CN107412949B - Electronic dressing for promoting wound healing and using method thereof - Google Patents
Electronic dressing for promoting wound healing and using method thereof Download PDFInfo
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- CN107412949B CN107412949B CN201710479121.2A CN201710479121A CN107412949B CN 107412949 B CN107412949 B CN 107412949B CN 201710479121 A CN201710479121 A CN 201710479121A CN 107412949 B CN107412949 B CN 107412949B
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- 230000029663 wound healing Effects 0.000 title claims abstract description 29
- 230000001737 promoting effect Effects 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title abstract description 12
- 230000000638 stimulation Effects 0.000 claims abstract description 45
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 33
- 206010052428 Wound Diseases 0.000 claims abstract description 32
- 238000004891 communication Methods 0.000 claims abstract description 27
- 230000005684 electric field Effects 0.000 claims abstract description 12
- 230000035876 healing Effects 0.000 claims abstract description 11
- 230000007646 directional migration Effects 0.000 claims abstract description 7
- 239000000758 substrate Substances 0.000 claims description 11
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 8
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- 239000004642 Polyimide Substances 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 4
- 239000011505 plaster Substances 0.000 claims description 4
- 229920001721 polyimide Polymers 0.000 claims description 4
- 208000033748 Device issues Diseases 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 19
- 206010072170 Skin wound Diseases 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
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- 238000010586 diagram Methods 0.000 description 2
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- 230000008569 process Effects 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
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- 208000014674 injury Diseases 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 238000005424 photoluminescence Methods 0.000 description 1
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- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0468—Specially adapted for promoting wound healing
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention provides an electronic application for promoting wound healing for solving the burden caused by the wound which is difficult for a wounded to heal, which comprises an electrical stimulation device, an electronic application and a signal transmitting device; the signal transmitting device is in signal connection with the electrical stimulation device, and the electrical stimulation device is connected with the electronic application; the electric stimulation device comprises a power supply, an MCU, a Bluetooth communication module, a constant current source circuit and an output interface; the invention also provides a using method of the electronic application for promoting wound healing; the electric stimulation device, the electronic application and the signal transmitting device work after being electrified, and the signal transmitting device sends a control command to the electric stimulation device; the electrical stimulation device receives a control instruction sent by the signal transmitting device, and controls and monitors the electronic application work according to the instruction; the electronic application applies a direct current electric field with physiological strength to the wound to guide cells to perform directional migration and promote the healing of the wound. The invention guides cells to perform directional migration while electrically stimulating the wound through the electronic application, thereby effectively promoting the recovery of the wound.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to an electronic dressing for promoting wound healing and a using method thereof.
Background
The wound which is difficult to heal causes burden to patients, but no novel effective repair treatment technology exists at present. Skin wounds present physiological electric fields that direct the directional migration of cells. At present, the physiological electric field is considered to be the strongest direction signal in the wound healing process, and the physiological electric field can promote wound healing and treat the wound difficult to heal.
The existing electronic application for promoting wound healing by electrical stimulation mostly adopts an electrical stimulation mode to accelerate blood circulation at a wound and accelerate medicine to enter skin, so that the healing of the wound is promoted.
Disclosure of Invention
The invention aims to solve the problem of providing the electronic plaster for promoting wound healing and the using method thereof.
In order to solve the technical problem, the invention provides an electronic application for promoting wound healing, which comprises an electrical stimulation device, an electronic application and a signal transmitting device; the signal emitting device is in signal connection with the electrical stimulation device, and the electrical stimulation device is connected with the electronic application;
the electric stimulation device comprises a power supply, an MCU, a Bluetooth communication module, a constant current source circuit and an output interface; the MCU, the Bluetooth communication module and the constant current source circuit are all connected with a power supply; the Bluetooth communication module, the constant current source circuit and the output interface are all connected with the MCU; the constant current source circuit is connected with the output interface.
As an improvement of the electronic application for promoting wound healing of the present invention: the electronic application comprises a flexible substrate and an electrode arranged on the flexible substrate, wherein the electrode is a copper electrode;
the electrodes comprise a central electrode and an outer ring electrode assembly, the central electrode is connected with the negative electrode of the output interface, and the outer ring electrode assembly is connected with the positive electrode of the output interface.
The electronic application for promoting wound healing is further improved as the invention: the outer ring electrode assembly comprises at least two rings of outer ring electrodes with overlapped circle centers.
The electronic application for promoting wound healing is further improved as the invention: the flexible substrate is made of polyimide-based composite materials, and the surface of the electrode is provided with a gold-plated layer.
The invention also provides a using method of the electronic dressing for promoting wound healing, which comprises the following steps:
1) the electric stimulation device, the electronic application and the signal transmitting device work after being electrified, and the signal transmitting device sends a control command to the electric stimulation device;
2) the electrical stimulation device receives the control instruction sent by the signal transmitting device in the step 1), and controls and monitors the electronic application work according to the instruction;
3) the electronic application applies a direct current electric field with physiological strength to the wound to guide cells to perform directional migration and promote the healing of the wound.
The invention relates to an improvement of the application method of the electronic paste for promoting wound healing, which comprises the following steps:
the Bluetooth communication module of the electrical stimulation device in the step 2) is in signal connection with the signal transmitting device, receives a control instruction sent by the signal transmitting device and transmits instruction information to the MCU;
after receiving the instruction information transmitted by the Bluetooth communication module, the MCU controls the constant current source circuit to output corresponding current according to the instruction information, and detects the power supply voltage and the current of the output interface;
the constant current source circuit outputs constant current to the output interface under the control of the MCU;
the output interface is connected with the electronic application and outputs constant current to the electronic application.
As a further improvement of the application method of the electronic paste for promoting wound healing of the invention:
and the MCU sends the detected power supply voltage and the current information of the output interface to the signal transmitting device through the Bluetooth communication module.
The technical advantages of the invention are as follows:
1. the invention can apply a direct current electric field with physiological strength outside the wound to guide cells to perform directional migration and promote the healing of the wound;
2. the current and stimulation time of electrical stimulation can be controlled through the signal emitting device, the power supply condition and the electronic application working condition are detected in real time when the electrical stimulation device works and are fed back to the signal emitting device, and a user can find and solve corresponding problems in time when a fault occurs;
3. the electronic application is provided with the outer ring electrodes with various diameters, so that the use requirements of wounds with different areas are met.
Drawings
The following describes embodiments of the present invention in further detail with reference to the accompanying drawings.
FIG. 1 is a schematic view of a module of an electrical stimulation device of the present invention;
FIG. 2 is a schematic circuit diagram of an electronic application 2 of the electronic application for promoting wound healing according to the present invention;
FIG. 3 is a schematic diagram showing the healing tendency of the skin wound of rats in groups 100uA and 50uA in this example 1;
FIG. 4 is a graph showing the comparison of the healing of the skin wound of rats in the 100. mu.A group and the blank control group in example 1.
Detailed Description
The invention will be further described with reference to specific examples, but the scope of the invention is not limited thereto.
Example 1, an electronic wound healing patch, as shown in fig. 1 to 4, comprising an electrical stimulation device, an electronic patch 2 and a signal emitting device; the signal transmitting device is in signal connection with the electrical stimulation device and is used for issuing a control command to the electrical stimulation device, and the control command comprises parameters such as current and duration of electrical stimulation; the electrical stimulation device is connected with the electronic application 2, and controls and detects the work of the electronic application 2 according to the received control instruction, and feeds back the detection condition to the signal transmitting device in real time; the electronic plaster 2 is used for applying a direct current electric field with physiological strength to the wound to guide cells to directionally migrate and promote the healing of the wound, wherein the electric field strength of human physiological strength is 25-200mV/mm, and the electronic plaster 2 is adhered to the wound when in use.
As shown in fig. 1, the electrical stimulation apparatus includes a power supply 10, an MCU11, a bluetooth communication module 12, a constant current source circuit 13, and an output interface 14; the MCU11, the Bluetooth communication module 12 and the constant current source circuit 13 are all connected with the power supply 10; the Bluetooth communication module 12, the constant current source circuit 13 and the output interface 14 are all connected with the MCU 11; the constant current source circuit 13 is connected with the output interface 14;
the bluetooth communication module 12 is in signal connection with the signal transmitting device, and is used for receiving a control instruction sent by the signal transmitting device and communicating with the MCU11 through a serial port; the Bluetooth communication module 12 transmits the instruction information to the MCU11 through the serial port; and receives the information detected by the MCU11 during the operation of the electrical stimulation device, and feeds the information back to the user through the signal transmitting device.
The MCU11 is configured to receive the instruction information transmitted by the bluetooth communication module 12, and control the constant current source circuit 13 to output a corresponding current according to the instruction information of the signal transmitting apparatus, and the specific control method is that after the MCU11 receives the corresponding instruction, a D/a converter (a Digital to Analog converter, a circuit that can convert a Digital signal into an Analog signal) outputs an input voltage for controlling the constant current source circuit 13, where the input voltage is between 0V and 3V, and the target current is between 0uA and 100uA, that is, the current is converted by the constant current source circuit 13, so as to output a required current to the output interface 14, where the current is between 0uA and 100uA and can be accurate to 1 uA. At the same time, the MCU11 detects the output interface 14 and ensures that the current value of the output interface 14 is the value set by the signal emitting device. The MCU11 detects the power 10 simultaneously, prevents that the electric quantity from crossing low normal work of electro photoluminescence device. The MCU11 sends the detected information, namely the current value of the output interface 14, the voltage value of the power supply 10, the working time of the electronic application 2 and the like, to the signal transmitting device through the Bluetooth communication module 12, and can timely remind the user to process when the electric stimulation device breaks down.
As shown in fig. 2, the electronic application 2 includes a flexible substrate made of polyimide-based composite material, and electrodes provided on the flexible substrate, the electrodes being copper electrodes, the surfaces of which are provided with gold plating layers; the electrodes include a center electrode connected to the negative electrode of the output port 14 and an outer ring electrode assembly connected to the positive electrode of the output port 14. Wherein the outer ring electrode assembly comprises at least two outer ring electrodes with overlapped circle centers.
In the embodiment, the electronic application 2 adopts a polyimide-based composite material (PI) with the thickness of 0.1mm as a substrate insulating material, and a copper foil with the thickness of 0.5oz is pressed on the substrate material for conducting, and the copper foil forms 2 circles of copper electrodes. In order to protect the electrodes and prevent the electrodes from being excessively corroded by the electrochemical reaction, gold foil with a thickness of 0.075 μm is plated on the copper surface. The base in this example is a circle with a diameter of 30 mm. Three circles of copper electrodes on the substrate are respectively a central electrode and two circles of outer ring electrodes, wherein the central electrode is a circular electrode slice with the diameter of 3.5mm and is connected with the negative electrode of the output interface 14; the two circles of outer ring electrodes are positive electrodes with diameters of 20mm and 10mm respectively, the diameters of circular electrode plates arranged on the two circles of outer ring electrodes are 3mm and 2mm respectively, and a user can select a proper outer ring electrode to be connected with the positive electrode of the output interface 14 according to the size of a wound.
The electronic application for promoting wound healing comprises the following working procedures:
1) the electrical stimulation device, the electronic application 2 and the signal transmitting device work after being electrified, and the signal transmitting device sends a control command to the electrical stimulation device; the control instruction comprises parameter information such as the intensity, the duration and the like of the constant current output by the electronic application 2.
2) The electrical stimulation device receives the control instruction sent by the signal sending device in the step 1), and controls and monitors the work of the electronic application 2 according to the instruction;
the bluetooth communication module 12 in the electrical stimulation device is connected with the signal transmitting device through signals. The signal transmitting device transmits a starting instruction to the Bluetooth communication module 12, and the starting instruction is transmitted to the MCU11 through the Bluetooth communication module 12, so that the output of a constant current in the setting is realized, the control instruction transmitted by the signal transmitting device is received, after the MCU11 receives instruction information transmitted by the Bluetooth communication module 12, the constant current source circuit 13 is controlled to output a corresponding current according to the instruction information, the corresponding working time is set, and the voltage of the power supply 10 and the current of the output interface 14 are detected; the constant current source circuit 13 outputs a constant current to the output interface 14 under the control of the MCU 11; the output interface 14 is connected to the electronic applicator 2 and outputs a constant current to the electronic applicator 2. The MCU11 transmits the detected voltage of the power supply 10 and the current information of the output interface 14 to the signal transmission apparatus through the bluetooth communication module 12.
3) And the electronic application 2 applies a direct current electric field with physiological strength to the wound to guide cells to perform directional migration and promote the healing of the wound.
The electronic application 2 detects the load every 30 seconds, if the load is not connected, the electric stimulation device feeds back information (information of the missed load) to the signal transmitting device through the Bluetooth communication module 12, and the signal transmitting device can prompt that the load is not connected;
the physiological electric field intensity of the skin wound of the SD rat is similar to that of a human body, the current density corresponding to the physiological electric field is 5-40uA/cm2, the wound area of the experimental rat is about 1.1cm2, the total current is calculated to be about 5-44uA., and the three types of 5, 50 and 100uA are additionally arranged according to the difference between the theoretical current intensity and the actual situation. The experimental contents are as follows:
taking 60 SD rats which are adaptively bred for 7-10 days, wherein the weight of the SD rats is 250-300 g, and the SD rats are half male and half female, randomly dividing the SD rats into 3 experimental groups and 3 control groups, wherein each group comprises 10 SD rats. Anesthesia is carried out by 10% (w/v) chloral hydrate intraperitoneal injection (0.3ml/100g), back unhairing is carried out, the prone position is fixed on an experimental operating table, positions on two sides of a spine are equidistant after the back is disinfected, 1 annular blot is respectively pressed by a sterilized stainless steel trephine with the outer diameter of 12mm and perpendicular to the skin of the back of a mouse, the visible trace is taken as the degree of pressing, the inner full-layer skin of the ring is cut off along the indentation by a surgical scissors, and the wound surface is exposed after injury.
After 24 hours, the SD rats were re-anesthetized and a small amount of hydrogel was applied to the center electrode of the electronic patch 2, and the electronic patch 2 was taped to the skin wound of the SD rats in the experimental group with the center electrode aligned with the center of the skin wound. The electric stimulation device is electrified, the signal transmitting device is in signal connection with the electric stimulation device through the Bluetooth communication module 12, the signal transmitting device controls the total current applied to the electronic application 2, the currents applied to the three groups of experimental groups are respectively 5 muA, 50 muA and 100 muA, and the electronic application 2 continuously works for 1 hour every day. SD rats are raised in single cage and disinfected with iodophor every day. The related operations all follow the ethical regulations and regulations of related animals of the ministry of laboratory animals of the national university and Zhejiang university.
The observation indexes are that the size of the wound surface is recorded by taking pictures of the rat after anesthesia and before electrical stimulation every day by a camera, and the area of the wound surface is measured and calculated by Image J medical Image analysis software (American national institute of health). Data are expressed in x ± s.d., and analysis of variance of replicate design was performed using SPSS 18.0 statistical software. P <0.05 is statistically significant for the differences.
Experimental group 1: the current applied by the electronic application 2 is 5 muA;
the research finds that the wound healing of the experimental group 1 is not obviously different from that of the control group 1 which is fed at the same time;
experimental group 2: the current applied by the electronic application 2 is 50 muA,
researches find that the experimental group 2 and the control group 2 fed in the same period contract quickly in the early period of wound healing, and the surface wettability of the wound is improved; the healing trend of the skin wound of the rats in the experimental group 2 and the control group 2 raised at the same time is shown in the right graph of FIG. 3.
Experimental group 3: the current applied by the electronic application 2 is 100 muA;
as shown in fig. 4. The first row in figure 4, EF group in Day1, is the wound size of rats No. 1-10 on Day1 of the start of the 100 μ a electrostimulation group experiment; the second row, Ctrl in Day1, is the wound size of rats No. 1-10 on Day1 from the start of the blank control experiment. The third row, EF group in Day2, was the wound size of rats No. 1-10 at Day 7 from the beginning of the 100 μ A electrostimulation group experiment 7 days after electrostimulation; the fourth row, Ctrl in Day1, is the wound size of rats No. 1-10 on Day 7 from the start of the blank control experiment.
Researches show that the experimental group 3 and the control group 3 raised in the same period have faster contraction in the early period of wound healing and improved surface wettability of the wound; the healing trend of the skin wound of the rats in the experimental group 3 and the control group 3 raised at the same time is shown in the left graph of FIG. 3.
Finally, it should be noted that: the above embodiments are only used for illustrating the technical solution of the present invention, and not for limiting the same; while the invention has been described in detail with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (5)
1. Promote wound healing electron and apply ointment or plaster, its characterized in that:
the electronic dressing for promoting wound healing comprises an electrical stimulation device, an electronic dressing (2) and a signal transmitting device; the signal emitting device is in signal connection with the electrical stimulation device, and the electrical stimulation device is connected with the electronic application (2);
the electric stimulation device comprises a power supply (10), an MCU (11), a Bluetooth communication module (12), a constant current source circuit (13) and an output interface (14); the MCU (11), the Bluetooth communication module (12) and the constant current source circuit (13) are all connected with the power supply (10); the Bluetooth communication module (12), the constant current source circuit (13) and the output interface (14) are all connected with the MCU (11); the constant current source circuit (13) is connected with the output interface (14);
the electronic application (2) comprises a flexible substrate and an electrode arranged on the flexible substrate, wherein the electrode is a copper electrode;
the electrodes comprise a central electrode and an outer ring electrode assembly, the central electrode is connected with the negative electrode of the output interface (14), and the outer ring electrode assembly is connected with the positive electrode of the output interface (14);
the electronic application for promoting wound healing has the working mode that:
1) the electrical stimulation device, the electronic application (2) and the signal transmitting device work after being electrified, and the signal transmitting device issues a control command to the electrical stimulation device; the control instruction comprises parameter information such as the intensity, the duration and the like of the constant current output by the electronic application (2);
the current is 50-100 muA;
2) the electrical stimulation device receives the control instruction sent by the signal sending device in the step 1), and controls and monitors the work of the electronic application (2) according to the instruction;
3) and the electronic application (2) applies a direct current electric field with physiological strength to the wound to guide cells to perform directional migration and promote the healing of the wound.
2. The wound healing promoting electronic patch according to claim 1, wherein:
the outer ring electrode assembly comprises at least two rings of outer ring electrodes with overlapped circle centers.
3. The wound healing promoting electronic patch according to claim 2, wherein:
the flexible substrate is made of polyimide-based composite materials, and the surface of the electrode is provided with a gold-plated layer.
4. A wound healing promotion electronic patch according to any one of claims 1 to 3, wherein:
the Bluetooth communication module (12) of the electrical stimulation device in the step 2) is in signal connection with the signal transmitting device, receives a control instruction sent by the signal transmitting device and transmits instruction information to the MCU (11);
after receiving the instruction information transmitted by the Bluetooth communication module (12), the MCU (11) controls the constant current source circuit (13) to output corresponding current according to the instruction information, and detects the voltage of the power supply (10) and the current of the output interface (14);
the constant current source circuit (13) outputs constant current to the output interface (14) through the control of the MCU (11);
the output interface (14) is connected with the electronic application (2) and outputs constant current to the electronic application (2).
5. The wound healing promoting electronic patch according to claim 4, wherein:
the MCU (11) sends the detected voltage of the power supply (10) and the current information of the output interface (14) to a signal transmitting device through the Bluetooth communication module (12).
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| CN201710479121.2A CN107412949B (en) | 2017-06-22 | 2017-06-22 | Electronic dressing for promoting wound healing and using method thereof |
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| CN109603004A (en) * | 2018-12-04 | 2019-04-12 | 苏州大学 | It is a kind of to drive electric stimulation, sticking plaster and inhibition of cancer cell capsule certainly |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02126861A (en) * | 1988-10-05 | 1990-05-15 | Niels Kornerup | Wound treatment device by electric stimulation |
| CN201015680Y (en) * | 2007-01-31 | 2008-02-06 | 龙丹 | Wound fast-concrescence paste-applying instrument |
| CN105852806A (en) * | 2016-03-24 | 2016-08-17 | 浙江大学 | Electronic skin for wound real-time monitoring |
| CN105920734A (en) * | 2016-06-07 | 2016-09-07 | 浙江中医药大学附属第三医院 | Miniature single-chip type flexible skin-friendly electric acupuncture needle |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090048651A1 (en) * | 2007-08-17 | 2009-02-19 | Biofisica Inc. | Medical electrode systems and methods |
| TWI581771B (en) * | 2015-04-14 | 2017-05-11 | 財團法人紡織產業綜合研究所 | Wound care dressing |
| CN106474630A (en) * | 2016-10-19 | 2017-03-08 | 中国人民解放军第四军医大学 | A kind of many physical union system of accelerating wound healing and its using method |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02126861A (en) * | 1988-10-05 | 1990-05-15 | Niels Kornerup | Wound treatment device by electric stimulation |
| CN201015680Y (en) * | 2007-01-31 | 2008-02-06 | 龙丹 | Wound fast-concrescence paste-applying instrument |
| CN105852806A (en) * | 2016-03-24 | 2016-08-17 | 浙江大学 | Electronic skin for wound real-time monitoring |
| CN105920734A (en) * | 2016-06-07 | 2016-09-07 | 浙江中医药大学附属第三医院 | Miniature single-chip type flexible skin-friendly electric acupuncture needle |
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