CN113543775B - 药物组合物 - Google Patents

药物组合物 Download PDF

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Publication number
CN113543775B
CN113543775B CN202080017968.9A CN202080017968A CN113543775B CN 113543775 B CN113543775 B CN 113543775B CN 202080017968 A CN202080017968 A CN 202080017968A CN 113543775 B CN113543775 B CN 113543775B
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China
Prior art keywords
composition
copolymer
formulation
branched
formula
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CN202080017968.9A
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English (en)
Chinese (zh)
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CN113543775A (zh
Inventor
C·罗贝热
A·略佩斯·诺列加
J·M·克罗
J·塞兰杜
M·奥斯特
刘芳
C·莫利尼耶
S·格里佐
T·弗尔利尼奇
F·吴
E·格甘
M-E·卡尼翁
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Matheson Ag
MEI DISEN
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Matheson Ag
MEI DISEN
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Publication of CN113543775A publication Critical patent/CN113543775A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080017968.9A 2019-01-08 2020-01-08 药物组合物 Active CN113543775B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1900258.3A GB201900258D0 (en) 2019-01-08 2019-01-08 Pharmaceutical composition
GB1900258.3 2019-01-08
PCT/EP2020/050333 WO2020144239A1 (en) 2019-01-08 2020-01-08 Pharmaceutical composition

Publications (2)

Publication Number Publication Date
CN113543775A CN113543775A (zh) 2021-10-22
CN113543775B true CN113543775B (zh) 2023-11-24

Family

ID=65528088

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080017968.9A Active CN113543775B (zh) 2019-01-08 2020-01-08 药物组合物

Country Status (25)

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US (3) US12485139B2 (enExample)
EP (2) EP4289429A3 (enExample)
JP (2) JP7680355B2 (enExample)
KR (1) KR102958459B1 (enExample)
CN (1) CN113543775B (enExample)
AU (1) AU2020205438B8 (enExample)
BR (1) BR112021013456A2 (enExample)
CA (1) CA3125372A1 (enExample)
DK (1) DK3908321T3 (enExample)
EA (1) EA202191603A1 (enExample)
ES (1) ES2968432T3 (enExample)
FI (1) FI3908321T3 (enExample)
GB (1) GB201900258D0 (enExample)
HR (1) HRP20231667T1 (enExample)
HU (1) HUE064916T2 (enExample)
LT (1) LT3908321T (enExample)
MX (1) MX2021008248A (enExample)
PH (1) PH12021551642A1 (enExample)
PL (1) PL3908321T3 (enExample)
PT (1) PT3908321T (enExample)
RS (1) RS65067B1 (enExample)
SI (1) SI3908321T1 (enExample)
SM (1) SMT202400011T1 (enExample)
WO (1) WO2020144239A1 (enExample)
ZA (1) ZA202104704B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022069799A1 (en) * 2020-10-01 2022-04-07 Turku University of Applied Sciences Ltd A hydrogel material
US20250009647A1 (en) 2021-08-05 2025-01-09 Medincell S.A. Pharmaceutical composition
WO2025104289A1 (en) 2023-11-17 2025-05-22 Medincell S.A. Antineoplastic combinations
WO2026013080A1 (en) 2024-07-08 2026-01-15 InnoCore Technologies Holding B.V. Pharmaceutical composition based on biodegradable polymers comprising polyoxazoline

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1413118A (zh) * 1999-12-22 2003-04-23 株式会社三养社 药物传递系统的生物可降解嵌段共聚物的液体组合物及其制备方法
CN1671362A (zh) * 2002-06-28 2005-09-21 麦克罗米德公司 用于药物递送的生物可降解嵌段共聚组合物
WO2008066787A2 (en) * 2006-11-27 2008-06-05 E. I. Du Pont De Nemours And Company Multi-functional polyalkylene oxides, hydrogels and tissue adhesives
CN102432852A (zh) * 2011-08-25 2012-05-02 复旦大学 一种聚乳酸基立构复合交联共聚物及其制备方法
CN103491946A (zh) * 2010-12-29 2014-01-01 美蒂森 可生物降解的药物释放组合物
CN104582733A (zh) * 2012-06-27 2015-04-29 美蒂森 用于疏水性组合物的可生物降解的药物释放系统
WO2017085561A1 (en) * 2015-11-16 2017-05-26 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
CN108586775A (zh) * 2018-05-04 2018-09-28 四川大学 可用于眼内长期填充的原位交联超支化聚醚类水凝胶及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2016A (en) 1841-03-26 Mode of constructing fireplaces and chimney-staoks ii
US5225521A (en) 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
FR2741628B1 (fr) 1995-11-29 1998-02-06 Centre Nat Rech Scient Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US7265186B2 (en) 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
ES2358416T3 (es) 2001-10-30 2011-05-10 Novartis Ag Formulaciones de liberación prolongada de iloperidona y polímero en forma de estrella.
US20050255091A1 (en) 2004-05-14 2005-11-17 Loomis Gary L Hydrogels for biomedical applications
US9248165B2 (en) * 2008-11-05 2016-02-02 Hancock-Jaffe Laboratories, Inc. Composite containing collagen and elastin as a dermal expander and tissue filler
US20110070320A1 (en) 2009-09-23 2011-03-24 Soonkap Hahn Biodegradable thermoresponsive 3-arm polyethylene glycol poly(lactide-co-glycolide) copolymer for ginseng administration
WO2014165923A1 (en) 2013-04-11 2014-10-16 Commonwealth Scientific And Industrial Research Organisation Composition for controlled delivery of bioactive agents
CA3174824A1 (en) * 2014-04-21 2015-10-29 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
CN103976976B (zh) 2014-06-03 2016-05-11 长春理工大学 一种包载重组人生长激素缓释药物微囊的制法
CN106543454B (zh) 2016-11-25 2019-05-28 山东师范大学 一种低溶胀可生物降解医用光聚合型水凝胶及其制备方法
CN106832844B (zh) 2017-02-10 2018-11-20 四川大学 一种四臂peg-pcl、氧化石墨烯复合材料及其制备方法
ES3015765T3 (en) 2017-07-17 2025-05-07 Medincell S A Pharmaceutical composition

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1413118A (zh) * 1999-12-22 2003-04-23 株式会社三养社 药物传递系统的生物可降解嵌段共聚物的液体组合物及其制备方法
CN1671362A (zh) * 2002-06-28 2005-09-21 麦克罗米德公司 用于药物递送的生物可降解嵌段共聚组合物
WO2008066787A2 (en) * 2006-11-27 2008-06-05 E. I. Du Pont De Nemours And Company Multi-functional polyalkylene oxides, hydrogels and tissue adhesives
CN101541857A (zh) * 2006-11-27 2009-09-23 纳幕尔杜邦公司 多官能聚环氧烷、水凝胶和组织粘合剂
CN103491946A (zh) * 2010-12-29 2014-01-01 美蒂森 可生物降解的药物释放组合物
CN102432852A (zh) * 2011-08-25 2012-05-02 复旦大学 一种聚乳酸基立构复合交联共聚物及其制备方法
CN104582733A (zh) * 2012-06-27 2015-04-29 美蒂森 用于疏水性组合物的可生物降解的药物释放系统
WO2017085561A1 (en) * 2015-11-16 2017-05-26 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
CN108586775A (zh) * 2018-05-04 2018-09-28 四川大学 可用于眼内长期填充的原位交联超支化聚醚类水凝胶及其制备方法

Also Published As

Publication number Publication date
GB201900258D0 (en) 2019-02-27
MX2021008248A (es) 2021-10-13
BR112021013456A2 (pt) 2021-09-14
CN113543775A (zh) 2021-10-22
EA202191603A1 (ru) 2021-10-20
ES2968432T3 (es) 2024-05-09
EP4289429A2 (en) 2023-12-13
FI3908321T3 (fi) 2024-01-11
EP3908321A1 (en) 2021-11-17
KR20210113251A (ko) 2021-09-15
SI3908321T1 (sl) 2024-03-29
PT3908321T (pt) 2024-01-15
JP7680355B2 (ja) 2025-05-20
HRP20231667T1 (hr) 2024-03-15
RS65067B1 (sr) 2024-02-29
EP4289429A3 (en) 2024-03-20
SMT202400011T1 (it) 2024-03-13
AU2020205438A1 (en) 2021-07-29
US20260115226A1 (en) 2026-04-30
AU2020205438B9 (en) 2025-03-27
KR102958459B1 (ko) 2026-04-29
ZA202104704B (en) 2024-11-27
DK3908321T3 (da) 2024-01-15
EP3908321B1 (en) 2023-11-15
PL3908321T3 (pl) 2024-03-25
AU2020205438B8 (en) 2025-03-27
AU2020205438B2 (en) 2025-02-06
WO2020144239A1 (en) 2020-07-16
US12485139B2 (en) 2025-12-02
US12427165B2 (en) 2025-09-30
HUE064916T2 (hu) 2024-04-28
LT3908321T (lt) 2024-01-25
US20240293444A1 (en) 2024-09-05
US20220118003A1 (en) 2022-04-21
CA3125372A1 (en) 2020-07-16
PH12021551642A1 (en) 2022-05-23
JP2025066716A (ja) 2025-04-23
JP2022517939A (ja) 2022-03-11

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