CN113855014B - Wireless power supply hybrid electronic system for postoperative flap and severed finger detection - Google Patents

Wireless power supply hybrid electronic system for postoperative flap and severed finger detection Download PDF

Info

Publication number
CN113855014B
CN113855014B CN202111234793.XA CN202111234793A CN113855014B CN 113855014 B CN113855014 B CN 113855014B CN 202111234793 A CN202111234793 A CN 202111234793A CN 113855014 B CN113855014 B CN 113855014B
Authority
CN
China
Prior art keywords
layer
power supply
self
dehydration
detection sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202111234793.XA
Other languages
Chinese (zh)
Other versions
CN113855014A (en
Inventor
吴豪
杨淦光
王书典
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Huazhong University of Science and Technology
Original Assignee
Huazhong University of Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huazhong University of Science and Technology filed Critical Huazhong University of Science and Technology
Priority to CN202111234793.XA priority Critical patent/CN113855014B/en
Publication of CN113855014A publication Critical patent/CN113855014A/en
Application granted granted Critical
Publication of CN113855014B publication Critical patent/CN113855014B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/24—Homopolymers or copolymers of amides or imides
    • C09J133/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K13/00—Thermometers specially adapted for specific purposes
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
    • H02J50/10—Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Power Engineering (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The invention belongs to the technical field related to medical detection, and discloses a wireless power supply hybrid electronic system for detecting postoperative skin flaps and severed fingers, which comprises: the double-sided flexible device integrated layer comprises a top surface detection module layer and a bottom surface signal processing output module layer which are in communication connection, and the top surface detection module layer comprises a blood oxygen detection sensor and a body temperature detection sensor; the self-adhesive anti-dehydration hydrogel adhesive layer is arranged on the surface of the double-sided flexible device integration layer, and the surface structure of the self-adhesive anti-dehydration hydrogel adhesive layer is a bulge and a micro-channel; the bottom surface signal processing output module layer comprises an NFC wireless power supply module and an output unit, the NFC wireless power supply module is used for realizing wireless charging, and the output unit is used for communicating with the mobile terminal App so as to visually display the detection results of the blood oxygen detection sensor and the body temperature detection sensor. The application provides an adhesion performance is good, and wireless integrated level that charges is high, small check out test set provides probably for the long-time human state that detects of sensor.

Description

Wireless power supply hybrid electronic system for postoperative flap and severed finger detection
Technical Field
The invention belongs to the technical field related to medical detection, and particularly relates to a wireless power supply hybrid electronic system for postoperative flap and severed finger detection.
Background
The severed finger replantation operation is to re-inosculate the completely or incompletely severed finger body and blood vessel, clean the wound thoroughly, and repair the bone, nerve, tendon and skin integrally. Medical personnel routinely reattach blood vessels under microscopic vision. Data show that the success rate of the implantation operation is about 95%, wherein the main reason for the failure of the amputated finger in the implantation operation is the blood vessel crisis caused by the skin flap transplantation, namely anastomotic spasm or embolism is generated after the microsurgery sews up a small blood vessel, so that the blood flow is not smooth, and the phenomenon of ischemia or blood stasis of organs or tissues is caused, which mostly occurs within 24 hours after the operation. Causes affecting vascular damage include pathological abnormalities of arteries and veins, such as external venous compression and venous thrombosis, 17% of free skin flaps present vascular damage during and after surgery, with rescue success rates of only 70% to 80%. The swelling of ischemic vascular cells leads to vessel collapse and the contraction of endothelial cells leads to the formation and proliferation of microthrombi. Would result in failure of the flap transplantation operation. Therefore, early real-time monitoring of the skin flap state is of great significance for improving the success rate of skin flap transplantation and reducing vascular damage. On the other hand, the existing method is lack of continuous nursing after replantation, the patient cannot evaluate the recovery condition of the affected limb in time, and the recovery degree of the finger tip function is low, so that the method has important significance in feeding back the numerical index detection of the real-time state of the severed finger clearly and easily under the requirement of continuous nursing at home.
For the conventional detection of the skin flap and severed finger after operation, the health state of the skin flap and the recovery condition of the severed finger are usually judged based on the observation of the characteristics of the skin flap, such as color, elasticity, capillary vessel filling degree, temperature, bleeding and the like, of medical staff, but the observation indexes are highly dependent on the experience of the medical staff, are difficult to quantify and are not beneficial to developing the continuous nursing in homes. Within 24 hours after the operation that the vascular crisis of skin flap is easy to happen, medical personnel need to untie the postoperative dressing repeatedly, regularly carry out skin flap monitoring to the patient, very be unfavorable for patient's wound to resume and aggravate medical personnel's nursing burden.
The skin flap severed finger detection technology and instrument in the prior art comprises the following steps: detection technologies based on flap angiography include color doppler ultrasound, computed Tomography Angiography (CTA), magnetic Resonance Angiography (MRA), digital Subtraction Angiography (DSA), and the like; techniques based on monitoring tissue metabolism and ischemia include near infrared spectroscopy and microdialysis techniques. The test instruments have important significance for improving the replantation success rate of severed fingers and early warning symptoms such as flap blood vessel injury, ischemia and the like, but the measurement technology has many limitations, such as complicated image reading related technology, related complications caused by injection radiography, invasive non-continuous measurement, long detection time consumption, high cost, large volume and the like. Some wearable flexible electronic sensing devices also appear, and monitoring of relevant indexes is achieved to a certain extent. However, the flexible sensing equipment at the present stage mostly adopts a conventional attachment means when in use, the adhesion layer is easy to lose performance, the service life is short, and meanwhile, the adaptability of the flexible sensing equipment in various dynamic scenes is also to be improved. Under the working condition of long-time continuous detection or dynamic large deformation, the continuous and stable work cannot be carried out. Therefore, the electronic system which is low in cost, wearable and capable of non-invasively and continuously detecting the blood flow states of the postoperative flap and the severed finger has a wide application prospect.
Disclosure of Invention
Aiming at the defects or the improvement requirements of the prior art, the invention provides a wireless power supply hybrid electronic system for postoperative flap and severed finger detection, provides a detection device with good adhesion performance, high wireless charging integration level and small volume, and provides possibility for a sensor to detect the state of a human body for a long time.
To achieve the above object, according to one aspect of the present invention, there is provided a wireless power supply hybrid electronic system for postoperative flap and severed finger detection, the system comprising a double-sided flexible device integration layer, a self-adhesive anti-dehydration hydrogel adhesion layer, and a mobile terminal App, wherein: the double-sided flexible device integration layer comprises a top surface detection module layer and a bottom surface signal processing output module layer which are in communication connection, and the top surface detection module layer comprises a blood oxygen detection sensor and a body temperature detection sensor which are respectively used for detecting blood oxygen and body temperature data of a detected object; the self-adhesive anti-dehydration hydrogel adhesive layer is arranged on the surface of the double-sided flexible device integrated layer, the self-adhesive anti-dehydration hydrogel adhesive layer comprises a hole matched with the blood oxygen detection sensor and the body temperature detection sensor so that the blood oxygen detection sensor and the body temperature detection sensor can be contacted with a measured object through the hole, and the surface structure of the self-adhesive anti-dehydration hydrogel adhesive layer is a protrusion and a micro-channel; the bottom surface signal processing output module layer comprises an NFC wireless power supply module and an output unit, the NFC wireless power supply module is used for realizing wireless charging, and the output unit is used for communicating with the mobile terminal App and then displaying the detection results of the blood oxygen detection sensor and the body temperature detection sensor in a visual mode.
Preferably, NFC wireless power supply module includes NFC power supply coil and the control unit, NFC power supply coil structure is the U-shaped structure of self-similar interconnection, the control unit includes power supply micro-processing chip, data receiving chip, energy receiving chip, step-up chip and decoupling capacitor, and when external power supply equipment was close to NFC power supply coil passed through the coil induction and produced voltage, through step-up chip and decoupling capacitor to blood oxygen detection sensor and body temperature detection sensor power supply.
Preferably, the surface structure of the self-adhesive anti-dehydration hydrogel adhesion layer is a wood frog bionic microstructure.
Preferably, the self-adhesive dehydrated-resistant hydrogel adhesive layer is prepared in the following manner: s1: uniformly mixing acrylamide monomers, SBMA zwitterionic monomers and sorbitol monomers, adding the mixture into a solvent, and mixing to obtain a mixed solution; s2: adding lithium chloride, a cross-linking agent and a photoinitiator into the mixed solution, mixing, performing ultrasonic oscillation, and performing degassing treatment to obtain a self-adhesive anti-dehydration hydrogel solution; s3: pouring the self-adhesive anti-dehydration hydrogel solution into a mould, and then carrying out photo-initiated polymerization demoulding to obtain the self-adhesive anti-dehydration hydrogel adhesive layer with the surface being provided with the protrusions and the micro-channels.
Preferably, the mold is prepared by a 3D printing technology, and the width of the mold corresponding to the micro-channel is 1.5-2.5 micrometers.
Preferably, the mass fractions of the acrylamide monomer, the SBMA zwitterionic monomer and the sorbitol monomer in the self-adhesive anti-dehydration hydrogel solution are respectively 25-29wt%,1.5-2.5wt% and 1-2 wt%.
Preferably, the acrylamide monomer comprises acrylamide and/or an acrylamide derivative, wherein the acrylamide derivative is one or a combination of N, N-diethylacrylamide and N-isopropylacrylamide, and the cross-linking agent is N, N' -methylenebisacrylamide or PEGDA, and the mass fraction of the cross-linking agent is 0.04-0.08 wt% of the mass fraction of the acrylamide monomer; the initiator is one or more of Irgacure2959, irgacure1173, APS and KPS, and the mass fraction of the initiator is 0.5-0.9 wt% of the self-adhesive dehydrated gel solution; the mass fraction of the lithium chloride is 15-20%.
Preferably, the top surface detection module layer and the bottom surface signal processing output module layer are communicatively connected by an I2C serial bus.
Preferably, the top surface detection module layer and the bottom surface signal processing output module layer are packaged by a flexible packaging layer.
Generally, compared with the prior art, the wireless power supply hybrid electronic system for post-operation skin flap and severed finger detection provided by the invention has the following beneficial effects:
1. the application provides a bilayer structure with top surface detection module layer and bottom surface signal processing output module layer, and the integrated level is high, and bottom surface signal processing output module layer includes wireless charging module, can realize wireless charging, need not the battery and has reduced the equipment volume, and top surface detection module can integrated sensor and be equipped with the adhesion layer that has special microstructure on it, and adhesion performance is better, does benefit to and wears the detection for a long time.
2. In the application process of the hydrogel, the surface of the hydrogel is provided with the protrusions or the microchannels, so that the adhesion performance is improved, and the sweat of a human body can be discharged through the microchannels, so that the adhesion performance of the hydrogel is further improved, the hydrophobic self-adhesion effect between the detection module and the skin is facilitated, the sweat is drained by utilizing the gaps built by the microstructures, the adhesion time of a system is prolonged, and the influence of bacterial breeding on wound recovery is avoided; furthermore, the shape of the bulges and the micro-channels is preferably a tree frog foot microstructure, so that the tree frog foot microstructure has good adhesion performance, is convenient for 3D printing and manufacturing, and is convenient for industrial application.
3. The viscosity and the dehydration resistance of the hydrogel are greatly improved by adding the SBMA zwitterionic monomer, the sorbitol monomer, the lithium chloride and the like into the hydrogel, so that the hydrogel can be attached to the skin for a long time without falling off.
4. On the basis of improving the adhesion performance of the hydrogel, the pathological detection device can be integrated on the hydrogel, so that the long-time contact between the pathological detection sensor and the skin of a human body can be realized, and the real-time detection of pathological sections becomes possible.
5. The sensor signal of the pathological detection sensor can be visually displayed on the mobile terminal through the output unit and the receiving unit, and a user can detect the physical condition of the user in real time.
6. This application adopts the wireless power supply mode of NFC to alleviate whole weight of system and volume, has effectively avoided wired charging to take off the loaded down with trivial details of wrapping, has the significance in clinical treatment and continuation nursing.
Drawings
FIG. 1 is a schematic diagram of a wireless power hybrid electronic system for post-operative skin flap and severed finger detection;
FIG. 2 is a process diagram of a method of making a self-adhesive dehydrated resistant hydrogel adhesive layer;
FIG. 3 is a structure of a self-adhesive dehydration resistant hydrogel adhesion layer;
FIG. 4 is a composition of a self-adhesive dehydrated resistant hydrogel adhesion layer;
FIG. 5 is a schematic diagram of the internal operation of a wireless power hybrid electronic system for post-operative flap and severed finger detection;
fig. 6 is a flow chart of the preparation of a wireless power hybrid electronic system for post-operative skin flap and severed finger detection.
The same reference numbers will be used throughout the drawings to refer to the same elements or structures, wherein:
1-integrated chip layer, 2-connected circuit layer, 3-flexible substrate, 4-flexible packaging layer, 5-benzophenone/ethanol solution, 6-acrylic mold, 7-self-adhesive anti-dehydration hydrogel solution, 8-photosensitive resin mold, 9-injector, 10-ultraviolet lamp, 11-hydrogel adhesion layer, 12-blood oxygen detection sensor, 13-through hole, 14-body temperature detection sensor, 15-double-sided flexible device integration layer, 16-NFC power supply coil, 17-CC2640R2F core processing output module, 18-NFC power supply module, 19-NFC power supply microprocessor, 20-NFC data reception, 21-PCA9431 energy reception, 22-boost chip, 23-decoupling capacitor, 24-Bluetooth radio frequency, 25-program burning module, 26-clock crystal vibration module, 27-mobile terminal App, 28-top surface detection module layer, 29-bottom surface signal processing output layer, 7-1-acrylamide, 7-2-N, N' -methylene bisacrylamide, 7-3-amphoteric SBMA, 7-iSBL-5-sorbitol monomer, and 296-sorbitol monomer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The invention provides a wireless power supply hybrid electronic system for postoperative flap and severed finger detection, which comprises a double-sided flexible device integration layer, a self-adhesive anti-dehydration hydrogel adhesion layer and a mobile terminal (App), as shown in figure 1.
The double-sided flexible device integration layer comprises a top surface detection module layer and a bottom surface signal processing output module layer which are in communication connection, and the top surface detection module layer comprises a blood oxygen detection sensor and a body temperature detection sensor which are respectively used for detecting blood oxygen and body temperature data of a measured object; the self-adhesive anti-dehydration hydrogel adhesive layer is arranged on the surface of the double-sided flexible device integrated layer, the self-adhesive anti-dehydration hydrogel adhesive layer comprises a hole matched with the blood oxygen detection sensor and the body temperature detection sensor so that the blood oxygen detection sensor and the body temperature detection sensor can be contacted with a measured object through the hole, and the surface structure of the self-adhesive anti-dehydration hydrogel adhesive layer is a protrusion and a micro-channel; the bottom surface signal processing output module layer comprises an NFC wireless power supply module and an output unit, the NFC wireless power supply module is used for realizing wireless charging, and the output unit is used for communicating with the mobile terminal App and then displaying the detection results of the blood oxygen detection sensor and the body temperature detection sensor in a visual mode.
The bottom signal processing output module layer filters the collected blood oxygen light volume waveforms of the red light and the infrared light in a fixed time domain length window to obtain direct current components and alternating current components of the blood oxygen light volume waveforms. The alternating current component of the blood oxygen optical volume waveform of the infrared light is processed by a peak searching algorithm to obtain the position of the peak value of the optical volume waveform in the window, so that the average pulse in a fixed time domain length can be calculated. Except for calculating average pulse, the ratio of alternating current component and direct current component of red light and infrared light at the peak point is determined by the position of the peak value of the light volume waveform, and then the blood oxygen saturation is mapped by using a calibration constant blood oxygen calculation formula. The time series signals of the blood oxygen saturation and the pulse can be obtained by moving the window according to the time intervals with equal length. The bottom surface signal processing and outputting module layer sends the blood oxygen saturation degree, the body temperature and the pulse signals to the mobile terminal App in real time through output.
The top surface detection module layer and the bottom surface signal processing output module layer are preferably prepared by adopting FPCB (printed Circuit Board) technology, the two-sided circuit is arranged on the flexible substrate, the flexible substrate is provided with a hole, and the two-sided circuit realizes I (in-line) through the hole 2 And C, communication can be performed by adopting a dark flexible material for packaging, then a layer of hydrogel with a microstructure is arranged on the packaging layer of the top surface detection module layer, so that the whole human body wearing the pathological detection device can be adhered to a skin code for a long time, the interference of motion artifacts is reduced, the accuracy of signals is improved, meanwhile, skin infection caused by sweat residue is avoided, and the whole preparation process does not need high-cost equipment and processes such as a purification room and ion etching, and the manufacturing cost is low.
As shown in fig. 2, the self-adhesive dehydrated-resistant hydrogel adhesive layer is prepared as follows:
s1: uniformly mixing acrylamide monomers, SBMA zwitterionic monomers and sorbitol monomers, adding the mixture into a solvent, and mixing to obtain a mixed solution.
The acrylamide monomer mainly comprises acrylamide and/or acrylamide derivatives, wherein the acrylamide derivatives comprise any one or more of N, N-diethyl acrylamide, N-isopropyl acrylamide and the like.
The solvent is preferably deionized water.
2.5g of acrylamide monomer is weighed; preparing the SBMA zwitterionic monomer and the sorbitol monomer into a uniform solution, and uniformly dropping the solution into a 30ml glass bottle through a pipette with the measuring range of 1000 microlitres; wherein the precursor monomer mixture is shaken on a shaker until the solution is uniformly mixed.
S2: and adding lithium chloride, a cross-linking agent and a photoinitiator into the mixed solution, mixing, performing ultrasonic oscillation, and performing degassing treatment to obtain the self-adhesive anti-dehydration hydrogel solution.
The cross-linking agent is preferably one or more of N, N' -methylene-bisacrylamide, PEGDA and the like, and the mass fraction of the cross-linking agent is 0.04 to 0.08 weight percent of the mass fraction of the acrylamide monomer; the photoinitiator is preferably one or more of Irgacure2959, irgacure1173, APS, KPS and the like, and the mass fraction of the photoinitiator is 0.5-0.9 wt% of the self-adhesive anhydrous gel solution; the mass fraction of the lithium chloride is 15-20%.
The mass fractions of the acrylamide monomer, the SBMA zwitterionic monomer and the sorbitol monomer in the self-adhesive anti-dehydration hydrogel solution are respectively 25-29wt%,1.5-2.5wt% and 1-2 wt%.
Injecting the deionized water into a 30ml sample bottle at a constant speed, and stirring by adopting a glass rod for 30min in the stirring operation; 2g LiCl was added; the cross-linking agent N, N' -methylene bisacrylamide aqueous solution and the photoinitiator Irgacure2959 are sequentially added into the mixed solution; wherein, ultrasonic oscillation is carried out for 30min by adopting an ultrasonic machine with the power of 100w and the ultrasonic temperature of 25 ℃; and the degassing treatment operation is to introduce nitrogen into the pre-polymerized hydrogel solution at a constant speed for 30min to obtain a completely degassed hydrogel solution.
S3: pouring the self-adhesive anti-dehydration hydrogel solution into a mould, and then carrying out photo-initiated polymerization demoulding to obtain the self-adhesive anti-dehydration hydrogel adhesive layer with the surface being provided with the protrusions and the micro-channels.
As shown in fig. 3, the mold is preferably a photosensitive resin micropore array mold, the photosensitive resin micropore array mold can be prepared by adopting a 3D printing technology, the precision reaches micron level, hydrogel is cast and formed in the mold, and a tree frog toe pad-like microstructure is achieved, the structure consists of hexagonal protrusions with the side length of about 10 microns and microchannels with the width of about 2 microns, sweat on the surface of a human body can be rapidly discharged along the microchannels, on one hand, the propagation of microorganisms such as bacteria is avoided, on the other hand, the direct contact between the skin surface and a hydrogel interface is favorably formed, and the adsorption force is increased.
As shown in fig. 4, the anti-adhesive dehydrated hydrogel adhesive layer can be obtained by polymerization in a mold by ultraviolet irradiation and then demolding.
The bottom signal processing output module layer is provided with an output unit, and the output unit can output the signal detected by the top detection module layer, for example, the signal can be output through a Bluetooth module.
The mobile terminal App can be arranged on mobile equipment, such as a mobile phone, an IPAD or a watch, and is used for displaying the blood oxygen saturation, the body temperature or the pulse signal of a measured object in real time. The monitoring can be realized by controlling the running and stopping of the whole detection system through the mobile terminal App. The mobile terminal App can store the received blood oxygen saturation, body temperature and pulse in real time to the mobile terminal platform locally according to a time sequence.
The bottom surface signal processing output module layer comprises an NFC wireless power supply module, the NFC wireless power supply module comprises an NFC power supply coil, and the NFC coil structure is a self-similar interconnected U-shaped structure. The NFC power supply coil is formed by winding a copper wire with good ductility and flexibility. The copper wire has good physical properties, and meanwhile, the power supply efficiency is improved. To increase the inductive charging area, the NFC power coil is laid around the edge of the topside flexible substrate. The control of the gap between every two coils is twice the width of the wire so as to increase the deformation capacity of the coils along with the top surface module, and the wiring shape is of a self-similar interconnected U-shaped structure so as to improve the overall ductility of the coils. The adhering mode is that inlaying is combined with chemical adhering, and before the flexible substrate is formed, the coil coated and polarized by the adhesive is placed on the flexible substrate and is solidified and formed together, so that the adhering is completed.
The NFC wireless power supply module further comprises a control unit, the control unit comprises a power supply micro-processing chip, a data receiving chip, an energy receiving chip, a boosting chip and a decoupling capacitor, when external power supply equipment is close to the NFC power supply coil, voltage is generated by the NFC power supply coil through coil induction, and power is supplied to the blood oxygen detection sensor and the body temperature detection sensor through the boosting chip and the decoupling capacitor. Specifically, electromotive force obtained by induction of the NFC power supply coil is processed by the boost chip to output 3V stable voltage, and then the power is supplied to a hardware layer of the whole system after decoupling is carried out through two 100nF grounding capacitors connected in parallel. When the power supply terminals approach, the battery-less direct power supply is started in accordance with the WPC standard.
As shown in fig. 5, the bottom signal processing output module layer further includes a CC2640R2F core processing output module 17, a program programming module 25, and a clock oscillator module 26. The CC2640R2F core processing module can control the operation of the modules in the top surface detection module layer, analyze and process physiological signals acquired by the modules in the top surface detection module layer, and perform data interaction with the receiving unit through the output unit. The program programming module is used for writing programs and protocols required to be operated by the system into the CC2640R2F core processing module. The clock crystal oscillator module is used for assisting the CC2640R2F core processing module to normally operate, and the clock crystal oscillator module adopts two passive crystal resonators of 24Mh and 32.768 kHz. The output unit is preferably a Bluetooth radio frequency, the Bluetooth radio frequency ensures excellent data communication in a form of a differential antenna, and the impedance of the Bluetooth radio frequency antenna is 50 omega.
The application has important effect in the field of severed finger replantation. A wearable paster that is used for wireless power supply hybrid electronic system of postoperative flap and severed finger detection can be to measurand's oxyhemoglobin saturation, skin temperature and pulse signal, rethread bluetooth and mobile terminal App27 communication. Specific examples are as follows.
In this embodiment, the MAX30102EFD + T blood oxygen detecting chip and the TMP117aid rvr semiconductor temperature sensing chip are selected to be respectively used as the blood oxygen detecting sensor 12 and the body temperature detecting sensor 14 on the top surface of the double-sided flexible device integrated layer 15. MAX30102EFD + T and TMP117AIDRVR both adopt I 2 The C bus is communicated with the CC2640R2F core processing output module 17 of the double-sided flexible device integrated layer 15, and can share the SCL and the SCLAn SDA port.
EPSON 24MHz TSX-3225 and 32.768kHz FC-135 passive crystal resonators are selected as the external clock crystal oscillator circuit 26 of the CC2640R2F core processing output module 17. AN2051-24 with impedance of 50 omega is selected as a Bluetooth antenna of the Bluetooth radio frequency 24, and the circuit adopts a differential design to enhance the stability of signals. An LPC804 chip is selected as an NFC power supply microprocessor 19, a CRN120 chip NFC data receiving 20, a PCA9431 energy receiving 21 processing chip, and the LPC chip, the CRN120 chip NFC data receiving chip and the PCA9431 energy receiving processing chip are used as a boost chip 22 and a decoupling capacitor 23 of an NFC power supply module 18 through a TPS63001DRCR to form a 3V input power supply of the NFC power supply module 18.
Fix FPCB top surface detection module layer that design has blood oxygen detection circuit and body temperature detection circuit on flexible substrate 3 to ensure that whole FPCB is level and smooth, then shift it to two-sided flexible device integrated layer 15 top surface, connect the connecting wire and pass and ally oneself with through-hole 13 and realize the chain of two sides UNICOM circuit layer 2, with bottom surface signal processing output module layer interconnect.
As shown in fig. 6, before pouring flexible encapsulation layer 4, the top test module layer 28 is wiped with a dry alcohol paper towel to ensure that the surface is free of contaminants. The flexible packaging layer can be prepared by mixing dark PDMS and carbon black, wherein the mass ratio of the prepolymer of the PDMS to the curing agent is 10: 1, and the mass ratio of the PDMS to the carbon black is 100: 1. The above materials were added sequentially and continuously stirred in a plastic preparation cup, which was continued for 5 minutes to ensure uniform mixing of the components. In order to remove bubbles in the prepolymer, the prepolymer after stirring and mixing is placed in a vacuum drying box with 0-0.08 atmospheric pressure for standing for half an hour, and is taken out after the bubbles are completely eliminated. Then, 2ml medical injector is adopted to absorb polydimethylsiloxane at uniform speed and evenly coat the polydimethylsiloxane on the upper layer of the integrated chip layer 1, standing is carried out for 2min, after the polydimethylsiloxane is evenly diffused, the device is placed on a temperature-adjustable hot plate, the temperature is adjusted to 95 ℃, the heating time is 28min, and then the flexible packaging of the top surface detection module layer 28 can be realized. After the pressed self-similar U-shaped NFC power supply coil is placed on the bottom surface, the steps are repeated, and the self-similar U-shaped NFC power supply coil can be used for flexible packaging of the bottom surface signal processing output module layer 29.
Placing the double-sided flexible device integrated layer 15 subjected to flexible packaging treatment in an acrylic mold 6, and uniformly coating a benzophenone/ethanol solution 5 on the flexible packaging layer, wherein the mass ratio of the benzophenone to the ethanol in the benzophenone/ethanol solution 5 is 3: 50; the time for treating the benzophenone/ethanol solution 5 is 10min, and then nitrogen is introduced to blow and dry the residual solution on the surface.
And then, completely covering the acrylic mold 6 with the photosensitive resin mold 8, injecting the self-adhesive dehydration-resistant hydrogel solution 7 into the upper surface of the flexible packaging layer 4 treated by the solution through a preformed hole of the mold by using a medical injector 9, and stopping injecting when the self-adhesive dehydration-resistant hydrogel solution 7 just overflows the photosensitive resin mold 8. Care was taken not to cause air bubbles to form in the pre-polymerized self-adhesive dehydrated hydrogel, which would otherwise interfere with the functioning of the hydrogel layer.
Subsequently, the double-sided flexible device integration layer 15 covered with the photosensitive resin mold 8 is placed under an ultraviolet lamp 10 with power of 75w and wavelength of 365nm for illumination for 32 minutes, and the hydrogel adhesion layer 11 with complete polymerization can be obtained.
And finally, removing the photosensitive resin mold 8 and the acrylic mold 6 from the front-section state detection module in sequence to obtain the complete chip device.
In the present example, the self-adhesive dehydration-resistant hydrogel solution 7 includes acrylamide 7-1, N' -methylenebisacrylamide 7-2, SBMA zwitterionic monomer 7-3, ir2959 photoinitiator 7-4, liCl7-5, sorbitol monomer 7-6; the mass fractions of the acrylamide, the SBMA zwitterionic monomer and the sorbitol monomer are respectively 25-29wt%,1.5-2.5wt% and 1-2wt%; further preferably, the weighed mass of the acrylamide monomer 7-1 is 2.5g; the SBMA zwitterionic monomer 7-3 and the sorbitol monomer 7-6 are respectively prepared into SBMA zwitterionic solution and sorbitol solution, and the SBMA zwitterionic solution and the sorbitol solution are uniformly sucked by a 1000-microliter liquid-transferring gun and dripped into a 30ml glass bottle; wherein the precursor monomer mixture is shaken on a shaker until the solution is uniformly mixed. Injecting the deionized water into a 30ml sample bottle at a constant speed; stirring by a glass rod for 30min in the stirring operation; the cross-linking agent is N, N' -methylene bisacrylamide aqueous solution 702, and the initiator is Ir2959 photoinitiator 7-4 which is sequentially added into the mixed solution; performing ultrasonic oscillation for 30min by adopting an ultrasonic machine with the power of 100w and the ultrasonic temperature of 25 ℃; and the degassing treatment operation is to introduce nitrogen into the self-adhesive dehydration-resistant hydrogel solution 7 at a constant speed for 30min to obtain the self-adhesive dehydration-resistant hydrogel solution 7 which is completely degassed. Simultaneously injecting a self-adhesive dehydration-resistant hydrogel solution 7 into a photosensitive resin mold 8 on the flexible packaging layer 4; wherein the flexible packaging layer 4 needs to be soaked for 10min by adopting a benzophenone/ethanol solution 5; a photosensitive resin mould 8 is adopted to completely cover the upper part of the acrylic mould 6; the ultraviolet lamp 10 initiates polymerization for 32min to obtain the hydrogel adhesive layer 11.
Firstly, an external power supply device is close to a hybrid electronic system, the external power supply device is induced to be electrified through an NFC power supply coil 16, and after being processed by an NFC power supply module 18, the external power supply device is not subjected to energy storage, and 3V working voltage is formed and directly used for driving the system to work. After the CC2640R2F core processing output module 17 reads the program to be run from the program programming module 25 of the bottom signal processing output module 29, the user can use the mobile terminal receiving unit 27 to control the running condition of the hybrid electronic system through bluetooth, the top detection module layer 28 transmits the collected blood oxygen volume waveform data of red light and infrared light and the body temperature data to the CC2640R2F core processing output module 17 of the bottom signal processing output module 29 through the data bus for processing and analysis, and then the CC2640R2F core processing output module 17 transmits the processed related signals to the mobile terminal receiving unit 27 through the bluetooth radio frequency 24 for real-time display.
The wireless power supply hybrid electronic system for postoperative flap and severed finger detection is combined with a matched mobile terminal App for use, and wireless Bluetooth communication data transmission is achieved with the mobile terminal APP. The APP is simple and convenient to operate, the interactive interface is friendly, and the APP can be used by people of different ages.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (7)

1. The utility model provides a wireless power supply hybrid electronic system that is used for postoperative flap and severed finger to detect, its characterized in that, the system includes two-sided flexible device integrated layer, self-adhesion anti-dehydration hydrogel adhesion layer and mobile terminal App, wherein:
the double-sided flexible device integration layer comprises a top surface detection module layer and a bottom surface signal processing output module layer which are in communication connection, and the top surface detection module layer comprises a blood oxygen detection sensor and a body temperature detection sensor which are respectively used for detecting blood oxygen and body temperature data of a measured object;
the self-adhesive anti-dehydration hydrogel adhesive layer is arranged on the surface of the double-sided flexible device integrated layer, the self-adhesive anti-dehydration hydrogel adhesive layer comprises a hole matched with the blood oxygen detection sensor and the body temperature detection sensor so that the blood oxygen detection sensor and the body temperature detection sensor can pass through the hole to be contacted with a detected object, the surface structure of the self-adhesive anti-dehydration hydrogel adhesive layer is a bulge and a micro-channel, the surface structure of the self-adhesive anti-dehydration hydrogel adhesive layer is a wood frog bionic micro-structure, and the self-adhesive anti-dehydration hydrogel adhesive layer is prepared in the following way: s1: uniformly mixing acrylamide monomers, SBMA zwitterionic monomers and sorbitol monomers, adding the mixture into a solvent, and mixing to obtain a mixed solution; s2: adding lithium chloride, a cross-linking agent and a photoinitiator into the mixed solution, mixing, performing ultrasonic oscillation, and performing degassing treatment to obtain a self-adhesive anti-dehydration hydrogel solution; s3: pouring the self-adhesive anti-dehydration hydrogel solution into a mould, and then carrying out photo-initiated polymerization demoulding to obtain a self-adhesive anti-dehydration hydrogel adhesive layer with the surface being a bulge and a micro-channel;
the bottom surface signal processing output module layer comprises an NFC wireless power supply module and an output unit, the NFC wireless power supply module is used for realizing wireless power supply, and the output unit is used for communicating with the mobile terminal App so as to visually display the detection results of the blood oxygen detection sensor and the body temperature detection sensor.
2. The system of claim 1, wherein the NFC wireless power supply module comprises an NFC power supply coil and a control unit, the NFC power supply coil is of a self-similar interconnected U-shaped structure, the control unit comprises a power supply micro-processing chip, a data receiving chip, an energy receiving chip, a boosting chip and a decoupling capacitor, when an external power supply device approaches, the NFC power supply coil induces and generates voltage through the coil, and power is supplied to the blood oxygen detection sensor and the body temperature detection sensor through the boosting chip and the decoupling capacitor.
3. The system of claim 1, wherein the mold is prepared using 3D printing technology, and the microchannel corresponds to a mold width of 1.5 to 2.5 microns.
4. The system of claim 1, wherein the mass fractions of the acrylamide-based monomer, the SBMA zwitterionic monomer and the sorbitol monomer in the self-adhesive anti-dehydration hydrogel solution are 25 to 29%,1.5 to 2.5% and 1 to 2%, respectively.
5. The system of claim 1, wherein the acrylamide monomer comprises acrylamide and/or an acrylamide derivative, wherein the acrylamide derivative is one or a combination of N, N-diethylacrylamide and N-isopropylacrylamide, and the cross-linking agent is N, N '-methylenebisacrylamide or PEGDA, and the mass fraction of the N, N' -methylenebisacrylamide is 0.04-0.08% of the mass fraction of the acrylamide monomer; the initiator is one or more of Irgacure2959, irgacure1173, APS and KPS, and the mass fraction of the initiator is 0.5-0.9% of that of the self-adhesive anti-dehydration hydrogel solution; the mass fraction of the lithium chloride is 15-20%.
6. The system of claim 1, wherein the top detection module layer and the bottom signal processing output module layer pass through I 2 C is connected in series with the bus communication.
7. The system of claim 1, wherein the top surface detection module layer and the bottom surface signal processing output module layer surface are encapsulated by a flexible encapsulation layer.
CN202111234793.XA 2021-10-22 2021-10-22 Wireless power supply hybrid electronic system for postoperative flap and severed finger detection Active CN113855014B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111234793.XA CN113855014B (en) 2021-10-22 2021-10-22 Wireless power supply hybrid electronic system for postoperative flap and severed finger detection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111234793.XA CN113855014B (en) 2021-10-22 2021-10-22 Wireless power supply hybrid electronic system for postoperative flap and severed finger detection

Publications (2)

Publication Number Publication Date
CN113855014A CN113855014A (en) 2021-12-31
CN113855014B true CN113855014B (en) 2023-02-10

Family

ID=78997281

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111234793.XA Active CN113855014B (en) 2021-10-22 2021-10-22 Wireless power supply hybrid electronic system for postoperative flap and severed finger detection

Country Status (1)

Country Link
CN (1) CN113855014B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111343902A (en) * 2017-06-07 2020-06-26 得克萨斯大学体系董事会 Wireless, wearable, and flexible biometric sensor
CN113180618A (en) * 2021-04-20 2021-07-30 华中科技大学 Skin-attached health detection system and preparation method thereof
US11116448B1 (en) * 2021-01-28 2021-09-14 Anexa Labs Llc Multi-sensor wearable patch

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111333872B (en) * 2020-04-10 2022-11-08 西安工业大学 Preparation method of anti-freezing organic-hydrogel with reversible adhesion and self-healing performance
CN111925476A (en) * 2020-07-17 2020-11-13 浙江工业大学 Conductive antibacterial hydrogel and preparation method and application thereof
CN112932551A (en) * 2021-01-28 2021-06-11 武汉大学 Chip for detecting trace body surface secretion and use method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111343902A (en) * 2017-06-07 2020-06-26 得克萨斯大学体系董事会 Wireless, wearable, and flexible biometric sensor
US11116448B1 (en) * 2021-01-28 2021-09-14 Anexa Labs Llc Multi-sensor wearable patch
CN113180618A (en) * 2021-04-20 2021-07-30 华中科技大学 Skin-attached health detection system and preparation method thereof

Also Published As

Publication number Publication date
CN113855014A (en) 2021-12-31

Similar Documents

Publication Publication Date Title
CN113729654B (en) Skin-attached sensing system for detecting postoperative skin flap and limb blood flow state reconstruction
Ying et al. Skin-like hydrogel devices for wearable sensing, soft robotics and beyond
CN105852806B (en) A kind of electronic skin monitored in real time for wound
Kim et al. Epidermal electronics
CN113801265B (en) Electrode and signal detection system
US11911154B2 (en) Skin-attached blood oxygen saturation detection system and preparation method thereof
US20170086684A1 (en) Electronic skin patch for health monitoring
Zhu et al. Hydrogel-based smart contact lens for highly sensitive wireless intraocular pressure monitoring
CN103622693A (en) Portable bio-electrical impedance measurement device
CN101773387A (en) Body feeling network-based sleeveless driven pulse pressure measurement and automatic calibration device
CN106725396A (en) A kind of noninvasive blood pressure measuring device by shooting and measuring method based on double pulse waves
CN203852348U (en) Detection circuit of skin surface conditions
CN111839503A (en) Skin-attached electrocardiogram acceleration detection system and preparation method thereof
Sun et al. Hydrogel-integrated multimodal response as a wearable and implantable bidirectional interface for biosensor and therapeutic electrostimulation
CN109793516A (en) A kind of skin pricktest impedance flexible detection device and skin pricktest impedance detection method
CN113855014B (en) Wireless power supply hybrid electronic system for postoperative flap and severed finger detection
CN111449637A (en) Evaluation system and method for arteriovenous internal fistula blood vessel
CN107320102A (en) A kind of bladder urination time reminding method and apparatus for evaluating based on forecast model
CN106073735A (en) A kind of integrated circuit structure for continuous detecting human blood-pressure
CN205041388U (en) Sphygmomanometry apparatus
CN114305431A (en) Myoelectricity and piezoelectric combined sensing system and control method thereof
CN1813629A (en) Micro-wound encephalic pressure detecting system and its use method
CN210204713U (en) Blood pressure monitoring system
CN114259219A (en) Disposable postoperative blood circulation detection monitoring system and preparation method
US20190313918A1 (en) Arterial pulse signal measurement device and pressure sensor

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant