CN113559322A - Face injection filler for beauty and plastic and preparation method thereof - Google Patents
Face injection filler for beauty and plastic and preparation method thereof Download PDFInfo
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- CN113559322A CN113559322A CN202110873278.XA CN202110873278A CN113559322A CN 113559322 A CN113559322 A CN 113559322A CN 202110873278 A CN202110873278 A CN 202110873278A CN 113559322 A CN113559322 A CN 113559322A
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- Prior art keywords
- hyaluronic acid
- injection
- powder
- vitamin
- cosmetic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Abstract
The invention discloses a facial injection filler for cosmetic and plastic surgery, which comprises the following raw materials: 4-6 ml of hyaluronic acid, 0.3-0.6 g of beta-tricalcium phosphate, 0.1-0.3 g of collagen powder, 0.3-0.5 g of excipient, 0.1-0.3 g of vitamin powder and 6-8 ml of water for injection. The facial injection filler is formed into a suspension by mixing hyaluronic acid and beta-tricalcium phosphate particles, has high compatibility by adding collagen powder, excipient and vitamin powder, and cannot generate sensitization after injection; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.
Description
Technical Field
The invention relates to the technical field of injection type cosmetic materials, in particular to a facial injection filler for cosmetic and plastic and a preparation method thereof.
Background
With the improvement of living standard of people, people pay more and more attention to the pursuit of external beauty, and various cosmetic reshaping is generally adopted by people.
Hyaluronic acid, also known as uronic acid and hyaluronic acid, is also called as a azululosidic carbon-based acid in the medical literature, and is a linear polymer polysaccharide composed of disaccharide units (glucuronic acid-N-ethylsulfanylglucose), which is a substance naturally present in tissues and also one of the components of human dermal tissues. The injection of hyaluronic acid is to inject hyaluronic acid into the depressed or abundant part of the skin fold, such as the lip, cheek, nose bridge, chin, scar, etc. by means of filler, so as to reach the effect of eliminating wrinkles and changing appearance immediately. At present, most people have a choice to build the nose for injection of hyaluronic acid, because the nose is not used for operation, does not hurt the skin, has good effect, has good biocompatibility and functions of storing moisture, and can make the skin look very full and elastic. Therefore, hyaluronic acid is a widely appreciated cosmetic product.
However, hyaluronic acid is metabolized in human bodies, belongs to a transient filling material, lasts for about 6 months, and therefore needs to be injected for a long time, so that economic, time and psychological burdens of customers are increased; meanwhile, the hyaluronic acid has insufficient supporting force at the positions of the nose, nasolabial sulcus, chin, temples and the like, so that the forming is not ideal and the effect is influenced.
Disclosure of Invention
The invention aims to overcome the problems that a hyaluronic acid face filler needs to be injected for a long time and the supporting force of the hyaluronic acid face filler at the nose, nasolabial sulcus, chin, temple and other parts is insufficient, and provides a face injection filler for beauty and plastic and a preparation method thereof.
A facial injection filler for cosmetic and plastic comprises the following raw materials: the hyaluronic acid injection comprises hyaluronic acid, beta-tricalcium phosphate, collagen powder, an excipient and vitamin powder, wherein the hyaluronic acid is 4-6 ml, the beta-tricalcium phosphate is 0.3-0.6 g, the collagen powder is 0.1-0.3 g, the excipient is 0.3-0.5 g, the vitamin powder is 0.1-0.3 g, and the water for injection is 6-8 ml.
Further, the excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
Furthermore, the hyaluronic acid is medium-small molecule hyaluronic acid or any one of medium-large molecule hyaluronic acid.
Further, the vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
A preparation method of a facial injection filler for cosmetic and plastic comprises the following steps:
s1: extracting water for injection by using an injector, pouring vitamin powder, protein powder and beta-tricalcium phosphate into the water for injection, and mixing and shaking uniformly to obtain a mixture A;
s2: adding hyaluronic acid into the mixture A, and stirring and mixing to obtain a mixture B;
s3: slowly adding the medium excipient into the mixture B, shaking up to mix thoroughly, and obtaining the face filling injection.
The invention has the beneficial effects that: the facial injection filler is formed into a suspension by mixing hyaluronic acid and beta-tricalcium phosphate particles, has high compatibility by adding collagen powder, excipient and vitamin powder, and cannot generate sensitization after injection; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.
Example 1:
a facial injection filler for cosmetic and plastic comprises the following raw materials: the hyaluronic acid injection comprises hyaluronic acid, beta-tricalcium phosphate, collagen powder, an excipient and vitamin powder, wherein 4ml of hyaluronic acid, 0.3g of beta-tricalcium phosphate, 0.1g of collagen powder, 0.3g of excipient, 0.1g of vitamin powder and 6ml of water for injection.
The excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
The hyaluronic acid is medium-small molecule hyaluronic acid.
The vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
The face injection filling agent of medium and small molecular hyaluronic acid, beta-tricalcium phosphate, collagen powder, excipient and vitamin powder can be used for filling nasolabial sulcus and temples.
Example 2:
a facial injection filler for cosmetic and plastic comprises the following raw materials: hyaluronic acid, beta-tricalcium phosphate, collagen powder, an excipient and vitamin powder, wherein the hyaluronic acid is 6ml, the beta-tricalcium phosphate is 0.6g, the collagen powder is 0.3g, the excipient is 0.5g, the vitamin powder is 0.3g, and the water for injection is 8 ml.
The excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
The hyaluronic acid is medium-small molecule hyaluronic acid.
The vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
The face injection filling agent of medium and small molecular hyaluronic acid, beta-tricalcium phosphate, collagen powder, excipient and vitamin powder can be used for filling nasolabial sulcus and temples.
Example 3:
a facial injection filler for cosmetic and plastic comprises the following raw materials: 5ml of hyaluronic acid, 0.4g of beta-tricalcium phosphate, 0.2g of collagen powder, 0.4g of excipient, 0.5g of vitamin powder and 8ml of water for injection.
The excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
The hyaluronic acid is medium-small molecule hyaluronic acid.
The vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
The face injection filling agent of medium and small molecular hyaluronic acid, beta-tricalcium phosphate, collagen powder, excipient and vitamin powder can be used for filling nasolabial sulcus and temples.
Example 4:
a facial injection filler for cosmetic and plastic comprises the following raw materials: the hyaluronic acid injection comprises hyaluronic acid, beta-tricalcium phosphate, collagen powder, an excipient and vitamin powder, wherein 4ml of hyaluronic acid, 0.3g of beta-tricalcium phosphate, 0.1g of collagen powder, 0.3g of excipient, 0.1g of vitamin powder and 6ml of water for injection.
The excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
The hyaluronic acid is medium-macromolecule hyaluronic acid.
The vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
The face injection filling agent of the medium-macromolecule hyaluronic acid, the beta-tricalcium phosphate, the collagen powder, the excipient and the vitamin powder can be used for filling the nose and the chin.
Example 5:
a facial injection filler for cosmetic and plastic comprises the following raw materials: hyaluronic acid, beta-tricalcium phosphate, collagen powder, an excipient and vitamin powder, wherein the hyaluronic acid is 6ml, the beta-tricalcium phosphate is 0.6g, the collagen powder is 0.3g, the excipient is 0.5g, the vitamin powder is 0.3g, and the water for injection is 8 ml.
The excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
The hyaluronic acid is medium-macromolecule hyaluronic acid.
The vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
The face injection filling agent of the medium-macromolecule hyaluronic acid, the beta-tricalcium phosphate, the collagen powder, the excipient and the vitamin powder can be used for filling the nose and the chin.
Example 6:
a facial injection filler for cosmetic and plastic comprises the following raw materials: 5ml of hyaluronic acid, 0.5g of beta-tricalcium phosphate, 0.3g of collagen powder, 0.5g of excipient, 0.3g of vitamin powder and 8ml of water for injection.
The excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
The hyaluronic acid is medium-macromolecule hyaluronic acid.
The vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
The face injection filling agent of the medium-macromolecule hyaluronic acid, the beta-tricalcium phosphate, the collagen powder, the excipient and the vitamin powder can be used for filling the nose and the chin.
Example 7:
a preparation method of a facial injection filler for cosmetic and plastic comprises the following steps:
s1: extracting water for injection by using an injector, pouring vitamin powder, protein powder and beta-tricalcium phosphate into the water for injection, and mixing and shaking uniformly to obtain a mixture A;
s2: adding hyaluronic acid into the mixture A, and stirring and mixing to obtain a mixture B;
s3: slowly adding the medium excipient into the mixture B, shaking up to mix thoroughly, and obtaining the face filling injection.
As in the following table: the experimental effects of examples 1 to 6 were shown.
The facial injection filler is formed into a suspension by mixing hyaluronic acid and beta-tricalcium phosphate particles, has high compatibility by adding collagen powder, excipient and vitamin powder, and cannot generate sensitization after injection; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (5)
1. A facial injection filler for cosmetic and plastic surgery, which is characterized in that: the method comprises the following raw materials: the hyaluronic acid injection comprises hyaluronic acid, beta-tricalcium phosphate, collagen powder, an excipient and vitamin powder, wherein the hyaluronic acid is 4-6 ml, the beta-tricalcium phosphate is 0.3-0.6 g, the collagen powder is 0.1-0.3 g, the excipient is 0.3-0.5 g, the vitamin powder is 0.1-0.3 g, and the water for injection is 6-8 ml.
2. The face injection filler for cosmetic and cosmetic use according to claim 1, wherein: the excipient is composed of an antioxidant and an osmotic pressure regulator according to the proportion of 2: 1.
3. The face injection filler for cosmetic and cosmetic use according to claim 1, wherein: the hyaluronic acid is any one of small-molecule hyaluronic acid or medium-molecule hyaluronic acid.
4. The face injection filler for cosmetic and cosmetic use according to claim 1, wherein: the vitamin powder is formed by mixing vitamin A and vitamin C according to the proportion of 1: 1.
5. The method for preparing a facial injection filler for cosmetic and cosmetic surgery according to any one of claims 1 to 4, comprising: the method comprises the following steps:
s1: extracting water for injection by using an injector, pouring vitamin powder, protein powder and beta-tricalcium phosphate into the water for injection, and mixing and shaking uniformly to obtain a mixture A;
s2: adding hyaluronic acid into the mixture A, and stirring and mixing to obtain a mixture B;
s3: slowly adding the medium excipient into the mixture B, shaking up to mix thoroughly, and obtaining the face filling injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110873278.XA CN113559322A (en) | 2021-07-30 | 2021-07-30 | Face injection filler for beauty and plastic and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110873278.XA CN113559322A (en) | 2021-07-30 | 2021-07-30 | Face injection filler for beauty and plastic and preparation method thereof |
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| CN113559322A true CN113559322A (en) | 2021-10-29 |
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| CN202110873278.XA Pending CN113559322A (en) | 2021-07-30 | 2021-07-30 | Face injection filler for beauty and plastic and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113952510A (en) * | 2021-11-09 | 2022-01-21 | 无锡本物医疗器械有限公司 | Targeted injection type filler composition and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999625A (en) * | 2014-11-13 | 2017-08-01 | 莫茨药物股份两合公司 | Dermal augmentation agent based on cross-linking type sodium hyaluronate and carboxymethyl cellulose |
| CN109966555A (en) * | 2019-05-06 | 2019-07-05 | 常州立新医疗美容诊所有限公司 | A kind of elastic cell's modeling face facial bulking agent compositions gel and preparation method thereof |
-
2021
- 2021-07-30 CN CN202110873278.XA patent/CN113559322A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999625A (en) * | 2014-11-13 | 2017-08-01 | 莫茨药物股份两合公司 | Dermal augmentation agent based on cross-linking type sodium hyaluronate and carboxymethyl cellulose |
| CN109966555A (en) * | 2019-05-06 | 2019-07-05 | 常州立新医疗美容诊所有限公司 | A kind of elastic cell's modeling face facial bulking agent compositions gel and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113952510A (en) * | 2021-11-09 | 2022-01-21 | 无锡本物医疗器械有限公司 | Targeted injection type filler composition and preparation method and application thereof |
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Application publication date: 20211029 |
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