CN113499365A - Gynecological gel - Google Patents

Gynecological gel Download PDF

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Publication number
CN113499365A
CN113499365A CN202110873776.4A CN202110873776A CN113499365A CN 113499365 A CN113499365 A CN 113499365A CN 202110873776 A CN202110873776 A CN 202110873776A CN 113499365 A CN113499365 A CN 113499365A
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China
Prior art keywords
extract
gel
mixture
nursing
deionized water
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CN202110873776.4A
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Chinese (zh)
Inventor
潘元明
李俊
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Beijing Qingdaier Biotechnology Co ltd
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Beijing Qingdaier Biotechnology Co ltd
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Priority to CN202110873776.4A priority Critical patent/CN113499365A/en
Publication of CN113499365A publication Critical patent/CN113499365A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Insects & Arthropods (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A gynecological gel comprises the following raw materials: natural plant antibacterial agent, nursing and nourishing component, gel, pH regulator, vaginal prebiotics and deionized water; the natural plant antibacterial agent is as follows: a mixture of caulis Spatholobi extract, flos Lonicerae extract, cortex Mori extract and ootheca Mantidis extract; the nursing and nourishing components are as follows: a mixture of calcined Os Draconis extract and stachydrine hydrochloride; the gel agent is: a mixture of triethanolamine and carbomer-940; the pH regulator is: vitamin C; the vaginal prebiotics are: inulin. The antibacterial gel for gynecological reproduction anti-inflammation maintenance has good antibacterial property and biocompatibility, and has multiple effects of diminishing inflammation, relieving itching, removing odor and repairing.

Description

Gynecological gel
Technical Field
The invention relates to the technical field of human nursing, in particular to gynecological gel.
Background
With the improvement of living standard, people pay more and more attention to physical health, wherein female privacy care becomes an important part of personal care. According to survey results, up to 91 percent of women suffer from private discomfort such as unclean secretion, stuffy and itchy secretion, peculiar smell and the like, particularly, the discomfort easily occurs before and after the days of fever, menstrual period, long sitting and intimacy in offices, and the women should pay attention to private cleaning and protection in daily life.
The health of the vaginal microenvironment is a complex microecological system, once the microecological balance of the vagina is maintained to be destroyed, the dysbacteriosis in the vagina can be caused, various diseases can be caused, the growth speed of harmful bacteria is controlled by only depending on sterilization and bacteriostasis, which is far from insufficient, and the bacterial colony balance of the vagina needs to be reestablished.
As an inorganic spectrum efficient sterilization material, the nano-silver has no stimulation to human skin, and is widely used for preparing female private gel, for example, Chinese patent with application number of CN200810016256.6 discloses a chitosan nano-silver gel and application thereof, and chitosan nano-silver is used as an antibacterial product.
However, the nano silver particles are easy to agglomerate and not easy to disperse, and have strong permeability, so that the nano silver particles can easily enter cells of various organs of a human body and can damage cell organisms to a certain extent, and therefore, the use of the nano silver particles is limited to a certain extent.
Disclosure of Invention
Objects of the invention
In order to solve the technical problems in the background art, the invention provides the gynecological gel, which is an antibacterial gel for gynecological reproduction anti-inflammation maintenance, has good antibacterial property and biocompatibility, and has multiple effects of diminishing inflammation, relieving itching, removing odor and repairing.
(II) technical scheme
In order to solve the problems, the invention provides a gynecological gel which comprises the following raw materials: natural plant antibacterial agent, nursing and nourishing component, gel, pH regulator, vaginal prebiotics and deionized water;
the natural plant antibacterial agent is as follows: a mixture of caulis Spatholobi extract, flos Lonicerae extract, cortex Mori extract and ootheca Mantidis extract;
the nursing and nourishing components are as follows: a mixture of calcined Os Draconis extract and stachydrine hydrochloride;
the gel agent is: a mixture of triethanolamine and carbomer-940;
the microenvironment pH regulator in the vagina is as follows: vitamin C;
the vaginal prebiotics are: inulin.
Preferably, the raw materials comprise the following components in percentage by mass:
5% -20% of natural plant antibacterial agent;
5% -20% of nursing and nourishing components;
20% -40% of gelling agent;
5% -10% of microenvironment pH regulator in vagina;
1% -5% of vaginal prebiotics;
the balance being deionized water.
Preferably, the method comprises the following preparation steps:
s1: mixing the following raw materials: 2g of caulis spatholobi extract, 2g of ootheca mantidis extract, 2g of calcined dragon bone extract, 2g of stachydrine hydrochloride, 2g of inulin, 3g of vitamin C, 15mL of honeysuckle extract, 15mL of cortex mori extract, 3.5mL of triethanolamine and 3g of carbomer-940, mixing in deionized water, and stirring until completely dissolved;
s2: deionized water was added to a volume of 200 mL.
The antibacterial gel for gynecological reproduction anti-inflammation maintenance has good antibacterial property and biocompatibility, and has multiple effects of diminishing inflammation, relieving itching, removing odor and repairing.
The invention combines the traditional Chinese medicine culture with long history and the modern western medicine theory, selects a plurality of natural plant medicines with the effects of bacteriostasis, inflammation diminishing and itching relieving as raw materials, extracts the effective components thereof to prepare the grass solution and the plant essence extraction process, can effectively kill the pathogenic bacteria at private parts, thereby achieving the effects of sterilization, itching relieving, odor removing, pathogenic bacteria infection prevention and vaginal epithelium repair, and having no irritation, convenient use, cleanness, comfort and naturalness. The formula of the invention has the advantages of effective anti-inflammation, moistening and maintenance, no synthetic surfactant, no artificial essence, safe and effective formula and the like, and particularly can be directly introduced in use without the traditional washing or irrigating mode, thereby being convenient and quick.
According to the vagina balance treatment method, the vagina balance treatment method is prepared by adopting a plurality of natural plant extracts, has no drug resistance, does not influence beneficial flora such as vaginal lactobacillus, and the like, can effectively maintain normal micro-ecological environment in the vagina, effectively relieve common gynecological inflammation such as trichomonas vaginitis, mycotic vaginitis, chronic cervicitis and the like, and reduce female reproductive system infection; in addition, the invention can nourish yin and blood, and relieve the symptoms of vaginal dryness, sexual intercourse pain, low libido and the like caused by the reduction of ovarian function of women. Mild medicinal effect, obvious curative effect and no toxic or side effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
The invention provides a gynecological gel which comprises the following raw materials: natural plant antibacterial agent, nursing and nourishing component, gel, microenvironment pH regulator in vagina, vagina prebiotics and deionized water;
the natural plant antibacterial agent is as follows: a mixture of caulis Spatholobi extract, flos Lonicerae extract, cortex Mori extract and ootheca Mantidis extract;
the nursing and nourishing components are as follows: a mixture of calcined Os Draconis extract and stachydrine hydrochloride;
the gel agent is: a mixture of triethanolamine and carbomer-940;
the pH regulator is: vitamin C;
the vaginal prebiotics are: inulin.
The antibacterial gel for gynecological reproduction anti-inflammation maintenance has good antibacterial property and biocompatibility, and has multiple effects of diminishing inflammation, relieving itching, removing odor and repairing.
Example 1:
the gynecological gel comprises the following raw materials in percentage by mass:
5% -20% of natural plant antibacterial agent;
5% -20% of nursing and nourishing components;
20% -40% of gelling agent;
5% -10% of microenvironment pH regulator in vagina;
1% -5% of vaginal prebiotics;
the balance being deionized water.
Example 2:
a gynecological gel comprises the following preparation steps:
s1: mixing the following raw materials: 2g of caulis spatholobi extract, 2g of ootheca mantidis extract, 2g of calcined dragon bone extract, 2g of stachydrine hydrochloride, 2g of inulin, 3g of vitamin C, 15mL of honeysuckle extract, 15mL of cortex mori extract, 3.5mL of triethanolamine and 3g of carbomer-940, mixing in deionized water, and stirring until completely dissolved;
s2: deionized water was added to a volume of 200 mL.
In conclusion, the invention combines the traditional Chinese medicine culture with long history and the modern western medicine theory, selects a plurality of natural plant medicines with the effects of bacteriostasis, inflammation diminishing and itching relieving as raw materials, extracts the effective components thereof to prepare the herbal liquid and the plant essence extraction process, can effectively kill the pathogenic bacteria at private parts, thereby achieving the effects of sterilizing, relieving itching, removing odor, effectively preventing the pathogenic bacteria infection and repairing the vaginal epithelium, and has no irritation, convenient use, cleanness, comfort and naturalness. The formula of the invention has the advantages of effective anti-inflammation, moistening and maintenance, no synthetic surfactant, no artificial essence, safe and effective formula and the like, and particularly can be directly introduced in use without the traditional washing or irrigating mode, thereby being convenient and quick.
According to the vagina balance treatment method, the vagina balance treatment method is prepared by adopting a plurality of natural plant extracts, has no drug resistance, does not influence beneficial flora such as vaginal lactobacillus, and the like, can effectively maintain normal micro-ecological environment in the vagina, effectively relieve common gynecological inflammation such as trichomonas vaginitis, mycotic vaginitis, chronic cervicitis and the like, and reduce female reproductive system infection; in addition, the invention can nourish yin and blood, and relieve the symptoms of vaginal dryness, sexual intercourse pain, low libido and the like caused by the reduction of ovarian function of women. Mild medicinal effect, obvious curative effect and no toxic or side effect.
Example 1:
for a 45-year-old female, the medicine is used for 2 weeks, and can improve vaginal itching and peculiar smell.
Example 2:
a42 year old female has dry and astringent vagina, is used for 2 weeks, and has fresh and moist lower body.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.

Claims (3)

1. The gynecological gel is characterized by comprising the following raw materials: natural plant antibacterial agent, nursing and nourishing component, gel, pH regulator, vaginal prebiotics and deionized water;
the natural plant antibacterial agent is as follows: a mixture of caulis Spatholobi extract, flos Lonicerae extract, cortex Mori extract and ootheca Mantidis extract;
the nursing and nourishing components are as follows: a mixture of calcined Os Draconis extract and stachydrine hydrochloride;
the gel agent is: a mixture of triethanolamine and carbomer-940;
intravaginal pH microenvironment modulators: vitamin C;
prebiotics to improve intravaginal lactobacilli: inulin.
2. The gynecological gel according to claim 1, characterized in that the raw materials comprise the following by mass volume percent:
5% -20% of natural plant antibacterial agent;
5% -20% of nursing and nourishing components;
20% -40% of gelling agent;
5% -10% of microenvironment pH regulator in vagina;
1% -5% of vaginal prebiotics;
the balance being deionized water.
3. The gynecological gel according to claim 1, characterized by comprising the following preparation steps:
s1: mixing the following raw materials: 2g of caulis spatholobi extract, 2g of ootheca mantidis extract, 2g of calcined dragon bone extract, 2g of stachydrine hydrochloride, 2g of inulin, 3g of vitamin C, 15mL of honeysuckle extract, 15mL of cortex mori extract, 3.5mL of triethanolamine and 3g of carbomer-940, mixing in deionized water, and stirring until completely dissolved;
s2: deionized water was added to a volume of 200 mL.
CN202110873776.4A 2021-07-30 2021-07-30 Gynecological gel Pending CN113499365A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110873776.4A CN113499365A (en) 2021-07-30 2021-07-30 Gynecological gel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110873776.4A CN113499365A (en) 2021-07-30 2021-07-30 Gynecological gel

Publications (1)

Publication Number Publication Date
CN113499365A true CN113499365A (en) 2021-10-15

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ID=78014697

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110873776.4A Pending CN113499365A (en) 2021-07-30 2021-07-30 Gynecological gel

Country Status (1)

Country Link
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110101655A (en) * 2019-05-31 2019-08-09 杨平芝 A kind of composition repaired uterine neck and prevent bacterial vaginitis
CN111481498A (en) * 2020-05-20 2020-08-04 西安贝迪斯可生物科技有限公司 Antibacterial gel for regulating microecological balance of female vagina and preparation method thereof
CN112675257A (en) * 2020-12-24 2021-04-20 许仲田 Gel for regulating female vaginal flora and preparation method and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110101655A (en) * 2019-05-31 2019-08-09 杨平芝 A kind of composition repaired uterine neck and prevent bacterial vaginitis
CN111481498A (en) * 2020-05-20 2020-08-04 西安贝迪斯可生物科技有限公司 Antibacterial gel for regulating microecological balance of female vagina and preparation method thereof
CN112675257A (en) * 2020-12-24 2021-04-20 许仲田 Gel for regulating female vaginal flora and preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
肖冰冰等: "蔗糖凝胶治疗细菌性阴道病Ⅱ期临床试验研究", 《北京大学学报(医学版)》 *

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