CN1134838A - Group of pharmaceutics made of selenium-rich northern cordyceps - Google Patents

Group of pharmaceutics made of selenium-rich northern cordyceps Download PDF

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Publication number
CN1134838A
CN1134838A CN 95118390 CN95118390A CN1134838A CN 1134838 A CN1134838 A CN 1134838A CN 95118390 CN95118390 CN 95118390 CN 95118390 A CN95118390 A CN 95118390A CN 1134838 A CN1134838 A CN 1134838A
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rich
selenium
preparation
link
cordyceps militaris
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李江
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Abstract

The present invention substitutes the selenium-rich northern cordyceps for cordyceps to recompose the prescription, the compatibility of which with various traditional Chinese medicinal herbs and meicines, Chinese proprietary medicine, medicinal fungus and their extracts and derivatives has been made, the concentrated liquid is made up through crushing, water decocting, alcohol extracting, then merging and processing into pills, electuary, mixture, capsule, sugarcoated tablet, injection, extract, powder, syrup and liquor, etc. It features lowering cost, heightening the curative effect, and without side effect. It is suitable for curing tumor, cancer, cardiocerebrovascular disease, renalsystem disease, blood disease, and diseases of liver, gallbladder, spleen, stomach, lungs and pancreas.

Description

One group of Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof
The present invention relates to one group of Cordyceps medicine preparation and preparation method thereof, particularly one group of Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof.
In present name class disease therapeuticing medicine, especially in the medicine of swollen disease, cancer, cardiovascular and cerebrovascular disease, renal system disease, hematopathy, liver, gallbladder systemic disease, hormonal system disease, be compatibility how, be aided with the medicine preparation that other drug processes with Cordyceps.
Chinese invention patent 93112181.7 discloses one group of Chinese medicine medicine for preventing preparation and preparation method thereof that lengthens one's life, conventional medicament and Cordyceps powder with kidney-boosting tonic are compatibility, make pill, a mixture, electuary, tablets and other formulations through composite extracting technique, strengthen the time-to-live of human body anti-cancer function, prolongation cancer patient effectively, adjuvant therapy medicaments as various cancers has no side effect.
The inventor discloses a kind of method for artificially culturing selenium-rich Northern Chinese caterpillar fungus in the patent application of China Patent No. 93117344.2, can produce the Cordyceps militaris (L.) Link. Rich in selenium that is equal to or higher than the natural cordyceps active ingredient.
The objective of the invention is to replace Cordyceps prescription again with Cordyceps militaris (L.) Link. Rich in selenium, solve Cordyceps price height, raw material is in short supply, and resource is on the verge of exhausted problem, makes curative effect more remarkable.
The object of the present invention is achieved like this:
Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof is with various Chinese herbal medicine, Chinese medicine, Chinese patent medicine, medical fungus and extract thereof with Cordyceps militaris (L.) Link. Rich in selenium, derivant is compatible, produces pill, electuary, mixture, capsule, tablet, sugar coated tablet, injection, unguentum, powder, syrup, medicated wine etc. and is the preparation method of dosage form.Earlier with the smart powder of valuable medicinals such as Cordyceps militaris (L.) Link. Rich in selenium, other medicinal material coarse powder are extracted concentrated solution with decocting method, alcohol extracting method or enzymatic isolation method, with the smart powder of valuable medicinals such as Cordyceps militaris (L.) Link. Rich in selenium and concentrated solution and the abundant hybrid combination of other drug, respectively through refined honey, drying, fragmentation, die mould, in flakes, dilution, concentrate, clarify and form.
Cordyceps militaris (L.) Link. Rich in selenium medicine preparation of the present invention and preparation method thereof has following advantage:
One. replace Cordyceps with Cordyceps militaris (L.) Link. Rich in selenium, can obviously reduce production costs, sufficient raw can solve the natural cordyceps resource and be on the verge of exhausted problem.
Two. the effective ingredient of Cordyceps militaris (L.) Link. Rich in selenium is impartial or be higher than natural cordyceps, replaces natural cordyceps can improve curative effect with Cordyceps militaris (L.) Link. Rich in selenium.
Three. in various diseases medicine compatibility, add or reuse Cordyceps militaris (L.) Link. Rich in selenium and can obviously improve medical effect.Without any side effects, the indication wide spectrum.
Four. Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and phase preparation method, technology is easy, implements easily, and cost is low.
Below in conjunction with the treatment tumor, the embodiment of the Cordyceps militaris (L.) Link. Rich in selenium medicine preparation of cancer further specifies: one. prescription: Cordyceps militaris (L.) Link. Rich in selenium 30--60 gram
Morchella esculenta (L.) Pers 20--50 gram
Gecko (foot of decaptitating) 10--20 gram
Radix Astragali is eaten the 30--50 gram
Hippocampus 5--15 gram
Radix Ginseng 5--15 gram
Radix Panacis Quinquefolii 5--15 gram
Poria 20--30 gram
Rhizoma Dioscoreae 20--30 gram
Fructus Trichosanthis 10--30 gram
Ganoderan 10--20 gram
Grifolan 10--20 gram
Krestin 10--20 gram two. preparation method:
1. pill preparation: Cordyceps militaris (L.) Link. Rich in selenium, Gecko (foot of decaptitating), Hippocampus pulverize separately are crossed the 100-120 mesh sieve, weigh, with other mushroom medicines, Chinese herbal medicine, respectively weigh after, the common pulverizing crossed the 80-100 mesh sieve, weighs, after two groups of medicated powder are mixed, refined honey to 100 ℃, medicated powder and three kinds of polysaccharide of adding mix homogeneously are made honeyed pill, and packing forms.
2. electuary preparation: with Cordyceps militaris (L.) Link. Rich in selenium, Hippocampus, Gecko (foot of decaptitating) was pulverized the 100-120 mesh sieve, other each medicines are after crushed with handling the water logging bubble 12-24 hour, slow fire boiled 2 hours, filter, medicinal residues slow fire again boiled 2 hours, fried in shallow oil altogether three times, and three filtrate merging are concentrated into paste, medicinal residues were added 95% soak with ethanol 2 days, sucking filtration reclaims ethanol, lixiviate three times, to there not being the alcohol flavor, ethanol concentrated solution and boiling liquid are merged, add the selenium-rich cordyceps powder, the Gecko powder, the Hippocampus powder, Grifola frondosa, Coriolous Dersicolor (Fr.) Quel, ganoderan, mix drying thoroughly after, fragmentation or pelletize, sealing is distributed into bag.
3. mixture (oral liquid) preparation:
Mixture preparation method and electuary preparation method are identical early stage, and the 5--20 that the weight that different is extracts amalgamation liquid accounts for the raw material gross weight doubly adds selenium-rich cordyceps, Gecko, Solenognathus three medicated powder and three kinds of polysaccharide and stirs, and adds proper honey or sugar.Sterilization, fill.
4. tablet, coated tablet preparation:
Press the method for making of electuary, extract the active ingredient of other each medicines, in the concentrated solution of paste, add Cordyceps militaris (L.) Link. Rich in selenium, Gecko, Hippocampus, three medicated powder, three kinds of polysaccharide etc. are mixed all, add auxilliary type medicine compression moulding, dry tablet, coated tablet is pressed into " protruding " matrix, last sugar-coat.
5. capsule preparation: press the method for making of electuary, merge at the concentrated solution of paste and add in the thing that three medicated powder and three kinds of polysaccharide stir evenly more than the Cordyceps militaris (L.) Link. Rich in selenium etc., drying, crushing packing.
6. unguentum preparation: promptly press the electuary method for making, produce concentrated solution and merge thing, and three medicated powder such as adding Cordyceps militaris (L.) Link. Rich in selenium and three kinds of polysaccharide and Mel, be concentrated into paste.
7. powder preparation: press the method for making of electuary, concentrated solution merges thing and admixes three medicated powder such as Cordyceps militaris (L.) Link. Rich in selenium and three kinds of polysaccharide and proper honey, stirs evenly, drying, fragmentation pack.
8. syrup: promptly extract each medicine by the electuary method for making, concentrated solution merges thing, adds polysaccharide, sugar or Mel, the sterilization fill.
9. medicated wine: with Cordyceps militaris (L.) Link. Rich in selenium etc. all each medicine immerse after crushed in the grain wine base, 7-15 days after-filtration, medicinal residues repeat to soak filtration with the grain wine base with the identical time and are total to leaching three times, get filtrate, add sugar or Mel, dilute required wine degree, precipitate, leave standstill, must clarify wine liquid, filtration back packing.
10. injection: the preparation method of pressing electuary is extracted concentrated solution and is merged thing, merges to add calcium hydroxide in the thing and regulate pH value to 8, after 24 hours, sucking filtration is removed precipitation, and filtrate is regulated pH value to 6 with sulphuric acid, and sucking filtration is removed precipitation, adding ethanol to solution, to contain alcohol amount be 85%, place more than 48 hours sucking filtration filtrate recovered alcohol, the concentrated solution remaining ethanol of rushing, to there not being the alcohol flavor, as go into 0.5% active carbon, and heating half an hour, sucking filtration is standby.Other gets 60 ℃ of aquae destillata heating, adds 1% benzyl alcohol, make it dissolving after, in the impouring Chinese caterpilar fungus concentrated solution, stir, add and fresh aquae destillata to capacity, fine straining, embedding, 100 ℃ of steam sterilizations that circulate, 30 minutes are promptly.
Cordyceps militaris (L.) Link. Rich in selenium is with Chinese herbal medicine, Chinese medicine, Chinese patent medicine, medical fungus and the extract thereof of the other kinds disease of treatment, and derivant is compatible, and production medicament preparation method is identical with the Cordyceps militaris (L.) Link. Rich in selenium medicament preparation method that is used for the treatment of tumor, cancer.
Cordyceps militaris (L.) Link. Rich in selenium replaces Cordyceps or adds in prescription or reuse Cordyceps militaris (L.) Link. Rich in selenium prescription again, the pill of various disease such as production and processing one-tenth treatment tumor, cancer, cardiovascular and cerebrovascular disease, renal system disease, hematopathy, liver, gallbladder systemic disease, spleen, stomach, lung, pancreas disease, viral disease, electuary, mixture, capsule, tablet, sugar coated tablet, injection, unguentum, powder, syrup, medicated wine etc. are dosage form, and be evident in efficacy.

Claims (6)

  1. One. one group of Cordyceps medicine preparation and preparation method thereof, one group of Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof particularly, it is characterized in that: with Cordyceps militaris (L.) Link. Rich in selenium with various Chinese herbal medicine, Chinese medicine, Chinese patent medicine, medical fungus and extract thereof, derivant is compatible, produces pill, electuary, mixture (oral liquid), capsule, tablet, sugar coated tablet, injection, unguentum, powder, syrup, medicated wine etc.
  2. Two. according to claim 1 described Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof, it is characterized in that:
    With the smart powder of valuable medicinals such as Cordyceps militaris (L.) Link. Rich in selenium, other medicinal material coarse powder, with decocting method, alcohol extracting method or enzymatic isolation method in conjunction with extracting concentrated solution, the smart powder of valuable medicinals such as Cordyceps militaris (L.) Link. Rich in selenium is fully mixed with concentrated solution and other drug, compatibility, respectively through refined honey, drying, fragmentation, pelletize, auxilliary type tabletting, concentrate, dilution, concentrate composite, leave standstill, clarify, make pill, electuary, mixture, capsule, tablet, sugar coated tablet, injection, unguentum, powder, syrup, medicated wine etc.
  3. Three. according to claim 1 described Cordyceps militaris (L.) Link. Rich in selenium medicine preparation that is used for the treatment of tumor, cancer and preparation method thereof, it is characterized in that:
    1. pill preparation: Cordyceps militaris (L.) Link. Rich in selenium, Gecko (foot of decaptitating), Hippocampus pulverize separately are crossed the 100-120 mesh sieve, weigh, with other mushroom medicines, Chinese herbal medicine, respectively weigh after, the common pulverizing crossed the 80-100 mesh sieve, weighs, after two groups of medicated powder are mixed, refined honey to 100 ℃, medicated powder and three kinds of polysaccharide of adding mix homogeneously are made honeyed pill, and packing forms.
    2. electuary preparation: with Cordyceps militaris (L.) Link. Rich in selenium, Hippocampus, Gecko (foot of decaptitating) was pulverized the 100-120 mesh sieve, other each medicines are after crushed with handling the water logging bubble 12-24 hour, slow fire boiled 2 hours, filter, medicinal residues slow fire again boiled 2 hours, fried in shallow oil altogether three times, and three filtrate merging are concentrated into paste, medicinal residues were added 95% soak with ethanol 2 days, sucking filtration reclaims ethanol, lixiviate three times, to there not being the alcohol flavor, ethanol concentrated solution and boiling liquid are merged, add the selenium-rich cordyceps powder, the Gecko powder, the Hippocampus powder, Grifola frondosa, Coriolous Dersicolor (Fr.) Quel, ganoderan, mix drying thoroughly after, fragmentation or pelletize, sealing is distributed into bag.
    3. mixture (oral liquid) preparation:
    Mixture preparation method and electuary preparation method are identical early stage, and the 5--20 that the weight that different is extracts amalgamation liquid accounts for the raw material gross weight doubly adds selenium-rich cordyceps, Gecko, Solenognathus three medicated powder and three kinds of polysaccharide and stirs, and adds proper honey or sugar.Sterilization, fill.
    4. tablet, coated tablet preparation:
    Press the method for making of electuary, extract the active ingredient of other each medicines, in the concentrated solution of paste, add Cordyceps militaris (L.) Link. Rich in selenium, Gecko, Hippocampus, three medicated powder, three kinds of polysaccharide etc. are mixed all, add auxilliary type medicine compression moulding, dry tablet, coated tablet is pressed into " protruding " matrix, last sugar-coat.
    5. capsule preparation: press the method for making of electuary, merge at the concentrated solution of paste and add in the thing that three medicated powder and three kinds of polysaccharide stir evenly more than the Cordyceps militaris (L.) Link. Rich in selenium etc., drying, crushing packing.
    6. unguentum preparation: promptly press the electuary method for making, produce concentrated solution and merge thing, and three medicated powder such as adding Cordyceps militaris (L.) Link. Rich in selenium and three kinds of polysaccharide and Mel, be concentrated into paste.
    7. powder preparation: press the method for making of electuary, concentrated solution merges thing and admixes three medicated powder such as Cordyceps militaris (L.) Link. Rich in selenium and three kinds of polysaccharide and proper honey, stirs evenly, drying, fragmentation pack.
    8. syrup: promptly extract each medicine by the electuary method for making, concentrated solution merges thing, adds polysaccharide, sugar or Mel, the sterilization fill.
    9. medicated wine: with Cordyceps militaris (L.) Link. Rich in selenium etc. all each medicine immerse after crushed in the grain wine base, 7-15 days after-filtration, medicinal residues repeat to soak filtration with the grain wine base with the identical time and are total to leaching three times, get filtrate, add sugar or Mel, dilute required wine degree, precipitate, leave standstill, must clarify wine liquid, filtration back packing.
    10. injection: the preparation method of pressing electuary is extracted concentrated solution and is merged thing, merges to add calcium hydroxide in the thing and regulate pH value to 8, after 24 hours, sucking filtration is removed precipitation, and filtrate is regulated pH value to 6 with sulphuric acid, and sucking filtration is removed precipitation, adding ethanol to solution, to contain alcohol amount be 85%, place more than 48 hours sucking filtration filtrate recovered alcohol, the concentrated solution remaining ethanol of rushing, to there not being the alcohol flavor, as go into 0.5% active carbon, heat half an hour, sucking filtration, filtrate for later use.Other gets distilled water and is heated to 60 ℃, adds 1% benzyl alcohol, make it dissolving after, in the impouring Chinese caterpilar fungus concentrated solution, stir, add and water recently distilled to capacity, fine straining, embedding, 100 ℃ of steam sterilizations that circulate, 30 minutes are promptly.
  4. Four. according to claim 1 described Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof, it is characterized in that:
    The Cordyceps militaris (L.) Link. Rich in selenium medicine preparation prescription that is used for tumor, cancer is:
    Cordyceps militaris (L.) Link. Rich in selenium 30--60 gram
    Morchella esculenta (L.) Pers 20--50 gram
    Gecko (foot of decaptitating) 10--20 gram
    Radix Astragali is eaten the 30--50 gram
    Hippocampus 5--15 gram
    Radix Ginseng 5--15 gram
    Radix Panacis Quinquefolii 5--15 gram
    Poria 20--30 gram
    Rhizoma Dioscoreae 20--30 gram
    Fructus Trichosanthis 10--30 gram
    Ganoderan 10--20 gram
    Grifolan 10--20 gram
    Krestin 10--20 gram
  5. Five. according to claim 1 described Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof, it is characterized in that:
    Cordyceps militaris (L.) Link. Rich in selenium is with Chinese herbal medicine, Chinese medicine, Chinese patent medicine, medical fungus and the extract thereof of the other kinds disease of treatment, and derivant is compatible, and production medicament preparation method is identical with the medicament preparation method that is used for tumor, cancer.
  6. Six. according to claim 1 described Cordyceps militaris (L.) Link. Rich in selenium medicine preparation and preparation method thereof, it is characterized in that:
    Cordyceps militaris (L.) Link. Rich in selenium can replace Cordyceps or add in compatibility or reuse Cordyceps militaris (L.) Link. Rich in selenium prescription again, dosage forms such as the pill of various disease conditions such as the swollen disease of production and processing one-tenth treatment, cancer, cardiovascular and cerebrovascular disease, renal system disease, hematopathy, liver, gallbladder systemic disease, spleen, stomach, lung, pancreas disease, viral disease, electuary, mixture, capsule, tablet, sugar coated tablet, injection, unguentum, powder, syrup, medicated wine make more remarkable treatment effect.
CN 95118390 1995-11-29 1995-11-29 Group of pharmaceutics made of selenium-rich northern cordyceps Pending CN1134838A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 95118390 CN1134838A (en) 1995-11-29 1995-11-29 Group of pharmaceutics made of selenium-rich northern cordyceps

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Application Number Priority Date Filing Date Title
CN 95118390 CN1134838A (en) 1995-11-29 1995-11-29 Group of pharmaceutics made of selenium-rich northern cordyceps

Publications (1)

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CN1134838A true CN1134838A (en) 1996-11-06

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101889707A (en) * 2010-07-16 2010-11-24 大庆市帅亿生物质技术有限公司 Cordyceps militaris oral liquid and preparation method thereof
CN102296014A (en) * 2011-07-26 2011-12-28 湖北圣峰药业有限公司 Preparation method for selenium cordyceps wine
CN101380346B (en) * 2008-10-10 2012-09-05 深圳市中科海外科技有限公司 Traditional Chinese composition for treating tumor and production method thereof
CN103271348A (en) * 2013-06-17 2013-09-04 崔学恒 Selenium-rich high-calcium health food
CN106038503A (en) * 2016-07-07 2016-10-26 孙备宽 Preparation method of pure cordyceps sinensis concentrated essence tablets
CN106418536A (en) * 2016-09-23 2017-02-22 河源市兴睿食品科技开发有限公司 Selenium-enriched extract and manufacture method thereof
CN106544213A (en) * 2016-10-25 2017-03-29 青海珠峰冬虫夏草工程技术研究有限公司 A kind of acid-adjusting method of cordyceps sinensis nutrient solution
CN108186921A (en) * 2018-02-08 2018-06-22 江西林丰药业有限公司 A kind of antitumor Chinese medicine composition containing selenium and preparation method thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101380346B (en) * 2008-10-10 2012-09-05 深圳市中科海外科技有限公司 Traditional Chinese composition for treating tumor and production method thereof
CN101889707A (en) * 2010-07-16 2010-11-24 大庆市帅亿生物质技术有限公司 Cordyceps militaris oral liquid and preparation method thereof
CN102296014A (en) * 2011-07-26 2011-12-28 湖北圣峰药业有限公司 Preparation method for selenium cordyceps wine
CN103271348A (en) * 2013-06-17 2013-09-04 崔学恒 Selenium-rich high-calcium health food
CN106038503A (en) * 2016-07-07 2016-10-26 孙备宽 Preparation method of pure cordyceps sinensis concentrated essence tablets
CN106418536A (en) * 2016-09-23 2017-02-22 河源市兴睿食品科技开发有限公司 Selenium-enriched extract and manufacture method thereof
CN106544213A (en) * 2016-10-25 2017-03-29 青海珠峰冬虫夏草工程技术研究有限公司 A kind of acid-adjusting method of cordyceps sinensis nutrient solution
CN108186921A (en) * 2018-02-08 2018-06-22 江西林丰药业有限公司 A kind of antitumor Chinese medicine composition containing selenium and preparation method thereof
CN108186921B (en) * 2018-02-08 2021-10-22 成都中医肿瘤研究院(普通合伙) An antitumor selenium-containing Chinese medicinal composition and its preparation method

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