surface lead layer on the first surface by using the process in the step (1), wherein the second surface lead layer comprises a skin electrode; mounting a MAX30102 chip to prepare a second surface chip layer, and pouring polydimethylsiloxane to prepare a flexible packaging layer, wherein the flexible packaging layer on the second surface is not required to cover the surface electrode;
(5) and preparing an organic polymer layer on the flexible packaging layer of the second surface as a viscous functional layer to obtain the front-end flexible physiological signal detection module.
10. The method for preparing the skin-attachment health detection system according to claim 9, wherein the step (1) of uniformly coating the mask with conductive silver paste by a doctor blade method specifically comprises the step of performing doctor blade coating on the conductive silver paste by a flat blade, and the conductive silver paste passes through the mask printed with the circuit pattern under the extrusion of the doctor blade, so as to form a conductor layer with a pre-designed circuit pattern on the flexible substrate layer.
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