CN113484121A - Separation and purification device and separation and purification method based on dynamic magnetic field - Google Patents
Separation and purification device and separation and purification method based on dynamic magnetic field Download PDFInfo
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- CN113484121A CN113484121A CN202110717401.9A CN202110717401A CN113484121A CN 113484121 A CN113484121 A CN 113484121A CN 202110717401 A CN202110717401 A CN 202110717401A CN 113484121 A CN113484121 A CN 113484121A
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- 238000000926 separation method Methods 0.000 title claims abstract description 57
- 238000000746 purification Methods 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000007246 mechanism Effects 0.000 claims abstract description 76
- 239000000126 substance Substances 0.000 claims abstract description 6
- 230000005540 biological transmission Effects 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 5
- 239000000523 sample Substances 0.000 description 62
- 238000007885 magnetic separation Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 7
- 230000033001 locomotion Effects 0.000 description 6
- 239000000696 magnetic material Substances 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 239000011324 bead Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
Abstract
The invention relates to a separation and purification device and a separation and purification method based on a dynamic magnetic field, wherein the separation and purification device comprises a magnet mechanism, a magnet moving mechanism, a base, a sample cell and a sample frame, the sample cell is fixed on the sample frame, the magnet mechanism is arranged at a position corresponding to the sample cell, the magnet mechanism is arranged on the magnet moving mechanism, the magnet moving mechanism is arranged on the base, and the magnet moving mechanism drives the magnet mechanism to move near the sample cell to generate the dynamic magnetic field so as to accelerate the separation and purification of substances in the sample cell. Compared with the prior art, the method has the advantages of high efficiency, high product purity, strong practicability and the like.
Description
Technical Field
The invention relates to the technical field of separation and purification, in particular to a separation and purification device and a separation and purification method based on a dynamic magnetic field.
Background
The traditional separation and purification methods, such as salting-out, ion exchange chromatography, gel chromatography and the like, have complex processes, and take several hours or days for purification. The magnetic separation and purification technology has the advantages of rapidness, simplicity and convenience, and is widely applied to the fields of magnetic ore separation, sewage treatment, biological sample separation (including protein, DNA and the like), magnetic material collection and the like.
The existing magnetic separation and purification devices comprise two modes: internal magnetic type and external magnetic type. The inner magnetic type is characterized in that a magnet coated with a protective sleeve is immersed into the liquid to be treated, and magnetic beads are adsorbed on the protective sleeve, so that a target object is separated; and the magnet is arranged on the outer wall of the liquid container to be treated in an external magnetic mode, and the magnetic beads are adsorbed to the position, close to the magnet, of the inner wall of the container. The internal magnetic type is great relatively to magnetic material effort, and separation efficiency is higher, nevertheless compares the external magnetic type, need elute the magnetic bead that adsorbs on the protective sheath in order to obtain the target object, and the flow is more complicated, and because electrostatic adsorption, the protective sheath can smuggle some impurity secretly when absorbing magnetic substance, influences the purity of product. The product obtained by the external magnetic type is purer than that obtained by the internal magnetic type, but has the defects of incomplete separation and low efficiency.
Most of the magnetic separation and purification methods use a static gradient magnetic field, which is convenient to operate, but generally only in the region close to the magnet, the magnetic field strength and gradient are high, while the magnetic field strength and gradient in other regions are low, so that the separation efficiency and effect are limited. In the aspect of dynamic magnetic field, chinese CN111621416A discloses a biomagnetic separation method based on a moving magnetic net, which can realize rapid capture and release of magnetic materials and improve separation effect by using a superparamagnetic magnetic net to rotate in a liquid to be treated, but in the method, the rotation of the magnetic net can capture not only magnetic targets, but also nonmagnetic substances can be captured by the magnetic net due to electrostatic adsorption, thereby reducing the purity of the product.
In summary, the existing magnetic separation and purification methods have the disadvantages of low yield, low efficiency, unsatisfactory purity, etc., and a magnetic separation and purification method for rapidly obtaining a sample with high yield and high purity is still lacking at present.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a separation and purification device and a separation and purification method based on a dynamic magnetic field, which have high efficiency, high product purity and strong practicability.
The purpose of the invention can be realized by the following technical scheme:
a separation and purification device based on a dynamic magnetic field comprises a magnet mechanism, a magnet moving mechanism, a base, a sample cell and a sample frame; the sample cell is fixed on the sample frame; the magnet mechanism is arranged at a position corresponding to the sample cell; the magnet mechanism is arranged on the magnet moving mechanism; the magnet moving mechanism is arranged on the base; the magnet moving mechanism drives the magnet mechanism to move near the sample cell to generate a dynamic magnetic field, so that the separation and purification of substances in the sample cell are accelerated.
Preferably, the magnet mechanism comprises a magnet fixing block and a magnet; the magnet is fixed in the magnet fixing block; the magnet fixing block is connected with the magnet moving mechanism.
More preferably, the magnet is a permanent magnet or an electromagnet.
More preferably, the magnet moving mechanism is a rotary magnet moving mechanism.
More preferably, the rotary magnet moving mechanism comprises a rotating shaft and a motor; the motor is arranged on the base; one end of the rotating shaft is connected with an output shaft of the motor, and the other end of the rotating shaft is connected with the magnet fixing block.
More preferably, the rotary magnet moving mechanism comprises a rotating shaft, a motor, a transmission belt and a transmission wheel; one end of the rotating shaft is connected with an output shaft of the motor, and the other end of the rotating shaft is connected with the driving wheel; one end of the transmission belt is sleeved on the transmission wheel, and the other end of the transmission belt is sleeved on the magnet fixing block.
More preferably, the rotary magnet moving mechanism further comprises a bearing; the bearing is arranged on the base; the magnetic block fixing block is arranged in the bearing.
More preferably, the magnet moving mechanism is a reciprocating magnet moving mechanism.
More preferably, the reciprocating magnet moving mechanism comprises a motor, a screw rod and a screw rod base; the screw rod base is arranged on the base; the motor and the screw rod are respectively arranged on the screw rod base; the screw rod is connected with an output shaft of the motor; the magnetic body fixing block is arranged on the screw rod base and is connected with the screw rod base in a sliding manner; the magnetic block fixing block is connected with the screw rod, and threads matched with the screw rod are arranged in the magnetic block fixing block; the motor drives the screw rod to rotate, and drives the magnetic block fixing block to reciprocate along the screw rod, so that the reciprocating motion of the magnet is realized.
A separation and purification method for the separation and purification device of any one of the above, the separation and purification method comprising:
step 1: filling a sample into the sample cell;
step 2: starting a motor, and executing the step 3 after the adhesion amount of the material of the side wall of the sample cell is stable and unchanged;
and step 3: separating the liquid out of the sample pool to realize the separation and purification of the sample;
and 4, step 4: the motor is turned off.
Compared with the prior art, the invention has the following beneficial effects:
firstly, the separation and purification efficiency is high: the separation and purification device adopts a dynamic magnetic field, increases the area and probability of a strong magnetic field region (namely the vicinity of a magnet) acting on a sample by the movement of the magnet around the sample pool, accelerates the response of the sample in different regions of the sample pool to the magnetic field, accelerates the liquid flow in a solution by the movement of the magnetic material in the sample pool along with the movement of the magnet, accelerates the action of the sample and the strong magnetic field region, and improves the magnetic separation speed; meanwhile, due to the adoption of the dynamic magnetic field, the effects of samples in all regions in the sample pool and a strong magnetic field region are enhanced, so that the magnetic separation yield is improved, and the separation and purification efficiency is effectively improved.
Secondly, the product purity is high: the separation and purification device adopts an external dynamic magnetic field magnetic separation method, so that the purity of the product is effectively improved.
Thirdly, the practicability is strong: the separation and purification device is simple, light, low in cost, convenient to move, strong in universality and strong in practicability.
Drawings
FIG. 1 is a schematic structural diagram of a first example of a separation and purification apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a first example of a sample cell and a sample holder according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of a second example of a sample cell and a sample holder according to an embodiment of the present invention;
fig. 4 is a perspective structural view of a first example of a magnet moving mechanism in the embodiment of the present invention;
fig. 5 is an isometric view of a first example of a magnet moving mechanism in an embodiment of the invention;
fig. 6 is a perspective structural view of a second example of a magnet moving mechanism in the embodiment of the present invention;
fig. 7 is an isometric view of a second example of a magnet moving mechanism in an embodiment of the invention;
fig. 8 is a perspective structural view of a third example of the magnet moving mechanism in the embodiment of the present invention;
fig. 9 is an isometric view of a third example of a magnet moving mechanism in an embodiment of the invention;
FIG. 10 is a schematic structural view of a second example of the separation and purification apparatus in the embodiment of the present invention;
fig. 11 is a schematic structural diagram of a third example of the separation and purification apparatus in the embodiment of the present invention.
The reference numbers in the figures indicate:
1. the device comprises a magnet mechanism 2, a magnet moving mechanism 3, a base 4, a sample cell 5, a sample frame 6, a water outlet 7, a plug 8, a bearing 9, a magnet fixing block 10, a magnet 11, a rotating shaft 12, a motor 13, a transmission belt 14, a transmission wheel 15, a screw rod 16 and a screw rod base.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, shall fall within the scope of protection of the present invention.
The embodiment relates to a separation and purification device based on a dynamic magnetic field, which comprises a magnet mechanism 1, a magnet moving mechanism 2, a base 3, a sample cell 4 and a sample frame 5, wherein the sample cell 4 is fixed on the sample frame 5, the magnet mechanism 1 is arranged at a position corresponding to the sample cell 4, the magnet mechanism 1 is arranged on the magnet moving mechanism 2, the magnet moving mechanism 2 is arranged on the base 3, the magnet moving mechanism 2 drives the magnet mechanism 1 to move near the sample cell 4 to generate the dynamic magnetic field, and the separation and purification of substances in the sample cell 4 are accelerated.
The magnet mechanism 1 comprises a magnet fixing block 9 and a magnet 10, the magnet 10 is fixed in the magnet fixing block 9, the magnet fixing block 9 is connected with the magnet moving mechanism 2, and the magnet 10 is an electromagnet or a permanent magnet.
The sample cell 4 is a conventional centrifuge tube or a characteristic sample cell, as shown in fig. 2 and fig. 3, respectively, fig. 2 is a diagram of a sample holder and a sample cell placement method for a common centrifuge tube design in a laboratory, and fig. 3 is a diagram of a square sample cell with a water outlet and a support thereof. Different specifications can be selected for the centrifuging tube sample cell, and the sample frame that matches with conventional centrifuging tube leaves the breach in both ends, makes magnet mechanism 1 can produce stronger magnetic force to the sample in sample cell 4. The square sample cell is flat, so that the distance between the sample in the sample cell and the magnet set can be reduced, and the magnetic separation speed is accelerated.
The magnet moving mechanism 2 in the present embodiment is a rotary magnet moving mechanism or a reciprocating magnet moving mechanism.
The perspective structure of the first example of the magnet moving mechanism is shown in fig. 4, and the perspective view is shown in fig. 5, and the magnet moving mechanism comprises a bearing 8, a rotating shaft 11 and a motor 12, wherein the motor 12 is installed on the base 3, one end of the rotating shaft 11 is connected with an output shaft of the motor 12, the other end of the rotating shaft is connected with a magnet fixing block 9, the bearing 8 is installed on the base 3, and the magnet fixing block 9 is installed in the bearing 8.
A perspective structure of a second example of the magnet moving mechanism is shown in fig. 6, and an isometric view is shown in fig. 7, and the magnet moving mechanism comprises a bearing 8, a rotating shaft 11, a motor 12, a transmission belt 13 and a transmission wheel 14, wherein one end of the rotating shaft 11 is connected with an output shaft of the motor 12, the other end of the rotating shaft is connected with the transmission wheel 14, one end of the transmission belt 13 is sleeved on the transmission wheel 14, the other end of the transmission belt is sleeved on a magnet fixing block 9, the bearing 8 is installed on the base 3, and the magnet fixing block 9 is installed in the bearing 8.
A perspective structure of a third example of the magnet moving mechanism is shown in fig. 8, an axonometric view is shown in fig. 9, and the magnet moving mechanism comprises a motor 12, a screw rod 15 and a screw rod base 16, the screw rod base 16 is installed on the base 3, the motor 12 and the screw rod 15 are respectively installed on the screw rod base 16, the screw rod 15 is connected with an output shaft of the motor 12, a magnet fixing block 9 is installed on the screw rod base 16, the magnet fixing block 9 is connected with the screw rod base 16 in a sliding manner, the magnet fixing block 9 is connected with the screw rod 15, threads matched with the screw rod 15 are arranged in the magnet fixing block 9, the motor 12 drives the screw rod 15 to rotate, and drives the magnet fixing block 9 to reciprocate along the screw rod 15, so that the reciprocating motion of the magnet 10 is realized.
The first and second examples are both rotary magnet moving mechanisms, and the third example is a complex motion magnet moving mechanism.
The embodiment also relates to a separation and purification method for the separation and purification device, which comprises the following steps:
step 1: filling a sample into the sample cell;
step 2: starting a motor, and executing the step 3 after the adhesion amount of the material of the side wall of the sample cell is stable and unchanged;
and step 3: separating the liquid out of the sample pool to realize the separation and purification of the sample;
and 4, step 4: the motor is turned off.
Fig. 10 and fig. 11 are schematic structural diagrams of a second example and a third example of the separation and purification device, respectively, wherein the second example adopts a combination of a conventional centrifuge tube and a reciprocating magnet moving mechanism, and the third example adopts a combination of a special sample cell and a rotary magnet moving mechanism.
For the second example and the third example of the separation and purification apparatus, respectively, there are provided corresponding separation and purification methods:
(1) second example
The first step is as follows: the sample holder 5 is placed beside the moving base 3 in the manner shown in fig. 10, with the sample holder gap aligned with the magnet fixing block 9;
the second step is that: the sample cell 4 containing the sample is placed in the sample holder;
the third step: according to the height of the liquid level, the rotating mode of the motor 12 is adjusted to set the moving distance and the up-down moving times of the magnet fixing block;
the fourth step: starting a motor, and sucking out liquid when the material attachment amount on the side wall of the sample cell 4 is stable and unchanged;
the fifth step: the motor is turned off.
(2) Third example
The first step is as follows: the sample holders 5 are placed on both sides of the magnet set 1 in the manner shown in fig. 11;
the second step is that: the sample cell 4 containing the sample is placed in the sample holder, and the plug 7 is placed in the water outlet 6;
the third step: starting a motor, and when the material attachment amount on the side wall of the sample cell 4 is stable and unchanged, pulling out the plug 7 to enable the liquid to flow out;
the fourth step: the motor is turned off.
While the invention has been described with reference to specific embodiments, the invention is not limited thereto, and various equivalent modifications and substitutions can be easily made by those skilled in the art within the technical scope of the invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A separation and purification device based on a dynamic magnetic field is characterized by comprising a magnet mechanism (1), a magnet moving mechanism (2), a base (3), a sample cell (4) and a sample rack (5); the sample cell (4) is fixed on the sample frame (5); the magnet mechanism (1) is arranged at a position corresponding to the sample cell (4); the magnet mechanism (1) is arranged on the magnet moving mechanism (2); the magnet moving mechanism (2) is arranged on the base (3); the magnet moving mechanism (2) drives the magnet mechanism (1) to move near the sample cell (4) to generate a dynamic magnetic field, so that the separation and purification of substances in the sample cell (4) are accelerated.
2. The separation and purification device based on the dynamic magnetic field as claimed in claim 1, wherein the magnet mechanism (1) comprises a magnet fixing block (9) and a magnet (10); the magnet (10) is fixed in the magnet fixing block (9); the magnet fixing block (9) is connected with the magnet moving mechanism (2).
3. A separation and purification device based on dynamic magnetic field as claimed in claim 2, characterized in that the magnet (10) is a permanent magnet or an electromagnet.
4. The separation and purification device based on dynamic magnetic field as claimed in claim 2, wherein the magnet moving mechanism (2) is a rotary magnet moving mechanism.
5. The separation and purification device based on dynamic magnetic field as claimed in claim 4, wherein the rotary magnet moving mechanism comprises a rotating shaft (11) and a motor (12); the motor (12) is arranged on the base (3); one end of the rotating shaft (11) is connected with an output shaft of the motor (12), and the other end of the rotating shaft is connected with the magnet fixing block (9).
6. The separation and purification device based on the dynamic magnetic field as claimed in claim 4, wherein the rotary magnet moving mechanism comprises a rotating shaft (11), a motor (12), a transmission belt (13) and a transmission wheel (14); one end of the rotating shaft (11) is connected with an output shaft of the motor (12), and the other end of the rotating shaft is connected with the driving wheel (14); one end of the transmission belt (13) is sleeved on the transmission wheel (14), and the other end is sleeved on the magnet fixing block (9).
7. The separation and purification device based on dynamic magnetic field as claimed in claim 5 or 6, wherein the rotary magnet moving mechanism further comprises a bearing (8); the bearing (8) is arranged on the base (3); the magnet fixing block (9) is arranged in the bearing (8).
8. The separation and purification device based on dynamic magnetic field as claimed in claim 2, wherein the magnet moving mechanism (2) is a reciprocating magnet moving mechanism.
9. The separation and purification device based on dynamic magnetic field as claimed in claim 8, wherein the reciprocating magnet moving mechanism comprises a motor (12), a screw (15) and a screw base (16); the screw rod base (16) is arranged on the base (3); the motor (12) and the screw rod (15) are respectively arranged on the screw rod base (16); the screw rod (15) is connected with an output shaft of the motor (12); the magnet fixing block (9) is arranged on the screw rod base (16), and the magnet fixing block (9) is connected with the screw rod base (16) in a sliding manner; the magnet fixing block (9) is connected with the screw rod (15), and threads matched with the screw rod (15) are arranged in the magnet fixing block (9); the motor (12) drives the screw rod (15) to rotate, and drives the magnetic block fixing block (9) to reciprocate along the screw rod (15), so that the magnet (10) reciprocates.
10. A separation and purification method for the separation and purification device according to any one of claims 1 to 9, wherein the separation and purification method comprises:
step 1: filling a sample into the sample cell;
step 2: starting a motor, and executing the step 3 after the adhesion amount of the material of the side wall of the sample cell is stable and unchanged;
and step 3: separating the liquid out of the sample pool to realize the separation and purification of the sample;
and 4, step 4: the motor is turned off.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110717401.9A CN113484121A (en) | 2021-06-28 | 2021-06-28 | Separation and purification device and separation and purification method based on dynamic magnetic field |
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| CN202110717401.9A CN113484121A (en) | 2021-06-28 | 2021-06-28 | Separation and purification device and separation and purification method based on dynamic magnetic field |
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Application publication date: 20211008 |