CN113476514A

CN113476514A - Cannabis diol-containing anti-stress composition for cats and preparation method thereof

Info

Publication number: CN113476514A
Application number: CN202110923045.6A
Authority: CN
Inventors: 冯秀晶; 唐琦超; 尹柏双; 秦宏宇; 辛秀; 云巾宴; 沙万里; 韩馥新; 赵劲炎
Original assignee: Jilin Agricultural Science and Technology College
Current assignee: Jilin Agricultural Science and Technology College
Priority date: 2021-08-12
Filing date: 2021-08-12
Publication date: 2021-10-08

Abstract

The invention provides an anti-stress composition containing cannabidiol for cats and a preparation method thereof, belonging to the technical field of pet medicines. The composition comprises the following components in parts by weight: 10-40 parts of acanthopanax, 20-50 parts of green tangerine peel, 20-50 parts of wrinkled gianthyssop herb, 20-50 parts of poria cocos, 15-45 parts of honeysuckle, 15-45 parts of astragalus membranaceus, 10-40 parts of spina date seed, 10-40 parts of schisandra chinensis, 10-40 parts of angelica sinensis and 1-10 parts of cannabidiol. The composition of the invention fundamentally relieves/treats stress, has good anti-stress treatment effect and small side effect; the medicine composition is prepared into powder or granules and the like, and is convenient to take and easy to absorb.

Description

Cannabis diol-containing anti-stress composition for cats and preparation method thereof

Technical Field

The invention belongs to the technical field of pet medicines, and particularly relates to a cannabidiol-containing anti-stress composition for cats and a preparation method thereof.

Background

With the development of economy and the improvement of living standard of people, various pets such as cats, dogs and the like gradually enter thousands of households. The rapid growth of pet families has attracted extensive social attention, and pet health is more and more valued by pet families. Cats are habit animals, like to stay in their own comfort zones, and once unpredictable changes occur in life, they may get into stress and anxiety, causing a series of stress reactions, and if so, they will hide and refuse to eat for the whole day; the disease is caused if the disease is serious. The existing medicines for treating cat stress have the problems of poor curative effect or low safety and the like in different degrees, so that the development of an anti-stress composition with definite curative effect and good safety, which is suitable for cat stress, is urgently needed.

The stress is often caused by weak livestock, and is caused by liver dysfunction, spleen dysfunction, and dysfunction of the two viscera. The liver qi stagnation caused by liver qi loss can further cause qi, blood, body fluids, emotional activities, viscera function and yin-yang imbalance, especially abnormal emotional activities. The stagnation of qi activity and the failure of the liver to reach the target can damage spleen qi, and spleen deficiency can lead to dampness, damp stagnation in the spleen and disharmony between the liver and the spleen. Spleen qi deficiency can lead to insufficient qi and blood generation, so it is manifested as lassitude, emaciation, hair dryness, lassitude and weakness. In treatment, the liver and spleen should be soothed, and the principle is to dry dampness, strengthen spleen, sooth liver and regulate qi. According to the guidance of the theory of traditional Chinese medicine, the traditional Chinese medicine compound developed for the sick animals develops the anti-stress and liver-spleen regulating traditional Chinese medicine compound consisting of acanthopanax, green tangerine orange peel, wrinkled gianthyssop herb, Indian buead, honeysuckle flower, membranous milkvetch root, spina date seed, Chinese magnoliavine fruit and Chinese angelica according to the clinical symptoms of liver depression and spleen deficiency, spleen and stomach weakness, dyspepsia, diarrhea and the like from the aspects of 'drying dampness and strengthening spleen, soothing liver and regulating qi, conditioning gastrointestinal tract, promoting appetite, relieving stress' and the like.

Cannabidiol (CBD) is a pure natural ingredient extracted from the cannabis plant, has no psychoactive, is green and safe, and has no addiction. Research shows that the CBD has good effects on calming mood, resisting depression, epilepsy, insomnia and pain when being applied to pets. The pet can not generate side effect and addiction in the using process.

Disclosure of Invention

The invention aims to provide an anti-stress composition containing cannabidiol for cats and a preparation method thereof, the anti-stress composition contains anti-stress traditional Chinese medicine components besides the cannabidiol, and the development of the anti-stress composition for cats can effectively regulate the health condition of cats and has good conditioning function on anorexia or constipation, diarrhea, vomiting, blood pressure rise, depression, mania, urine disorder, excessive licking/scratching and the like caused by cat stress. Reducing the occurrence of various diseases caused by the stress problem of the cat, improving the life quality of the cat and prolonging the life of the cat.

In order to solve the technical problems, the invention adopts the technical scheme that:

the invention firstly provides an anti-stress traditional Chinese medicine composition containing cannabidiol for cats, which comprises the following components in parts by weight:

10-40 parts of acanthopanax, 20-50 parts of green tangerine peel, 20-50 parts of wrinkled gianthyssop herb, 20-50 parts of poria cocos, 15-45 parts of honeysuckle, 15-45 parts of astragalus membranaceus, 10-40 parts of spina date seed, 10-40 parts of schisandra chinensis, 10-40 parts of angelica sinensis and 1-10 parts of cannabidiol.

Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight:

15-35 parts of acanthopanax, 25-45 parts of green tangerine peel, 25-45 parts of wrinkled gianthyssop herb, 25-45 parts of poria cocos, 20-40 parts of honeysuckle, 20-40 parts of astragalus membranaceus, 15-35 parts of spina date seed, 15-35 parts of schisandra chinensis, 15-35 parts of angelica sinensis and 5-10 parts of cannabidiol;

30 parts of acanthopanax, 30 parts of green tangerine peel, 30 parts of wrinkled gianthyssop herb, 30 parts of tuckahoe, 30 parts of honeysuckle, 30 parts of astragalus, 30 parts of spina date seed, 30 parts of schisandra chinensis, 30 parts of angelica and 5 parts of cannabidiol.

Preferably, the traditional Chinese medicine composition is powder, granules or oral liquid.

The invention also provides a preparation method of the cannabidiol-containing anti-stress traditional Chinese medicine composition for cats, which comprises the following steps:

grinding radix Acanthopanacis Senticosi, pericarpium Citri Reticulatae viride, herba Agastaches, Poria, flos Lonicerae, radix astragali, semen Ziziphi Spinosae, fructus Schisandrae chinensis and radix Angelicae sinensis, sieving, and mixing with cannabidiol to obtain the anti-stress traditional Chinese medicinal composition for cat containing cannabidiol.

decocting acanthopanax, green tangerine peel, wrinkled gianthyssop herb, Indian buead, honeysuckle, astragalus, spina date seed, Chinese magnoliavine fruit and Chinese angelica with water according to a ratio, filtering decoction, concentrating obtained traditional Chinese medicine extracting solution to form traditional Chinese medicine clear paste, drying the clear paste, smashing to obtain fine dry powder for later use;

② adding cannabidiol powder into the fine dry powder, and mixing uniformly to obtain the stress-resistant traditional Chinese medicine composition containing cannabidiol for cats.

Preferably, the decocting in the step (i) is to decoct the traditional Chinese medicine with water for 2 times; wherein 10 times of water by weight is added for the first time, and after 2 hours of decoction, the decoction is collected; adding 8 times of water by weight for the second time, decocting for 1.5 hours, and collecting decoction; mixing the two decoctions, filtering, concentrating the filtrate to obtain Chinese medicinal fluid extract with relative density of 1.15-1.20 at 50 deg.C, oven drying, and crushing to obtain dry powder.

After the traditional Chinese medicine composition is obtained according to the invention, various auxiliary materials or additives are added according to different dosage form requirements, and clinically applicable oral preparations including powder, granules or oral liquid and the like can be prepared.

The traditional Chinese medicine composition provided by the invention comprises the following components in terms of medicinal properties and effects:

acanthopanax root: is dried root, rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) harms of Araliaceae. Warm in nature, pungent and slightly bitter in flavor. It enters spleen, kidney and heart meridians. Replenishing qi to invigorate the spleen, tonifying the kidney and soothing the nerves.

Green tangerine peel: is pericarp of dry young fruit or immature fruit of Citrus reticulata Blanco of Rutaceae and its cultivar. Bitter and pungent in flavor and warm in nature. It enters liver, gallbladder and stomach meridians. Has the effects of soothing liver, breaking qi, removing food retention and resolving stagnation.

Agastache rugosus: is dried aerial parts of Agastache rugosa belonging to family Labiatae. Pungent in flavor and slightly warm in nature. It enters spleen, stomach and lung meridians. Fragrant, resolving dampness, regulating the middle warmer, arresting vomiting, dispersing exterior pathogen, and promoting qi circulation.

Tuckahoe, poria cocos: is dried sclerotium of Wolf of Poria cocos (Schw.) Cos (belonging to family Polyporaceae). Sweet and bland in flavor and mild in nature. It enters heart, lung, spleen and kidney meridians. Excrete dampness and induce diuresis, invigorate spleen and calm heart.

Honeysuckle flower: is dried bud or flower with initial blossom of Lonicera japonica Thunb, Lonicera hypoglauca Miq, Lonicera confusa or Lonicera dasystyla of Caprifoliaceae. Sweet taste and cold nature; it enters lung, heart and stomach meridians. Clearing away heat and toxic material, dissipating heat and dispelling wind.

Astragalus root: is prepared by sun drying root of Astragalus mongholicus (Fisch.) bge of Leguminosae. Sweet in flavor and slightly warm in nature; it enters spleen and lung meridians. Tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, and promote granulation.

Wild jujube seed: named as semen Ziziphi Spinosae, and semen Ziziphi Spinosae. Removing pulp and core shell from mature fruit of Ziziphus jujube Mill of Rhamnaceae, collecting seed, and sun drying; sweet and sour in flavor and neutral in nature. It enters liver, gallbladder and heart meridians. It has effects in nourishing heart and liver, tranquilizing mind, and arresting sweating. Nourish liver, calm heart, induce tranquilization, arrest sweating.

Schisandra chinensis: is dried mature fruit of Schisandra chinensis of Magnoliaceae. Sour and sweet in flavor and warm in nature. It enters lung, heart and kidney meridians. Astringe lung and intestines, promote the production of body fluid to check sweating, strengthen kidney and check nocturnal emission.

Chinese angelica: sweet, pungent and warm in nature; it enters liver, heart and spleen meridians. Has the functions of enriching the blood; promoting blood circulation; regulating menstruation and relieving pain; the effects of moistening dryness and smoothing intestine.

The invention has the advantages of

The invention is based on the theory of five organs, namely liver, heart, spleen, lung and kidney; five spirits are spirit, soul, mind and will; five spirits belong to five zang organs, namely heart storing spirit, lung storing soul, liver storing spirit, spleen storing spirit and kidney storing spirit, and are called five spirit organs. Essential qi stored in the five zang organs is the material basis for the generation of the five gods. The five zang organs are full of essence and qi, so five gods are stored and kept in a house, and the spirit is clear, the thinking is quick, the reaction is sensitive, the movement is flexible, the sleep is good, and the mind is firm and flexible. According to the theory, acanthopanax, green tangerine peel, wrinkled gianthyssop, tuckahoe, honeysuckle, astragalus, spina date seed, schisandra, angelica and the like are combined into a traditional Chinese medicine formula. Meanwhile, cannabidiol is added into the formula, and the release of glucocorticoid and corticotropin and the like is reduced by inhibiting over-activity of HPA axis; and a plurality of traditional Chinese medicines for eliminating dampness, strengthening spleen, soothing liver and regulating qi are combined to form a traditional Chinese medicine compound, so that anxiety of cats can be effectively relieved, the anxiety can be relaxed, and the stress reaction of the cats can be relieved.

The traditional Chinese medicine composition has the effects of tonifying spleen and calming heart, soothing liver and breaking qi, tonifying qi and consolidating exterior, clearing heart and relieving depression, tonifying kidney and soothing nerves, clearing heat and removing toxicity and clearing damp, and has a definite curative effect on stress reaction of cats. The traditional Chinese medicine composition is non-toxic, harmless, safe and reliable, has no adverse reaction after being used, and is safe for clinical use.

Detailed Description

The present invention will be described in further detail with reference to specific examples, wherein cannabidiol (Shanghai Hotan Biotechnology Co., Ltd., E-3691) and various raw materials and Chinese herbs are commercially available, and the specifications thereof meet the national pharmaceutical standards.

EXAMPLE 1 preparation of powders

Weighing the following components in parts by weight: 30g of acanthopanax, 30g of green tangerine peel, 30g of wrinkled gianthyssop herb, 30g of tuckahoe, 30g of honeysuckle, 30g of astragalus, 30g of spina date seed, 30g of schisandra and 30g of angelica; mixing the above Chinese medicinal materials, grinding into powder, and sieving. And mixing with 5g of cannabidiol to obtain the finished product.

EXAMPLE 2 preparation of powders

Weighing the following components in parts by weight: 10g of acanthopanax, 20g of green tangerine peel, 20g of wrinkled gianthyssop herb, 20g of tuckahoe, 15g of honeysuckle, 15g of astragalus, 10g of spina date seed, 10g of schisandra and 10g of angelica; mixing the above Chinese medicinal materials, grinding into powder, and sieving. And mixing with 5g of cannabidiol to obtain the finished product.

EXAMPLE 3 preparation of powders

Weighing the following components in parts by weight: 40g of acanthopanax, 50g of green tangerine peel, 50g of wrinkled gianthyssop herb, 50g of tuckahoe, 45g of honeysuckle, 45g of astragalus, 40g of spina date seed, 40g of schisandra and 40g of angelica; mixing the above Chinese medicinal materials, grinding into powder, and sieving. And mixing with 10g of cannabidiol to obtain the finished product.

EXAMPLE 4 preparation of granules

(1) Weighing the following raw material medicines by weight: 15g of acanthopanax, 25g of green tangerine peel, 25g of wrinkled gianthyssop herb, 25g of tuckahoe, 20g of honeysuckle, 20g of astragalus, 15g of spina date seed, 15g of schisandra chinensis and 15g of angelica;

(2) decocting the raw materials in water for 2 times, adding 10 times of water for the first time, decocting for 2 hr, and filtering to obtain Chinese medicinal filtrate; adding 8 times of water into the Chinese medicinal residue, decocting for 1.5 hr, and filtering to obtain Chinese medicinal filtrate; mixing the two Chinese medicinal filtrates, and filtering;

(3) concentrating the filtrate obtained in the step (2) to an extract with a relative density of 1.15-1.20 when measured at 50 ℃, and performing spray drying to obtain dry extract powder;

(4) adding cannabidiol 5g into the dry extract powder, adding starch, mixing, dry-pressing into granules, adding appropriate amount of sucrose and dextrin, mixing, granulating, and drying to obtain the final product.

EXAMPLE 5 preparation of granules

(1) Weighing the following raw material medicines by weight: 35g of acanthopanax, 45g of green tangerine peel, 45g of wrinkled gianthyssop herb, 25g of poria cocos, 40g of honeysuckle, 40g of astragalus membranaceus, 35g of spina date seed, 35g of schisandra chinensis and 35g of angelica sinensis;

(2) decocting the raw materials in water for 2 times, adding 10 times of water for the first time, decocting for 2 hr, and filtering to obtain Chinese medicinal filtrate; adding 8 times of water into the traditional Chinese medicine residues, decocting for 1 hour, and filtering to obtain traditional Chinese medicine filtrate; mixing the two Chinese medicinal filtrates, and filtering;

(4) adding cannabidiol 10g into the dry extract powder, adding starch, mixing, dry-pressing into granules, adding appropriate amount of sucrose and dextrin, mixing, granulating, and drying to obtain the final product.

Test example 1 Effect study of a cannabidiol-containing composition having an anti-Cat stress Effect

1. Test method

1.1 anti-Cat stress drug composition and feeding

30g of acanthopanax, 30g of green tangerine peel, 30g of wrinkled gianthyssop herb, 30g of tuckahoe, 30g of honeysuckle, 30g of astragalus, 30g of spina date seed, 30g of schisandra and 30g of angelica. Mixing, grinding into powder, and sieving with No. 2 sieve (type specified in national pharmacopoeia) to obtain powder A.

Powder prepared in example 1: 30g of acanthopanax, 30g of green tangerine peel, 30g of wrinkled gianthyssop herb, 30g of tuckahoe, 30g of honeysuckle, 30g of astragalus, 30g of spina date seed, 30g of schisandra and 30g of angelica; mixing the Chinese medicinal materials, grinding into powder, and sieving with No. 2 sieve (type specified in national pharmacopoeia). And mixing with cannabidiol 5g to obtain powder B.

1.2 grouping and testing indexes of test animals

30 pandas received from each pet hospital were randomly divided into three groups of 10 cats, experiment a, experiment B and control. Three groups are fed with the same number of cat foods every day, the cats in the experiment group A take 4g of powder A every day (not containing cannabidiol, divided into two parts, and stirred with flavoring agent in cat foods for feeding), the cats in the experiment group B take 4g of powder B every day (containing cannabidiol, divided into two parts, and stirred with flavoring agent in cat foods for feeding), the control group is not treated, and the normal cat foods (French Royal cat foods K36) are fed, and each group is fed for 30 days. And observing and recording the sleep condition, the mood condition, the ingestion condition, the weight and the illness occurrence rate of the three groups of cats.

2. Test results

2.1 Effect observation of anti-stress composition containing cannabidiol on application to cats

As shown in table 1, compared with the control group, the group a had good sleep quality, mild mood, occasional mania, good eating status, occasional food retention, a higher weight gain rate than the control group, and a lower morbidity than the control group; experiment group B has good sleep quality, mild emotion, good eating state, no food left, much higher weight growth rate than that of the control group, and much lower morbidity rate than that of the control group. And experimental data show that the effect of the traditional Chinese medicine compound added with the cannabidiol is obviously better than that of the traditional Chinese medicine compound without the cannabidiol, so that the anti-stress composition for the cats containing the cannabidiol prepared by the invention has good effect, improves the sleeping quality of the wandering cats, improves the weight growth rate, reduces the illness rate and the like.

TABLE 1 sleep, mood, food intake, and morbidity results for each group of cats

Test example 2 anti-stress Effect study of a cannabidiol-containing composition having an anti-cat-stress Effect

1. Test method

1.1 anti-Cat stress drug composition and feeding

Powder prepared in example 1: 30g of acanthopanax, 30g of green tangerine peel, 30g of wrinkled gianthyssop herb, 30g of tuckahoe, 30g of honeysuckle, 30g of astragalus, 30g of spina date seed, 30g of schisandra and 30g of angelica; mixing the Chinese medicinal materials, grinding into powder, and sieving with No. 2 sieve (type specified in national pharmacopoeia). And mixing with cannabidiol 10g to obtain powder B.

1.2 grouping and testing indexes of test animals

30 cats with stress conditions collected from pet hospitals were randomly divided into three groups of 10 cats, experiment a, experiment B and control. Three groups were fed with the same number of cat foods per day, the cats in group a were fed with 4g of powder a per day (no cannabidiol, divided into two portions, mixed with a flavoring agent and fed in cat foods), the cats in group B were fed with 4g of powder B per day (containing cannabidiol, divided into two portions, mixed with a flavoring agent and fed in cat foods), the control group was not treated and fed with normal cat foods (french queen cat foods K36), and each group was fed for 7 days. The behavior change performance of the cat in the stress is detailed in table 2, the cat owners are visited again every day, and the stress conditions of three groups of cats are observed and recorded.

TABLE 2 determination of various groups of behavioral change indicators

1.3 blood sample Collection and detection

Collecting 3mL of saphenous vein blood on days 1, 3, 5 and 7 after stress, standing for 30min, centrifuging at 3000rpm for 10min, collecting supernatant, and storing at-80 deg.C. Serum alanine Aminotransferase (ALT), aspartate Aminotransferase (AST), urea nitrogen (BUN), Creatinine (CREA), Cortisol (CORT), and adrenocorticotropic hormone (ACTH) levels are determined.

1.4 statistical analysis

All data were processed using SPSS18.0 statistical data analysis software and the values were reported as "mean. + -. standard deviation"

Formally, the data was subjected to one-way anova with P<0.05 had significant differences.

2 results of the test

2.1 results of the behavioural test

By counting the behavioral detection indexes such as destructiveness (scratching/digging/scratching), mania (calling/disorganizing running, fleeing), excretion (urination/defecation) and alertness, the test result shows that: compared with the A group and the B group of the experiment, the stress behavior of the cat is more obvious (P is less than 0.05), and compared with the A group and the B group of the experiment, the obvious difference is not existed (P is more than 0.05), which indicates that the compound traditional Chinese medicine containing cannabidiol has obvious inhibition effect on the cat stress and plays a protective role. The specific results are shown in Table 3.

Table 3 behavioral changes (min, n ═ 10)

Group of	Post-stress 1d	Post-stress 3d	Poststress 5d	Poststress 7d
					Control group	1.22±1.00^A	1.19±0.92^A	1.07±0.81^A	0.93±0.72^A
Experiment group A	0.75±0.51^B	0.61±0.54^B	0.57±0.49^B	0.51±0.55^B
					Experiment group B	0.31±0.38^C	0.26±0.46^C	0.27±0.42^C	0.22±0.44^C

Note: compared among groups (the same columns are compared with each other), the difference of the shoulder marks represents significant difference (P is less than 0.05), and the difference of the shoulder marks represents no significant difference (P is more than 0.05).

2.2 Cortisol assay results

The detection result of the cortisol content shows that: compared with the data in the groups, the control group is compared with the experiment group A and the experiment group B, the serum cortisol content is obviously reduced (P is less than 0.05) at 1, 3, 5 and 7d after stress, which shows that the compound traditional Chinese medicine containing cannabidiol has obvious inhibition effect on the increase of cortisol caused by cat stress, the effect is obviously better than that of the compound traditional Chinese medicine without cannabidiol, and the compound traditional Chinese medicine has more obvious anti-stress effect. The specific results are shown in Table 4.

TABLE 4 Cortisol content test results (ng/mL, n 10)

Group of	Post-stress 1d	Post-stress 3d	Poststress 5d	Poststress 7d
					Control group	112.35±12.27^A	106.56±10.53^A	101.55±11.84^A	91.23±12.35^A
Experiment group A	88.92±9.75^B	81.43±8.73^B	77.72±8.36^B	73.67±9.65^B
					Experiment group B	78.73±9.64^C	70.73±8.89^C	66.63±7.96^C	64.12±8.27^C

Note: the statistical markers are as in Table 3.

2.3 corticotropin assay results

The results of the test of the content of the adrenocortical hormone show that: compared with the data in the groups, the comparison of the control group with the experiment group A and the experiment group B shows that the adrenal cortical hormone in the serum is obviously reduced (P is less than 0.05) at the 1 st, 3 rd, 5 th and 7 th days after stress, which indicates that the compound traditional Chinese medicine containing cannabidiol has obvious inhibition effect on the increase of the adrenal cortical hormone caused by the stress of cats, and the effect is obviously better than that of the compound traditional Chinese medicine without cannabidiol, thus playing a more obvious anti-stress role. The specific results are shown in Table 5.

TABLE 5 test results of corticotropin content (ng/L, n ═ 10) for each group

Group of	Post-stress 1d	Post-stress 3d	Poststress 5d	Poststress 7d
					Control group	6.32±0.87^A	6.08±0.76^A	5.48±0.69^A	5.87±0.79^A
Experiment group A	4.84±0.52^B	4.73±0.67^B	4.53±0.59^B	4.69±0.52^A
					Experiment group B	3.49±0.52^C	3.46±0.59^C	3.37±0.51^C	3.26±0.61^C

Note: the statistical markers are as in Table 3.

2.4 liver and kidney function test results

The detection results of liver and kidney functions of cats in each group show that: data comparison among the groups is carried out, and ALT, AST, BUN and CREA do not have significant difference (P is more than 0.05) among the groups, which indicates that the anti-stress composition containing cannabidiol has no obvious toxic or side effect on cats and no adverse effect on liver and kidney functions. The specific results are shown in Table 6.

TABLE 6 liver and renal function test results of each group: (

n＝10)

Note: the statistical markers are as in Table 3.

2.5 Observation of anti-stress Effect

Experiments A and B have good treatment effects on the stress state of cats, effectively relieve the anxiety of cats, are willing to play with owners, improve anorexia, improve temperament, escape, and improve excessive licking, and the effect of experiment B is obviously superior to that of experiment A, which shows that the compound traditional Chinese medicine containing cannabidiol has good improvement/treatment effects on the stress state of cats. The specific results are shown in Table 7.

TABLE 7 recovery of cats following stress for 7d

Claims

1. The anti-stress traditional Chinese medicine composition containing cannabidiol for cats is characterized by comprising the following components in parts by weight:

2. The cannabidiol-containing anti-stress traditional Chinese medicine composition for cats according to claim 1, which comprises the following components in parts by weight:

15-35 parts of acanthopanax, 25-45 parts of green tangerine peel, 25-45 parts of wrinkled gianthyssop herb, 25-45 parts of poria cocos, 20-40 parts of honeysuckle, 20-40 parts of astragalus membranaceus, 15-35 parts of spina date seed, 15-35 parts of schisandra chinensis, 15-35 parts of angelica sinensis and 5-10 parts of cannabidiol.

3. The cannabidiol-containing anti-stress traditional Chinese medicine composition for cats according to claim 1, which comprises the following components in parts by weight:

4. The anti-stress traditional Chinese medicine composition containing cannabidiol for cats according to claim 1, wherein the traditional Chinese medicine composition is powder, granules or oral liquid.

5. The method for preparing the anti-stress traditional Chinese medicine composition containing cannabidiol for cats according to claim 1, which comprises:

6. The method for preparing the anti-stress traditional Chinese medicine composition containing cannabidiol for cats according to claim 1, which comprises:

7. The method for preparing the anti-stress traditional Chinese medicine composition containing cannabidiol for cats according to claim 6, wherein the decocting in the step (i) is to decoct the traditional Chinese medicine with water for 2 times; wherein 10 times of water by weight is added for the first time, and after 2 hours of decoction, the decoction is collected; adding 8 times of water by weight for the second time, decocting for 1.5 hours, and collecting decoction; mixing the two decoctions, filtering, concentrating the filtrate to obtain Chinese medicinal fluid extract with relative density of 1.15-1.20 at 50 deg.C, oven drying, and crushing to obtain dry powder.