CN113558998A - 一种纳米纤维面膜及其制备方法 - Google Patents
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Abstract
本发明公开了一种纳米纤维面膜及其制备方法，方法包括：(1)将聚乙二醇分散于水中，室温条件下搅拌溶解，得到聚乙二醇溶液；(2)向聚乙二醇溶液加入胶原蛋白、透明质酸钠，加酸调节PH，室温条件下搅拌均匀；(3)将步骤(2)制得的混合纺丝溶液通过静电纺丝，得到负载胶原蛋白、透明质酸钠的纳米纤维；将步骤(3)制得的纳米纤维与无纺基布用模具一起分切，处理后制成纳米纤维面膜。本发明所得到的纳米纤维面膜除了具有高效的美白、保湿功能，同时产品不需要配精华液、营养液，更加容易包装、保存。整个制备工艺流程短，操作简单。所述的纳米纤维面膜有良好的应用前景，可以作为民用和医用面膜，伤口敷料等。
Description
技术领域
本发明属于纳米纤维材料及其制备领域，特别涉及一种纳米纤维面膜及其制备方法。
背景技术
静电纺丝是高分子流体静电雾化的特殊形式，雾化分裂出的物质是聚合物微小射流，可以运行较长的距离，最终固化成纤维。随着纳米技术的发展，静电纺丝作为一种简便有效的可生产纳米纤维的新型加工技术，将在生物医用材料、过滤及防护、催化、能源、光电、食品工程、化妆品等领域发挥巨大作用。
在生物医学领域，纳米纤维的直径小于细胞，可以模拟天然的细胞外基质的结构和生物功能；人的大多数组织、器官在形式和结构上与纳米纤维类似，这为纳米纤维用于组织和器官的修复提供了可能；一些静电纺丝原料具有很好的生物相容性及可降解性，可作为载体进入人体，并容易被吸收；加之静电纺纳米纤维还有大的比表面积、孔隙率等优良特性，因此，其在生物医学领域引起了研究者的持续关注，并已在药物控释、创伤修复、生物组织工程等方面得到了很好的应用。
在化妆品领域，基于纳米纤维的美容面膜使药物、美容活性成分的经皮吸收大大优于其他面膜载体。药物、美容活性成分以极小的颗粒存在于聚合物纳米纤维中，溶出或释放的效率更高。纳米纤维作为给药的载体，具有极大的比表面积和多孔结构，极强的与其它物质的相互渗透力，极利于药物的扩散和溶出，提高药物的经皮透过量，提高药物的经皮吸收。
发明内容
本发明涉及一种纳米纤维面膜及其制备方法，所要解决的技术问题是解决目前市场上面膜形式(面膜通常是精华液加面膜基布组合)比较单一的问题。本发明提供一种纳米纤维面膜及其制备方法，该面膜是一种新型的固态、遇水速溶面膜，通过纳米纤维负载皮肤所需要的营养物质物质，提供高效美白、保湿及修复功能。该方法包括：
(1)将聚乙二醇分散于水中，室温条件下搅拌溶解，得到聚乙二醇溶液；
(2)向聚乙二醇溶液加入胶原蛋白、透明质酸钠，加酸调节PH，室温条件下搅拌均匀；
(3)将步骤(2)制得的混合纺丝溶液通过静电纺丝，得到负载胶原蛋白、透明质酸钠的纳米纤维；
(4)将步骤(3)制得的纳米纤维与无纺基布用模具一起分切，处理后制成纳米纤维面膜。
所述纳米纤维面膜可以作为民用和医用面膜、伤口敷料等，具备美白、保湿以及修复创伤等功效。该纳米纤维面膜包括无纺布基材层和纳米纤维层，其中，所述的纳米纤维层通过静电纺丝工艺制备得到，接收在所述的无纺布基材层上复合；
所述的纳米纤维层得主要成分为聚乙二醇、胶原蛋白、透明质酸钠；
所述步骤(1)中聚乙二醇的平均分子量在4000-20000；
所述步骤(1)中聚乙二醇溶液质量分数为3-10wt％；
所述步骤(2)中胶原蛋白的平均分子量在1000-5000；PH值调节范围为2-4；
所述步骤(2)中酸为甲酸、乙酸或柠檬酸中的一种或几种；
所述步骤(2)溶液中的胶原蛋白的质量分数为1-5wt％，透明质酸钠的质量分数为1-10wt％；
所述步骤(3)中静电纺丝参数：静电纺丝施加电压为10-20KV，接收距离为10-25cm，溶液流速为0.5-1.5mL/h；
所述步骤(3)中静电纺丝条件为：20-30℃；相对湿度30-50％。
本发明中胶原蛋白的三股螺旋结构决定了胶原具有良好的力学性能及生物相容性。胶原蛋白不仅可以通过物理填充除皱，还能够增强组织活性，促进胶原蛋白再生长，与细胞周围的基质有着良好的相互作用，成为细胞与组织正常功能整体的一部分。此外，胶原作为创面敷料具有粘附性好、适用于肉芽组织和上皮细胞形成、减少伤口挛缩和抗原反应、止血性能好、具备类似于真皮的物理形态结构和可以适度交联及被组织吸收等优点，可用于灼伤和外力所致伤口的治疗。
本发明中，透明质酸钠是一种水溶性物质，具有良好的保湿作用，保湿作用的是透明质酸钠在化妆品中最重要的作用，其他的保湿剂相比，周边环境的相对湿度对透明质酸钠保湿性的影响较小。二是营养作用，透明质酸钠是皮肤固有的生物物质，外源性透明质酸钠是对皮肤内源性的补充，较小的透明质酸钠可深入皮肤表皮层促进皮肤营养的供给和废物的排泄，从而防止皮肤老化，起到美容和养颜的作用。三是对于皮肤损伤修复和预防可以起到一定的作用，透明质酸钠通过促进表皮细胞增殖和分化以及清除氧自由基的作用，可以促进受伤部位皮肤的再生。
有益效果
(1)本发明所涉及的纳米纤维制备过程操作简单、对设备和处理环境要求不苛刻，产生污染较小；
(2)本发明所得到的纳米纤维面膜通过纳米纤维负载皮肤所需要的营养物质物质，提供了高效美白、保湿及修复功能，对人体有益；
(3)本发明所得到的纳米纤维面膜除了具有高效的美白、保湿功能，同时产品不需要配精华液、营养液，更加容易包装、保存。
附图说明
图1：本发明面膜中静电纺丝所形成的纳米纤维扫描电镜图。
具体实施方式
为使本发明更明显易懂，下面结合具体实施例，进一步阐述本发明。应理解，这些实施例仅用于说明本发明而不用于限制本发明的范围。此外应理解，在阅读了本发明讲授的内容之后，本领域的技术人员可以对本发明作各种改动和修改，这些等价形式同样落于本申请所附权利要求书所限定的范围。
实施例1
(1)将5g聚乙二醇加入80g水中，在室温条件下搅拌溶解，得到聚乙二醇溶液；
(2)向聚乙二醇溶液分别加入5g胶原蛋白，10g透明质酸钠，滴加2ml的乙酸，室温条件下搅拌均匀；
(3)将步骤(2)制得的混合纺丝液通过静电纺丝得到负载胶原蛋白，透明质酸钠成分的纳米纤维，纺丝条件：纺丝电压为15KV，接收距离为12cm，溶液流速为0.8ml/h，温度：20-30℃，相对湿度：30-50％。
(4)将步骤(3)的纳米纤维与无纺基布用模具一起分切，处理后制成纳米纤维面膜。
实施例2
(1)将10g聚乙二醇加入80g水中，在室温条件下搅拌溶解，得到聚乙二醇溶液；
(2)向聚乙二醇溶液加入5g胶原蛋白，5g透明质酸钠，滴加2ml的乙酸，室温条件下搅拌均匀；
(3)将步骤(2)制得的混合纺丝液通过静电纺丝得到负载胶原蛋白，透明质酸钠成分的纳米纤维，纺丝条件：纺丝电压为15KV，接收距离为12cm，溶液流速为0.8ml/h，温度：20-30℃，相对湿度：30-50％。
(4)将步骤(3)的纳米纤维与无纺基布用模具一起分切，处理后制成纳米纤维面膜。
实施例3
(1)将10g聚乙二醇加入80g水中，在室温条件下搅拌溶解，得到聚乙二醇溶液；
(2)向聚乙二醇溶液加入3g胶原蛋白，7g透明质酸钠，滴加2ml的乙酸，室温条件下搅拌均匀；
(3)将步骤(2)制得的混合纺丝液通过静电纺丝得到负载胶原蛋白，透明质酸钠成分的纳米纤维，纺丝条件：纺丝电压为15KV，接收距离为12cm，溶液流速为0.8ml/h，温度：20-30℃，相对湿度：30-50％。
(4)将步骤(3)的纳米纤维与无纺基布用模具一起分切，处理后制成纳米纤维面膜。
Claims (10)
1.一种纳米纤维面膜及其制备方法,包括：
(1)将聚乙二醇分散于水中，室温条件下搅拌溶解，得到聚乙二醇溶液；
(2)向聚乙二醇溶液加入胶原蛋白、透明质酸钠，加酸调节PH，室温条件下搅拌均匀；
(3)将步骤(2)制得的混合纺丝溶液通过静电纺丝，得到负载胶原蛋白、透明质酸钠的纳米纤维；
(4)将步骤(3)制得的纳米纤维与无纺基布用模具一起分切，处理后制成纳米纤维面膜。
2.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于：所述纳米纤维面膜可以作为民用和医用面膜、伤口敷料等，具备美白、保湿以及修复创伤等功效。该纳米纤维面膜包括无纺布基材层和纳米纤维层，其中，所述的纳米纤维层通过静电纺丝工艺制备得到，接收在所述的无纺布基材层上复合。
3.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于：纳米纤维层主要成分为聚乙二醇、胶原蛋白、透明质酸钠。
4.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于：所述步骤(1)中聚乙二醇的平均分子量在4000-20000。
5.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于：所述步骤(1)中聚乙二醇溶液质量分数为3-10wt％。
6.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于：所述步骤(2)中胶原蛋白的平均分子量在1000-5000；PH值调节范围为2-4。
7.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于，所述步骤(2)中酸为甲酸、乙酸或柠檬酸中的一种或几种。
8.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于：所述步骤(2)溶液中的胶原蛋白的质量分数为1-5wt％，透明质酸钠的质量分数为1-10wt％。
9.根据权利要求1所述的一种纳米纤维面膜的制备方法，其特征在于：所述步骤(3)中静电纺丝参数：静电纺丝施加电压为10-20KV，接收距离为10-25cm，溶液流速为0.5-1.5mL/h。
10.根据权利要求1所述的一种纳米纤维面膜及其制备方法，其特征在于：所述步骤(3)中静电纺丝条件为：20-30℃；相对湿度30-50％。
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498396A (zh) * | 2018-04-24 | 2018-09-07 | 上海益好纳米科技有限公司 | 一系列免洗全吸收型纳米纤维功能面膜及其制备方法 |
| CN109431821A (zh) * | 2018-12-26 | 2019-03-08 | 河南工程学院 | 一种含蛋白石页岩的纳米纤维面膜及其制备方法 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN109431821A (zh) * | 2018-12-26 | 2019-03-08 | 河南工程学院 | 一种含蛋白石页岩的纳米纤维面膜及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 李秀梅: "《抗衰老完全手册》", 31 January 2009 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117530880A (zh) * | 2024-01-09 | 2024-02-09 | 深圳市华新纳微科技有限公司 | 速溶型胶原蛋白肽纳米纤维美容膜及其制备方法 |
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