CN113474359B - 对cd137和gpc3特异性的新型融合蛋白 - Google Patents

对cd137和gpc3特异性的新型融合蛋白 Download PDF

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CN113474359B
CN113474359B CN202080016379.9A CN202080016379A CN113474359B CN 113474359 B CN113474359 B CN 113474359B CN 202080016379 A CN202080016379 A CN 202080016379A CN 113474359 B CN113474359 B CN 113474359B
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fusion protein
gpc3
leu
ser
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CN113474359A (zh
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R·S·贝莱巴
B·博森梅尔
T·乔奎因
J·佩珀-加布里埃尔
E-M·汉斯鲍尔
C·施洛瑟
S·奥维尔
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Pieris Pharmaceuticals GmbH
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    • A61K38/00—Medicinal preparations containing peptides
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080016379.9A 2019-02-26 2020-02-25 对cd137和gpc3特异性的新型融合蛋白 Active CN113474359B (zh)

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EP19000100.8 2019-02-26
EP19000100 2019-02-26
PCT/EP2020/054821 WO2020173897A1 (en) 2019-02-26 2020-02-25 Novel fusion proteins specific for cd137 and gpc3

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CN113474359A CN113474359A (zh) 2021-10-01
CN113474359B true CN113474359B (zh) 2025-02-21

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KR (1) KR20210133254A (enExample)
CN (1) CN113474359B (enExample)
AU (1) AU2020229436B2 (enExample)
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CA (1) CA3124441A1 (enExample)
IL (1) IL284687B2 (enExample)
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MX2023011775A (es) * 2021-04-05 2023-11-29 Cytovia Therapeutics Llc Anticuerpos biespecificos dirigidos a nkp46 y gpc3 y metodos de uso de los mismos.
IL307923A (en) * 2021-04-23 2023-12-01 Shanghai Henlius Biotech Inc Anti-gpc3 antibodies, multispecific antibodies and methods of use
WO2022242682A1 (en) * 2021-05-21 2022-11-24 Beigene, Ltd. Anti-gpc3 and anti-cd137 multispecific antibodies and methods of use
EP4386007A1 (en) * 2021-08-12 2024-06-19 Shanghai TTM-BIO Technology Co., Ltd. Bispecific recombinant protein and use thereof
CN115960242B (zh) * 2021-09-09 2023-10-17 广东东阳光药业股份有限公司 抗癌结合分子及其应用
CN113956344A (zh) * 2021-10-14 2022-01-21 江南大学 一种新型治疗肝癌的fgf类似物及其应用
CN113912699A (zh) * 2021-10-14 2022-01-11 江南大学 一种新型治疗乳腺癌的fgf类似物及其应用
CN116640224A (zh) * 2022-02-16 2023-08-25 北京免疫方舟医药科技有限公司 Cd137抗体和cd40l的融合蛋白及其应用
TWI864640B (zh) * 2022-03-18 2024-12-01 大陸商映恩生物製藥（蘇州）有限公司 Gpc3抗體藥物偶聯物及其用途
WO2023180523A1 (en) 2022-03-24 2023-09-28 Pieris Pharmaceuticals Gmbh Process for purifying fusion proteins
CN119613552B (zh) * 2024-07-23 2025-11-28 艾可泰科(浙江)控股有限公司 一组抗人gpc3纳米抗体突变体及嵌合抗原受体和应用

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JP7476219B2 (ja) 2024-04-30
SG11202106353VA (en) 2021-07-29
BR112021016829A2 (pt) 2021-10-19
US12486330B2 (en) 2025-12-02
KR20210133254A (ko) 2021-11-05
EP3931209A1 (en) 2022-01-05
JP2022523524A (ja) 2022-04-25
CN113474359A (zh) 2021-10-01
MX2021010039A (es) 2021-09-21
US20220153864A1 (en) 2022-05-19
AU2020229436A1 (en) 2021-07-01
MA55069A (fr) 2022-01-05
WO2020173897A1 (en) 2020-09-03
AU2020229436B2 (en) 2024-12-19
IL284687A (en) 2021-08-31
IL284687B2 (en) 2025-11-01
CA3124441A1 (en) 2020-09-03
IL284687B1 (en) 2025-07-01

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