CN220335211U - Magnetic separation device for nucleic acid extraction - Google Patents
Magnetic separation device for nucleic acid extraction Download PDFInfo
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- CN220335211U CN220335211U CN202321776703.4U CN202321776703U CN220335211U CN 220335211 U CN220335211 U CN 220335211U CN 202321776703 U CN202321776703 U CN 202321776703U CN 220335211 U CN220335211 U CN 220335211U
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 38
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 38
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 38
- 238000007885 magnetic separation Methods 0.000 title claims abstract description 24
- 238000000605 extraction Methods 0.000 title claims abstract description 22
- 238000000926 separation method Methods 0.000 claims abstract description 55
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 35
- 230000007246 mechanism Effects 0.000 claims abstract description 27
- 230000000712 assembly Effects 0.000 claims abstract description 10
- 238000000429 assembly Methods 0.000 claims abstract description 10
- 239000011324 bead Substances 0.000 description 24
- 239000007788 liquid Substances 0.000 description 8
- 238000001514 detection method Methods 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 5
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 230000002427 irreversible effect Effects 0.000 description 3
- 230000005426 magnetic field effect Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 239000003480 eluent Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The present utility model relates to a magnetic separation device for nucleic acid extraction, comprising: the device comprises a support, a placing frame, an electromagnetic module, a lifting mechanism and a rotating mechanism. The placing frame is arranged above the support, the placing frame comprises a plurality of clamping assemblies which are annularly arranged at intervals, the clamping assemblies comprise clamping parts and fixing parts, clamping spaces for placing the separating pipes are formed between the clamping parts and the fixing parts, and the clamping parts and the fixing parts can be mutually close to reduce the clamping spaces or mutually far away from each other to enlarge the clamping spaces; the electromagnetic module is arranged on the support and below the placement frame and comprises a plurality of iron cores, the iron cores are adjacently arranged on the inner sides of the separation pipes, and the iron cores are connected end to form an annular arrangement, so that magnetic fields generated by the iron cores are uniformly distributed among the separation pipes; the lifting mechanism is arranged on the support and drives the placement frame to move up and down; the rotating mechanism is arranged on the support and drives the placing frame and the electromagnetic module to rotate.
Description
Technical Field
The utility model relates to the technical field of molecular biology, in particular to a magnetic separation device for extracting nucleic acid.
Background
The nucleic acid extraction by using the magnetic bead separation method is a detection technology and an analysis method which are widely applied to the fields of disease diagnosis and the like at present. The magnetic beads are used as carriers, the magnetic beads are used for adsorbing nucleic acid under the conditions of high salt and low pH value, the nucleic acid is separated from the magnetic beads under the conditions of low salt and high pH value, and the whole extraction and purification process of the nucleic acid is realized by moving the magnetic beads or transferring liquid.
In the related magnetic bead separation equipment, the separation tube is placed on the separation tube support provided with the magnet, and the magnet on the separation tube support is arranged in a single position, so that the magnetic beads are easily aggregated in a single position, and the detection result is influenced. And the aperture of the placing hole for placing the separating tube on the separating tube bracket is of a fixed size, so that the universality is not enough.
Disclosure of Invention
The purpose of the present utility model is to provide a magnetic separation device for nucleic acid extraction, which can improve the detection accuracy and the versatility of the magnetic separation device for nucleic acid extraction.
In order to solve the technical problems, the utility model adopts the following technical scheme.
The present utility model provides a magnetic separation device for nucleic acid extraction, comprising: a support; the placing frame is arranged above the support and comprises a plurality of clamping assemblies which are annularly arranged at intervals, the clamping assemblies comprise clamping parts and fixing parts, clamping spaces for placing separation pipes are formed between the clamping parts and the fixing parts, and the clamping parts and the fixing parts can be mutually close to reduce the clamping spaces or mutually far away from each other to enlarge the clamping spaces; the electromagnetic module is arranged on the support and positioned below the placement frame, and comprises a plurality of iron cores, wherein the iron cores are adjacently arranged on the inner sides of the separation pipes, and the iron cores are connected end to form an annular arrangement so that magnetic fields generated by the iron cores are uniformly distributed among the separation pipes; the lifting mechanism is arranged on the support and drives the placing frame to move up and down; the rotating mechanism is arranged on the support and drives the placing frame and the electromagnetic module to rotate.
According to some embodiments of the application, the placement frame further comprises an inner support ring and an outer support ring, wherein the outer support ring is coaxially arranged on the outer side of the inner support ring; the inner support ring is arranged above the support, the fixing part is arranged on the inner support ring, and the clamping part is movably connected to the outer support ring; the clamping part moves relative to the outer support ring and is close to the fixing part to reduce the clamping space, or moves relative to the outer support ring and is far away from the fixing part to increase the clamping space.
In some embodiments of the present application, a side of the clamping portion facing the fixing portion has a first clamping surface; the side of the fixing part facing the clamping part is provided with a second clamping surface; the first clamping surface and the second clamping surface are matched with the shape of the separating tube.
In some embodiments of the present application, the clamping portion further includes a clamping block and an adjusting rod; the clamping block is provided with a mounting hole; the adjusting rod is rotatably connected in the mounting hole, and is in threaded connection with the outer support ring.
According to some embodiments of the present application, the first clamping surface is provided with a first anti-slip pad, and the second clamping surface is provided with a second anti-slip pad.
In some embodiments of the present application, the stand further comprises a support platform; the placing frame and the electromagnetic module are arranged on the supporting platform; the supporting platform is provided with a groove corresponding to the clamping assembly, and the bottom of the separating tube is abutted in the groove.
In some embodiments of the present application, the height of the iron core is greater than or equal to one half of the maximum height of the placement frame from the support platform.
In some embodiments of the present application, the lifting mechanism comprises a first circular sleeve and a second circular sleeve; the first circular sleeve is connected to the supporting platform, the iron cores are annularly arranged on the outer periphery of the first circular sleeve, the placing frame is connected to the second circular sleeve, and the second circular sleeve can vertically movably penetrate through the first circular sleeve.
In some embodiments of the present application, the support has a circular hole; the rotating mechanism comprises a rotating shaft, one end of the rotating shaft is rotatably connected in the round hole, and the other end of the rotating shaft is fixedly connected below the supporting platform.
As can be seen from the technical scheme, the embodiment of the utility model has at least the following advantages and positive effects:
in the magnetic separation device for extracting nucleic acid, the plurality of clamping assemblies are arranged in the annular space through the placement frame, the iron cores of the electromagnetic modules are adjacently arranged on the inner side of the separation tube, the iron cores are prevented from shielding the sight, the separation tube is convenient to observe from the side, the plurality of iron cores are connected end to end and are annularly arranged below the placement frame, so that the magnetic field generated by the electromagnetic modules can be uniformly distributed, the separation tube can be uniformly subjected to the magnetic field effect of the annular electromagnetic array after being placed in the clamping space, the interaction force between the magnetic beads and the magnets is improved, and irreversible aggregation of the magnetic beads in the separation tube is avoided. And the detection accuracy is improved.
The clamping part and the fixing part can be mutually close to reduce the clamping space or mutually far away from to enlarge the clamping space, the size of the clamping space can be adjusted according to the separation pipes with different pipe diameters, the supporting frame is driven to move up and down by the cooperation of the lifting mechanism, the height of the supporting frame can be adjusted according to the separation pipes with different heights so as to adapt to the separation pipes with different specifications, and the magnetic separation device for extracting the nucleic acid has universality. And the rotating mechanism drives the placing frame and the electromagnetic module to rotate, so that a plurality of separating pipes can be placed and taken out easily. Easy to use and improves the separation efficiency.
Drawings
FIG. 1 is a top view of a magnetic separation device for nucleic acid extraction according to an embodiment of the present utility model.
Fig. 2 is a cross-sectional view of fig. 1.
Fig. 3 is a top view of the electromagnetic module and support platform of fig. 1.
Fig. 4 is an enlarged view of the area a in fig. 1.
Fig. 5 is a cross-sectional view of the separator tube of fig. 2 with the separator tube removed.
The reference numerals are explained as follows:
1. a support; 11. a support platform; 110. a groove; 2. a placement frame; 21. a clamping assembly; 211. a clamping part; 2111. a first clamping surface; 2112. a clamping block; 2113. an adjusting rod; 2114. a first cleat; 212. a fixing part; 2121. a second clamping surface; 2122. a second cleat; 213. a clamping space; 22. an inner support ring; 23. an outer support ring; 3. an electromagnetic module; 31. an iron core; 4. a lifting mechanism; 41. a first circular sleeve; 42. a second circular sleeve; 5. a rotation mechanism; 51. a rotating shaft; 6. separating tube.
Detailed Description
While this utility model is susceptible of embodiment in different forms, there is shown in the drawings and will herein be described in detail, specific embodiments thereof with the understanding that the present disclosure is to be considered as an exemplification of the principles of the utility model and is not intended to limit the utility model to that as illustrated.
Thus, rather than implying that each embodiment of the present utility model must have the characteristics described, one of the characteristics indicated in this specification will be used to describe one embodiment of the present utility model. Furthermore, it should be noted that the present specification describes a number of features. Although certain features may be combined together to illustrate a possible system design, such features may be used in other combinations not explicitly described. Thus, unless otherwise indicated, the illustrated combinations are not intended to be limiting.
In the embodiments shown in the drawings, indications of orientation (such as up, down, left, right, front and rear) are used to explain the structure and movement of the various elements of the utility model are not absolute but relative. These descriptions are appropriate when these elements are in the positions shown in the drawings. If the description of the position of these elements changes, the indication of these directions changes accordingly.
Preferred embodiments of the present utility model will be further elaborated below in conjunction with the drawings of the present specification.
Referring to fig. 1 to 3, a magnetic separation device for nucleic acid extraction according to an embodiment of the present utility model is used for nucleic acid extraction in combination with a separation tube 6 and a magnetic bead separation method. Wherein, the separating tube 6 can be made of high transparent polypropylene raw material, is hollow and has a circular tube shape with an open top, and has various specifications of tube diameter and tube height.
The magnetic separation device for nucleic acid extraction comprises a support 1, a placement frame 2, an electromagnetic module 3, a lifting mechanism 4 and a rotating mechanism 5. The placing rack 2 is arranged above the support 1, the placing rack 2 comprises a plurality of clamping assemblies 21 which are annularly arranged at intervals, the clamping assemblies 21 comprise clamping parts 211 and fixing parts 212, a clamping space 213 for placing the separating tube 6 is formed between the clamping parts 211 and the fixing parts 212, and the clamping parts 211 and the fixing parts 212 can be mutually close to reduce the clamping space 213 or mutually far away from each other to enlarge the clamping space 213. Specifically, the separation tube 6 is held by the holding portion 211 and the fixing portion 212, and the separation tubes 6 of different specifications are held by mutual adjustment of the holding portion 211 and the fixing portion 212, so that the separation tube has versatility.
The electromagnetic module 3 is arranged on the support 1 and positioned below the placement frame 2, the electromagnetic module 3 comprises a plurality of iron cores 31, the iron cores 31 are adjacently arranged on the inner sides of the separation pipes 6, and the plurality of iron cores 31 are annularly arranged in an end-to-end mode, so that magnetic fields generated by the plurality of iron cores 31 are uniformly distributed among the plurality of separation pipes 6. The electromagnetic module 3 is connected to an external power source to control the plurality of cores 31 so that the plurality of cores 31 are simultaneously excited, magnetic attraction force is generated, or the plurality of cores 31 are simultaneously demagnetized, and the magnetic attraction force is vanished. The magnetic field generated by the annular electromagnetic array is uniformly distributed below the placement frame 2 by matching with the annular arrangement of the plurality of iron cores 31, so that the magnetic beads in the separation tubes 6 after the plurality of separation tubes 6 are placed in the placement frame 2 can be uniformly subjected to the magnetic field effect of the annular electromagnetic array. I.e., each separator tube 6 has a magnetic field effect in the peripheral region near the core 31. The magnetic field is uniformly distributed. Irreversible aggregation of the magnetic beads in the separation tube 6 is avoided. And the detection accuracy is improved.
The lifting mechanism 4 is arranged on the support 1 and drives the placement frame 2 to move up and down. It will be appreciated that the lifting mechanism 4 can adjust the height of the cage 2 on the support 1. For example, the placement frame 2 is moved downwards by the lifting mechanism 4 to lower the height of the placement frame 2, and the separation tube 6 with a short pipe body length is adapted, so that the separation tube 6 can be subjected to the magnetic field of the electromagnetic module 3. Meanwhile, the clamping assembly 21 is matched to clamp the separating pipes 6 with different pipe diameters, so that the magnetic separating device for extracting the nucleic acid is matched with the separating pipes 6 with more specifications, and the magnetic separating device has universality.
The rotating mechanism 5 is arranged on the support 1 and drives the placing frame 2 and the electromagnetic module 3 to rotate. The plurality of separating pipes 6 can be easily placed and taken out by a person by rotating the placing frame 2, and the state of all separating pipes 6 can be observed without moving the body or switching the view angles.
Therefore, in the magnetic separation device for extracting nucleic acid according to the embodiment of the utility model, the holding frame 2 is provided with the plurality of holding assemblies 21 which are annularly arranged at intervals, the iron cores 31 of the electromagnetic module 3 are adjacently arranged on the inner side of the separation tube 6, the iron cores 31 are prevented from shielding the sight, the separation tube 6 is convenient to observe from the side, and the plurality of iron cores 31 are annularly arranged below the holding frame 2 in an end-to-end manner, so that the magnetic field generated by the electromagnetic module 3 can be uniformly distributed, the separation tube 6 can be uniformly subjected to the magnetic field action of the annular electromagnetic array after being placed in the holding space 213, the interaction force between the magnetic beads and the magnets is improved, and the irreversible aggregation of the magnetic beads in the separation tube 6 is avoided. And the detection accuracy is improved.
The clamping part 211 and the fixing part 212 can be mutually close to reduce the clamping space 213 or mutually far away from to enlarge the clamping space 213, the size of the clamping space 213 can be adjusted according to the separation tubes 6 with different tube diameters, the placing frame 2 is driven to move up and down by matching with the lifting mechanism 4, the height of the separation tubes 6 with different heights can be adjusted to adapt to the separation tubes 6 with different specifications, and the magnetic separation device for extracting nucleic acid has universality. And the rotating mechanism 5 drives the placing frame 2 and the electromagnetic module 3 to rotate, so that a plurality of separating pipes 6 can be placed and taken out easily. Easy to use and improves the separation efficiency.
Referring to fig. 1, the placement frame 2 further includes an inner support ring 22 and an outer support ring 23, and the outer support ring 23 is coaxially disposed outside the inner support ring 22. In this embodiment, the inner support ring 22 and the outer support ring 23 are both circular, and the placement frame 2 further includes a plurality of cross bars disposed between the inner support ring 22 and the outer support ring 23 at annular intervals to connect the outer support ring 23 to the inner support ring 22. The structural strength is increased. The inner support ring 22 is disposed above the support 1, the fixing portion 212 is disposed on the inner support ring 22, and the clamping portion 211 is movably connected to the outer support ring 23. It will be appreciated that, in the operation, after the separation tube 6 is abutted against the fixing portion 212, the holding portion 211 is moved to perform the operation of holding the separation tube 6.
Wherein the clamping portion 211 moves relative to the outer support ring 23 and approaches the fixing portion 212 to reduce the clamping space 213, or the clamping portion 211 moves relative to the outer support ring 23 and away from the fixing portion 212 to increase the clamping space 213. The clamping operation of the separating tube 6 is convenient, the adjustment of the clamping assembly 21 is facilitated, and the separating tube 6 with different specifications is adapted, so that the separating tube has universality.
Referring to fig. 4, a side of the clamping portion 211 facing the fixing portion 212 has a first clamping surface 2111. The side of the fixing portion 212 facing the clamping portion 211 has a second clamping surface 2121. The first clamping surface 2111 and the second clamping surface 2121 are adapted to the shape of the separating tube 6. So that the first clamping surface 2111 and the second clamping surface 2121 are more attached to the pipe body of the separation pipe 6, the contact surface during clamping can be increased, and the clamping is more stable. In this embodiment, the separating tube 6 has a cylindrical shape, and the first clamping surface 2111 and the second clamping surface 2121 are each arc-shaped.
The clamping portion 211 further includes a clamping block 2112 and an adjustment lever 2113. The clamping block 2112 has a mounting hole. An adjusting rod 2113 is rotatably coupled to the inside of the mounting hole, and the adjusting rod 2113 is screw-coupled to the outer support ring 23. The clamping assembly 21 is adjusted, so that when the adjusting rod 2113 is screwed on the outer supporting ring 23, the clamping block 2112 can not rotate, the first clamping surface 2111 of the clamping block 2112 is accurately aligned with the separating tube 6, the first clamping surface 2111 is propped against the separating tube 6, and the clamping stability is improved.
The first clamping surface 2111 is provided with a first anti-slip pad 2114 and the second clamping surface 2121 is provided with a second anti-slip pad 2122. The first and second anti-slip pads 2114 and 2122 can increase friction when they are abutted against the surface of the separation pipe 6, so that the clamping is more stable. The first anti-slip pad 2114 and the second anti-slip pad 2122 may be made of rubber material, but are not limited thereto.
Referring to fig. 5, the stand 1 further includes a support platform 11. The placement frame 2 and the electromagnetic module 3 are mounted on a support platform 11. The supporting platform 11 is provided with a groove 110 corresponding to the clamping assembly 21, and the bottom of the separating tube 6 is abutted in the groove 110. So that the separating tube 6 can be more stably fixed to the apparatus.
Referring to fig. 2, in some embodiments, the sample liquid level of the separation tube 6 is generally at the middle lower portion of the separation tube 6, so that the magnetic beads are located at the middle lower portion of the separation tube 6, and it can be understood that when the placement frame 2 is adjusted to the maximum height by the lifting mechanism 4, the maximum height of the separation tube 6 can be placed, that is, one half of the maximum height of the placement frame 2 from the supporting platform 11 is approximately one half of the height of the separation tube 6, so as to ensure that the magnetic field distribution is uniform and the magnetic beads in the separation tube 6 generate magnetic field acting force, and the height of the iron core 31 is greater than or equal to one half of the maximum height of the placement frame 2 from the supporting platform 11.
Referring to fig. 5, in the present embodiment, the lifting mechanism 4 includes a first circular sleeve 41 and a second circular sleeve 42. The first circular sleeve 41 and the second circular sleeve 42 are both cylindrical, the diameter of the first circular sleeve 41 is larger than that of the second circular sleeve 42, the first circular sleeve 41 is connected to the supporting platform 11, the plurality of iron cores 31 are annularly arranged on the outer periphery side of the first circular sleeve 41, the placing frame 2 is connected to the second circular sleeve 42, and the second circular sleeve 42 can be vertically movably arranged in the first circular sleeve 41 in a penetrating mode. The stability of the up-and-down movement of the placement frame 2 is increased, the placement frame 2 and the plurality of iron cores 31 are conveniently installed in a ring-shaped arrangement, and the plurality of iron cores 31 can always face to one side where the separation tube 6 is placed when the placement frame 2 moves up and down.
The support 1 has a circular hole. The rotating mechanism 5 comprises a rotating shaft 51, one end of the rotating shaft 51 is rotatably connected in the round hole, and the other end of the rotating shaft is fixedly connected below the supporting platform 11. The supporting platform 11 is convenient to rotate so as to drive the placing frame 2 and the separating tube 6 to rotate together.
The use process of the magnetic bead separation by the magnetic separation device for nucleic acid extraction in the embodiment of the utility model comprises the following steps: firstly, an operator adds a sample of nucleic acid to be extracted into a separating tube 6, and places the separating tube 6 into a clamping space 213 formed by a clamping part 211 and a fixing part 212, specifically, the separating tube 6 is abutted against a second clamping surface 2121 of the fixing part 212, an adjusting rod 2113 is rotated to move relative to an outer supporting ring 23, a clamping block 2112 is close to the fixing part 212, a first clamping surface 2111 is abutted against the separating tube 6, thereby clamping the separating tube 6, then a lysate is added, after a certain reaction time, magnetic beads are added, the magnetic beads are fully combined with nucleic acid polymers, at this time, an electromagnetic module 3 is started, a plurality of iron cores 31 generate magnetic fields, the magnetic beads and the nucleic acid polymers are adsorbed on the side wall of the separating tube 6, and then unnecessary impurity liquid is sucked away, adding a washing liquid, closing the electromagnetic module 3, eliminating the magnetic field generated by the iron cores 31, fully washing the nucleic acid sample liquid, fully combining the magnetic beads with the nucleic acid polymer, restarting the electromagnetic module 3 after a certain reaction time, enabling the magnetic beads and the nucleic acid polymer to be adsorbed on the side surface of the separation tube 6, sucking away unnecessary impurity liquid, adding an eluent, closing the electromagnetic module 3, eliminating the magnetic field generated by the iron cores 31, fully washing the nucleic acid sample liquid, fully separating the magnetic beads from the nucleic acid polymer, restarting the electromagnetic module 3, enabling the iron cores 31 to generate the magnetic field, enabling the magnetic beads to be adsorbed on the side surface of the separation tube 6, and sucking away the liquid containing the eluent to realize nucleic acid extraction.
While the utility model has been described with reference to several exemplary embodiments, it is to be understood that the terminology used is intended to be in the nature of words of description and of limitation. As the present utility model may be embodied in several forms without departing from the spirit or essential characteristics thereof, it should also be understood that the above-described embodiments are not limited by any of the details of the foregoing description, but rather should be construed broadly within its spirit and scope as defined in the appended claims, and therefore all changes and modifications that fall within the meets and bounds of the claims, or equivalences of such meets and bounds are therefore intended to be embraced by the appended claims.
Claims (9)
1. A magnetic separation device for nucleic acid extraction, comprising:
a support;
the placing frame is arranged above the support and comprises a plurality of clamping assemblies which are annularly arranged at intervals, the clamping assemblies comprise clamping parts and fixing parts, clamping spaces for placing separation pipes are formed between the clamping parts and the fixing parts, and the clamping parts and the fixing parts can be mutually close to reduce the clamping spaces or mutually far away from each other to enlarge the clamping spaces;
the electromagnetic module is arranged on the support and positioned below the placement frame, and comprises a plurality of iron cores, wherein the iron cores are adjacently arranged on the inner sides of the separation pipes, and the iron cores are connected end to form an annular arrangement so that magnetic fields generated by the iron cores are uniformly distributed among the separation pipes;
the lifting mechanism is arranged on the support and drives the placing frame to move up and down;
the rotating mechanism is arranged on the support and drives the placing frame and the electromagnetic module to rotate.
2. The magnetic separation device for nucleic acid extraction according to claim 1 wherein the placement frame further comprises an inner support ring and an outer support ring, the outer support ring being coaxially disposed outside the inner support ring;
the inner support ring is arranged above the support, the fixing part is arranged on the inner support ring, and the clamping part is movably connected to the outer support ring;
the clamping part moves relative to the outer support ring and is close to the fixing part to reduce the clamping space, or moves relative to the outer support ring and is far away from the fixing part to increase the clamping space.
3. The magnetic separation device for nucleic acid extraction according to claim 2, wherein a side of the holding portion facing the fixing portion has a first holding surface;
the side of the fixing part facing the clamping part is provided with a second clamping surface;
the first clamping surface and the second clamping surface are matched with the shape of the separating tube.
4. The magnetic separation device for nucleic acid extraction according to claim 3, wherein the holding portion further comprises a holding block and an adjusting lever;
the clamping block is provided with a mounting hole;
the adjusting rod is rotatably connected in the mounting hole, and is in threaded connection with the outer support ring.
5. The magnetic separation device according to claim 3 wherein the first holding surface is provided with a first anti-slip pad and the second holding surface is provided with a second anti-slip pad.
6. The magnetic separation device for nucleic acid extraction of claim 1 wherein the support further comprises a support platform;
the placing frame and the electromagnetic module are arranged on the supporting platform;
the supporting platform is provided with a groove corresponding to the clamping assembly, and the bottom of the separating tube is abutted in the groove.
7. The magnetic separation device for nucleic acid extraction of claim 6 wherein the height of the core is greater than or equal to one half the maximum height of the cage from the support platform.
8. The magnetic separation device for nucleic acid extraction of claim 6 wherein the lifting mechanism comprises a first circular sleeve and a second circular sleeve;
the first circular sleeve is connected to the supporting platform, the iron cores are annularly arranged on the outer periphery of the first circular sleeve, the placing frame is connected to the second circular sleeve, and the second circular sleeve can vertically movably penetrate through the first circular sleeve.
9. The magnetic separation device for nucleic acid extraction of claim 6 wherein the support has a circular aperture;
the rotating mechanism comprises a rotating shaft, one end of the rotating shaft is rotatably connected in the round hole, and the other end of the rotating shaft is fixedly connected below the supporting platform.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321776703.4U CN220335211U (en) | 2023-07-07 | 2023-07-07 | Magnetic separation device for nucleic acid extraction |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321776703.4U CN220335211U (en) | 2023-07-07 | 2023-07-07 | Magnetic separation device for nucleic acid extraction |
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| Publication Number | Publication Date |
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| CN220335211U true CN220335211U (en) | 2024-01-12 |
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| CN202321776703.4U Active CN220335211U (en) | 2023-07-07 | 2023-07-07 | Magnetic separation device for nucleic acid extraction |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118064269A (en) * | 2024-04-18 | 2024-05-24 | 苏州欣协生物科技有限公司 | Full-automatic closed cell preparation all-in-one |
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2023
- 2023-07-07 CN CN202321776703.4U patent/CN220335211U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118064269A (en) * | 2024-04-18 | 2024-05-24 | 苏州欣协生物科技有限公司 | Full-automatic closed cell preparation all-in-one |
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