CN105852806B - A kind of electronic skin monitored in real time for wound - Google Patents
A kind of electronic skin monitored in real time for wound Download PDFInfo
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- CN105852806B CN105852806B CN201610172862.1A CN201610172862A CN105852806B CN 105852806 B CN105852806 B CN 105852806B CN 201610172862 A CN201610172862 A CN 201610172862A CN 105852806 B CN105852806 B CN 105852806B
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- 206010052428 Wound Diseases 0.000 claims abstract description 113
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 113
- 239000000463 material Substances 0.000 claims abstract description 17
- 238000012544 monitoring process Methods 0.000 claims abstract description 16
- 230000029663 wound healing Effects 0.000 claims abstract description 6
- 229920002379 silicone rubber Polymers 0.000 claims abstract description 5
- 210000003491 skin Anatomy 0.000 claims description 29
- 238000004891 communication Methods 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 230000036560 skin regeneration Effects 0.000 claims description 9
- 238000007405 data analysis Methods 0.000 claims description 8
- 238000013079 data visualisation Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 6
- 230000035876 healing Effects 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 238000012549 training Methods 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 5
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 5
- 238000005424 photoluminescence Methods 0.000 claims description 5
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 5
- 230000002491 angiogenic effect Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000012010 growth Effects 0.000 claims description 4
- 230000002159 abnormal effect Effects 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 3
- 210000004207 dermis Anatomy 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000004945 silicone rubber Substances 0.000 claims description 3
- 230000008961 swelling Effects 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims description 2
- 230000005284 excitation Effects 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 6
- 239000004642 Polyimide Substances 0.000 abstract description 2
- 230000005540 biological transmission Effects 0.000 abstract description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract description 2
- 229920001721 polyimide Polymers 0.000 abstract description 2
- 229920005573 silicon-containing polymer Polymers 0.000 abstract description 2
- 229920001661 Chitosan Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 description 8
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 7
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 6
- 229940116269 uric acid Drugs 0.000 description 6
- 210000000416 exudates and transudate Anatomy 0.000 description 4
- 229920002101 Chitin Polymers 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 241001269238 Data Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000000558 Varicose Ulcer Diseases 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 230000001741 anti-phlogistic effect Effects 0.000 description 2
- 238000007705 chemical test Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
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- 238000011069 regeneration method Methods 0.000 description 2
- 230000008470 skin growth Effects 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- NAFSTSRULRIERK-UHFFFAOYSA-M monosodium urate Chemical compound [Na+].N1C([O-])=NC(=O)C2=C1NC(=O)N2 NAFSTSRULRIERK-UHFFFAOYSA-M 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
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- 230000004144 purine metabolism Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- 231100000241 scar Toxicity 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0531—Measuring skin impedance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0052—Body part for treatment of skin or hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- Health & Medical Sciences (AREA)
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a kind of electronic skins monitored in real time for wound, the electronic skin lays various kinds of sensors on the flexible material (dimethyl silicone polymer, flexible polyimide, collagen-chitosan/silicon rubber) of bio-compatible, the abundant physics and chemistry information of acquisition wound in real time, and realize real-time transmission of the data to software service system using Bluetooth Low Energy technology.Invention software system obtains wound physics and chemistry information in real time, and information is analyzed in real time, the current state of wound is obtained, sends out instruction to electronic skin as needed, and wound is improved by presupposed solution using wound thermoregulator, promote wound healing.Electronic skin software and hardware system of the present invention cooperates, and realizes the real-time monitoring to wound and improves on demand.
Description
Technical field
The invention belongs to software-hardware synergism field of medical technology, and in particular to a kind of electronics skin monitored in real time for wound
Skin.
Background technology
In recent years, soft electronic industry development is swift and violent, is got in the performance of the industries such as flexible screen, flexible battery, flexible sensor
Carry out bigger effect.But soft electronics permeates still inadequate in medical field.Medical field is due to its particularity, for soft material
Expect, the bio-compatibility of material has tightened up demand.On the other hand, in terms of specific to wound monitoring, traditional wound prison
Survey method mainly relies on unaided eye discrimination wound situation, more more complicated, is that extraction wound surface body fluid is further managed
Change detection.The former needs to rely on medical experience, and poor accuracy, easily by subjective impact, then flow is complicated by the latter, somewhat expensive, also
Pain may be brought to patient.Since the poor accuracy either flow of said program is complicated, lead to not carry out wound real
When monitoring, optimal processing can not be carried out to wound on optimal opportunity, therefore to the real-time monitoring system of wound
Demand is objective reality and urgent.
Traditional wound monitoring method is exactly mainly to take away bandage to observe wound, is sentenced according to the physics and chemistry form of wound tissue
Its disconnected healing situation.On the one hand, it if wound does not heal also, is likely to that wound is made to be infected in this way, leaving can not smear
The scar fallen increases patient suffering；On the other hand, the conclusion obtained is observed by the naked eye to need to rely on medical experience, accuracy
Difference easily by subjective impact, and can only obtain qualitative conclusions.
More complicated monitoring method is then that extraction wound surface body fluid carries out further Physico-chemical tests.For example, in the recent period
One of Melissa L Fernande etc. has found the uric acid content in detection wound exudate for the research of Venous Ulcers
Contribute to the severity of differentiation wound.Uric acid can deposit sodium urate crystals (Monosodium urate in wound
Crystal) cause inflammatory reaction, to inhibit wound healing.By detecting the composition of wound exudate, researcher has found when urine
When sour water is flat higher, wound is more serious, and healing time is also longer.Researcher thinks can be by monitoring in wound exudate
Uric acid or a variety of uric acid precursor levels differentiate the severity with predicted wound, have certain diagnostic value.Uric acid level
Raising be often proportionate with wound seriousness, and the raising of uric acid precursor such as purine level show wound severity compared with
It is low.Therefore the purine metabolism variation in monitoring wound exudate will be seen that the healing of chronic wounds such as Venous Ulcers etc.
Journey.In addition, Harvard Medical School's professor's Kang Na L Evans has developed a kind of bandage.This bandage adds fluorescent powder, it can
To absorb light, while being discharged again.When wound lacks oxygen, the fluorescent powder in this bandage will redden, such as
Fruit oxygen is sufficient, then can show green light.The oxygen supply situation of wound can be thus judged by fluorescence color.More than but
The method flow of these monitoring wound surface body fluid physicochemical properties is complicated, somewhat expensive, and cannot be carried out to wound real-time
Monitoring can not carry out optimal processing on optimal opportunity to wound.
It can be seen that the prior art is primarily present following defect：
(1) poor accuracy, a large amount of subjectivities and experience for relying on people.
(2) according to Physico-chemical tests method, somewhat expensive, flow is complicated, poor in timeliness.
(3) it can not monitor in real time, to adjust wound physicochemical environment in real time, miss best conditioning opportunity.
Invention content
For the above-mentioned technical problem present in the prior art, the present invention provides a kind of electricity monitored in real time for wound
Sub- skin can realize the real-time monitoring to wound and improve on demand.
A kind of electronic skin monitored in real time for wound, including hardware system and software systems；
The hardware system includes main control unit, sensing unit and execution unit；Sensing unit and execution unit pass through
PDMS (dimethyl silicone polymer) is fitted in wound site, and main control unit is then made in flexible PI (polyimides) substrate and leads to
Extending conducting wire is crossed to connect with sensing unit and execution unit；Wherein：
The sensing unit is for acquiring wound about temperature, humidity, swelling tensile stress, Skin Resistance, the ECG (hearts
Electrograph) and blood oxygen variation sensing data；
The execution unit is used to carry out electro photoluminescence to wound to wrap to accelerate angiogenic growth, or by heating and melting fat
The drug wrapped up in wound carry out anti-inflammatory, or by ultraviolet excitation stimulate antibacterials wound is discharged, or to wound into
Row cooling；
The main control unit is used to collect the sensing data of sensing unit offer and is transmitted sensing data by bluetooth
To software systems, while the control instruction that software systems are sent out is received, and then control execution unit is adjusted wound climate,
Promote wound healing；
The software systems load on intelligent terminal comprising bluetooth communication module, data calibration module, data can
Depending on changing module, data analysis module and warning module；Wherein：
The sensing data that the bluetooth communication module is used to collect by Bluetooth protocol wireless receiving main control unit；
The data calibration module is for calibrating the sensing data that bluetooth communication module receives；
The data visualization module takes various forms carries out visualized operation to the sensing data after calibration；
The data analysis module judges that wound is in initial stage, mid-term or healing stage based on the sensing data after calibration
The specific stage, analysis wound climate it is whether normal；When abnormal conditions occurs in wound climate, by bluetooth communication module to master
Control the control instruction that unit sends adjustment wound climate；
The warning module is analyzed based on the sensing data after calibration, and when judging wound surface, nearby there are weight
Or in the case of excessively boiling hot object, alarm is sent out to the wounded.
Further, the main control unit includes central processing unit, memory, I2C interface and Bluetooth antenna etc..
Further, the flexible PI substrates are combined with skin regeneration material, and skin regeneration material is in direct contact wound
The surface of a wound has good biocompatibility, can induce skin corium regeneration.
The skin regeneration material uses by collagen-chitin dermis scaffold and leads to certain thickness silicone rubber membrane
The good adhesive bonds of biocompatibility are crossed to form.
Further, the sensing unit includes interdigital electrode, tensile stress meter, temperature sensor, humidity sensor, light
Electric diode etc..The execution unit includes heater, cooler, ultraviolet leds and Electric radiant Heating Film etc..Wherein, interdigital electrode
It realizes that Skin Resistance and ECG measure, judges skin growth situation, while can be used for applying electro photoluminescence stimulation angiogenic growth；Add
Hot device can heat wound, and can also inflammatory sites be heated with fatty inclusion enclave release antiphlogistic (different temperatures)；Blood oxygen uses
Photodiode, which receives, to be measured.
Further, the visualized operation of the data visualization module includes the monitoring for showing each sensor of sensing unit
The semantic information of data, the curve graph of each sensor historic data of display, each sensing data of display.
Further, the data analysis module is collected all the sensors of the wound of different patients in each stage and is gone through
History data form multigroup training sample；Then SVM classifier is trained using training sample, forms wound disaggregated model；
And then classified to the stage residing for wound using the model, form diagnostic result.
Further, the warning module using vibrating alert, sound prompting, pictograph remind etc. various ways to
The wounded sends out alarm.
The software systems have analysis, operational capability, are responsible for the life to the acquisition of data, analysis and control instruction
At；The hardware system is responsible for the acquisition of data and the execution to control instruction, and the two is wound monitoring service jointly.
The intelligent terminal can be smart mobile phone, tablet computer or PC machine etc..
The hardware components of electronic skin of the present invention acquire the abundant physics and chemistry information of wound in real time using various kinds of sensors, utilize
Bluetooth Low Energy technology realizes real-time transmission of the data to software systems, and bio-compatible is realized using polydimethyl siloxane material
Property, wound is improved by presupposed solution using wound thermoregulator；Software section obtains wound physics and chemistry information in real time,
And information is analyzed in real time, the current state of wound is obtained, instruction is sent out as needed, the environment of wound is adjusted
It is whole, promote wound healing；Software and hardware system cooperates, and to wound monitor and improve on demand in real time.
Description of the drawings
Fig. 1 is the structural schematic diagram of electronic skin of the present invention.
Fig. 2 is the collaborative work flow schematic diagram of electronic skin software and hardware system of the present invention.
Specific implementation mode
In order to more specifically describe the present invention, below in conjunction with the accompanying drawings and specific implementation mode is to technical scheme of the present invention
It is described in detail.
Electronic skin of the present invention for wound to monitor in real time includes hardware system and software systems two parts, and the two is mutual
Coordinate control, target is to monitor the variation of wound, is improved wound by presupposed solution, promotes wound healing；Such as Fig. 1 institutes
Show：
Hardware system is based on 1.4 platforms of TI companies CC2541 Sensor Tag, including main control chip, sensor, execution
The parts such as device, pro-skin encapsulating material, skin regeneration material.
Pro-skin encapsulating material is the flexible material of MULTILAYER COMPOSITE, including PDMS, flexibility PI substrates；Skin regeneration material uses
By collagen-chitin dermis scaffold and with certain thickness silicone rubber membrane by biocompatibility good adhesive bonds
At.Flexible PI substrates are combined with collagen-chitin/silicon rubber skin regeneration material, and regrown material is in direct contact the surface of a wound, are had good
Good biocompatibility can induce skin corium regeneration.
Main control chip is TI companies CC2541, it includes central processing unit, 4.0 mould of memory, I2C interface and bluetooth
Block；Main control chip is made in pro-skin encapsulating material flexibility PI substrates (1 centimetre or so of diameter), has flexible foldable spy
Property, and be embedded in gauze, it is connect with sensor/actuator by the extending conducting wires of PDMS, sensor/actuator, which is made in, to prolong
On the PDMS of exhibition, it can be fitted in wound site completely and keep being in close contact with wound site during exercise, and with permeable
It is ventilative to wait bio-compatibilities.
Multiple sensors, the temperature of wound site, humidity, pressure (swelling tensile stress), skin resistance are distributed in electronic skin
Anti-, ECG electrocardios and blood oxygen change 6 sensing amounts；The actuators such as ultraviolet leds, Electric radiant Heating Film, fat packaging medicine are distributed with simultaneously.
The device of transducing part is using multiplexing integrated technology：Interdigital electrode realizes that Skin Resistance and ECG measure, and judges skin growth feelings
Condition, while can be used for applying electro photoluminescence stimulation angiogenic growth, heater can heat wound, can also be heated to inflammatory sites
Fatty inclusion enclave release antiphlogistic (different temperatures).Blood oxygen is received using the infrared light-emitting diode and photodiode of TI platforms
It measures.It is to give mobile phone and its cloud platform operation that major calculations, which diagnose and obtain data in real time with doctor, and main control MCU is using TI companies
Sensor TAG platforms, be merely sensing data collect scheduling, wireless receiving and dispatching coding and output actuator work effect.
Sensor side using flexible electronic technology realize it is extending it is flexible it is folding design, it can be achieved that elongation 200% flexibility
Connection.
Software system deployment is communicated on external smart mobile phone, by Bluetooth Low Energy agreement with hardware system, and one
Aspect receives the sensing data monitored, and on the other hand according to preset scheme, adjustment wound climate is sent out to hardware system
Instruction, and according to data such as pressure, temperature, simulated skin sense of touch carries out early warning.Software systems are divided into bluetooth communication module, number
According to calibration module, data visualization module, data analysis module, warning module；Wherein：
Bluetooth communication module docks simultaneously real-time reception multiple sensors with hardware system using Bluetooth Low Energy agreement
Data.The module can need to set the data collection capacity of the acquisition frequency and single of data according to user, in power consumption and adopt
Foundation balances between collecting packing density, and uses database purchase historical data.
Data calibration module calibrates collected initial data, improves the data precision.In general, it passes
Sensor can have Systematic Errors because of its individual difference, initial data.Therefore hardware system is deployed to before wound, first to temperature
The sensors such as degree, pressure do data pre-sampling, while the correction data of one group of temperature, pressure etc. is obtained using special instrument.So
Sensing data and correction data are done into linear fit using least square method afterwards, one group of fitting coefficient is obtained, this coefficient is made
Calibration process is carried out to the initial data of sensor, can be reduced by passing in wound monitoring process later for calibration parameter
Systematic Errors caused by sensor individual difference.
Data visualization module visualizes data with diversified forms, patient is facilitated to check wound real-time status.
Three levels of visualization point：
(1) monitoring data of each sensor are shown.To the sensing data after calibration, its real time value is directly displayed.
(2) curve graph of historical data is shown.To the sensing data in nearest a period of time, its variation of real-time display is bent
Line；Since historical data has stored in intelligent mobile phone terminal, when can also show after disposing hardware system any one section
Interior data movement curve, so that the evolution to wound status diagnoses.
(3) semantic information of display data.Since patient does not often know the meaning of each sensor concrete numerical value, need
The numerical value such as temperature, pressure are switched into semantic information according to medical practice.Here five grades are classified as：Excessively high, high, normal,
Low, too low, each grade of threshold value is set according to medical practice.For each shelves, different figures is shown on intelligent mobile phone terminal
Case and word can tell whether its wound situation is in normal range (NR) to patient in real time in this way.
Data analysis module analyzes the wound data received in real time, according to existing medical practice, judges
Wound is in the different phases such as initial stage, mid-term, healing stage；Whether normal analyze wound climate, and feed back to adjust to hardware system
Whole wound climate.Sensor historic data of the wound in each stage of different patients are collected first, form training sample；Then
SVM classifier is trained using training sample, forms wound disaggregated model；SVM classifier is applied to newly deployed hard
Part system classifies to the stage residing for wound, forms diagnostic result.In each stage, according to the temperature of wound, humidity,
The environmental datas such as pressure judge whether it is normal.When abnormal conditions occurs in wound climate, feedback command is sent out to hardware system,
The processing such as heated or freezed to it, wherein for the relatively low wound of partially slow blood oxygen that heals, pass through electro photoluminescence and accelerate blood vessel life
It is long；Anti-inflammatory is carried out by the drug that heating and melting fat wraps up for light inflammation；For infective wound surface, swashed by ultraviolet light
Hair, stimulation antibacterials discharge.
Warning module can be sentenced after being analyzed (given threshold) to the perception numerical values recited such as pressure, temperature and range
Whether disconnected wound surface nearby has weight, sharp thing contact, scalds object etc. excessively, soft if there is above-mentioned unsafe condition (being more than threshold value)
Part system can send out alarm to the wounded；Alert methods have the various ways such as vibrating alert, sound prompting, pictograph prompting.
Present embodiment electronic skin software-hardware synergism flow, as shown in Figure 2：
1. a pair hardware system is powered, and is deployed on wound.
2. hardware system wireless communication module sends out waiting communication signal.
3. software systems are opened and hardware system foundation is regularly wirelessly connected.
4. software systems obtain all kinds of sensing datas from hardware system in real time.
5. software systems carry out comprehensive analysis to the data of acquisition：
5.1 under dangerous situation software systems issue the user with early warning alarm.
5.2 need influence wound in the case of software systems send out control instruction to hardware system, such as carry out wound add
Heat etc..
This hair can be understood and applied the above description of the embodiments is intended to facilitate those skilled in the art
It is bright.Person skilled in the art obviously easily can make various modifications to above-described embodiment, and described herein
General Principle is applied in other embodiment without having to go through creative labor.Therefore, the present invention is not limited to the above embodiments,
Those skilled in the art's announcement according to the present invention, the improvement made for the present invention and modification all should be in the protections of the present invention
Within the scope of.
Claims (10)
1. a kind of electronic skin monitored in real time for wound, including hardware system and software systems；It is characterized in that：
The hardware system includes main control unit, sensing unit and execution unit；Sensing unit and execution unit pass through PDMS
It is fitted in wound site, main control unit is then made in flexible PI substrates and by extending conducting wire and sensing unit and executes list
Member connection；Wherein：
The sensing unit becomes for acquiring wound about temperature, humidity, swelling tensile stress, Skin Resistance, ECG and blood oxygen
The sensing data of change；
The execution unit is used to carry out electro photoluminescence to wound to accelerate angiogenic growth, or wrapped up by heating and melting fat
Drug carries out anti-inflammatory to wound, or stimulates antibacterials to discharge wound by ultraviolet excitation, or is carried out to wound cold
But；
The main control unit is used to collect the sensing data of sensing unit offer and is sent to sensing data by bluetooth soft
Part system, while the control instruction that software systems are sent out is received, and then control execution unit is adjusted wound climate, promotes
Wound healing；
The software systems load on intelligent terminal comprising bluetooth communication module, data calibration module, data visualization
Module, data analysis module and warning module；Wherein：
The sensing data that the bluetooth communication module is used to collect by Bluetooth protocol wireless receiving main control unit；
The data calibration module is for calibrating the sensing data that bluetooth communication module receives；
The data visualization module takes various forms carries out visualized operation to the sensing data after calibration；
The data analysis module based on the sensing data after calibration, judge wound be in initial stage, mid-term or healing stage tool
Whether body stage, analysis wound climate are normal；When abnormal conditions occurs in wound climate, by bluetooth communication module to master control list
Member sends the control instruction of adjustment wound climate；
The warning module is analyzed based on the sensing data after calibration, and when judging wound surface, nearby there are weight or mistakes
In the case of scalding object, alarm is sent out to the wounded.
2. electronic skin according to claim 1, it is characterised in that：The main control unit includes central processing unit, deposits
Reservoir, I2C interface and Bluetooth antenna.
3. electronic skin according to claim 1, it is characterised in that：The flexible PI substrates and skin regeneration material knot
It closes, skin regeneration material is in direct contact wound surface.
4. electronic skin according to claim 3, it is characterised in that：The skin regeneration material is used by collagen-shell
It glycan dermis scaffold and is formed by the good adhesive bonds of biocompatibility with certain thickness silicone rubber membrane.
5. electronic skin according to claim 1, it is characterised in that：The sensing unit includes interdigital electrode, draws and answer
Power meter, temperature sensor, humidity sensor and photodiode.
6. electronic skin according to claim 1, it is characterised in that：The execution unit includes interdigital electrode, heating
Device, cooler, ultraviolet leds and Electric radiant Heating Film.
7. electronic skin according to claim 1, it is characterised in that：The visualized operation packet of the data visualization module
Include the monitoring data of display each sensor of sensing unit, the curve graph of each sensor historic data of display, each sensor number of display
According to semantic information.
8. electronic skin according to claim 1, it is characterised in that：The data analysis module collects different patients'
Wound forms multigroup training sample in all the sensors historical data in each stage；Then use training sample to svm classifier
Device is trained, and forms wound disaggregated model；And then classified to the stage residing for wound using the model, form diagnosis knot
Fruit.
9. electronic skin according to claim 1, it is characterised in that：The warning module is using vibrating alert, sound
It reminds or pictograph is reminded to the wounded and sends out alarm.
10. electronic skin according to claim 1, it is characterised in that：The intelligent terminal is smart mobile phone, tablet electricity
Brain or PC machine.
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| CN201610172862.1A CN105852806B (en) | 2016-03-24 | 2016-03-24 | A kind of electronic skin monitored in real time for wound |
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Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377256B (en) * | 2016-08-30 | 2019-05-31 | 苏州涵轩信息科技有限公司 | A kind of wound blood flow state detection device and acquisition methods |
| CN107811616B (en) * | 2016-09-14 | 2021-01-15 | 中国科学院宁波材料技术与工程研究所 | Flexible multi-parameter human body sign detector and use method thereof |
| CN106474630A (en) * | 2016-10-19 | 2017-03-08 | 中国人民解放军第四军医大学 | A kind of many physical union system of accelerating wound healing and its using method |
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| CN107412949B (en) * | 2017-06-22 | 2020-11-13 | 浙江大学 | Electronic dressing for promoting wound healing and using method thereof |
| CN107684433B (en) * | 2017-07-24 | 2019-12-10 | 浙江大学 | device and method for simultaneously detecting multiple physiological parameter indexes of wound surface |
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| CN109528392A (en) * | 2018-10-19 | 2019-03-29 | 浙江大学 | A kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention |
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| CN109793516B (en) * | 2019-01-21 | 2021-05-11 | 浙江大学 | Skin electrical impedance flexible detection device and skin electrical impedance detection method |
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| CN114041799B (en) * | 2021-10-29 | 2023-07-25 | 南京大学 | Stretchable patterned metal wire for electrical interconnection in flexible sensor and processing technology |
| CN113842270A (en) * | 2021-11-09 | 2021-12-28 | 清华大学 | Contraction hemostatic plaster based on liquid crystal elastomer reticular lattice structure and preparation method thereof |
| CN114469519B (en) * | 2022-01-27 | 2022-08-05 | 长沙海润生物技术有限公司 | Negative-pressure coupling electric field signal feedback treatment system |
| CN115645149B (en) * | 2022-12-14 | 2024-01-23 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
| CN117653913A (en) * | 2023-10-19 | 2024-03-08 | 中国科学院苏州生物医学工程技术研究所 | Wound treatment device and application method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017927A2 (en) * | 2006-08-10 | 2008-02-14 | Universite Rene Descartes - Paris V | Method for treating skin wounds |
| CN102481112A (en) * | 2009-07-10 | 2012-05-30 | 斯特拉斯克莱德大学 | Wound dressing with impedance sensor |
| CN104523285A (en) * | 2014-12-12 | 2015-04-22 | 广东东邦科技有限公司 | Electronic skin and preparation method thereof |
| CN204971866U (en) * | 2015-09-12 | 2016-01-20 | 深圳市前海安测信息技术有限公司 | Monitoring wound infection degree and quickening wound healing's intelligent bandage and monitoring devices |
| CN105326495A (en) * | 2015-10-19 | 2016-02-17 | 杨军 | Method for manufacturing and using wearable flexible skin electrode |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090234305A1 (en) * | 2008-03-15 | 2009-09-17 | Ernest Aubrey Woodroof | Temporary skin substitute comprised of biological compounds of plant and animal origins |
-
2016
- 2016-03-24 CN CN201610172862.1A patent/CN105852806B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017927A2 (en) * | 2006-08-10 | 2008-02-14 | Universite Rene Descartes - Paris V | Method for treating skin wounds |
| CN102481112A (en) * | 2009-07-10 | 2012-05-30 | 斯特拉斯克莱德大学 | Wound dressing with impedance sensor |
| CN104523285A (en) * | 2014-12-12 | 2015-04-22 | 广东东邦科技有限公司 | Electronic skin and preparation method thereof |
| CN204971866U (en) * | 2015-09-12 | 2016-01-20 | 深圳市前海安测信息技术有限公司 | Monitoring wound infection degree and quickening wound healing's intelligent bandage and monitoring devices |
| CN105326495A (en) * | 2015-10-19 | 2016-02-17 | 杨军 | Method for manufacturing and using wearable flexible skin electrode |
Non-Patent Citations (1)
| Title |
|---|
| Angiogenesis Is Induced and Wound Size Is Reduced by Electrical Stimulation in an Acute Wound Healing Model in Human Skin;Sara Ud-Din等;《PLOS ONE》;20150430;全文 * |
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