TWM602945U - Processing device for accelerating the dispersion of injection-type fillers by means of pressurization - Google Patents

Abstract

This creation is a processing device that uses pressurization to accelerate the dispersion of injection-type fillings. It includes: a first containing device, a second containing device, and a connecting device. The first containing device is connected to the first containing device through a first interface. The spout port and the second interface are connected to the second spout port of the second container, so that the first container and the second container communicate with each other. By alternately operating the first pressurizing element of the first containment device and the second pressurizing element of the second containment device to perform the step of reciprocating pressure and mixing, the flow rate of the mixture is increased and shear stress is formed, thereby causing injection The colloidal solute in the type filling is uniformly dissolved in the solvent, and the dispersoid in the injection type filling is uniformly dispersed in the solvent.

Description

Processing device for accelerating the dispersion of injection-type fillers by means of pressurization

This creation is about a processing device for accelerating the dispersion of injection-type fillings, especially a processing device that uses back-and-forth pressure to accelerate the dispersion of injection-type fillings for medical beauty.

Injectable poly (D, L- lactic _{acid) (injectable poly- D, L -lactic} acid, PDLLA) is a new stimulation of collagen injectable fillers (injectable filler), may be filled in the soft tissue of the human body through injection, So as to achieve medical beauty effects such as wrinkle removal, contour modification or tissue plumping. The PDLLA filler contains PDLLA microspheres and hydroxymethyl cellulose (CMC). PDLLA microspheres are ingredients used to stimulate collagen proliferation, but they are insoluble in injection solvents (for example, distilled water for injection). Hydroxymethyl cellulose is a water-soluble polymer, which can become a colloidal solution when dissolved in a solvent for injection, which has the effect of increasing viscosity, providing dispersion and suspension, etc., so that PDLLA microspheres can be well dispersed and suspended in injection In addition, the injection solution containing hydroxymethyl cellulose has a certain viscosity, which can be better retained in the target tissue after injection without transferring to other tissues.

PDLLA fillers gradually stimulate the proliferation of collagen to achieve medical cosmetic effects. Compared with the traditional direct injection of hyaluronic acid or collagen, the medical cosmetic effects can be more natural and lasting. However, when formulated as a solution for injection, PDLLA microspheres are gradually decomposed into lactic acid due to hydrolysis, and CMC hydrogel will also be gradually hydrolyzed. Therefore, the PDLLA filling needs to be freeze-dried and stored after the preparation is completed, and the injection solvent is used for reconstitution before use.

In the above reduction step, the injection solvent is usually added to a sample bottle containing freeze-dried PDLLA filling, and the sample bottle is sealed or transferred to a centrifuge tube (or microcentrifuge tube) for mixing. The traditional mixing method is divided into hand-shaking method and vortex method. In the case where the required filler concentration is low, for example, in the case of reducing 200 mg of PDLLA filler with 8 mL of solvent, the hand shake method can be used for mixing, but it often takes more than 30 minutes to mix it uniformly. In addition, when the required filler concentration is high, for example, when 200 mg of PDLLA filler is reduced with 1.4 mL of solvent, it is more suitable to use the vortex method for mixing. That is, the sample bottle or centrifuge tube filled with the filler and the solvent is placed on the vortex generator (vortex generator) oscillating platform and then pressed down, and the liquid is vortexed at 2700 rpm to aid mixing. However, in the case of the above-mentioned high concentration, even if the mixing is performed by the vortex method, it takes more than 1 hour to mix it uniformly.

Moreover, the disadvantage of the above-mentioned traditional method of using hand-crank method or vortex method is that even if the vortex method produces a higher shear force on the fluid than the hand-crank method, it accelerates and enhances the PDLLA filler. The dispersing speed and effect during solvent reduction are still quite time-consuming, and after being evenly dispersed, after standing for 30 minutes, there will still be the phenomenon of solvent and filler layering (as shown in Figure 13), making the traditional temporary use The conditions of use of the formulation method are more stringent. For similar injectable poly(L-lactic acid) (injectable PLLA) products (including PLLA, CMC and mannitol), it takes 48 hours to evenly disperse.

Filler solutions for injection that cannot be uniformly dispersed will not only cause uneven medical cosmetic effects of the target tissue, but also may cause complications such as papules and nodules due to the aggregation of fillers.

In view of the above problems, there is a need for a processing device that uses pressurization to accelerate the dispersion of injection-type fillings. Compared with the traditional method using vortex generators, it can provide greater shear force, thereby preventing the injection-type filling from gathering. In order to shorten the time required for the dispersion of injection-type fillers, and can improve its dispersion effect and stability.

The main purpose of this creation is to provide a processing device that uses pressurization to accelerate the dispersion of injection-type fillings, including: a first containing device having a first containing body and a first pressing element, the first containing body It has a first accommodating space and a first spout, the diameter of the first spout is smaller than the inner diameter of the first accommodating space, and the first pressing element is movably coupled to the first accommodating space of the first accommodating body The volume of the first accommodating space is changed through the action of the first pressing element; a second accommodating device has a second accommodating body and a second pressing element, and the second accommodating body has a second The accommodating space and a second injection port, the diameter of the second injection port is smaller than the inner diameter of the second accommodating space, the second pressing element is movably combined in the second accommodating space of the second accommodating body, and passes through the The actuation of the second pressurizing element changes the volume of the second accommodating space; and a connecting device having a first interface, a second interface, and a channel connecting the first interface and the second interface, through the first interface An interface is connected to the first spout port of the first container, and the second interface is connected to the second spout port of the second container, so that the first container and the second container communicate with each other; wherein , The first containing space of the first containing device is loaded with a predetermined amount of solvent, and the second containing space of the second containing device is loaded with an injectable filler, the injectable filler containing soluble The colloidal solute of the solvent and the dispersant insoluble in the solvent, by alternately operating the first pressing element of the first containing device and the second pressing element of the second containing device, the solvent is pressurized to enter the first The second accommodating space of the second accommodating device so that the injection-type filling and the solvent form a mixture, and after removing excess air, the mixture is pressurized and then enters the first accommodating device from the second accommodating space In the first containing space, through the step of reciprocating pressure mixing, the flow rate of the mixture is increased and shear stress is formed, so that the colloidal solute in the injection-type filling is uniformly dissolved in the solvent, and the The dispersion in the injection-type filling is uniformly dispersed in the solvent.

Preferably, the first containing device is a syringe.

Preferably, the second containing device is a syringe.

Preferably, the connecting device is selected from one of three-way valves, L-shaped tubes, and V-shaped tubes.

Preferably, the cross-sectional areas of the first interface and the second interface of the connecting device are smaller than the cross-sectional areas of the first accommodating space and the second accommodating space, respectively.

Preferably, the dispersant comprises at least one selected from the group consisting of: poly(D,L-lactic acid) (PDLLA); poly(L-lactic acid) (PLLA); polycaprolactone (PCL) ); hyaluronic acid (HA); hydroxyapatite (HAP); and collagen (Collagen).

Preferably, the colloidal solute includes at least one selected from the group consisting of: carboxymethyl cellulose (CMC); hyaluronic acid (HA); and a mixture of hyaluronic acid (HA) and calcium phosphate (TCP).

Preferably, the solvent includes at least one selected from the group consisting of: sodium bicarbonate (sodium bicarbonate) aqueous solution; sterile water for injection (SWFI); normal saline (normal saline) ; Lidocaine (lidocaine, anesthetic); lidocaine with epinephrine (lidocaine + E); and mannitol (mannitol).

Preferably, the dispersion is porous microspheres.

By using the processing device of this creation to disperse the injection-type filler, the uniform dispersion effect is maintained even after being allowed to stand for 30 minutes after the uniform dispersion, and the dispersion stability is improved.

In addition, no matter what the dispersing effect of the solvent, the injection-type filling did not aggregate. And the dispersion effect in the solvent with the best dispersion effect is also better than the prior art, which also proves that this creation has a significant improvement effect in dispersing injection-type fillings.

1 to 2, the present invention provides a processing device 100 that uses pressurization to accelerate the dispersion of injectable fillers, including a first containing device 10, a second containing device 20 and a connecting device 30.

The first containing device 10 has a first containing body 101 and a first pressurizing element 102. The first containing body 101 has a first containing space 1011 and a first injection port 1012. The diameter of the first injection port 1012 is Smaller than the inner diameter of the first accommodating space 1011, the first pressing element 102 is movably combined with the first accommodating space 1011 of the first accommodating body 101, and the first pressing element 102 is actuated to change the The internal volume of an accommodation space 1011.

The second containing device 20 has a second containing body 201 and a second pressurizing element 202. The second containing body 201 has a second containing space 2011 and a second injection port 2012. The caliber is smaller than the inner diameter of the second accommodating space 2011, the second pressing element 202 is movably combined in the second accommodating space 2011 of the second accommodating body 201, and the action of the second pressing element 202 changes the The internal volume of the second accommodation space 2011.

The connecting device 30 has a first interface 301, a second interface 302, a third interface 303, and a channel 304 connecting the first interface 301, the second interface 302, and the third interface 303. The first port 301 is connected to the first spout port 1012 of the first container device 10, and the second port 302 is connected to the second spout port 2012 of the second container device 20, so that the first container device 10 and The second receiving device 20 communicates with each other.

Here, the basic operation mode of the connecting device 30 in this embodiment will be briefly described as follows: a predetermined amount of solvent 40 is loaded in the first containing space 1011 of the first containing device 10, and in the second containing device 20 The second accommodating space 2011 is loaded with an injectable filling 50, which includes a colloidal solute 52 soluble in the solvent 40 and a dispersant 51 insoluble in the solvent 40 (as shown in FIG. 5). Operate the first pressurizing element 102 of the first containing device 10 and the second pressurizing element 202 of the second containing device 20, so that the solvent 40 is pressurized to enter the second containing space 2011 of the second containing device 20 , The injectable filler 50 and the solvent 40 form a mixture 503 (as shown in FIG. 4), and after removing excess air, the mixture 503 is pressurized and then enters the first containing space from the second containing space 2011 In the first containing space 1011 of the device 10, through this step of reciprocating pressure mixing, the flow rate of the mixture 503 is increased and shear stress is formed, so that the colloidal solute 52 in the injection-type filling 50 is uniformly dissolved in In the solvent 40, the dispersoid 51 in the injection-type filling 50 is uniformly dispersed in the solvent 40.

The cross-sectional areas of the first interface 301 and the second interface 302 of the connecting device 30 are smaller than the cross-sectional areas of the first accommodating space 1011 and the second accommodating space 2011, respectively, so that the smaller cross-sectional area can be used for solvent treatment in subsequent steps. 40 or the mixture 503 composed of the solvent 40 and the injection-type filling 50 is pressurized.

The first containing device 10 and the second containing device 20 may be syringes or other pressurizing devices with similar functions. Taking the syringe of this embodiment as an example, its corresponding first pressurizing element 102 and second pressurizing element 202 (that is, piston) can be used to adjust the first accommodating space 1011 and the first accommodating space 1011 by pushing or pulling back. The volume of the two accommodating spaces 2011, and the syringes have openings respectively matched with the channels of the connecting device 30, that is, for connecting to the channels of the connecting device 30 respectively.

Next, the solvent 40 is added to the first containing space 1011, and the injection type filling 50 is added to the first containing space 2011. The injection type filling 50 includes a colloidal solute 52 that is soluble in the solvent 40 and a dispersion that is insoluble in the solvent 40. Quality 51 (refer to Figure 6).

Injectable fillers 50 may be an injection of Poly (D, L- lactic _{acid) (injectable poly- D, L -lactic} acid), which is a method for stimulating collagen medical cosmetic products.

The solvent 40 can be, for example, a sodium bicarbonate (sodium bicarbonate) aqueous solution, a sterile water for injection (SWFI), a normal saline (normal saline), a lidocaine (lidocaine, an anesthetic), an adrenaline-containing Lidocaine with epinephrine (lidocaine + E) or mannitol, preferably distilled water for injection (SWFI).

The dispersoid 51 can be, for example, poly(D,L-lactic acid) (poly- _D,L- lactic acid, PDLLA), poly(L-lactic acid) (PLLA), polycaprolactone (PCL), hyaluronic acid (HA) , Hydroxyapatite (HAP) or Collagen (Collagen), preferably poly(D,L-lactic acid) (PDLLA).

The dispersant 51 may be a porous microsphere with a high-density surface structure and a hollow internal structure.

The colloidal solute 52 can be, for example, carboxymethyl cellulose (CMC), hyaluronic acid (HA), or a mixture of hyaluronic acid (HA) and calcium phosphate (tricalcium phosphate, TCP), preferably carboxymethyl cellulose (CMC) Methyl cellulose (CMC).

Then, in the connecting step S30, the first accommodating device 10 is connected to the second accommodating device 20 through the connecting device 30, so that the first accommodating space 1011, the passage of the connecting device 30, and the first accommodating space 2011 are communicated with each other.

2, in one embodiment, the connecting device 30 may be a three-way valve, having a first interface 301, a second interface 302, a third interface 303, and the first interface 301 and the second interface 302 and A channel 304 of the third interface 303 and a valve 30a for controlling the communication state between the three interfaces. Preferably, adjacent (that is, right-angled) first interface 301 and second interface 302 can be used to connect to the first containment device 10 and the second containment device 20, respectively, so that the reciprocating pressure mixing can be operated separately The angle of the two hands of the first containing device 10 and the second containing device 20 is 90 degrees, which is beneficial to the ergonomics during single-person operation.

3, in another embodiment, the connecting device 31 can be replaced with an L-shaped tube with two channels 31a, 31b, with only two openings with an angle of 90 degrees, namely, the first interface 311 and the second interface 312 . Alternatively, the connecting device 31 may be replaced with a V-shaped tube (not shown in the figure). Preferably, the opening of the V-shaped tube may be composed of two branch channels with an included angle of 60 degrees to 120 degrees, so that the reciprocating pressure mixing It is more ergonomic, and is preferably a 90-degree angle, that is, an L-shaped tube.

As shown in FIG. 4, during the preliminary mixing, the first pressurizing element 102 of the first accommodating device 10 is pressurized along the A direction to reduce the volume of the first accommodating space 1011, so as to reduce the volume of the first accommodating space 1011. The solvent 40 is pressurized to partially or completely squeeze the solvent 40 into the second accommodating space 2011, so that the injectable filler 50 and the solvent 40 form a mixture 503.

Since the part of the first accommodating space 2011 other than the injectable filler 50 also contains air (as shown in FIG. 2, hereinafter referred to as the first air 60), the air can be further processed after the preliminary mixing. Exclude to eliminate the first air 60.

The reason for air removal is that if there is a large amount of air in the communication space between the first accommodating space 1011, the first interface 301 of the connecting device 30, and the second accommodating space 2011, the air will occupy a large amount in the communication space. The space and the air pressure (about 1 atmosphere) is formed, which is not conducive to the subsequent reciprocating pressure mixing.

As shown in FIG. 6, when the air is removed, the first accommodating device 10 is separated from the connecting device 30, and the volume of the first accommodating space 1011 is fixed (that is, the position of the first pressing element 102 of the first accommodating device 10 is maintained No change) to block outside air from entering the first accommodating space 1011; and pressurizing the second pressurizing element 202 of the second accommodating device 20 along the C direction to reduce the volume of the second accommodating space 2011, thereby preventing The mixture 503 in the second containing space 2011 is pressurized to exhaust the first air 60 in the first containing space 2011 through the first interface 301 of the connecting device 30; then, the first containing device 10 is reconnected to the connecting device 30 ( As shown in Figure 8).

Or, as shown in FIG. 7, the first accommodating device 10 and the connecting device 30 may not be separated, but the valve 30a of the connecting device 30 may be converted to connect the second accommodating space 2011 with the outside, and the first accommodating device may be closed 10 and the communication between the second receiving device 20. Thus, it is also possible to block external air from entering the first accommodating space 1011 and pressurize along the C direction to discharge the first air 60 in the second accommodating space 2011 from the third port 303 of the connecting device 30, and then Then turn the valve 30a back to the state shown in FIG. 8 to reconnect the first receiving device 10.

Finally, when performing reciprocating pressure mixing, first, referring to FIG. 8, continue to pressurize the second pressurizing element 202 of the second accommodating device 20 along the C direction to reduce the volume of the second accommodating space 2011, so as to The mixture 503 in the accommodation space 2011 is pressurized to partially or completely squeeze the mixture into the first accommodation space 1011. Then, referring to FIG. 9, the first pressing element 102 of the first containing device 10 is pressurized again along the A direction to reduce the volume of the first containing space 1011, thereby pressurizing the mixture 503 in the first containing space 1011 To partially or completely squeeze the mixture into the first receiving space 2011. Wherein, by repeating the step of reciprocating pressure mixing, the flow rate of the mixture in the first containing space 1011 and the second containing space 2011 that are connected is increased and a shear force is formed to prevent the colloidal solute 52 or the dispersoid 51 from gathering, thereby The colloidal solute 52 in the injection-type filling 50 is uniformly dissolved in the solvent 40, and the dispersoid 51 in the injection-type filling 50 is uniformly dispersed in the solvent 40.

Referring to FIG. 5, which is a partial enlarged schematic view of part 5A of FIG. 5. According to an embodiment of the present creation, before mixing, the injectable filler 50 has a flocculent structure, which includes a surface layer part (from boundary B to boundary B'in FIG. 6) and an inner core part (boundary in FIG. 6 B'), and the second air 70 is also contained in the inner core portion. During the initial mixing, the solvent 40 infiltrates the surface part of the injection-type filling 50 to make the surface part of the injection-type filling 50 swell (such as from the boundary B'to the boundary B"), and the solvent 40 also interacts with the inner core part The second air 70 in the air-liquid interface (such as at the boundary B') forms a bubble in the air-liquid interface B', that is, the air-liquid interface B'is the surface of the bubble, and the second air 70 and the injection filling The inner core part of the substance 50 is contained in the bubble; and, in the reciprocating pressure mixing step S60, the bubble is destroyed by pressurizing the mixture to increase the flow rate of the mixture and form a shear force, so that the solvent 40 enters In this bubble, the colloidal solute 52 in the inner core part of the injection-type filling 50 is uniformly dissolved in the solvent 40, and the dispersoid 51 in the inner core part of the injection-type filling 50 is uniformly dispersed in the solvent 40 In this way, a uniform dispersion 80 is formed.

Since the surface tension of the gas-liquid interface B'of the bubbles prevents the solvent 40 from uniformly mixing with the injection-type filler 50, it is necessary to accelerate the mixing by destroying the gas-liquid interface B'of the bubbles.

Preferably, the total time for the reciprocating pressure mixing step is less than 30 seconds to achieve the uniform dissolution of the colloidal solute 52 and the uniform dispersion of the insoluble dispersoid 51 (as shown in Figure 10, which is part of Figure 5) 5A is a partial enlarged schematic diagram after repeated reciprocating pressure mixing steps). Compared with the prior art, it takes 20 minutes to 48 hours, which has a significant improvement effect.

As shown in Figure 11, choose 4 common solvents for injection: distilled water for injection (SWFI), normal saline (NS), lidocaine (lidocaine), and lidocaine containing epinephrine (lidocaine + E); And two solvents used for comparison: sodium bicarbonate (NaHCO ₃ ) aqueous solution with strong ionic strength, and mannitol as a strong osmotic dehydrating agent. The above 6 kinds of solvents were used to infiltrate one injection-type filling 50 in 3 minutes. In the absence of external stirring, SWFI and mannitol have a better dispersion effect due to the weakest ionic strength. This is because stronger ionic strength will cause more aggregation.

In order to further verify the dispersion effect of the processing device of this creation, a mixture of 200 mg injection-type filler and 8 mL of solvent was dispersed using the processing device of this creation, and the results are shown in Figures 14 and 15. In addition, as a control, a mixture of 200 mg of injectable filler and 8 mL of solvent was dispersed using a general vortex generator. The results are shown in FIGS. 12 and 13.

Referring to Figure 15, it can be seen that by using the processing device of this creation to disperse the injectable filler, even after being evenly dispersed and allowed to stand for 30 minutes, the injectable filler in various solvents remains uniformly dispersed without being mixed with the solvent. In contrast to this, in the prior art, the injection-type filling and solvent layering occurs after being left for 30 minutes after being processed by the vortex generator (as shown in Figure 12). This creation has good dispersion stability and has Very significant improvement effect.

And, referring to Figure 15, Figure 15 is a photomicrograph taken after uniform dispersion of the injection-type filling dispersed by using the processing device of this creation (the left and right images use SWFI and NS respectively as solvents). It can be seen that no matter in the SWFI solvent with the best dispersion effect or in the NS with poor dispersion effect, the injection-type filler (the black dot in Figure 15) does not produce aggregation. In contrast, the prior art uses vortex The injection-type filler processed by the generator has serious aggregation in the poorly dispersed NS solvent (Figure 13 right), and the dispersion effect of the SWFI solvent with the best dispersion effect (Figure 13 left) It is not as uniform as this creation, and it also proves that this creation has a significant improvement effect in dispersing injectable fillings.

To sum up, the processing device of this creation uses pressure to accelerate the dispersion of injection-type fillers, and uses a back-and-forth pressure method to provide a larger shear than traditional hand-cranked or vortex generation methods. The shear force is sufficient to prevent the aggregation of colloidal solutes or dispersoids in the injection-type filling, and can destroy the bubbles formed by the air in the injection-type filling, so as to produce a good dispersion effect in a short time, and after uniform dispersion Maintain good stability.

To sum up, this creation has its excellent progress in similar products. At the same time, we have checked the domestic and foreign technical data on this type of structure. The same structure has not been found in the literature. Therefore, this At the time of creation, the new patent requirements were already in place, and Yan filed an application in accordance with the law.

However, the above are only the preferred and feasible embodiments of the present creation. If there is no obvious conflict between the embodiments, the features can be combined with each other and replaced. In addition, any equivalent structural changes made by applying the specification of this model and the scope of patent application should be included in the scope of patent of this creation.

100: processing device 10: The first containment device 101: The first containing body 1011: first accommodation space 1012: The first injection outlet 102: The first pressing element 20: second containment device 201: The second containing body 2011: second accommodation space 2012: Second injection 202: second pressing element 2011: second accommodation space 30: Connect the device 30a: Valve 301: First interface 302: second interface 303: third interface 304: Channel 31: Connect the device 311: first interface 312: second interface 40: Solvent 5A: Part 50: Injectable filler 51: Dispersion 52: colloidal solute 503: Mixture 60: First Air 70: second air 80: dispersion A: Direction B: boundary B’: boundary, gas-liquid interface B’’: boundary C: direction

Figure 1 is a schematic diagram of the processing device created; Fig. 2 is a schematic diagram of an embodiment of a connecting device; Figure 3 is a schematic diagram of another embodiment of a connecting device; Figure 4 is a schematic diagram of a preliminary mixing step performed by the processing device; Figure 5 is a partial enlarged view of bubbles in the preliminary mixing step of Figure 4; Figure 6 is a schematic diagram of an embodiment of the air removal step performed by the processing device; FIG. 7 is a schematic diagram of another embodiment of the air removal step performed by the processing device; Figures 8-9 are schematic diagrams of reciprocating pressure mixing steps performed by the processing device; 10 is a partial enlarged view of the bubbles of FIG. 5 after the reciprocating pressure mixing step; Figure 11 is a photograph of the dispersion state of the injection-type filling after being immersed in various solvents for 3 minutes; Figure 12 is a photograph of the dispersion state after the injection-type filler is uniformly dispersed in various solvents by using a vortex generator and left for 30 minutes; Figure 13 is a photomicrograph of the dispersion state of the injectable filler uniformly dispersed in various solvents using a vortex generator; Figure 14 is a photograph of the dispersion state of the injection-type filling after being evenly dispersed in various solvents using the processing device of this creation; and Figure 15 is a photomicrograph of the dispersion state of the injection-type filler uniformly dispersed in various solvents using the processing device of this creation.

100: processing device

10: The first containment device

101: The first containing body

1011: first accommodation space

1012: The first injection outlet

102: The first pressing element

20: second containment device

201: The second containing body

2011: second accommodation space

2012: Second injection

202: second pressing element

2011: second accommodation space

30: Connect the device

30a: Valve

40: Solvent

50: Injectable filler

60: First Air

A: Direction

Claims (9)

A processing device that uses pressurization to accelerate the dispersion of injection-type fillers, including: A first accommodating device has a first accommodating body and a first pressurizing element, the first accommodating body has a first accommodating space and a first injection port, the diameter of the first injection port is smaller than the first accommodation The inner diameter of the space, the first pressurizing element is movably combined in the first accommodation space of the first accommodation body, and the volume of the first accommodation space is changed through the actuation of the first pressurizing element; A second accommodating device has a second accommodating body and a second pressurizing element, the second accommodating body has a second accommodating space and a second injection port, the second injection port has a smaller diameter than the second accommodation The inner diameter of the space, the second pressing element is movably combined in the second receiving space of the second receiving body, and the volume of the second receiving space is changed by the action of the second pressing element; and A connecting device has a first interface, a second interface, and a channel connecting the first interface and the second interface, and is connected to the first injection port of the first receiving device through the first interface, and the first Two interfaces are connected to the second injection port of the second containing device, so that the first containing device and the second containing device communicate with each other; Wherein, the first containing space of the first containing device is loaded with a predetermined amount of solvent, and the second containing space of the second containing device is loaded with an injection-type filling, and the injection-type filling contains soluble The colloidal solute of the solvent and the dispersant insoluble in the solvent, by alternately operating the first pressing element of the first containing device and the second pressing element of the second containing device, the solvent is pressurized to enter the The second accommodating space of the second accommodating device is such that the injection-type filling and the solvent form a mixture, and after removing excess air, the mixture is pressurized and then enters the first accommodating device from the second accommodating space Through this step of reciprocating pressure mixing, the flow rate of the mixture is increased and shear stress is formed, so that the colloidal solute in the injection-type filling is uniformly dissolved in the solvent, and The dispersant in the injection-type filling is uniformly dispersed in the solvent. Such as the processing device of claim 1, wherein the first containing device is a syringe. Such as the processing device of claim 1, wherein the second containing device is a syringe. Such as the processing device of claim 1, wherein the connecting device is selected from one of a three-way valve, an L-shaped tube, and a V-shaped tube. Such as the processing device of claim 1, wherein the cross-sectional areas of the first interface and the second interface are smaller than the cross-sectional areas of the first accommodating space and the second accommodating space. The processing device of claim 1, wherein the dispersoid comprises at least one selected from the group consisting of: poly(D,L-lactic acid) (PDLLA); poly(L-lactic acid) (PLLA); Lactone (PCL); Hyaluronic acid (HA); Hydroxyapatite (HAP); and Collagen (Collagen). The processing device of claim 1, wherein the colloidal solute comprises at least one selected from the group consisting of: carboxymethyl cellulose (CMC); hyaluronic acid (HA); and hyaluronic acid (HA) and calcium phosphate (TCP) )mixture. The processing device of claim 1, wherein the solvent comprises at least one selected from the group consisting of: sodium bicarbonate (sodium bicarbonate) aqueous solution; sterile water for injection (SWFI); general physiological saline (Normal saline); lidocaine (lidocaine, anesthetic); lidocaine with epinephrine (lidocaine + E); and mannitol. The processing device of claim 1, wherein the dispersion is porous microspheres.

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