CN113456284A

CN113456284A - Rat craniocerebral model preparation device

Info

Publication number: CN113456284A
Application number: CN202110929334.7A
Authority: CN
Inventors: 张�杰; 张博友; 李锦光; 王李佳; 徐姣; 谷风康; 任飞
Original assignee: Second Xiangya Hospital of Central South University
Current assignee: Second Xiangya Hospital of Central South University
Priority date: 2021-08-13
Filing date: 2021-08-13
Publication date: 2021-10-01
Anticipated expiration: 2041-08-13
Also published as: CN113456284B

Abstract

The invention discloses a rat brain model manufacturing device which comprises a sliding block, a drill rod, at least two limiting insertion holes and a limiting insertion sheet, wherein the sliding block is slidably arranged and provided with a guide hole, the drill rod is sleeved with a locking sleeve, the at least two limiting insertion holes are axially distributed on one side of the sliding block along the guide hole and are radially communicated with the guide hole, and the limiting insertion sheet is alternatively inserted into the limiting insertion holes. When the sliding block slides to a designated area, the limiting insertion piece is inserted into the limiting insertion hole positioned on the uppermost layer, the drill rod moves downwards along the guide hole until the drill rod abuts against the skull, the unlocked locking sleeve moves downwards along the drill rod when the drill rod moves downwards along the guide hole to abut against the skull to abut against the limiting insertion piece, the locking sleeve is locked on the drill rod, and the limiting insertion piece is pulled out; when the limiting insertion pieces are sequentially inserted into the limiting insertion holes of each subsequent layer from top to bottom, the locked locking sleeve is drilled into the skull along with the drill rod until the locking sleeve abuts against the limiting insertion pieces again, the drilling depth of the drill rod is equal to the distance between all the limiting insertion holes, the drilling depth of the drill rod is accurately controlled, and the damage to the skull caused by the drill rod is avoided.

Description

Rat craniocerebral model preparation device

Technical Field

The invention relates to the technical field of biological experimental instruments, in particular to a rat brain model manufacturing device.

Background

The rat craniocerebral model manufacturing device windows the rat cranium through the bony mark on the surface of the rat cranium, completes the directional injection, puncture, damage or guiding and positioning and the like of the neural structure in the cranium, and can be used for the research of establishing a Parkinson animal model, an epileptic animal model, an intracerebral tumor model, cerebral ischemia and the like.

When the model is prepared, accurate intervention on the cranium of a specific experimental region can be realized only by accurately windowing the skull of a rat. However, limited by the prior art, in order to ensure the puncturing precision, the experimenter usually punctures the target brain region directly by means of different auxiliary puncturing devices, and this method has higher requirements on the operation experience of the experimenter, higher technical difficulty, often inaccurate puncturing, and is easy to cause craniocerebral injury under the skull.

Disclosure of Invention

In view of this, the present invention provides a rat brain model making apparatus, wherein the sum of distances between all the limiting insertion holes arranged on one side of the sliding block is equal to the thickness of the skull, so that the limiting insertion pieces are sequentially inserted into the limiting insertion holes from top to bottom, the drilling depth of the drill rod in the skull is accurately controlled, and the injury to the skull caused by the drilling of the drill rod into the skull is avoided.

The invention provides a rat brain model making device, which comprises:

a drill rod sleeved with a locking sleeve;

a sliding block which is arranged in a sliding way and is provided with a guide hole;

at least two limiting jacks axially distributed on one side of the sliding block along the guide hole and radially communicated with the guide hole, wherein the sum of the distances of all the limiting jacks is equal to the thickness of the skull;

a limit inserting sheet is inserted into the limit inserting hole;

when the limiting insertion piece is inserted into the limiting insertion hole positioned on the uppermost layer, the unlocked locking sleeve moves downwards along the drill rod to abut against the skull when the drill rod moves downwards along the guide hole and then is locked after moving downwards along the drill rod to abut against the limiting insertion piece;

when the limiting insertion pieces are sequentially inserted into the limiting insertion holes of each layer from top to bottom, the locked locking sleeve drills into the skull along with the drill rod until the locking sleeve abuts against the limiting insertion pieces again.

Preferably, the device also comprises an inclination angle adjusting component which is arranged on one side of the sliding block and is used for adjusting the inclination angle of the sliding block until the penetrating drill rod is vertical to the skull surface.

Preferably, the sliding block comprises a first slide having an adjusting plate and a second slide having a supporting plane, and the tilt angle adjusting assembly comprises a connecting screw passing through the adjusting plate and connected to the second slide, and an adjusting nut sleeved on the connecting screw and located between the adjusting plate and the supporting plane to adjust the distance therebetween.

Preferably, the skull fixator further comprises a support frame and at least one group of positioning needle assemblies which are slidably arranged on the support frame and used for fixing the skull.

Preferably, the support frame includes at least one and positioning needle subassembly matched with comb shape crossbeam, and arbitrary one comb shape crossbeam is equipped with a plurality of along the spacing broach of linear distribution, and when arbitrary a set of positioning needle subassembly slided to the target location along the comb shape crossbeam, positioning needle subassembly rotated around the comb shape crossbeam, and positioning needle subassembly's spacing recess cooperatees with relative spacing broach.

Preferably, any group of the positioning needle assemblies comprises a positioning needle, a rotary lock sleeve with a limiting groove and a hinged threaded sleeve which is matched with the positioning needle and is hinged with the rotary lock sleeve.

Preferably, the sliding frame is slidably sleeved on the support frame, and the sliding block is slidably sleeved on the sliding frame.

Preferably, the carriage is arranged parallel between the two comb beams.

Preferably, the jaw plate further comprises a fixed seat and an elastic seat which is fixedly arranged on the fixed seat and is attached to the mandible, and the elastic seat is V-shaped.

Preferably, the anesthesia apparatus further comprises an anesthesia mask fixedly arranged on the fixed seat and opposite to the elastic seat and an anesthesia trachea communicated with the anesthesia mask.

Compared with the background art, the rat brain model manufacturing device provided by the invention comprises a sliding block which is arranged in a sliding mode and is provided with a guide hole, a drill rod which is sleeved with a locking sleeve, at least two limiting insertion holes which are axially distributed on one side of the sliding block along the guide hole and are axially communicated with the guide hole, and a limiting insertion sheet which is alternatively inserted into the limiting insertion holes.

When the sliding block slides to a designated area, firstly inserting the limiting insertion piece into the limiting insertion hole positioned on the uppermost layer, positioning the limiting insertion piece at a certain height of the guide hole, inserting the drill rod into the guide hole, continuously moving the drill rod downwards after the drill rod passes through the limiting insertion piece until the drill rod props against a skull, moving the locking sleeve which is not locked downwards along the drill rod until the locking sleeve is abutted against the limiting insertion piece, locking the locking sleeve on the drill rod, and pulling out the limiting insertion piece; inserting the limiting insertion piece into the limiting insertion hole in the second layer, descending the limiting insertion piece into the next limiting insertion hole from the previous limiting insertion hole, starting the drill rod after the drill rod abuts against the skull, and drilling the drill rod into the skull until the locking sleeve abuts against the limiting insertion piece again; and then the limiting insertion pieces are sequentially inserted into the limiting insertion holes in the third layer, the fourth layer … … and the last layer, the steps are repeated, the sum of the distances of all the limiting insertion holes is equal to the thickness of the skull, so that the continuous drilling depth of the drill rod is equal to the distance between all the limiting insertion holes, the drilling of the drill rod is accurately guaranteed to be equal to the thickness of the skull, and the drill rod is prevented from being drilled into the skull.

Obviously, the invention can accurately control the drilling depth of the drill rod by optimizing the whole structure, and prevent the drill rod from drilling into the cranium of the rat, thereby avoiding the injury to the cranium.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

FIG. 1 is a diagram illustrating a state of a rat brain model creation apparatus according to an embodiment of the present invention when the rat brain model creation apparatus is fixed to a skull;

FIG. 2 is a diagram of a rat brain model building apparatus according to an embodiment of the present invention;

FIG. 3 is another view of FIG. 2;

FIG. 4 is a front view of FIG. 2;

FIG. 5 is a top view of FIG. 2;

FIG. 6 is an assembly view of the carriage, slider, locking sleeve and tilt hinge assembly of FIG. 2;

FIG. 7 is an assembled view of the locking collar, drill rod and stop insert of FIG. 6;

FIG. 8 is an exploded view of the locking sleeve of FIG. 7;

FIG. 9 is an assembled view of the slide block and tilt hinge assembly of FIG. 6;

fig. 10 is an assembly view of the tilt hinge assembly and the second slide of fig. 9;

FIG. 11 is a block diagram of the first slider of FIG. 9;

fig. 12 is a structural view of the second slider in fig. 9;

FIG. 13 is a block diagram of the stop tab of FIG. 9;

FIG. 14 is an assembled view of the comb beam and positioning needle assembly of FIG. 2;

FIG. 15 is an assembly view of the rotary lock sleeve and the swivel nut of FIG. 14;

FIG. 16 is a block diagram of the rotating sleeve of FIG. 14;

FIG. 17 is a block diagram of the articulating nut of FIG. 14;

FIG. 18 is a block diagram of the positioning pin of FIG. 14;

FIG. 19 is an assembled view of the supporting frame, the fixing base, the anesthetic mask and the elastic base shown in FIG. 2;

FIG. 20 is an assembly view of the supporting frame, the fixing base, the magnetic block and the fixing seat shown in FIG. 2;

FIG. 21 is a block diagram of the fixed cartridge of FIG. 19;

FIG. 22 is a block diagram of the elastomeric seat of FIG. 19;

FIG. 23 is an assembled view of the anaesthetic mask and anaesthetic tube of FIG. 19.

The reference numbers are as follows:

the device comprises a drill rod 1, a locking sleeve 2, a sliding block 3, a limiting inserting sheet 4, an inclination angle adjusting component 5, a supporting frame 6, a positioning needle component 7, a sliding frame 8, a fixed seat 9, an elastic seat 10, an anesthesia mask 11 and an anesthesia trachea 12;

a locking ferrule 21 and a locking nut 22;

an abutment latch 211;

a first slider 31 and a second slider 32;

the first sliding sleeve 311, the first supporting plate 312, the guide hole 313, the limit insertion hole 314 and the adjusting plate 315;

a U-shaped groove 3151;

the support plane 321;

an escape groove 41 and a long stopper bar 42;

a connecting screw 51 and an adjusting nut 52;

the supporting upright post 61, the supporting longitudinal beam 62 and the comb-shaped cross beam 63;

the limiting comb teeth 631;

a positioning pin 71, a rotary lock sleeve 72 and a hinge screw sleeve 73;

a rotating head 711, a fixing pin 712, and a fitting screw 713;

a limit groove 721, a hinge groove 722 and a hinge rotation shaft 723;

hinge brace 731 and stop bulb 732;

a guide sliding sleeve 81, a support sliding sleeve 82 and a locking screw 83;

a magnetic stopper 91 and a fixed card holder 92;

a fixed slot 921;

a stopper groove 101;

a pipe connector 111.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In order that those skilled in the art will better understand the disclosure, the invention will be described in further detail with reference to the accompanying drawings and specific examples.

Referring to fig. 1 to 23, fig. 1 is a diagram illustrating a state of a rat brain model making device according to an embodiment of the present invention when the rat brain model making device is fixed to a skull; FIG. 2 is a diagram of a rat brain model building apparatus according to an embodiment of the present invention; FIG. 3 is another view of FIG. 2; FIG. 4 is a front view of FIG. 2; FIG. 5 is a top view of FIG. 2; FIG. 6 is an assembly view of the carriage, slider, locking sleeve and tilt hinge assembly of FIG. 2; FIG. 7 is an assembled view of the locking collar, drill rod and stop insert of FIG. 6; FIG. 8 is an exploded view of the locking sleeve of FIG. 7; FIG. 9 is an assembled view of the slide block and tilt hinge assembly of FIG. 6; fig. 10 is an assembly view of the tilt hinge assembly and the second slide of fig. 9; FIG. 11 is a block diagram of the first slider of FIG. 9; fig. 12 is a structural view of the second slider in fig. 9; FIG. 13 is a block diagram of the stop tab of FIG. 9; FIG. 14 is an assembled view of the comb beam and positioning needle assembly of FIG. 2; FIG. 15 is an assembly view of the rotary lock sleeve and the swivel nut of FIG. 14; FIG. 16 is a block diagram of the rotating sleeve of FIG. 14; FIG. 17 is a block diagram of the articulating nut of FIG. 14; FIG. 18 is a block diagram of the positioning pin of FIG. 14; FIG. 19 is an assembled view of the supporting frame, the fixing base, the anesthetic mask and the elastic base shown in FIG. 2;

FIG. 20 is an assembly view of the supporting frame, the fixing base, the magnetic block and the fixing seat shown in FIG. 2; FIG. 21 is a block diagram of the fixed cartridge of FIG. 19; FIG. 22 is a block diagram of the elastomeric seat of FIG. 19; FIG. 23 is an assembled view of the anaesthetic mask and anaesthetic tube of FIG. 19.

The embodiment of the invention discloses a rat brain model manufacturing device, which is used for manufacturing a rat brain model and comprises a drill rod 1, a sliding block 3, at least two limiting jacks 314 and a limiting inserting sheet 4.

The outside cover of drilling rod 1 is equipped with lock sleeve 2, utilizes lock sleeve 2 control drilling depth of drilling rod 1, and lock sleeve 2 still is used for restricting drilling rod 1 swing at the drilling in-process in addition. The locking sleeve 2 comprises a locking clamping sleeve 21 and a locking nut 22 which are coaxially sleeved on the drill rod 1, a plurality of butt clamping teeth 211 which are annularly distributed are integrally arranged at one end, close to the locking nut 22, of the locking clamping sleeve 21, and all the butt clamping teeth 211 enclose a conical clamping sleeve. When the locking nut 22 is sleeved on the locking cutting sleeve 21, the conical cutting sleeve is matched with the locking nut 22, the diameter of the small-diameter end of the conical cutting sleeve is gradually reduced under the extrusion of the locking nut 22 until all the abutting cutting teeth 211 abut against the drill rod 1, and the locking sleeve 2 is fixed on the drill rod 1 to realize locking; when the toper cutting ferrule and lock nut 22 break away from the contact, the toper cutting ferrule resumes elastic deformation, and whole butt latch 211 breaks away from the contact with drilling rod 1, and lock sleeve 2 can follow drilling rod 1 relative slip, and lock sleeve 2 removes the locking this moment. Of course, the structure of the locking sleeve 2 is not limited thereto.

The sliding block 3 has a guide hole 313 formed through the center thereof, and when the drill rod 1 is inserted into the guide hole 313, the guide hole 313 guides the drill rod 1 to move toward the rat skull. The guide hole 313 is a stepped hole, a stop ring is arranged on the inner side surface of the bottom end of the stepped hole, the inner diameter of the large-diameter section of the stepped hole is slightly larger than the outer diameter of the locking sleeve 2, and the locking sleeve 2 is accommodated by the large-diameter section. The inner diameter of the small-diameter section of the stepped hole is equal to the diameter of the drill rod 1, so that the guide hole 313 can guide the drill rod 1 to move, the locking sleeve 2 can be prevented from sliding out of the bottom end of the guide hole 313 by the aid of the stop ring, and the cranium of a rat is prevented from being injured by misoperation when the locking sleeve 2 slides along the drill rod 1.

The sliding block 3 is arranged in a sliding mode, the position of the drill rod 1 is indirectly adjusted through the position of the adjusting sliding block 3, the position of the drill rod 1 is flexibly adjusted, the drill rod 1 can be aligned to different modeling areas of the cranium, and the drill rod 1 is accurately positioned.

At least two limiting insertion holes 314 are axially distributed on one side of the sliding block 3 along the guide hole 313, all the limiting insertion holes 314 are radially communicated with the guide hole 313, the limiting insertion sheet 4 is alternatively inserted into the limiting insertion holes 314, the limiting insertion sheet 4 prevents the drill rod 1 from moving downwards in each layer of limiting insertion holes 314, the drill rod 1 generates different drilling depths at different positions of the limiting insertion holes 313 by means of the locking sleeve 2 and the limiting insertion sheet 4, the distance that the drill rod 1 moves downwards each time is the distance between the upper limiting insertion hole 314 and the lower limiting insertion hole 314, the sum of the distances of all the limiting insertion holes 314 is equal to the thickness of a skull, the drilling depth of the drill rod 1 is accurately controlled, the drilling depth of the drill rod 1 is ensured to be just equal to the thickness of the skull, and the drill rod 1 is prevented from drilling into the skull due to insufficient operation experience.

When the sliding block 3 slides to a designated area, the limiting insertion sheet 4 is firstly inserted into the limiting insertion hole 314 positioned on the uppermost layer, the limiting insertion sheet 4 is positioned at a certain height of the guide hole 313, the drill rod 1 is inserted into the guide hole 313, the drill rod 1 passes through the limiting insertion sheet 4 and then continuously moves downwards until the drill rod 1 abuts against the skull, the locking sleeve 2 which is not locked moves downwards along the drill rod 1 until the locking sleeve 2 abuts against the limiting insertion sheet 4, the locking sleeve 2 is locked on the drill rod 1, and the limiting insertion sheet 4 is pulled out; then inserting the limiting insertion sheet 4 into the limiting insertion hole 314 positioned on the second layer, namely, the limiting insertion sheet 4 descends from the previous limiting insertion hole 314 to the next limiting insertion hole 314, starting the drill rod 1 after the drill rod 1 abuts against the skull, and drilling the drill rod 1 into the skull until the locking sleeve 2 abuts against the limiting insertion sheet 4 again; and then the limiting insertion pieces 4 are sequentially inserted into the limiting insertion holes 314 from the third layer … … to the last layer, the steps are repeated, the sum of the distances of all the limiting insertion holes 314 is equal to the thickness of the skull, so that the continuous drilling depth of the drill rod 1 is equal to the sum of the distances of all the limiting insertion holes 314, the drilling depth of the drill rod 1 is a preset depth, the drilling depth of the drill rod 1 is accurately guaranteed to be equal to the thickness of the skull, and the drill rod 1 is prevented from drilling into the skull. The designated area refers to a target modeling area of the rat cranium, and can be set according to experimental requirements.

Specifically, three layers of limiting insertion holes 314 are arranged on the side surface of the sliding block 3, the thickness of each layer of limiting insertion holes 314 is equal and parallel to each other, the distance between any two adjacent layers of limiting insertion holes 314 is 0.5mm, the thickness of the skull is usually about 1mm, namely the thickness of the skull is an integral multiple of the distance between each two adjacent layers of limiting insertion holes 314, and therefore the drill rod 1 can be ensured to accurately drill through the skull without damaging tissues in the skull by inserting the limiting insertion pieces 4 twice. Of course, the distance between any two adjacent limiting insertion holes 314 may also be unequal, for example, the distance between any two adjacent limiting insertion holes 314 may be set according to an increasing rule or an increasing rule, as long as the sum of the distances of all the limiting insertion holes 314 is ensured to be equal to the thickness of the skull. The number of the limiting insertion holes 314 is not limited to these three layers, and may be specifically set according to the thicknesses of craniums of different rat species, and is not specifically limited herein.

The limiting insertion sheet 4 is in a sheet shape, and the thickness of the limiting insertion sheet is equal to that of each layer of limiting insertion holes 314. One side of the limiting insertion sheet 4 inserted into the limiting insertion hole 314 is provided with an avoiding groove 41 for guiding the drill rod 1 to be inserted and pulled out, the drill rod 1 is favorably fixed, and the inserting and pulling-out times of the drill rod 1 can be reduced. The arrangement of the avoiding groove 41 can directly pull out the limiting insertion sheet 4 without taking out the drill rod 1, and then insert into the other layer of limiting insertion hole 314, so that the purpose of depth limiting is achieved. The avoiding groove 41 is U-shaped, the width of the avoiding groove is equal to the diameter of the drill rod 1, the avoiding groove 41 is arranged at the center of the limiting insertion sheet 4, the center line of the guide hole 313 is perpendicular to the symmetrical center line of the avoiding groove 41, the drill rod 1 is ensured to pass through the avoiding groove 41, the locking sleeve 2 is ensured to be capable of abutting against the groove edge of the limiting groove 721, and the limiting insertion sheet 4 is ensured to enable the drill rod 1 to pass through but not enable the locking sleeve 2 to pass through. The width of spacing inserted sheet 4 equals with the width of spacing jack 314, and one side integral type that spacing inserted sheet 4 kept away from dodging recess 41 is equipped with long backstop strip 42, and the width of long backstop strip 42 is greater than the width of spacing jack 314, and when spacing inserted sheet 4 inserted arbitrary one deck spacing jack 314, long backstop strip 42 offsets with the hole edge of spacing jack 314, avoids in spacing inserted sheet 4 bored spacing jack 314 completely, makes things convenient for the spacing inserted sheet 4 of plug. Of course, the structure of the stopper tab 4 is not limited thereto.

In conclusion, the rat brain model manufacturing device provided by the invention has the advantages that the whole structure is optimized, the drilling depth of the drill rod 1 is accurately controlled, the drill rod 1 is prevented from drilling into the rat brain, and the injury to the brain is further avoided.

Considering that the skull surface is usually in an arc shape, the skull puncture needle further comprises an inclination angle adjusting assembly 5 arranged on one side of the sliding block 3, so that one side of the sliding block 3 is turned over in a small range relative to the other side and is used for adjusting the inclination angle of the sliding block 3, and further, the inclination angle of the drill rod 1 penetrating through the sliding block 3 is indirectly adjusted, so that the drill rod 1 is perpendicular to the skull surface, the drilling direction of the drill rod 1 is accurately controlled, and conditions are provided for accurate subsequent puncture and drug administration of the cranium.

The sliding block 3 comprises a first sliding piece 31 and a second sliding piece 32 which are respectively slidably sleeved on the two guide sliding sleeves 81, and sliding tracks of the first sliding piece 31 and the second sliding piece 32 are parallel. The first slider 31 includes a first sliding sleeve 311 and a first supporting plate 312 vertically connected to the first sliding sleeve 311 in an integrated manner, a cubic protruding block is disposed at the center of the first supporting plate 312, a guiding hole 313 is disposed at the center of the protruding block, an adjusting plate 315 is disposed at an end of the first supporting plate 312 away from the first sliding sleeve 311, the adjusting plate 315 is in a flat plate shape, a U-shaped groove 3151 is disposed at a center of a side of the adjusting plate 315 away from the first sliding sleeve 311, on one hand, the U-shaped groove 3151 is used for a connection screw 51 of the tilt angle adjusting assembly 5 to pass through, and on the other hand, the slider 31 can avoid the connection screw 51 when the first slider 31 is turned around the guiding sliding sleeve 81, so as to prevent the connection screw 51 from obstructing the first slider 31 from turning. The second slider 32 is cylindrical and has the same structure as the first runner 311 of the first slider 31, and the two are symmetrically arranged. The top of the second slide 32 has a support plane 321.

The reclining assembly 5 includes a connection screw 51 and an adjusting nut 52, the connection screw 51 passes through the adjusting plate 315 and is connected to the second slider 32, and a threaded groove is formed at the top of the second slider 32 to be engaged with the connection screw 51. The adjusting nut 52 is sleeved on the connecting screw 51 and located between the adjusting plate 315 and the supporting plane 321. When the adjusting nut 52 moves along the direction of the connecting screw 51 away from the supporting plane 321, the adjusting nut 52 lifts the adjusting plate 315 to move away from the supporting plane 321, the distance between the adjusting plate 315 and the supporting plane 321 increases, the first sliding member 31 is turned around the guide sliding sleeve 81, and the inclination angle of the sliding block 3 increases. On the contrary, when the adjusting nut 52 moves along the direction in which the connecting screw 51 approaches the supporting plane 321, the distance between the adjusting plate 315 and the supporting plane 321 decreases, and the inclination angle of the sliding block 3 decreases accordingly. Specifically, the diameter of the adjustment nut 52 is larger than the width of the U-shaped groove 3151, ensuring that the adjustment nut 52 can reliably jack up the adjustment plate 315. Of course, the structure and the installation manner of the tilt angle adjusting assembly 5 are not limited to these, for example, the first sliding sleeve 311 and the first supporting plate 312 of the first slider 31 are separated, and a set of tilt angle adjusting assemblies 5 can be respectively arranged between the first supporting plate 312 and the first sliding sleeve 311 and between the first supporting plate 312 and the second slider 32, so that the sliding block 3 can be flexibly tilted in the left and right directions, and the adaptability is better.

In order to fix the skull of a rat, the invention also comprises a support frame 6 and at least one group of positioning needle assemblies 7, wherein all the positioning needle assemblies 7 are slidably arranged on the support frame 6, so that the positioning needle assemblies 7 penetrate into the skull from multiple angles without penetrating through the skull, the aim of reliably fixing the skull is achieved, the skull is prevented from shaking in the drilling process of the drill rod 1, and the manufactured model can be ensured to be more accurate.

The supporting frame 6 comprises four fixedly arranged supporting upright posts 61 and supporting longitudinal beams 62 which are fixed at the tops of any two supporting upright posts 61 in parallel, two comb-shaped cross beams 63 are respectively fixed at two ends of each supporting longitudinal beam 62, and each supporting longitudinal beam 62 is connected with the comb-shaped cross beam 63 through bolts. The both ends of every comb shape crossbeam 63 all are equipped with the arc recess, and the concave-convex cooperation of arc recess and support longeron 62's lateral surface makes support longeron 62 be connected more reliably with comb shape crossbeam 63. The head of each bolt is provided with an inner hexagonal groove, so that the bolt is convenient to disassemble and assemble. Of course, the two support stringers 62 can also be replaced by a comb cross beam 63.

All the positioning needle assemblies 7 are slidably mounted on the comb-shaped beam 63, so that the positioning needle assemblies 7 slide along the axial direction of the comb-shaped beam 63 until all the positioning needle assemblies 7 slide along the comb-shaped beam 63 to a target position, wherein the target position refers to the position of each positioning needle assembly 7 when all the positioning needle assemblies 7 fix the skull of a rat.

Specifically, based on the particularity of the skull structure of the rat, only one positioning needle assembly 7 is sleeved on one comb-shaped beam 63 and is used for abutting against the front end of the skull; the other comb-shaped beam 63 is sleeved with two positioning needle assemblies 7 which are respectively used for propping against the rear end of the skull; thus, the skull can be reliably fixed from the front and rear ends of the skull. Of course, the number of positioning pin assemblies 7 carried by each comb beam 63 is not limited thereto.

An arbitrary comb shape crossbeam 63 is equipped with a plurality of spacing broach 631 along linear evenly distributed, specifically, the inboard of every comb shape crossbeam 63 is equipped with one row of spacing broach 631, and every spacing broach 631 extends along the radial direction of comb shape crossbeam 63, and the length of every spacing broach 631 equals.

Each group of the positioning needle assemblies 7 has the same structure, and any group of the positioning needle assemblies 7 comprises a positioning needle 71, a rotary lock sleeve 72 and a hinged screw sleeve 73.

The positioning needle 71 is provided with a rotating head 711 at one end, a fixing needle 712 at the other end, a matching screw 713 is arranged between the rotating head 711 and the fixing needle 712, the matching screw 713 is in threaded matching with the hinged threaded sleeve 73, and when the rotating head 711 is manually rotated, the matching screw 713 linearly moves along the hinged threaded sleeve 73 in the axial direction to enable the fixing needle 712 to be close to or far away from the skull.

The rotary lock sleeve 72 is provided with a limiting groove 721, one end of the rotary lock sleeve 72 is rotatably sleeved on the comb-shaped cross beam 63, when the rotary lock sleeve 72 rotates around the comb-shaped cross beam 63, the limiting groove 721 is abutted against limiting comb teeth 631, the rotary lock sleeve 72 is limited to rotate relative to the comb-shaped cross beam 63, the positions of each group of positioning needle assemblies 7 are ensured to be firm and unchanged in the process of fixing the skull, and misoperation of the positioning needle assemblies 7 in the process of fixing the skull is avoided. One end of the rotating lock sleeve 72, which is sleeved on the comb-shaped beam 63, is provided with a notch, and the limiting groove 721 is arranged on one side of the notch. The end of the rotary lock sleeve 72 remote from the comb beam 63 is hinged to a hinge nut 73.

Specifically, a hinge groove 722 is formed at one end of the rotary lock sleeve 72, which is away from the comb-shaped beam 63, a hinge rotating shaft 723 is installed in the hinge groove 722, a hinge support 731 is integrally and fixedly arranged outside the hinge nut 73, the hinge support 731 extends along the radial direction of the hinge nut 73, the hinge support 731 penetrates through the hinge rotating shaft 723, and a stop ball 732 is arranged at one end of the hinge support 731, which is away from the hinge nut 73, so as to prevent the hinge support 731 from disengaging from the hinge rotating shaft 723, so that the rotary lock sleeve 72 is reliably connected with the hinge nut 73.

When any group of the positioning needle assemblies 7 slide to the target position along the comb-shaped beam 63, the rotary lock sleeve 72 of the positioning needle assembly 7 rotates circumferentially around the comb-shaped beam 63 until the limit groove 721 of the rotary lock sleeve 72 is matched with the opposite limit comb 631, so as to limit the positioning needle assembly 7 to continuously slide; then, the positioning needle 71 is manually shifted, the hinge screw sleeve 73 drives the positioning needle 71 to rotate around the hinge rotating shaft 723 of the rotary lock sleeve 72, and the positioning needle 71 swings along an arc until the positioning needle 71 is aligned with a target position; finally, the positioning pin 71 is rotated relative to the articulating screw 73, and the positioning pin 71 is moved toward the skull bone until the positioning pin 71 penetrates the skull bone.

The sliding frame 8 is slidably sleeved on the support frame 6, the sliding block 3 is slidably sleeved on the sliding frame 8, the sliding frame 8 can drive the sliding block 3 to slide relative to the support frame 6, and the sliding frame 8 can support the sliding block 3 to slide relative to the sliding frame 8, so that the position of the sliding block 3 can be flexibly adjusted. Specifically, the sliding frame 8 includes two guide sliding sleeves 81 and two support sliding sleeves 82, and the two guide sliding sleeves are fixed between the two support sliding sleeves 82 in parallel. The two support sliding sleeves 82 are respectively slidably sleeved on the two support longitudinal beams 62 of the support frame 6, so that the two support sliding sleeves 82 slide along the support frame 6; the first slider 31 and the second slider 32 of the sliding block 3 are slidably sleeved on the two guide sliding sleeves 81 respectively, so that the sliding frame 8 slides along the two guide sliding sleeves 81. Of course, the structure of the carriage 8 is not limited thereto.

For fixing the sliding frame 8, the sliding frame 8 is provided with a locking screw 83, one end of the locking screw 83 penetrates through the supporting sliding sleeve 82, when the sliding block 3 slides to a designated area, the locking screw 83 is screwed, the locking screw 83 abuts against the supporting longitudinal beam 62 of the supporting frame 6, the sliding frame 8 is fixed on the supporting frame 6, and misoperation of the sliding frame 8 in the process of fixing the skull is avoided.

In order to securely fix the positioning needle assembly 7 to the skull, the carriage 8 is disposed in parallel between the two comb-shaped beams 63, and the positioning needle assemblies 7 mounted on the two comb-shaped beams 63 are arranged in a triangular arrangement in tandem to fix the skull.

The invention also comprises a fixed seat 9 and an elastic seat 10, wherein the fixed seat 9 is fixedly arranged at the bottom of the support frame 6 and is in a flat plate shape and used for placing a rat. The elastic seat 10 is fixed on the fixed seat 9 and is in a V shape, so that the elastic seat 10 is attached to the mandible, the auxiliary positioning needle assembly 7 reliably fixes the skull, and in addition, the elastic seat 10 can also prevent the mandible from being abraded. Of course, the structure of the elastic seat 10 is not limited to V-shape, and may be a line, for example, and still achieve the object of the present invention.

The elastic seat 10 is specifically a rubber seat, but the material is not limited thereto. The elastic seat 10 can be fixed on the fixed seat 9 by means of magnetic attraction, so that the elastic seat 10 is convenient to disassemble and assemble. Specifically, fixing base 9 is the iron fixing base, and the iron fixing base adsorbs has a plurality of magnetism dog 91, and the bottom of elastic seat 10 is equipped with a plurality of backstop recess 101, and backstop recess 101 cooperatees with magnetism dog 91, fixes elastic seat 10 on fixing base 9. The magnetic stoppers 91 are movably arranged, so that the position of the elastic seat 10 can be flexibly adjusted according to the body type of the rat. Of course, the fixing manner of the elastic seat 10 is not limited thereto.

The invention also comprises an anaesthetic mask 11 and an anaesthetic trachea 12, wherein the anaesthetic mask 11 is conical and is fully attached to the head of a rat. The fixing seat 9 is fixedly provided with a fixing clamping seat 92, and the fixing clamping seat 92 is detachably fixed on the fixing seat 9 by means of a fastening screw. The top of fixed cassette 92 is equipped with fixed slot 921, and fixed slot 921 is circular-arc recess. The small diameter end of the anesthetic mask 11 is integrally provided with a pipe connector 111, and the pipe connector 111 and the fixing clamp slot 921 are in clamping fit, so that the anesthetic mask 11 is fixed on the fixing clamp seat 92. The anesthetic gas tube 12 is communicated with the anesthetic mask 11 through a tube connector 111, one end of the anesthetic gas tube is externally connected with an anesthetic gas source, anesthetic gas is conveyed for the anesthetic mask 11, and continuous anesthesia of rats is ensured.

The invention also comprises a puncture needle, when the drill rod 1 drills open the skull, the puncture needle enters the cranium along the drill hole, and the molding of the living rat in an anesthesia state is accurately completed.

Of course, the funnel or syringe can accurately administer the drug to the cranium after the window is opened by the aid of the whole device.

The working principle of the rat brain model manufacturing device provided by the invention is as follows:

placing the anesthetized rat on the fixed seat 9, extending the head of the rat into the anesthetic mask 11, enabling the rat to stand still after a certain volume of anesthetic gas is inhaled, and adjusting the position of the elastic seat 10 to enable the mandible of the rat to be tightly attached to the elastic seat 10;

each positioning needle assembly 7 slides along the comb-shaped beam 63, when all the positioning needle assemblies 7 slide at the target positions, the rotary lock sleeve 72 is rotated, and the rotary lock sleeve 72 circumferentially rotates around the comb-shaped beam 63 until the limiting grooves 721 of the rotary lock sleeve 72 are matched with the corresponding limiting comb teeth 631; then the positioning needle 71 is manually shifted, and the hinged threaded sleeve 73 drives the positioning needle 71 to rotate around the hinged rotating shaft 723 of the rotating lock sleeve 72 until the positioning needle 71 is aligned with the skull; finally, the positioning needle 71 is rotated relative to the hinged threaded sleeve 73, and the positioning needle 71 moves towards the skull until the positioning needle 71 penetrates into the skull to fix the skull;

the sliding frame 8 is pulled, and the sliding block 3 slides along the support longitudinal beam 62 of the support frame 6 along with the sliding frame 8; then the sliding block 3 is shifted, the sliding block 3 slides along the sliding frame 8, and the sliding block 3 is aligned to the designated area of the skull, namely the modeling area; inserting the limiting insertion sheet 4 into the limiting insertion hole 314 positioned at the uppermost layer, inserting the drill rod 1 into the guide hole 313, continuously moving the drill rod 1 downwards after the drill rod 1 passes through the limiting insertion sheet 4 until the drill rod 1 abuts against a skull, moving the unlocked locking sleeve 2 downwards along the drill rod 1 until the locking sleeve 2 abuts against the limiting insertion sheet 4, locking the locking sleeve 2 on the drill rod 1, and pulling out the limiting insertion sheet 4; inserting the limiting insertion piece 4 into the limiting insertion hole 314 positioned on the second layer, screwing the adjusting nut 52, enabling the adjusting nut 52 to jack the adjusting plate 315 to move towards the direction far away from the supporting plane 321, indirectly adjusting the inclination angle of the drill rod 1 by the sliding block 3 until the drill rod 1 is vertical to the skull surface, starting the drill rod 1 to drill into the skull until the locking sleeve 2 abuts against the limiting insertion piece 4 again, and pulling out the limiting insertion piece 4 again; inserting the limiting insertion piece 4 into the limiting insertion hole 314 in the third layer, starting the drill rod 1 after the drill rod 1 abuts against the skull, drilling the drill rod 1 into the skull until the locking sleeve 2 abuts against the limiting insertion piece 4 again, enabling the continuous drilling depth of the drill rod 1 to be equal to the thickness of the skull, and accurately controlling the drilling depth of the drill rod 1;

finally, a puncture needle or a syringe is inserted into the drill hole, and the cranium is accurately punctured or dosed.

The rat brain model making device provided by the invention is described in detail, the principle and the implementation mode of the invention are explained by applying specific examples, and the description of the examples is only used for helping to understand the method and the core idea of the invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.

Claims

1. A rat brain model making device is characterized by comprising:

a drill rod (1) sleeved with a locking sleeve (2);

a sliding block (3) which is slidably provided and has a guide hole (313);

at least two limiting insertion holes (314) axially distributed on one side of the sliding block (3) along the guide hole (313) and radially communicated with the guide hole (313), wherein the sum of the distances of all the limiting insertion holes (314) is equal to the thickness of a skull;

a limiting insertion sheet (4) which is alternatively inserted into the limiting insertion hole (314);

when the limiting insertion piece (4) is inserted into the limiting insertion hole (314) on the uppermost layer, the locking sleeve (2) which is not locked moves downwards along the drill rod (1) to abut against the skull when the drill rod (1) moves downwards along the guide hole (313) and then is locked after moving downwards along the drill rod (1) to abut against the limiting insertion piece (4);

when the limiting insertion pieces (4) are sequentially inserted into the limiting insertion holes (314) from top to bottom, the locked locking sleeve (2) drills into the skull along with the drill rod (1) until the locking sleeve (2) abuts against the limiting insertion pieces (4) again.

2. A rat brain model making device according to claim 1, further comprising an inclination angle adjusting component (5) arranged at one side of the sliding block (3) and used for adjusting the inclination angle of the sliding block (3) until the passing drill rod (1) is perpendicular to the skull surface.

3. Rat brain modelling device according to claim 2, characterized in that said sliding block (3) comprises a first slide (31) having an adjustment plate (315) and a second slide (32) having a support plane (321), said inclination adjustment assembly (5) comprising a connection screw (51) passing through said adjustment plate (315) and connected to said second slide (32) and an adjustment nut (52) engaging said connection screw (51) and located between said adjustment plate (315) and said support plane (321) for adjusting the distance therebetween.

4. A rat brain model creation device according to any one of claims 1 to 3, further comprising a support frame (6) and at least one set of positioning needle assemblies (7) slidably arranged on the support frame (6) and used for fixing the skull.

5. The rat brain model making device according to claim 4, characterized in that the supporting frame (6) comprises at least one comb-shaped beam (63) matching with the positioning needle assembly (7), any one of the comb-shaped beams (63) is provided with a plurality of limiting comb teeth (631) distributed linearly, when any group of the positioning needle assemblies (7) slide along the comb-shaped beam (63) to a target position, the positioning needle assembly (7) rotates around the comb-shaped beam (63), and the limiting grooves (721) of the positioning needle assembly (7) match with the opposite limiting comb teeth (631).

6. A rat brain model making device according to claim 5, characterized in that any group of the positioning needle assemblies (7) comprises a positioning needle (71), a rotary lock sleeve (72) with the limit groove (721) and an articulated screw sleeve (73) which is matched with the positioning needle (71) and the rotary lock sleeve (72) is articulated.

7. A rat brain model making device according to claim 5, further comprising a sliding frame (8) slidably sleeved on the supporting frame (6), wherein the sliding block (3) is slidably sleeved on the sliding frame (8).

8. Rat brain modelling device according to claim 7, characterized in that said carriage (8) is arranged parallel between two of said comb beams (63).

9. A rat brain model making device according to any one of claims 1 to 3, further comprising a fixed seat (9) and an elastic seat (10) fixed on the fixed seat (9) and used for jointing with mandible, wherein the elastic seat (10) is in a V shape.

10. A rat brain model making device according to claim 9, further comprising an anesthesia mask (11) fixedly arranged on the fixing seat (9) and opposite to the elastic seat (10) and an anesthesia trachea (12) communicated with the anesthesia mask (11).