CN113454112B - 识别tau的抗体 - Google Patents

识别tau的抗体 Download PDF

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Publication number
CN113454112B
CN113454112B CN201980073684.9A CN201980073684A CN113454112B CN 113454112 B CN113454112 B CN 113454112B CN 201980073684 A CN201980073684 A CN 201980073684A CN 113454112 B CN113454112 B CN 113454112B
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antibody
seq
antigen
antibodies
tau
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CN113454112A (zh
Inventor
塔洛陈·S.·尼扎
罗宾·巴伯尔
菲利普·詹姆斯·多兰三世
刘跃
斯维特拉娜·亚历山大
马克·E.·伦茨
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Prothena Biosciences Ltd
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Prothena Biosciences Ltd
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Priority claimed from PCT/US2018/059895 external-priority patent/WO2020096608A1/en
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Publication of CN113454112A publication Critical patent/CN113454112A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/55—Fab or Fab'
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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CN201980073684.9A 2018-11-08 2019-11-08 识别tau的抗体 Active CN113454112B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411549401.2A CN119409813A (zh) 2018-11-08 2019-11-08 识别tau的抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2018/059895 WO2020096608A1 (en) 2018-11-08 2018-11-08 Antibodies recognizing tau
USPCT/US2018/059895 2018-11-08
US201862758421P 2018-11-09 2018-11-09
US62/758,421 2018-11-09
PCT/US2019/060616 WO2020097561A1 (en) 2018-11-08 2019-11-08 Antibodies recognizing tau

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CN113454112A CN113454112A (zh) 2021-09-28
CN113454112B true CN113454112B (zh) 2024-11-22

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US (1) US20220153821A1 (https=)
EP (1) EP3877410A4 (https=)
JP (2) JP7623699B2 (https=)
KR (1) KR20210090184A (https=)
CN (2) CN113454112B (https=)
AU (1) AU2019377595A1 (https=)
BR (1) BR112021008624A2 (https=)
CL (1) CL2021001158A1 (https=)
CO (1) CO2021007370A2 (https=)
CU (1) CU24781B1 (https=)
IL (1) IL283049A (https=)
JO (1) JOP20210098A1 (https=)
MX (1) MX2021005411A (https=)
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CA2902026C (en) 2013-03-13 2023-08-29 Prothena Biosciences Limited Tau immunotherapy
EP3452507B1 (en) 2016-05-02 2022-10-19 Prothena Biosciences Limited Tau immunotherapy
CA3022515A1 (en) 2016-05-02 2017-11-09 Prothena Biosciences Limited Antibodies recognizing tau
PE20190208A1 (es) 2016-05-02 2019-02-07 Prothena Biosciences Ltd Anticuerpos que reconocen tau
CN110881274B (zh) 2017-05-02 2024-11-15 普罗塞纳生物科学有限公司 识别tau的抗体
SG11202104549TA (en) * 2018-11-08 2021-05-28 Prothena Biosciences Ltd Antibodies recognizing tau
EP3935083A4 (en) 2019-03-03 2022-11-30 Prothena Biosciences Limited Antibodies recognizing tau
US20250034559A1 (en) 2021-11-17 2025-01-30 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders
CA3266790A1 (en) 2022-09-15 2024-03-21 Voyager Therapeutics, Inc. TAU PROTEIN BINDING COMPOUNDS
CN115724967A (zh) * 2022-09-21 2023-03-03 天津鸿宇泰生物科技有限公司 一种识别Tau蛋白N端区域的单克隆抗体及其应用
CN116925217B (zh) * 2023-09-14 2024-03-08 北京凯祥弘康生物科技有限公司 针对Tau蛋白的抗体
WO2025122634A1 (en) 2023-12-05 2025-06-12 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders

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