CN113493790A - 具有免疫调节功能的CpG ODN及其应用 - Google Patents

具有免疫调节功能的CpG ODN及其应用 Download PDF

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Publication number
CN113493790A
CN113493790A CN202010253089.8A CN202010253089A CN113493790A CN 113493790 A CN113493790 A CN 113493790A CN 202010253089 A CN202010253089 A CN 202010253089A CN 113493790 A CN113493790 A CN 113493790A
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cpg odn
cells
cpg
vaccine
immunomodulatory
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CN202010253089.8A
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Chinese (zh)
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王立公
邵彦
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Nanjing Huapu Biotechnology Co ltd
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Nanjing Huapu Biotechnology Co ltd
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Priority to CN202010253089.8A priority Critical patent/CN113493790A/zh
Priority to PCT/CN2021/084467 priority patent/WO2021197381A1/zh
Priority to US17/915,805 priority patent/US12600973B2/en
Priority to CN202180019364.2A priority patent/CN115413298A/zh
Priority to JP2022559536A priority patent/JP7777874B2/ja
Priority to EP21778756.3A priority patent/EP4130268A4/en
Publication of CN113493790A publication Critical patent/CN113493790A/zh
Pending legal-status Critical Current

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN202010253089.8A 2020-04-01 2020-04-01 具有免疫调节功能的CpG ODN及其应用 Pending CN113493790A (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN202010253089.8A CN113493790A (zh) 2020-04-01 2020-04-01 具有免疫调节功能的CpG ODN及其应用
PCT/CN2021/084467 WO2021197381A1 (zh) 2020-04-01 2021-03-31 具有免疫调节功能的CpG ODN及其应用
US17/915,805 US12600973B2 (en) 2020-04-01 2021-03-31 CpG ODN having immunoregulatory function and use thereof
CN202180019364.2A CN115413298A (zh) 2020-04-01 2021-03-31 具有免疫调节功能的CpG ODN及其应用
JP2022559536A JP7777874B2 (ja) 2020-04-01 2021-03-31 免疫調節機能を有するＣｐＧ ＯＤＮ及びその使用
EP21778756.3A EP4130268A4 (en) 2020-04-01 2021-03-31 ODN CPG WITH IMMUNOREGULATORY FUNCTION AND CORRESPONDING USE

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Application Number Priority Date Filing Date Title
CN202010253089.8A CN113493790A (zh) 2020-04-01 2020-04-01 具有免疫调节功能的CpG ODN及其应用

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CN113493790A true CN113493790A (zh) 2021-10-12

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CN202010253089.8A Pending CN113493790A (zh) 2020-04-01 2020-04-01 具有免疫调节功能的CpG ODN及其应用
CN202180019364.2A Pending CN115413298A (zh) 2020-04-01 2021-03-31 具有免疫调节功能的CpG ODN及其应用

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US (1) US12600973B2 (https=)
EP (1) EP4130268A4 (https=)
JP (1) JP7777874B2 (https=)
CN (2) CN113493790A (https=)
WO (1) WO2021197381A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113797329A (zh) * 2021-10-19 2021-12-17 启锰生物科技(江苏)有限公司 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法
WO2024152998A1 (zh) * 2023-01-19 2024-07-25 华普生物技术(河北)股份有限公司 CpG佐剂在制备新型冠状病毒疫苗中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252772A (zh) * 2021-04-30 2022-11-01 华普生物技术(江苏)股份有限公司 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用
CN116064548B (zh) * 2022-12-01 2023-07-28 北京吉诺卫生物科技有限公司 一种新型CpG疫苗佐剂及其应用

Family Cites Families (9)

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CN1271733A (zh) * 2000-04-04 2000-11-01 中国预防医学科学院病毒学研究所 对人免疫细胞有特异免疫刺激活性的CpG寡核酸
WO2004005476A2 (en) * 2002-07-03 2004-01-15 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7491706B2 (en) * 2003-07-25 2009-02-17 Changchun Huapu Biotechnology Co., Ltd. Artificial cpg single-stranded oligodeoxynucleotide and antiviral use thereof
CA2549173A1 (en) * 2003-12-08 2005-07-07 Hybridon, Inc. Modulation of immunostimulatory properties by small oligonucleotide-based compounds
CN101492672B (zh) 2008-01-23 2011-01-26 许洪林 具有免疫刺激活性的硫代寡聚脱氧核苷酸及其应用
PL3096786T3 (pl) * 2014-01-21 2021-11-08 Pfizer Inc. Polisacharydy otoczkowe streptococcus pneumoniae i ich koniugaty
CN105214083A (zh) * 2014-06-26 2016-01-06 长春华普生物技术有限公司 含有CpG寡核苷酸的药物组合物
CR20200260A (es) * 2017-12-15 2020-08-01 Bayer Animal Health Gmbh Composiciones inmunoestimulantes
JP7048102B2 (ja) * 2019-05-23 2022-04-05 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113797329A (zh) * 2021-10-19 2021-12-17 启锰生物科技(江苏)有限公司 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法
WO2024152998A1 (zh) * 2023-01-19 2024-07-25 华普生物技术(河北)股份有限公司 CpG佐剂在制备新型冠状病毒疫苗中的应用

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Publication number Publication date
JP2023519413A (ja) 2023-05-10
WO2021197381A1 (zh) 2021-10-07
US20230159936A1 (en) 2023-05-25
EP4130268A1 (en) 2023-02-08
CN115413298A (zh) 2022-11-29
EP4130268A4 (en) 2024-10-02
JP7777874B2 (ja) 2025-12-01
US12600973B2 (en) 2026-04-14

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