CN113543790A - 用于实现减脂效果的用途的a3腺苷受体配体 - Google Patents

用于实现减脂效果的用途的a3腺苷受体配体 Download PDF

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Publication number
CN113543790A
CN113543790A CN202080008167.6A CN202080008167A CN113543790A CN 113543790 A CN113543790 A CN 113543790A CN 202080008167 A CN202080008167 A CN 202080008167A CN 113543790 A CN113543790 A CN 113543790A
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CN
China
Prior art keywords
subject
a3ar
ligand
group
pharmaceutical composition
Prior art date
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Pending
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CN202080008167.6A
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English (en)
Chinese (zh)
Inventor
莫蒂·法布斯坦
因巴尔·伊扎克
希拉·柯亨
P·菲什曼
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Can Fite Biopharma Ltd
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Can Fite Biopharma Ltd
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Publication date
Application filed by Can Fite Biopharma Ltd filed Critical Can Fite Biopharma Ltd
Publication of CN113543790A publication Critical patent/CN113543790A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080008167.6A 2019-01-06 2020-01-05 用于实现减脂效果的用途的a3腺苷受体配体 Pending CN113543790A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL264112 2019-01-06
IL264112A IL264112A (en) 2019-01-06 2019-01-06 An a3 adenosine receptor ligand for use for reducing level of adipocytes
PCT/IL2020/050011 WO2020141535A1 (en) 2019-01-06 2020-01-05 An a3 adenosine receptor ligand for use for achieving a fat loss effect

Publications (1)

Publication Number Publication Date
CN113543790A true CN113543790A (zh) 2021-10-22

Family

ID=65656120

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080008167.6A Pending CN113543790A (zh) 2019-01-06 2020-01-05 用于实现减脂效果的用途的a3腺苷受体配体

Country Status (11)

Country Link
US (1) US12213990B2 (https=)
EP (1) EP3906034A1 (https=)
JP (3) JP2022517753A (https=)
KR (1) KR20210113279A (https=)
CN (1) CN113543790A (https=)
AU (1) AU2020205042B2 (https=)
BR (1) BR112021013084A2 (https=)
CA (1) CA3126002A1 (https=)
IL (2) IL264112A (https=)
MX (1) MX2021008172A (https=)
WO (1) WO2020141535A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202300014340A1 (it) * 2023-07-10 2025-01-10 Consiglio Nazionale Ricerche Trattamento di malattie associate alla disfunzione del gene ocrl.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101881441B1 (ko) * 2017-01-20 2018-07-24 서울대학교산학협력단 다중 약리단 특성에 기반한 비정상적 아디포넥틴 관련 질환 치료용 조성물
CN108367016A (zh) * 2015-11-23 2018-08-03 坎-菲特生物药物有限公司 用于治疗异位脂肪堆积的a3腺苷受体配体

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US5443836A (en) 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5688774A (en) 1993-07-13 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
DE69428536T2 (de) 1993-07-13 2002-06-06 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services A3 -adenosin -rezeptor agonisten
AU1399297A (en) 1996-01-24 1997-08-20 Sumitomo Chemical Company, Limited Dihalopropene compounds, their use as insecticides/acaricides and intermediates for their production
US6048865A (en) 1997-07-29 2000-04-11 Medco Research, Inc. N6 -substituted-adenosine-5'-uronamides as adenosine receptor modulator
AU8764398A (en) 1997-07-29 1999-02-22 Medco Research, Inc. N6-substituted-adenosine-5'-uronamides as adenosine receptor modulators
WO1999020284A1 (en) 1997-10-23 1999-04-29 Trustees Of The University Of Pennsylvania Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid a and adenosine receptor agents
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
US6946449B2 (en) 2001-07-13 2005-09-20 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
CN101410114B (zh) 2006-01-26 2012-07-04 美国政府卫生与公共服务部 A3腺苷受体别构调节剂
EP2608794A4 (en) * 2010-08-26 2014-01-22 Univ Northeastern METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING OIL CONTAINER
CN104159589A (zh) 2012-01-23 2014-11-19 坎-菲特生物药物有限公司 肝脏状况的治疗

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108367016A (zh) * 2015-11-23 2018-08-03 坎-菲特生物药物有限公司 用于治疗异位脂肪堆积的a3腺苷受体配体
KR101881441B1 (ko) * 2017-01-20 2018-07-24 서울대학교산학협력단 다중 약리단 특성에 기반한 비정상적 아디포넥틴 관련 질환 치료용 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERSILIA NIGRO等: "New insight into adiponectin role in obesity and obesity-related diseases", 《BIOMED RESEARCH INTERNATIONAL》, vol. 2014, pages 1 - 14, XP055486972, DOI: 10.1155/2014/658913 *
NEDA RASOULI等: "Ectopic fat accumulation and metabolic syndrome", 《DIABETES, OBESITY AND METABOLISM》, vol. 9, pages 1 - 10, XP055682029, DOI: 10.1111/j.1463-1326.2006.00590.x *

Also Published As

Publication number Publication date
IL264112A (en) 2020-07-30
WO2020141535A1 (en) 2020-07-09
JP2023100928A (ja) 2023-07-19
IL284463B1 (en) 2026-04-01
IL284463A (en) 2021-08-31
JP2022517753A (ja) 2022-03-10
KR20210113279A (ko) 2021-09-15
CA3126002A1 (en) 2020-07-09
EP3906034A1 (en) 2021-11-10
JP2025098147A (ja) 2025-07-01
MX2021008172A (es) 2021-08-11
AU2020205042A1 (en) 2021-07-15
US20220079968A1 (en) 2022-03-17
AU2020205042B2 (en) 2024-10-10
US12213990B2 (en) 2025-02-04
BR112021013084A2 (pt) 2021-09-21

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