CN113456514A - Scalp care composition containing hyaluronic acid and preparation method and application thereof - Google Patents
Scalp care composition containing hyaluronic acid and preparation method and application thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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Abstract
The invention discloses a scalp care composition containing hyaluronic acid, a preparation method and application thereof. The invention solves the problem that the cationic surfactant is easy to precipitate when being added into a non-surface active system when coexisting with hyaluronic acid and tetrahydro-methyl pyrimidine carboxylic acid, ensures that the composition can be used for the non-surface active system, is beneficial to being added into non-surface active systems such as essence and the like, and enlarges the application range of the composition. Meanwhile, the invention can obviously improve the adhesion of cations on the scalp or the hair, thereby effectively increasing the adsorbability of each component in the composition to the skin or the hair, improving the retention time of the product on the scalp and the hair, being beneficial to the absorption and utilization of the composition, and further being capable of better increasing the glossiness of the hair, repairing the damage of the scalp and the hair root and reducing the damage of environmental pollution to the scalp.
Description
Technical Field
The invention relates to a scalp care composition containing hyaluronic acid, a preparation method and application thereof, and belongs to the technical fields of biological medicines and cosmetics.
Background
There are many kinds of facial skin care products on the market, but the maintenance type products for the scalp are not many, the scalp is exposed to the environment every day, and the scalp problems are more and more along with the aggravation of pollution, so that the development of a product capable of being used in the scalp is more important for protecting the scalp.
Hyaluronic acid, also known as hyaluronic acid, is a high-molecular polysaccharide naturally present in the intercellular spaces of human tissues, is formed of alternating units of D-glucuronic acid and N-acetylglucosamine in a linear chain, is widely used in the fields of medicines, skin care products, foods and the like, and has high safety. The hyaluronic acid molecule is in a rigid spiral column shape in space, strong water absorption is generated on the inner side of the column due to the existence of a large number of hydroxyl groups, and on the other hand, a hydrophobic region is formed on a hyaluronic acid molecular chain due to the continuous directional arrangement of the hydroxyl groups, so that the hyaluronic acid can form a three-dimensional network structure. Hyaluronic acid HAs a variety of different molecular weights, and HA of each molecular weight HAs different efficacy and performance. At present, hyaluronic acid also has good application in hair washing and protecting products. However, hyaluronic acid has strong water solubility, and the surface of skin and hair is generally negatively charged, and hyaluronic acid is also generally negatively charged, so that hyaluronic acid has poor adsorbability on skin or hair, and thus cannot be well acted on skin or hair.
In order to solve this problem, the most commonly used method at present is to modify hyaluronic acid with cations, and the hyaluronic acid is chemically modified by a cationic polymer to be charged with cations, so as to increase the adhesion on skin and hair, and to perform the function better. For example, CN200680044541.8 and CN2088001002.7 adopt chemical modification to cationize hyaluronic acid, but these methods are complicated in process and high in cost.
Hyaluronic acid can also be increased in association with living tissue (skin) by mixing or complexing hyaluronic acid with a cationic polymerSkin care productsOr hair), as disclosed in patent CN105853254A, at least one cationic polymer and at least one hyaluronic acid with molecular weight are mixed and subjected to complexation, and the obtained product can stably take on a liquid state through the control of temperature, pH and the like, which simplifies the preparation process and saves cost, however, such compositions are only suitable for surfactant systems, and when used in non-surfactant systems, a stable and uniform system cannot be formed due to the fact that no surfactant is dispersed, thereby precipitating or generating precipitates.
Disclosure of Invention
In order to solve the problems, the invention provides a scalp care composition containing hyaluronic acid, in particular to a scalp care composition suitable for a non-superficial living system, the composition is prepared by compounding a cationic surfactant, anionic hyaluronic acid and salt thereof and tetrahydro-methyl pyrimidine carboxylic acid, the components are matched with each other, a critical flocculation state can be formed in the non-superficial living system, the stability is good, and the obtained composition also has the effects of caring scalp and repairing skin barrier, and can well improve symptoms such as scalp pruritus, alopecia and the like.
The specific technical scheme of the invention is as follows:
a scalp care composition containing hyaluronic acid comprises hyaluronic acid and its salt, cationic surfactant and tetrahydro-methyl pyrimidine carboxylic acid.
Further, the hyaluronic acid and the salt thereof are a mixture of high molecular hyaluronic acid and the salt thereof and low molecular hyaluronic acid and the salt thereof, or a mixture of high molecular hyaluronic acid and the salt thereof, low molecular hyaluronic acid and the salt thereof, and hydrolyzed hyaluronic acid and the salt thereof. When two combination modes of hyaluronic acid and hyaluronic acid salt are selected, the composition can achieve good stability.
The invention selects cationic surfactant, tetrahydro-methyl pyrimidine carboxylic acid, hyaluronic acid and salt thereof as effective components. In the research, the cationic surfactant contains cations, hyaluronic acid and salts thereof and tetrahydro-methyl pyrimidine carboxylic acid carry anions, when hyaluronic acid and salts thereof and the cationic surfactant coexist in a non-surface active system such as water, precipitation is formed immediately, the appearance and the stability of the product are influenced, and the application of the components in the non-surface active system is also prevented. However, when the three components are compounded, the composition obtained by compounding the cationic surfactant, the tetrahydromethyl pyrimidine carboxylic acid, the hyaluronic acid and the salt thereof can form a critical flocculation state in a non-surface active system, and does not generate precipitates. In addition, the adhesion of hyaluronic acid and its salt, and tetrahydro-methyl pyrimidine carboxylic acid on hair or scalp are poor, when the cationic surfactant exists, the cationic content of the system is increased, the adhesion of each component in the composition on scalp and hair is increased, the retention time of the composition on scalp and hair is increased, and the functions of each component can be better played.
Further, the high molecular hyaluronic acid and the salt thereof refer to high molecular hyaluronic acid, high molecular hyaluronate, or a combination thereof. The molecular weight of the high molecular hyaluronic acid and the salt thereof is 1000-1800 kDa. The mass percentage of the polymer hyaluronic acid and the salt thereof in the scalp care composition is 0.01 to 10%, preferably 0.01 to 5%, and more preferably 0.5 to 5%. When the preferable content is selected, the scalp care effect is more excellent.
Further, the low molecular hyaluronic acid and the salt thereof refer to low molecular hyaluronic acid, low molecular hyaluronate, or a combination thereof. The molecular weight of the low molecular hyaluronic acid and the salt thereof is 30kDa-100 kDa. The mass percentage of the low molecular weight hyaluronic acid and the salt thereof in the scalp care composition is 0.5-10%, preferably 0.5-5%. When the preferable content is selected, the scalp care effect is more excellent.
Further, the hydrolyzed hyaluronic acid and salts thereof refer to hydrolyzed molecular hyaluronic acid, hydrolyzed molecular hyaluronate, or a combination thereof. The molecular weight of the hydrolyzed hyaluronic acid and the salt thereof is 1kDa-10 kDa. The mass percentage of the hydrolyzed hyaluronic acid and the salt thereof in the scalp care composition is 0 to 10%, preferably 0.05 to 10%, and more preferably 0.1 to 2%. When the preferable content is selected, the scalp care effect is more excellent.
Further, the salts of the high molecular hyaluronic acid, the low molecular hyaluronic acid and the hydrolyzed hyaluronic acid are sodium salts, potassium salts, calcium salts or zinc salts of the high molecular hyaluronic acid, the low molecular hyaluronic acid and the hydrolyzed hyaluronic acid.
Further, the cationic surfactant means that the hydrophilic group linked to the lipophilic group is a surfactant having a cation. Cationic surfactants are widely used in hair products, and are mainly used for conditioning hair, improving the combing property of hair, increasing the softness of hair and eliminating static electricity. The cationic surfactant may be various types of cationic surfactants reported in the art, and may be, for example, one or both of cationic guar gum and polyquaternium. The cationic guar gum is guar gum hydroxypropyl trimethyl ammonium chloride, and the polyquaternary ammonium salt can be one or two of polyquaternary ammonium salt-7 and polyquaternary ammonium salt-10.
Further, the mass percent of the cationic surfactant is 0.05-5%, preferably 0.1-2%.
Furthermore, the systematic name of the tetrahydromethylpyrimidine carboxylic acid, namely the ectoine, is 2-methyl-1, 4,5, 6-tetrahydropyrimidine-4-carboxylic acid, and the tetrahydromethylpyrimidine carboxylic acid is not only an important osmotic pressure compensation solute, but also has good protection effect on cells and biological macromolecules (biological membranes, proteins, enzymes and nucleic acids) under the stimulation of adverse environments such as high temperature, high salt, freezing, drying, radiation and the like. In the composition system, the adhesion of the tetrahydro-methyl pyrimidine carboxylic acid and the hyaluronic acid and the salt thereof of the invention on hair and scalp is increased, and the tetrahydro-methyl pyrimidine carboxylic acid and the hyaluronic acid and the salt thereof of the invention can stay on scalp hair for a longer time.
Further, the weight percentage of the tetrahydromethylpyrimidine carboxylic acid is 0.1 to 5%, preferably 0.1 to 3%, more preferably 0.1 to 1%, and still more preferably 0.5 to 1%.
Further, the scalp care composition further comprises a preservative, a polyhydric alcohol and water. The preservative may be selected from phenoxyethanol, benzoic acid or potassium sorbate. The polyol may be selected from propylene glycol, glycerol, butylene glycol or pentylene glycol.
Further, the preservative is 0.1-2% by mass, preferably 0.1-1% by mass.
Further, the mass percent of the polyhydric alcohol is 1-5%, preferably 2-5%.
Further, the scalp care composition described above contains water to make up 100% in addition to other components.
Furthermore, the preparation method of the scalp care composition containing hyaluronic acid is simple, and the method can adopt the following steps: mixing the cationic surfactant with water, stirring until the cationic surfactant and the water are completely dissolved, then sequentially adding hyaluronic acid and salt thereof and tetrahydro-methylpyrimidine carboxylic acid into the solution, and uniformly stirring to obtain the hyaluronic acid.
Furthermore, the preparation method comprises the following steps: mixing the cationic surfactant with water, stirring to dissolve completely, sequentially adding high molecular hyaluronic acid and its salt, low molecular hyaluronic acid and its salt, hydrolyzed hyaluronic acid and its salt (if any), and tetrahydro-methylpyrimidine carboxylic acid, and stirring.
Further, when the composition also contains a preservative and a polyhydric alcohol, the preparation method comprises the following steps: mixing the cationic surfactant with water, stirring to completely dissolve, adding antiseptic and polyalcohol into the solution, stirring, sequentially adding high molecular hyaluronic acid and its salt, low molecular hyaluronic acid and its salt, hydrolyzed hyaluronic acid and its salt (if any) and tetrahydro-methyl pyrimidine carboxylic acid, and stirring.
The scalp care composition containing hyaluronic acid well solves the problem that when a cationic surfactant coexists with hyaluronic acid and tetrahydro-methyl pyrimidine carboxylic acid, the cationic surfactant is easily precipitated when added into a non-surfactant system, can be used in the non-surfactant system, and is more suitable for hair care products of the non-surfactant system; meanwhile, the adhesion of cations on the scalp or the hair can be obviously improved, the adhesion of hyaluronic acid and tetrahydro-methyl pyrimidine carboxylic acid on the scalp or the hair can be improved, so that the adsorbability of the composition on the skin or the hair can be effectively improved, the retention time of the composition on the scalp and the hair can be prolonged, the scalp-care shampoo has good effects of nourishing the scalp, improving deep water environment of the scalp and repairing damaged scalp barriers, and has good application prospects. Based on the excellent performance and effect, the invention also provides the application of the scalp care composition containing the hyaluronic acid in hair products.
Further, the invention also provides a hair product which comprises the scalp care composition containing the hyaluronic acid.
Furthermore, the weight percentage of the scalp care composition containing the hyaluronic acid in the preparation of the hair product is 1-10%.
The invention has the following beneficial effects:
1. according to the invention, the tetrahydro-methyl pyrimidine carboxylic acid, the hyaluronic acid and the salt thereof, and the cationic surfactant are compounded, and the tetrahydro-methyl pyrimidine carboxylic acid, the hyaluronic acid and the salt thereof can form a critical flocculation state in a non-surface active system, so that the problem that the cationic surfactant, the hyaluronic acid and the tetrahydro-methyl pyrimidine carboxylic acid are easily separated out when being added into the non-surface active system in the coexistence is solved, the composition can be used in the non-surface active system, the addition of the composition in the non-surface active system such as essence is facilitated, and the application range of the composition is expanded.
2. According to the invention, through the compounding of the tetrahydro-methyl pyrimidine carboxylic acid, the hyaluronic acid and the salt thereof, and the cationic surfactant, the adhesiveness of the cation, the tetrahydro-methyl pyrimidine carboxylic acid, the hyaluronic acid and the salt thereof on the scalp or hair can be improved, so that the adsorbability of the composition on the skin or hair is effectively increased, the retention time of the composition on the scalp and the hair is prolonged, and the absorption and utilization of the composition are facilitated, so that the effects of nourishing the scalp, improving the deep water environment of the scalp and repairing the damaged scalp barrier are achieved, and the application prospect is good.
3. According to the invention, preferably, through the cooperation of three hyaluronic acids, namely high-molecular hyaluronic acid, low-molecular hyaluronic acid and hydrolyzed hyaluronic acid, the high-molecular hyaluronic acid and the low-molecular hyaluronic acid can form a protective film on the scalp to nourish damaged scalp tissues, and the hydrolyzed hyaluronic acid and salts thereof can deeply nourish the scalp to improve the deep water environment of the scalp; the tetrahydro-methyl pyrimidine carboxylic acid can exert a mechanism for a long time under the action of a protective film formed by the hyaluronic acid substances, and can repair the damaged scalp barrier for a long time.
Detailed Description
The present invention is further illustrated by the following examples, which are intended to be purely exemplary of the invention and are not intended to be limiting.
Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. Although methods and materials similar or equivalent to those described herein can be used in experimental or practical applications, the materials and methods are described below. In case of conflict, the present specification, including definitions, will control, and the materials, methods, and examples are illustrative only and not intended to be limiting. The present invention is further illustrated by the following examples, which are not intended to limit the scope of the invention.
The scalp care composition containing hyaluronic acid comprises hyaluronic acid and salt thereof, cationic surfactant, tetrahydromethyl pyrimidine carboxylic acid as main components, and auxiliary components such as preservative, polyalcohol and water.
In a specific embodiment, the hyaluronic acid and the salt thereof are a composition of both high molecular weight hyaluronic acid and the salt thereof and low molecular weight hyaluronic acid and the salt thereof, or a composition of three of high molecular weight hyaluronic acid and the salt thereof, low molecular weight hyaluronic acid and the salt thereof, and hydrolyzed hyaluronic acid and the salt thereof.
In one embodiment, the mass percentage of the polymeric hyaluronic acid and the salt thereof is 0.01 to 10%, and may be, for example, 0.01%, 0.05%, 0.1%, 0.25%, 0.3%, 0.5%, 0.9%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, preferably 0.01 to 5%, and more preferably 0.5 to 5%.
In a specific embodiment, the mass percentage of the low molecular weight hyaluronic acid and the salt thereof is 0.5 to 10%, for example, 0.5%, 0.67%, 1%, 1.5%, 2%, 3%, 4%, 5%, 7.89%, 9%, 10%, preferably 0.5 to 5%.
In a specific embodiment, the mass percentage of the hydrolyzed hyaluronic acid and the salt thereof is 0 to 10%, for example, 0%, 0.05%, 0.079%, 0.1%, 0.15%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, preferably 0.05 to 10%, and more preferably 0.1 to 2%.
In a specific embodiment, the cationic surfactant is 0.05 to 5% by mass, for example, 0.05%, 0.079%, 0.1%, 0.15%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, 3%, 4%, 5%, preferably 0.1 to 2%.
In a specific embodiment, the percentage by mass of the tetrahydromethylpyrimidine carboxylic acid is 0.1 to 5%, for example, 0.1%, 0.13%, 0.2%, 0.55%, 0.8%, 1%, 2%, 3%, 4%, 5%, preferably 0.1 to 3%, more preferably 0.1 to 1%, and still more preferably 0.5 to 1%.
In a specific embodiment, the preservative is 0.1 to 2% by mass, for example, 0.1%, 0.2%, 0.45%, 0.5%, 1%, 1.5%, 2%, preferably 0.1 to 1%.
In a specific embodiment, the polyol is present in a mass percentage of 1 to 5%, for example 1%, 2%, 3.2%, 4%, 5%, preferably 2 to 5%.
Furthermore, Hyaluronic Acid (HA) is a high-molecular polysaccharide naturally present in human interstitial tissue, widely used in the fields of medicine, skin care products, food and the like, and HAs various molecular weights, and HA of each molecular weight HAs different efficacies and expressions.
In a specific embodiment, the molecular weight of the high molecular weight hyaluronic acid and the salt thereof is 1000 kDa-1800 kDa, such as 1000kDa, 1100kDa, 1200kDa, 1300kDa, 1400kDa, 1500kDa, 1600kDa, 1700kDa, 1800kDa, and the properties are similar in this range. The molecular weight of the low molecular hyaluronic acid and the salt thereof is 30kDa-100kDa, and can be 30kDa, 40kDa, 50kDa, 60kDa, 70kDa, 80kDa, 90kDa, 100kDa, for example, within this range, the performance is similar. The molecular weight of the hydrolyzed hyaluronic acid and the salt thereof is 1kDa to 10kDa, and may be, for example, 1kDa, 2kDa, 3kDa, 4kDa, 5kDa, 6kDa, 7kDa, 8kDa, 9kDa, 10kDa, within this range, the properties are similar.
Examples
The present invention is further illustrated by the following examples, which are intended to be purely exemplary of the invention and are not intended to be limiting.
The experimental methods used in the following examples are all conventional methods, unless otherwise specified.
Materials, reagents and the like used in the following examples are commercially available unless otherwise specified. Wherein the high molecular sodium hyaluronate, the low molecular sodium hyaluronate, the hydrolyzed sodium hyaluronate and the tetrahydro-methylpyrimidine carboxylic acid are all from Huaxi Biotechnology corporation.
Examples 1 to 13 and comparative examples 1 to 4
The scalp care composition containing hyaluronic acid consists of high molecular sodium hyaluronate (1000 kDa-1800 kDa), low molecular sodium hyaluronate (30 kDa-100 kDa), hydrolyzed sodium hyaluronate (1 kDa-10 kDa), a cationic surfactant, tetrahydromethyl pyrimidine carboxylic acid, phenoxyethanol, glycerol and water. Wherein, the content of phenoxyethanol is 0.9wt%, the content of glycerin is 4wt%, water is used as solvent to make up the balance, and the other 5 effective components are shown in the following table 1.
The preparation method comprises the following steps:
weighing the components according to a formula table for later use; adding a cationic surfactant with a formula amount into a beaker containing a certain amount of water, stirring until the cationic surfactant is completely dissolved, then adding phenoxyethanol with the formula amount, then adding glycerol, stirring for 5 minutes, adding high-molecular-weight sodium hyaluronate, stirring until the high-molecular-weight sodium hyaluronate is completely dissolved, adding low-molecular-weight sodium hyaluronate, stirring until the low-molecular-weight sodium hyaluronate is completely dissolved, adding hydrolyzed sodium hyaluronate (if any), stirring until the high-molecular-weight sodium hyaluronate is completely dissolved, adding tetrahydro-methyl pyrimidine carboxylic acid, and uniformly stirring to obtain the hyaluronic acid scalp care composition.
Verification example 1 stability test
5g of the composition of example 1 was added with 95g of water, and stirred uniformly to obtain a 5% essence of example 1. According to this method, 5% solutions of each example and comparative example were prepared. An accelerated test was conducted at 45 ℃ to observe whether or not there was precipitation.
From the experimental results, under the condition that a certain content of the tetrahydromethyl pyrimidine carboxylic acid exists, the composite sodium hyaluronate, the cationic surfactant and the tetrahydromethyl pyrimidine carboxylic acid are added into a non-surfactant system, namely the system is stable without precipitation, which shows that the composition can be suitable for the non-surfactant system. The combination of comparative example 1 without the tetrahydro-methyl pyrimidine carboxylic acid and the combination of comparative example 3 without the compound sodium hyaluronate cannot form a critical flocculation state because the ion balance among the three is not achieved, so that precipitation is not suitable for a non-surface active system, and is most obvious in the precipitation of the comparative example 1; comparative example 2 also generated white flocculent precipitate in one month due to the lower content of the tetrahydro-methylpyrimidine carboxylic acid, and comparative example 4 instantly generated white flocculent precipitate in the preparation process due to the excessively high content of the cationic surfactant.
Verification example 2 skin barrier repair experiment
Cell wound repair regular scratch regions were formed in 24-well culture plates using ibidi chambers, and the effect of the samples on the ability of human epidermal keratinocytes (HaCaT) to migrate to the scratch regions was examined to evaluate whether the samples had the ability to repair wounds.
In a new 24-well plate, an ibidi cell was placed, and human epidermal keratinocytes HaCaT in logarithmic growth phase were taken at 3X 105Density of one/mLThe cells were inoculated into an ibidi chamber in a 24-well plate, 70. mu.L of each cell suspension was added to each of the left and right wells of the chamber, 400. mu.L of complete medium was supplemented outside the chamber, and the cells were cultured at 37 ℃ under 5% CO2 for 24 hours. The chamber was removed, the old culture medium was aspirated off, and 1mL of sample solution was added. The sample solution was: the samples of examples 1 to 13 and comparative examples 1 to 3 were prepared at a concentration of 5% (v/v) using DMEM high-sugar medium, and were sterilized by filtration using a 0.22 μm filter, wherein the sample of comparative example 1 was stirred to disperse flocs at the time of use. The control group was replaced with culture medium without sample. After further incubation for 24h, photographs were observed. Results mobility was calculated by analysis using Image J software.
Mobility = area of scratch area of experimental group/area of scratch area of control group × 100%
The data in the table show that the composition prepared by the embodiment of the invention can well repair damaged skin barriers, and particularly, the composition has a good repairing effect on the skin barriers when the high-molecular sodium hyaluronate, the low-molecular sodium hyaluronate, the hydrolyzed sodium hyaluronate and the tetrahydro-methyl pyrimidine carboxylic acid are in a certain proportioning range, and the cationic surfactant has no obvious influence on the repairing effect on the skin barriers.
Verification example 3 human body test
1. Sample preparation
5g of each of the compositions of example 1 and comparative example 1 was added with 95g of water, and stirred uniformly to prepare a 5% essence.
2. Volunteer recruitment
20 volunteers with scalp itching acute attack more than 5 times per day, obvious red and swollen radius measurable and serious hair loss after combing 20 times, male and female ginseng halves, were recruited and randomly divided into 2 groups.
3. Test of use effect
Each group of volunteers respectively smeared with the essence liquid of example 1 and comparative example 1, and the essence liquid is used once a day, and when the essence liquid is used, the essence liquid is directly smeared at the root of a hair, and the essence liquid is continuously used for 4 weeks, and effect evaluation is respectively carried out on the 1 st week and the 4 th week of the use, and the effective rate is calculated. Wherein, the essence of comparative example 1 is stirred or shaken up when in use.
4. Evaluation criteria:
has the following remarkable effects: the number of times of scalp itching attacks every day is reduced by more than 4 times, the diameter of the red and swollen area is reduced by more than 30%, and the hair loss ratio is reduced by more than 50% after the hair is combed for 20 times;
has slight effect: the frequency of the scalp itch per day is reduced by more than 2 times, the diameter of the red and swollen area is reduced by 10-30%, and the hair loss ratio is reduced by 20-50% after the hair is combed for 20 times;
and (4) invalidation: scalp itching, redness, swelling, hair loss were unchanged or less changed.
Effective rate = (number of persons with significant effect + number of persons with slight effect)/total number of persons
5. The experimental results are as follows:
the essence prepared from the composition disclosed by the embodiment of the invention can effectively relieve the problems of scalp or hair and the like, and has a certain effect on scalp pruritus, alopecia and scalp barrier damage.
Verification example 4 cation adhesiveness
1. Sample preparation
The same shampoo base was divided into four portions, one portion to which 10% of the scalp care composition prepared in example 1 was added as sample 1, the second portion to which 10% of the scalp care composition prepared in example 12 was added as sample 2, the third portion to which 10% of the scalp care composition prepared in comparative example 1 was added as sample 3, and the other portion to which no ingredients were added as a control.
2. Sample testing
Taking 40 parts of wig bundles, dividing the wig bundles into four groups, wherein each group comprises 10 parts, 1 group is washed by the shampoo of the sample 1, 2 groups are washed by the shampoo of the sample 2, 3 groups are washed by the shampoo of the sample 3, and 4 groups are washed by the shampoo of the control group, wherein the shampoo of the sample 3 is stirred or shaken before use. After cleaning, respectively drying by using a blower, fixing one end of the hair bundle on a wood board, allowing the hair bundle to naturally droop, combing for 10 times by using a comb, and recording the opening angle (namely the upwarping angle) of the hair bundle, wherein the larger the opening angle is, the larger the static electricity is, and the more the cations are.
3. Results of the experiment
From the above results, the angle of opening the hair is the largest in example 1, which shows that the hair comb has a large amount of charges, strong repulsive force and more cations, and the comparison shows that the examples can better increase the adhesion of the cations, thereby effectively increasing the adsorption of the composition to the skin or hair, improving the retention time of the composition on the scalp and hair, and being beneficial to the absorption and utilization of the composition.
Claims (10)
1. A scalp care composition containing hyaluronic acid is characterized in that: comprises hyaluronic acid and salt thereof, cationic surfactant and tetrahydro-methyl pyrimidine carboxylic acid.
2. The scalp care composition according to claim 1, wherein: the hyaluronic acid and the salt thereof are a mixture of high molecular hyaluronic acid and the salt thereof and low molecular hyaluronic acid and the salt thereof, or a mixture of high molecular hyaluronic acid and the salt thereof, low molecular hyaluronic acid and the salt thereof and hydrolyzed hyaluronic acid and the salt thereof.
3. The scalp care composition according to claim 2, wherein: the mass percent of the high molecular hyaluronic acid and the salt thereof is 0.01-10%, preferably 0.5-5%; the mass percentage of the low molecular weight hyaluronic acid and the salt thereof is 0.5-10%, preferably 0.5-5%; the mass percentage of the hydrolyzed hyaluronic acid and the salt thereof is 0-10%, preferably 0.05-10%, and more preferably 0.1-2%; the mass percent of the cationic surfactant is 0.05-5%, preferably 0.1-2%; the weight percentage of the tetrahydromethyl pyrimidine carboxylic acid is 0.1-5%, preferably 0.1-1%.
4. A scalp care composition according to claim 2 or 3, characterized in that: the molecular weight of the high molecular hyaluronic acid and the salt thereof is 1800kDa, the molecular weight of the low molecular hyaluronic acid and the salt thereof is 30kDa-100kDa, and the molecular weight of the hydrolyzed hyaluronic acid and the salt thereof is 1kDa-10 kDa; preferably, the salts of the high molecular weight hyaluronic acid, the low molecular weight hyaluronic acid and the hydrolyzed hyaluronic acid are sodium salts, potassium salts, calcium salts or zinc salts.
5. A scalp care composition according to claim 1 or 3, characterized in that: the cationic surfactant is one or two of cationic guar gum and polyquaternium.
6. A scalp care composition according to claim 1, 2 or 3 wherein: also comprises a preservative, polyhydric alcohol and water; preferably, the preservative is selected from phenoxyethanol, benzoic acid or potassium sorbate, and the polyol is selected from propylene glycol, glycerol, butylene glycol or pentylene glycol.
7. The scalp care composition according to claim 6, wherein: the preservative is 0.1-2% by mass, preferably 0.1-1% by mass; the mass percent of the polyalcohol is 1-5%, preferably 2-5%.
8. A method of preparing a hyaluronic acid-containing scalp care composition according to any of claims 1-7, characterized in that it comprises the steps of: mixing the cationic surfactant with water, stirring until the cationic surfactant and the water are completely dissolved, then sequentially adding hyaluronic acid and salt thereof and tetrahydro-methylpyrimidine carboxylic acid into the solution, and uniformly stirring to obtain the hyaluronic acid.
9. Use of a hyaluronic acid-containing scalp care composition according to any of claims 1-7 for the preparation of a hair product.
10. A hair product is characterized in that: a scalp care composition comprising hyaluronic acid according to any of claims 1-7; preferably, the weight percentage of the scalp care composition containing the hyaluronic acid in the hair product is 1-10%.
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