CN113521388A - An injectable facial filler composition for skin care and plastic, and its preparation method - Google Patents

An injectable facial filler composition for skin care and plastic, and its preparation method Download PDF

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Publication number
CN113521388A
CN113521388A CN202110871096.9A CN202110871096A CN113521388A CN 113521388 A CN113521388 A CN 113521388A CN 202110871096 A CN202110871096 A CN 202110871096A CN 113521388 A CN113521388 A CN 113521388A
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Prior art keywords
hyaluronic acid
dexamethasone
lidocaine
mixture
beta
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Chinese (zh)
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张广利
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Abstract

The invention discloses an injection type face filler composition for beauty and plastic and a preparation method thereof. Comprises 2-3 ml of hyaluronic acid, 0.3-0.6 g of beta-tricalcium phosphate and 0.2-0.4 ml of a mixture of dexamethasone and lidocaine. S1: drawing the mixture of dexamethasone and lidocaine by using a syringe; s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture; s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler. The face filler is filled by mixing hyaluronic acid and beta-tricalcium phosphate particles to form a suspension, and has high compatibility; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.

Description

An injectable facial filler composition for skin care and plastic, and its preparation method
Technical Field
The invention relates to the technical field of injection type cosmetic materials, in particular to an injection type face filler composition for cosmetic and plastic and a preparation method thereof.
Background
With the improvement of living standard of people, people pay more and more attention to the pursuit of external beauty, and various cosmetic reshaping is generally adopted by people.
Hyaluronic acid, also known as uronic acid and hyaluronic acid, is also called as a azululosidic carbon-based acid in the medical literature, and is a linear polymer polysaccharide composed of disaccharide units (glucuronic acid-N-ethylsulfanylglucose), which is a substance naturally present in tissues and also one of the components of human dermal tissues. The injection of hyaluronic acid is to inject hyaluronic acid into the depressed or abundant part of the skin fold, such as the lip, cheek, nose bridge, chin, scar, etc. by means of filler, so as to reach the effect of eliminating wrinkles and changing appearance immediately. At present, most people have a choice to build the nose for injection of hyaluronic acid, because the nose is not used for operation, does not hurt the skin, has good effect, has good biocompatibility and functions of storing moisture, and can make the skin look very full and elastic. Therefore, hyaluronic acid is a widely appreciated cosmetic product.
However, hyaluronic acid is metabolized in human bodies, belongs to a transient filling material, lasts for about 6 months, and therefore needs to be injected for a long time, so that economic, time and psychological burdens of customers are increased; meanwhile, the hyaluronic acid has insufficient supporting force at the positions of the nose, nasolabial sulcus, chin, temples and the like, so that the forming is not ideal and the effect is influenced.
Disclosure of Invention
The invention aims to overcome the problems that the existing hyaluronic acid facial filler needs to be injected for a long time and has insufficient supporting force at the positions of nose, nasolabial sulcus, chin, temple and the like, and provides an injection type facial filler composition for beautifying and reshaping and a preparation method thereof.
An injection type face filler composition for beautifying and reshaping comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and a lidocaine mixture, wherein the hyaluronic acid is 2-3 ml, the beta-tricalcium phosphate is 0.3-0.6 g, and the dexamethasone and the lidocaine mixture is 0.2-0.4 ml.
Further, the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the mixture of dexamethasone and lidocaine is 0.3 ml.
Further, the mixture of dexamethasone and lidocaine is formed by mixing dexamethasone and lidocaine according to the proportion of 1-5.
Furthermore, the hyaluronic acid is medium-small molecule hyaluronic acid or any one of medium-large molecule hyaluronic acid.
A preparation method of an injection type face filler composition for cosmetic and plastic comprises the following steps:
s1: drawing the mixture of dexamethasone and lidocaine by using a syringe;
s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture;
s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler.
The invention has the beneficial effects that: the face filler is filled by mixing hyaluronic acid and beta-tricalcium phosphate particles to form a suspension, and has high compatibility; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.
Example 1:
an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 2ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.2 ml.
The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 1.
The hyaluronic acid is medium-small molecule hyaluronic acid.
The face filler prepared by mixing medium and small molecular hyaluronic acid with beta-tricalcium phosphate, dexamethasone and lidocaine can be used for filling nasolabial sulcus and temples.
Example 2:
an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine mixture, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.6g, and the dexamethasone and lidocaine mixture is 0.4 ml.
The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 2.
The hyaluronic acid is medium-small molecule hyaluronic acid.
The face filler prepared by mixing medium and small molecular hyaluronic acid with beta-tricalcium phosphate, dexamethasone and lidocaine can be used for filling nasolabial sulcus and temples.
Example 3:
an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 2ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.2 ml.
The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 2.
The hyaluronic acid is medium-macromolecule hyaluronic acid.
The face filler prepared by mixing the medium-macromolecule hyaluronic acid with the beta-tricalcium phosphate, the dexamethasone and the lidocaine can be used for filling the nose and the chin.
Example 4:
an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine mixture, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.6g, and the dexamethasone and lidocaine mixture is 0.4 ml.
The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 3.
The hyaluronic acid is medium-macromolecule hyaluronic acid.
The face filler prepared by mixing the medium-macromolecule hyaluronic acid with the beta-tricalcium phosphate, the dexamethasone and the lidocaine can be used for filling the nose and the chin.
Example 5:
an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.3 ml.
The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 5.
The hyaluronic acid is medium-small molecule hyaluronic acid.
The face filler prepared by mixing medium and small molecular hyaluronic acid with beta-tricalcium phosphate, dexamethasone and lidocaine can be used for filling nasolabial sulcus and temples.
Example 6:
an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.3 ml.
The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 4.
The hyaluronic acid is medium-macromolecule hyaluronic acid.
The face filler prepared by mixing the medium-macromolecule hyaluronic acid with the beta-tricalcium phosphate, the dexamethasone and the lidocaine can be used for filling the nose and the chin.
Example 7:
a preparation method of an injection type face filler composition for cosmetic and plastic comprises the following steps:
s1: drawing the mixture of dexamethasone and lidocaine by using a syringe;
s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture;
s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler.
Hyaluronic acid and beta-tricalcium phosphate particles are mixed to form a suspension for filling, and the suspension has good compatibility with surrounding tissues after filling and has no rejection and allergic reaction. The results showed that no significant fibrous capsule formation was seen around the material, and that no BMP2 was expressed. The stable porous crystal balls form a stable bracket for the growth of blood vessels and cells, the stable framework forms a result of lasting curative effect and no displacement, and the beta-tricalcium phosphate and the hyaluronic acid can be safely used as a tissue filler in combination.
As in the following table: the experimental effects of examples 1 to 6 were shown.
Figure BDA0003189182090000041
The above table shows that the facial filler is filled by mixing hyaluronic acid and beta-tricalcium phosphate particles to form a suspension, and has high compatibility; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.

Claims (5)

1. An injectable cosmetic face filler composition characterized by comprising: the hyaluronic acid injection comprises a mixture of hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 2-3 ml, the beta-tricalcium phosphate is 0.3-0.6 g, and the mixture of dexamethasone and lidocaine is 0.2-0.4 ml.
2. An injectable cosmetic face pack composition according to claim 1, wherein: the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the mixture of dexamethasone and lidocaine is 0.3 ml.
3. An injectable cosmetic face pack composition according to claim 1, wherein: the mixture of dexamethasone and lidocaine is formed by mixing dexamethasone and lidocaine according to the proportion of 1-5.
4. An injectable cosmetic face pack composition according to claim 1, wherein: the hyaluronic acid is any one of small-molecule hyaluronic acid or medium-molecule hyaluronic acid.
5. The method for preparing the injectable cosmetic/plastic face pack composition according to any one of claims 1 to 4, wherein the method comprises the steps of: the method comprises the following steps:
s1: drawing the mixture of dexamethasone and lidocaine by using a syringe;
s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture;
s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler.
CN202110871096.9A 2021-07-30 2021-07-30 An injectable facial filler composition for skin care and plastic, and its preparation method Pending CN113521388A (en)

Priority Applications (1)

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Application Number Priority Date Filing Date Title
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WO2014199022A1 (en) * 2013-06-11 2014-12-18 Tauzin Bénédicte Vincente Method for cross-linking hyaluronic acid, method for preparing an injectable hydrogel, resulting hydrogel and use thereof
CN106999625A (en) * 2014-11-13 2017-08-01 莫茨药物股份两合公司 Dermal augmentation agent based on cross-linking type sodium hyaluronate and carboxymethyl cellulose
CN111132705A (en) * 2017-05-29 2020-05-08 Kh医学技术有限责任公司 Sterile injection composition containing cross-linked hyaluronic acid and articaine
TWM602945U (en) * 2020-04-24 2020-10-21 透策生技股份有限公司 Processing device for accelerating the dispersion of injection-type fillers by means of pressurization

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WO2014199022A1 (en) * 2013-06-11 2014-12-18 Tauzin Bénédicte Vincente Method for cross-linking hyaluronic acid, method for preparing an injectable hydrogel, resulting hydrogel and use thereof
CN106999625A (en) * 2014-11-13 2017-08-01 莫茨药物股份两合公司 Dermal augmentation agent based on cross-linking type sodium hyaluronate and carboxymethyl cellulose
EP3218023A1 (en) * 2014-11-13 2017-09-20 Merz Pharma GmbH & Co. KGaA Dermal filler based on crosslinked hyaluronic acid and carboxymethyl cellulose lubricant
CN111132705A (en) * 2017-05-29 2020-05-08 Kh医学技术有限责任公司 Sterile injection composition containing cross-linked hyaluronic acid and articaine
TWM602945U (en) * 2020-04-24 2020-10-21 透策生技股份有限公司 Processing device for accelerating the dispersion of injection-type fillers by means of pressurization

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Application publication date: 20211022