CN109528392A - A kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention - Google Patents
A kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention Download PDFInfo
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- CN109528392A CN109528392A CN201811223273.7A CN201811223273A CN109528392A CN 109528392 A CN109528392 A CN 109528392A CN 201811223273 A CN201811223273 A CN 201811223273A CN 109528392 A CN109528392 A CN 109528392A
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- antiseptic dressing
- therapeutic intervention
- wound
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- 230000001524 infective effect Effects 0.000 title claims abstract description 22
- 230000008447 perception Effects 0.000 title claims abstract description 18
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 18
- 230000003115 biocidal effect Effects 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 11
- 230000006870 function Effects 0.000 claims abstract description 8
- 230000004298 light response Effects 0.000 claims abstract description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 19
- 239000002202 Polyethylene glycol Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 7
- 230000000844 anti-bacterial effect Effects 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 6
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 5
- 229930182566 Gentamicin Natural products 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 150000003384 small molecules Chemical class 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- TZRXHJWUDPFEEY-UHFFFAOYSA-N Pentaerythritol Tetranitrate Chemical compound [O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O TZRXHJWUDPFEEY-UHFFFAOYSA-N 0.000 claims description 3
- 229920002873 Polyethylenimine Polymers 0.000 claims description 3
- 239000003431 cross linking reagent Substances 0.000 claims description 3
- 125000004386 diacrylate group Chemical group 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
- 229960002518 gentamicin Drugs 0.000 claims description 3
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 40
- 208000027418 Wounds and injury Diseases 0.000 abstract description 40
- 206010061217 Infestation Diseases 0.000 abstract description 8
- 208000015181 infectious disease Diseases 0.000 abstract description 8
- 208000014674 injury Diseases 0.000 abstract description 8
- 230000008733 trauma Effects 0.000 abstract description 8
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- 230000000694 effects Effects 0.000 abstract description 4
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- 108090000790 Enzymes Proteins 0.000 description 2
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- 239000003242 anti bacterial agent Substances 0.000 description 2
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- 230000036541 health Effects 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 125000006502 nitrobenzyl group Chemical group 0.000 description 2
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- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Natural products CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 1
- 241001062009 Indigofera Species 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000012650 click reaction Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
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- 238000010168 coupling process Methods 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00429—Plasters use for conducting tests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
Abstract
The present invention relates to a kind of intelligent antiseptic dressings for infective wound surface perception and therapeutic intervention, which includes the ultraviolet light response intelligence antiseptic dressing layer for having the flexible electronic device layer of wound temperature perceptional function and having treatment function；The intelligence dressing can be prejudged by wound temperature data and the generation of timely learning trauma surface infestation, and acts on intelligent antiseptic dressing layer by emitting ultraviolet light in situ and realize that effective control of antibiotic discharges, and is treated in time to infective wound surface.The present invention has broken the incomprehensiveness that infection occurs caused by the covering of dressing in traditional surface of a wound nursing process, so that infection can be perceived and be obtained in time, dressing is and guided to carry out effective prevention treatment to the surface of a wound, promote wound repair, avoids a large amount of uncontrollable release bring side effects of antibiotic in traditional antiseptic dressing.Raw material of the present invention has good describing property of biology, and preparation process is simple, strong operability.
Description
Technical field
The present invention relates to intelligent antiseptic dressing field, in particular to a kind of intelligence for infective wound surface perception and therapeutic intervention
It can antiseptic dressing.
Background technique
Skin is outer since large area is exposed to, and is highly prone to damage in daily life, the reparation of the surface of a wound be a complexity and
Dynamic process again, trauma surface infestation has become most common complication during wound repair, serious to result even in extremely
It dies.However from the point of view of current clinical care means, wounds infection can only often be checked by replacing wound dressing, this
The delay of acquisition of information probably delays the best period of Wound treating, brings pain to patient；Meanwhile traditional antibacterial wound
Mouth dressing can not accomplish effective control release of antibiotic, and causing a large amount of abuse problems of antibiotic is also clinically to be badly in need of solving
The problem of.Therefore Development of Novel antiseptic dressing, can break the "black box" state of wound repair, obtain surface of a wound letter in time
Breath realizes the early monitoring to trauma surface infestation and prevention, while to surface of a wound abnormality can timely and effectively intervene and control
It treats, reduces antibiotic and largely abuse the High-Interest Object that bring side effect is current antibacterial wound dressing research.
Flexible electronic sensing technology is an emerging in recent years cutting edge technology, and is widely used in wearable device, people
The research fields such as body clinical diagnosis, health evaluating, health monitoring, flexible electronic skin, or even industrial robot.Flexible electronic passes
Sensor is that the sensor element that can perceive various physiochemical signals is produced in extendable flexible substrates, then with
Stimulus signal is converted to the form that electric signal etc. is easy to export by the mode of signal transduction, wherein the appreciable physics of sensor
Chemical signal includes temperature, humidity, pressure, pH, frequency, ionized water equality.And skin wound is a dynamic and complicated
Environment, the various signal levels (temperature, humidity, pH, enzyme, ion etc.) on the surface of a wound become with the variation of wound repair different phase
Change, therefore such flexible electronic sensor can be by being bonded the real-time prison realized to surface of a wound signal specific with the close of skin
It surveys.Using trauma surface infestation as model, using this apparent signature variations of temperature during trauma surface infestation, temperature sensor can
To realize to the early stage perception of trauma surface infestation and intelligent early-warning.
Stimulating responsive material is a kind of new type functional material booming in recent years.This kind of material can be right
Minor change in external environment generates quickly response, so as to cause the variation of its physical and chemical performance.Common stimuli responsive
Property include temperature-responsive, pH response, photoresponse, ionic strength response, enzyme response, redox response etc..Stimulating responsive material
At present in drug delivery, the fields such as organizational project are widely applied material, therefore can realize antibiotic by introducing environmental stimuli
Effectively control release, and in all stimulation types, light as it is a kind of it is efficient, convenient, can remote control means with it
Unique advantage.Therefore, the present invention is by flexible electronic sensor technology and stimulating responsive intelligence wound dressing composite design structure
A kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention has been built, has realized wound site temperature using temperature sensor
The real-time monitoring of degree, and use light as effective control on demand release that stimulus realizes infective wound surface antibiotic.
Summary of the invention
The object of the present invention is to provide a kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention, the dressing
Used raw material has good describing property of biology, and preparation process is simple, strong operability, is expected to break traditional surface of a wound nursing
The incomprehensiveness that infection occurs caused by the covering of dressing in the process, so that infection can be perceived and be obtained in time,
It and guides dressing to carry out effective prevention treatment to the surface of a wound, promotes wound repair, it is a large amount of to avoid antibiotic in traditional antiseptic dressing
Uncontrollable release bring side effect.
The intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention of the invention, including flexible electronic device layer and
Antiseptic dressing layer, the flexible electronic device layer have the function of wound temperature perceptional function and ultraviolet light, flexible electronic
Device layer controls ultraviolet light antiseptic dressing layer according to wound temperature, and antiseptic dressing layer directly contacts the surface of a wound can ultraviolet light response
Discharge antibacterials.
In above-mentioned technical proposal, the antiseptic dressing layer uses modified poly (ethylene glycol) base anti-bacterial hydrogel dressing, uses
Following method is made: the small molecule covalent modification that antibiotic can be broken by ultraviolet light is big to the double bond containing polyethylene glycol in end
Macromonomer is obtained on strand, crosslinking agent is then made with the double bond containing polyethylene glycol of both-end, and heat causes double bond crosslinking preparation
It obtains, the ester bond connecting in resulting materials with antibiotic can be broken to release antibiotic under ultraviolet light.Described
Antibiotic can be gentamicin, and the small molecule that ultraviolet light can be broken can be 1- (5- methoxyl group -2- nitro -2-propynyl) -
Acetophenone, the double bond containing polyethylene glycol in the end can be nitrine polyethylene glycol acrylate, and the both-end contains double bond
Polyethylene glycol can be polyethyleneglycol diacrylate.
The flexible electronic device layer include the temperature sensor being produced on polyethyleneimine substrate, transmitting it is ultraviolet
The LED light and power supply and control unit of light, and power supply and control unit and temperature sensor, LED light pass through respectively it is snakelike curved
Curve connection, entire flexible electronic device layer are encapsulated using PDMS.
The monitoring accuracy of the temperature sensor is ± 0.3 DEG C (such as chip of model SHT21), and the wavelength of LED light is
365nm (such as model NVSU233A, can in situ emitting ultraviolet light).
Bluetooth antenna (such as model CC2541) is also provided in the flexible electronic device layer, for blue with outside
Tooth equipment is communicated.
The intelligence antiseptic dressing can use bandage form, and flexible electronic device layer is bonded composition with antiseptic dressing layer
Integration, antiseptic dressing layer are directly contacted with the surface of a wound, and responsiveness discharges antibiotic under the action of emitting ultraviolet light in situ, are realized
Effective treatment to wound site.
Dressing of the invention is mainly used for infective wound surface, and intelligence is embodied in the intelligence sense that can be realized infective wound surface
Know, and effective therapeutic intervention can be provided for trauma surface infestation.
Detailed description of the invention
Fig. 1 is the building schematic diagram of intelligent antiseptic dressing system；
Fig. 2 is (a) photomacrograph (front and back sides) and physical property (b) fatigue performance of intelligent antiseptic dressing system；(c)
Tensile property；
Fig. 3 is the temperature real-time monitoring performance of the intelligent antiseptic dressing system In vivo infection surface of a wound；
Fig. 4 is intelligent anti-microbial property in intelligent antiseptic dressing system body；
Fig. 5 is the biocompatibility of intelligent antiseptic dressing system.
Specific embodiment
Elaborate below with reference to specific example to the present invention, it should be understood that these examples be merely to illustrate the present invention without
For limiting the scope of the invention.In addition, it should also be understood that, those skilled in the art can be right after having read elaboration content of the invention
The present invention makes an amendment, and such equivalent forms equally fall within the application the appended claims and limit range.
Example 1
(a) has the flexible electronic device layer building method of wound temperature perceptional function
Flexible circuit board mainly includes three modules: power management module, sensing and execution module, control circuit module.
Wherein power management module includes DC-DC module TPS62730 and boost module LM3410X two parts, for powering, sensing with
Execution module includes temperature sensor SHT21 and four LED ultraviolet lamp NVSU233A-U365, and control circuit module is mainly indigo plant
Tooth chip CC2541.The main chip in three modules is produced on by polyethyleneimine using FPC technique processing method first
In flexible substrate, wherein temperature sensor is located at the center of circuit board, and four LED light are distributed in the four of temperature sensor
Week.Coupling part makes system have certain ductility convenient for fitting closely with wound using serpentine bend line, and system uses
External 3.3V lithium battery power supply.Obtained circuit board is encapsulated by the method that PDMS is poured.Temperature sensor detects
Data be transferred in the cell phone application of receiving end by bluetooth approach, acquisition data simultaneously analyzed.
(b) has the ultraviolet light response intelligence antiseptic dressing layer building method for the treatment of function
The antibiotics gentamycin for selecting aminoglycoside is model drug, by gentamicin by way of covalence graft
With adjacent nitro benzyl molecule 1- (5- methoxyl group -2- nitro -2-propynyl)-acetophenone covalent bond of ultraviolet photo-labile, institute
Molecular end the further polyethylene glycol acrylate (N with end containing nitrine of alkynyl3- PEG5000-DA) click-reaction system
It is standby to obtain modified poly (ethylene glycol) base macromonomer, the monomer and unmodified polyethylene glycol acrylate (PEG5000-DA) with
1:7 (w/w) ratio mixing be used as co-monomer, while with crosslinking agent polyethyleneglycol diacrylate (DA-PEG2000-DA) with
And initiator A PS/TEMED is blended, mixed solution pours into the mold of polytetrafluoroethylene (PTFE), and 90 DEG C of heating 30min cause double bond and hand over
The polyethylene glycol groups aerogel dressing with ultraviolet light response anti-microbial property is prepared in connection.In the aerogel dressing, celebrating
The ester bond that the adjacent nitro benzyl molecule covalent of big mycin and ultraviolet photo-labile is formed can be under the ultraviolet light irradiation of 365nm wavelength
Fracture occurs to release antibiotics gentamycin.The dressing layer is set to below the LED light of flexible electronic device layer, entirely
Dressing is designed as bandage form.
Intelligent dressing of the invention can be prejudged by wound temperature data and the generation of timely learning trauma surface infestation, and passes through
Emitting ultraviolet light in situ acts on effective control release that intelligent antiseptic dressing layer realizes antibiotic, carries out to infective wound surface timely
Treatment.The present invention has broken the incomprehensiveness that infection occurs caused by the covering of dressing in traditional surface of a wound nursing process,
So that infection can be perceived and be obtained in time, dressing is and guided to carry out effective prevention treatment to the surface of a wound, promotes wound repair, keep away
The a large amount of uncontrollable release bring side effects of antibiotic in traditional antiseptic dressing are exempted from.
Claims (10)
1. a kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention, which is characterized in that the dressing includes flexibility
Electronic device layer and antiseptic dressing layer, the flexible electronic device layer have wound temperature perceptional function and ultraviolet light function
Can, flexible electronic device layer controls ultraviolet light antiseptic dressing layer according to wound temperature, and antiseptic dressing layer directly contacts the surface of a wound
It can ultraviolet light response release antibacterials.
2. the intelligent antiseptic dressing according to claim 1 for infective wound surface perception and therapeutic intervention, which is characterized in that
The antiseptic dressing layer uses modified poly (ethylene glycol) base anti-bacterial hydrogel dressing, is made with the following method: antibiotic is led to
It crosses on the small molecule covalent modification to the double bond containing polyethylene glycol macromolecular chain in end that ultraviolet light can be broken and obtains macromonomer,
Then crosslinking agent is made with the double bond containing polyethylene glycol of both-end, heat causes double bond crosslinking and prepares, in resulting materials with antibiotic
The ester bond of connection can be broken to release antibiotic under ultraviolet light.
3. the intelligent antiseptic dressing according to claim 2 for infective wound surface perception and therapeutic intervention, which is characterized in that
The antibiotic is gentamicin.
4. the intelligent antiseptic dressing according to claim 2 for infective wound surface perception and therapeutic intervention, which is characterized in that
The small molecule that the ultraviolet light can be broken is 1- (5- methoxyl group -2- nitro -2-propynyl)-acetophenone.
5. the intelligent antiseptic dressing according to claim 2 for infective wound surface perception and therapeutic intervention, which is characterized in that
The double bond containing polyethylene glycol in the end is nitrine polyethylene glycol acrylate.
6. the intelligent antiseptic dressing according to claim 2 for infective wound surface perception and therapeutic intervention, which is characterized in that
The double bond containing polyethylene glycol of the both-end is polyethyleneglycol diacrylate.
7. the intelligent antiseptic dressing according to claim 1 for infective wound surface perception and therapeutic intervention, which is characterized in that
The flexible electronic device layer includes the temperature sensor being produced on polyethyleneimine substrate, the LED of emitting ultraviolet light
Lamp and power supply and control unit, power supply and control unit pass through serpentine bend line with temperature sensor, LED light respectively and connect,
Entire flexible electronic device layer is encapsulated using PDMS.
8. the intelligent antiseptic dressing according to claim 7 for infective wound surface perception and therapeutic intervention, which is characterized in that
The monitoring accuracy of the temperature sensor is ± 0.3 DEG C, and the wavelength of LED light is 365nm.
9. the intelligent antiseptic dressing according to claim 1 for infective wound surface perception and therapeutic intervention, which is characterized in that
The intelligence antiseptic dressing uses bandage form.
10. the intelligent antiseptic dressing according to claim 1 for infective wound surface perception and therapeutic intervention, feature exist
In Bluetooth antenna being additionally provided in the flexible electronic device layer, for being communicated with external bluetooth equipment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811223273.7A CN109528392A (en) | 2018-10-19 | 2018-10-19 | A kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811223273.7A CN109528392A (en) | 2018-10-19 | 2018-10-19 | A kind of intelligent antiseptic dressing for infective wound surface perception and therapeutic intervention |
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| CN110314039A (en) * | 2019-07-09 | 2019-10-11 | 黄冈市维科曼医用材料有限责任公司 | A kind of medical dressing automatic production line |
| CN111135341A (en) * | 2020-01-20 | 2020-05-12 | 浙江大学 | Intelligent hydrogel dressing for early warning and controllable treatment of infected wound |
| CN111603298A (en) * | 2020-05-19 | 2020-09-01 | 成都怀慈福佑电子科技有限公司 | Preparation process method of transient medical chip |
| WO2021156711A1 (en) * | 2020-02-06 | 2021-08-12 | Kci Licensing, Inc. | Wound dressing with integral uv disinfection |
| CN115645149A (en) * | 2022-12-14 | 2023-01-31 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
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| CN111135341B (en) * | 2020-01-20 | 2021-10-29 | 浙江大学 | Intelligent hydrogel dressing for early warning and controllable treatment of infected wound |
| WO2021156711A1 (en) * | 2020-02-06 | 2021-08-12 | Kci Licensing, Inc. | Wound dressing with integral uv disinfection |
| CN111603298A (en) * | 2020-05-19 | 2020-09-01 | 成都怀慈福佑电子科技有限公司 | Preparation process method of transient medical chip |
| CN111603298B (en) * | 2020-05-19 | 2022-03-25 | 成都怀慈福佑电子科技有限公司 | Preparation process method of transient medical chip |
| CN115645149A (en) * | 2022-12-14 | 2023-01-31 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
| CN115645149B (en) * | 2022-12-14 | 2024-01-23 | 宁夏医科大学总医院 | Intelligent dressing system for chronic wounds |
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