CN113444643B - Clinical laboratory is with bacterin research and development virus culture apparatus - Google Patents
Clinical laboratory is with bacterin research and development virus culture apparatus Download PDFInfo
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- CN113444643B CN113444643B CN202110566736.5A CN202110566736A CN113444643B CN 113444643 B CN113444643 B CN 113444643B CN 202110566736 A CN202110566736 A CN 202110566736A CN 113444643 B CN113444643 B CN 113444643B
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- 241000700605 Viruses Species 0.000 title claims abstract description 25
- 238000012827 research and development Methods 0.000 title claims description 8
- 238000007789 sealing Methods 0.000 claims abstract description 63
- 230000007246 mechanism Effects 0.000 claims abstract description 29
- 235000013601 eggs Nutrition 0.000 claims description 137
- 239000002184 metal Substances 0.000 claims description 9
- 210000001503 joint Anatomy 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 abstract description 17
- 238000000034 method Methods 0.000 abstract description 7
- 241000894006 Bacteria Species 0.000 abstract description 5
- 238000005192 partition Methods 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 12
- 238000011161 development Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 239000002390 adhesive tape Substances 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 210000003837 chick embryo Anatomy 0.000 description 2
- 229960003971 influenza vaccine Drugs 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000005723 virus inoculator Substances 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/10—Bioreactors or fermenters specially adapted for specific uses adapted for the cultivation of avian eggs or in avian eggs, e.g. for vaccine production
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
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- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to the technical field of vaccine culture, in particular to a virus culture device for researching and developing vaccine for clinical laboratory, which comprises a box body, a plurality of egg supporting mechanisms and a plurality of partition boards, wherein the partition boards are fixedly connected to the upper end of the interior of the box body at equal intervals, sterile egg taking cavities are clamped between two adjacent partition boards and the side walls of the box body, the egg supporting mechanisms are in one-to-one correspondence with the sterile egg taking cavities, the egg supporting mechanisms are positioned under the sterile egg taking cavities, the bottoms of the sterile egg taking cavities are open, the bottom ends of the partition boards are hinged with sealing boards, the bottom openings of the sterile egg taking cavities can be closed when the two sealing boards are mutually abutted and butted, the egg supporting mechanisms and the sealing boards are provided with control mechanisms for driving the sealing boards to be abutted and butted, and holes are formed in the side walls of the box body at the tops of the sterile egg taking cavities. The invention solves the defect that bacteria in the external environment possibly enter the incubator along with the air in the opening process of the incubator in the prior art, has obvious beneficial effects and is suitable for popularization.
Description
Technical Field
The invention relates to the technical field of vaccine culture, in particular to a virus culture device for researching and developing vaccine for clinical laboratory.
Background
Vaccines refer to biological products for vaccination made with a variety of pathogenic microorganisms. The existing influenza vaccine generally uses chick embryos as virus breeding materials in the manufacturing process, and the chick embryos need to be placed into a closed, sterile and constant-temperature incubator for culture after virus inoculation, so that the virus inoculated by the allantoic cavity way can reach the inside of the embryo body for propagation through the body fluid circulation of the embryo body and continuously accumulate in the allantoic cavity, the allantoic fluid content is increased, and the virus cultivation is completed. When research and development are carried out on novel influenza vaccines in the technical field of vaccines, the optimal time for culturing viruses in embryo bodies needs to be measured through a large number of experiments, the research and development time of the vaccines can be influenced due to overlong culture time, the culture time is too short, enough virus stock solution cannot be obtained, the embryo bodies cultured in the incubator are required to be taken out for inspection in the same interval time, but when the embryo bodies are taken out, an incubator needs to be started, when the incubator is in the starting process, the incubator is in contact with the external environment at the moment, the temperature of the incubator can be changed, and bacteria in the external environment can enter the incubator along with air, so that a virus culture device for researching and developing the vaccine for the clinical laboratory needs to be designed.
Disclosure of Invention
The invention aims to solve the defect that bacteria in the external environment possibly enter the incubator along with air in the opening process of the incubator in the prior art, and provides a virus culture device for researching and developing vaccine for a clinical laboratory.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the utility model provides a clinical laboratory is with bacterin research and development virus culture apparatus, includes box, a plurality of egg supporting mechanism and a plurality of baffle, a plurality of equidistant fixed connection of baffle is in the inside upper end of box, adjacent two the clamp has the aseptic egg cavity of getting between baffle and the lateral wall of box, egg supporting mechanism with the aseptic egg cavity one-to-one of getting, egg supporting mechanism is located under the aseptic egg cavity of getting, the bottom of aseptic egg cavity of getting is uncovered to be set up, the bottom of baffle articulates there is the closing plate, two can be with the bottom opening closure in aseptic egg cavity of getting when the closing plate supports each other to press the butt joint, be provided with on egg supporting mechanism and the closing plate and drive the closing plate and support the control mechanism who presses the butt joint, the aseptic egg cavity of getting is seted up on the box lateral wall at egg cavity top, articulated on the outer wall of box has can be with the confined shrouding of egg cavity of getting.
Preferably, the egg supporting mechanism comprises a plurality of sections of electric telescopic rods fixedly arranged at the bottom end of the box body, egg holders are fixedly connected to the top ends of the plurality of sections of electric telescopic rods, and eggs are limited on the egg holders.
Preferably, the control mechanism comprises two hooks, two hanging rings and two connecting pieces, extension lines of the two connecting pieces coincide, the connecting pieces are fixedly connected to the outer wall of the egg holder, the hooks are fixedly connected to one ends of the connecting pieces, which are far away from the egg holder, of the connecting pieces, the hanging rings are fixedly connected to the end parts of the sealing plates, the hanging rings are far away from the rotating shafts of the sealing plates, the hanging rings are made of rubber and are horizontally arranged in a state without external force, and the projection of the hooks on the vertical direction falls into the hanging rings.
Preferably, the bottom of the sterile egg taking cavity is fixedly connected with a metal square frame, the edge of the side wall, close to the sealing plate, of the metal square frame is fixedly connected with a magnetic seal, the magnetic seal can be adsorbed with the sealing plate in a sealing manner, and the two side walls, in abutting contact with the sealing plates, are fixedly connected with sealing seals.
Preferably, the sealing strip is provided with a hole for the multi-section electric telescopic rod to pass through, and the hole can be tightly attached to the outer wall of the multi-section electric telescopic rod.
Preferably, guide rails are fixedly connected to two symmetrical vertical side walls inside the box body, a supporting plate capable of horizontally sliding is arranged between the two guide rails, a round hole for placing eggs is formed in the supporting plate, the egg holder can penetrate through the round hole, square holes for the connecting piece and the hooks to pass through are formed in the edge of the round hole, a door opening for the supporting plate to pass through is formed in the side wall of the box body, and a sealing door plate is mounted on the outer side wall of the box body where the door opening is located in a matched mode.
Preferably, the egg support comprises a cylindrical block and a plurality of supporting pieces, wherein a circular groove is formed in the plane side wall of the cylindrical block, the supporting pieces are fixedly connected to the edge of the circular groove, the supporting pieces are uniformly distributed around the axis of the cylindrical block, the projection of the supporting pieces in the vertical direction is all located in the cylindrical block, and the supporting pieces are made of rubber materials.
The virus culture device for researching and developing vaccine for clinical laboratory provided by the invention has the beneficial effects that: this clinical laboratory is with bacterin research and development virus culture apparatus is through setting up aseptic egg chamber of getting in box inside upper end to the bottom opening accessible closing plate in aseptic egg chamber of getting is closed, when need take out the egg embryo body in the thermostated container, first through egg supporting mechanism control egg upward movement, in-process that egg supporting mechanism carried the egg upward moved, the last control mechanism of egg supporting mechanism can drive two closing plates and support the butt joint and seal the bottom opening in aseptic egg chamber of getting, the aseptic egg chamber of getting and the inside of box is cut apart completely this moment, we can open the shrouding at aseptic egg chamber top this moment, take out the egg and detect, and can not influence the inside constant temperature of box, aseptic environment, the shortcoming that has the artificial containers in the in-process of opening in prior art has been solved, bacteria in the external environment probably can enter into the artificial containers along the air, the beneficial effect is obvious, be fit for promoting.
Drawings
FIG. 1 is a schematic diagram of the external perspective structure of a virus culture device for vaccine development for clinical laboratory;
FIG. 2 is a schematic diagram showing a cross-sectional front view of a virus culture apparatus for vaccine development for clinical laboratory according to the present invention;
FIG. 3 is an enlarged schematic view of the portion A of FIG. 2;
fig. 4 is a schematic diagram of a three-dimensional structure of a sterile egg taking cavity of a virus culture device for researching and developing vaccine for clinical laboratory;
fig. 5 is a schematic diagram of a top view structure of a sterile egg taking cavity of a virus culture device for researching and developing vaccine for clinical laboratory;
fig. 6 is a schematic diagram of a three-dimensional structure of an egg supporting mechanism of a virus culture device for vaccine development for clinical laboratory provided by the invention;
FIG. 7 is a schematic perspective view of a support plate of a virus culture device for vaccine development for clinical laboratory according to the present invention;
fig. 8 is a schematic side sectional view of a virus culture device for clinical laboratory vaccine development according to the present invention.
In the figure: 1 box, 2 baffle, 3 aseptic egg chamber, 4 closing plate, 5 egg holes, 6 shrouding, 7 multisection electric telescopic handle, 8 egg support, 9 couple, 10 link, 11 connecting pieces, 12 magnetism inhale the strip of paper used for sealing, 13 airtight strip of paper used for sealing, 14 guide rails, 15 backup pad, 16 round holes, 17 square holes, 18 door openings, 19 sealing door plant, 20 holes, 21 cylinder piece, 22 support piece, 23 circular slot, 24 metal square frame.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments.
Example 1
Referring to fig. 1-8, a clinical laboratory is with bacterin research and development virus culture apparatus, including box 1, a plurality of egg supporting mechanism and a plurality of baffle 2, equidistant fixed connection of a plurality of baffles 2 is in the inside upper end of box 1, the inner upper end at box 1 has been cut apart to the aseptic egg chamber 3 of getting between adjacent two baffles 2 and the lateral wall of box 1, egg supporting mechanism and aseptic egg chamber 3 one-to-one, egg supporting mechanism is located under the aseptic egg chamber 3 of getting, the bottom of aseptic egg chamber 3 of getting is uncovered to set up, the bottom of baffle 2 articulates there is closing plate 4, closing plate 4 is made by metal material, the edge fixedly connected with adhesive tape of closing plate 4, can be with aseptic egg chamber 3 of getting bottom opening closure when two closing plates 4 are mutually supported and are butted, thereby make aseptic egg chamber 3 and box 1's inside split completely, when getting egg chamber 3 from the aseptic egg chamber 3 in, can not influence the inside of box 1, the constant temperature egg environment, so we need send into the egg chamber 3 of getting to aseptic egg chamber 3 and have the closing plate 5 to be used for taking out the closing plate 5 to open the closing plate 5 when the side wall of aseptic chamber 4 is closed, the closing plate 5 is opened to be used for taking out the closing plate 5.
According to the invention, the egg supporting mechanism comprises a plurality of sections of electric telescopic rods 7 fixedly arranged at the bottom end inside the box body 1, the top ends of the plurality of sections of electric telescopic rods 7 are fixedly connected with egg holders 8, eggs are limited on the egg holders 8, the eggs are placed on the egg holders 8, when the plurality of sections of electric telescopic rods 7 extend to drive the egg holders 8 to move upwards, the eggs also move upwards along with the egg holders 8 and enter the sterile egg taking cavity 3, the egg holders 8 comprise cylindrical blocks 21 and a plurality of supporting pieces 22, circular grooves 23 are formed in the plane side walls of the cylindrical blocks 21, the eggs are placed in the circular grooves 23 and can be limited and stable, the supporting pieces 22 are fixedly connected to the edges of the circular grooves 23, the supporting pieces 22 are uniformly distributed around the axis of the cylindrical blocks 21, the supporting pieces 22 surround the eggs and are used for assisting in stabilizing the eggs, and the projection of the supporting pieces 22 in the vertical direction is completely fallen into the cylindrical blocks 21, and the supporting pieces 22 are made of rubber materials and can adapt to eggs with different sizes.
In the invention, the control mechanism comprises two hooks 9, two hanging rings 10 and two connecting pieces 11, the extension lines of the two connecting pieces 11 coincide, the connecting pieces 11 are fixedly connected to the outer wall of the egg tray 8, the hooks 9 are fixedly connected to the middle part of one end of the connecting piece 11 far away from the egg tray 8, the diameter of each hook 9 is smaller than any side length of the connecting piece 11, the hanging rings 10 are fixedly connected to the end part of the sealing plate 4, the hanging rings 10 are arranged far away from the rotating shaft of the sealing plate 4, the hanging rings 10 are made of rubber and are horizontally arranged in a state without external force, the projection of each hook 9 in the vertical direction falls into the hanging rings 10, when the egg tray 8 is lifted under the action of the multi-section electric telescopic rod 7, the connecting piece 11 fixed on the egg tray 8 and the hook 9 fixedly connected to the connecting piece 11 also start to lift, when the hooks 9 lift to the position of the hanging rings 10, the hanging rings 10 are hooked at the moment and move together, the hanging rings 10 can rotate along with the sealing plate 4 when the hanging rings 10 start to move, and when two egg sealing plates 4 are pressed and are butted, the bottom ends of the sealing plate 3 are taken out of the sterile box 3, the sterile box 3 is not in contact with the sterile box 1, and the sterile box is also stretched out of the sterile box 1, and the sterile box is not in the sterile box is closed, and the sterile box is not in the environment; in addition, the hanging ring 10 can be restored after being used, and the annular part can be automatically unfolded, so that the hanging ring is convenient to use next time; the deformation of the hanging ring 10 can be increased due to the arrangement of the connecting piece 11, when the two sealing plates 4 are abutted against and butted, the hanging ring 10 is limited between the connecting piece 11 and the hanging hook 9, if the connecting piece 11 is not arranged, the hanging ring 10 can be abutted against the cylindrical block 21, the deformation of the hanging ring 10 is reduced, the pulling force of the hanging ring 10 can be reduced, the two sealing plates 4 are more stable when being abutted against, the deformation of the hanging ring 10 is increased, and in addition, the connecting piece 11 can have a telescopic function.
When the egg box is used, the sealing plate 4 is vertically arranged in an initial state, the hanging ring 10 is horizontally arranged and the annular part can be automatically opened, eggs are placed on the egg holder 8 through the egg taking holes 5, after the eggs are stable, the egg taking holes 5 are sealed through the sealing plate 6, the internal environment of the box body 1 is regulated, the egg blank is cultivated in a constant-temperature and nontoxic environment, after a period of time passes, one egg blank is firstly taken out to observe the breeding condition of viruses in the egg blank, the multisection electric telescopic rod 7 is controlled to stretch, the multisection electric telescopic rod 7 carries the egg holder 8 to rise, the egg holder 8 carries the connecting piece 11 fixedly connected to the egg holder 8 and the hanging hook 9 fixedly connected to the connecting piece 11 to rise, when the hanging hook 9 rises to the position of the hanging ring 10, the hanging hook 9 hooks the hanging ring 10 and carries the hanging ring 10 to move together, when the hanging ring 10 starts to move, the two sealing plates 4 are pressed and butted to observe the breeding condition of viruses in the egg blank, the multisection electric telescopic rod 7 is firstly taken out, the egg blank 7 is stopped from being stretched out, the inner side of the sterile box 3 is independently detected, the defect that the inner environment of the sterile box 3 is not influenced in the whole process is overcome, and the existing process is not influenced by the existing bacteria in the sterile box is detected, and the inner environment of the sterile box 3 is completely opened, and the inner space is completely opened; in addition, after the egg embryo in the box body 1 is completely taken out, the multi-section electric telescopic rod 7 is controlled to shrink, and at the moment, the egg tray 8 can abut against the sealing plate 4, so that the sealing plate 4 is restored to the initial state, and the egg tray 8 is stopped to the initial position.
Example 2
In the embodiment 1, the sealing plate 4 seals the opening of the aseptic egg taking cavity 3, although the edge of the sealing plate 4 is provided with the adhesive tape, as the sealing plate 4 is hinged on the partition plate 2, the hinged position is difficult to ensure good sealing state, and when the sealing plate 4 rotates, the adhesive tape at the edge of the sealing plate 4 can rub against the inner wall of the box body 1 to influence the normal movement of the sealing plate 4, in order to solve the problem, in the embodiment 1, the original sealing tape at the edge of the sealing plate 4 is completely removed, and referring to fig. 2-5, as another preferred embodiment of the invention, the difference with the embodiment 1 is that the bottom of the aseptic egg taking cavity 3 is fixedly connected with the metal square frame 24, the side wall edge of the metal square frame 24 close to the sealing plate 4 is fixedly connected with the magnetic seal 12, the magnetic seal 12 can be adsorbed with the sealing plate 4 in a sealing way, the side walls of the two sealing plates 4 in abutting contact are fixedly connected with a sealing strip 13, a hole 20 for the passage of the multi-section electric telescopic rod 7 is reserved on the sealing strip 13, the hole 20 can be tightly attached to the outer wall of the multi-section electric telescopic rod 7, a metal square frame 24 is fixedly connected inside the sterile egg taking cavity 3, the edge of the metal square frame 24 is fixedly connected with a magnetic sealing strip 12, when the bottom end opening of the sterile egg taking cavity 3 is sealed by the sealing plate 4, the sealing plate 4 is adsorbed on the magnetic sealing strip 12, the peripheral gap of the sealing plate 4 is completely covered by the magnetic sealing strip 12, the gap between the two sealing plates 4 is filled by the sealing strip 13, the sterile egg taking cavity 3 is isolated from the inside of the box body 1, the sealing strip 13 is not contacted with the inner wall of the box body 1 at the moment, the normal rotation of the sealing plate 4 is not influenced, in addition, the holes 20 can prevent the multi-section electric telescopic rod 7 from affecting the normal closing of the sealing plate 4.
Example 3
In embodiment 1, egg embryo is put into box 1 through getting egg hole 5 inside, but can only put one at a time, it is inconvenient to operate, and when placing egg embryo on egg support 8, experimenter hardly observes the inside situation of box 1, it is difficult to ensure that the egg can stable place on egg support 8, for solving this problem we improve embodiment 1, refer to fig. 2 and 7, as another preferred embodiment of the invention, the difference with embodiment 1 lies in, fixedly connected with guide rail 14 on two symmetrical vertical lateral walls of box 1 inside, but be provided with backup pad 15 that can horizontal slip between two guide rails 14, offer round hole 16 for placing the egg on backup pad 15, egg support 8 can pass round hole 16, offer square hole 17 that supplies connecting piece 11 and couple 9 to pass through this moment on the edge of round hole 16, it can be difficult to ensure that the egg can stable place on egg support 8, install sealing 19 on box 1 lateral wall matching that door plant 18 place in order to solve this problem, when we need place egg embryo, then place egg embryo on the door plant 19, can move into the inner wall 15 just before the inner wall of egg support piece 15 is followed to the inner wall of egg support 15 on the round hole 16, can be followed egg support piece 15 and can be stretched out and put into the round hole 15 just in order to the round hole 15, and can be followed egg support piece 15 and put egg embryo 15 on the inner wall 15, and just one piece is stretched out and stretched into on the round hole 15, and put into the round hole 15 just in order to be just one piece on the round hole 15, and the round hole is just in order to be placed on the round hole 15 and can be placed on the round hole 15 and put into the round hole 15 and can be stretched into the round hole 15 and the round hole is just 13 and the round hole can be put into.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (1)
1. The utility model provides a clinical laboratory uses bacterin research and development virus culture apparatus, its characterized in that includes box (1), a plurality of egg supporting mechanism and a plurality of baffle (2), a plurality of equidistant fixed connection of baffle (2) is in the inside upper end of box (1), and two adjacent baffle (2) and the lateral wall of box (1) between the clamp connect aseptic egg chamber (3), egg supporting mechanism with aseptic egg chamber (3) one-to-one of getting, egg supporting mechanism is located under aseptic egg chamber (3), the bottom open setting of egg chamber (3) is got in the aseptic, the bottom of baffle (2) articulates there is closing plate (4), two can be with aseptic egg chamber (3) of getting's bottom opening when closing plate (4) are mutually supported and pressed the butt joint, egg supporting mechanism and closing plate (4) are provided with the control mechanism that drives closing plate (4) and support and press the butt joint, egg chamber (1) lateral wall at egg chamber (3) top is seted up egg chamber (1) and is got egg chamber (5), can be articulated on the outer wall (6) of getting that can be closed;
the egg supporting mechanism comprises a plurality of sections of electric telescopic rods (7) fixedly arranged at the bottom end inside the box body (1), egg holders (8) are fixedly connected to the top ends of the plurality of sections of electric telescopic rods (7), and eggs are limited on the egg holders (8);
the control mechanism comprises two hooks (9), two hanging rings (10) and two connecting pieces (11), extension lines of the two connecting pieces (11) are overlapped, the connecting pieces (11) are fixedly connected to the outer wall of the egg tray (8), the hooks (9) are fixedly connected to one end, far away from the egg tray (8), of the connecting pieces (11), the hanging rings (10) are fixedly connected to the end portions of the sealing plates (4), the hanging rings (10) are far away from the rotating shafts of the sealing plates (4), the hanging rings (10) are made of rubber and are horizontally arranged in a state without external force, and the projection of the hooks (9) in the vertical direction falls into the hanging rings (10);
the bottom of the sterile egg taking cavity (3) is fixedly connected with a metal square frame (24), the edge of the side wall, close to the sealing plate (4), of the metal square frame (24) is fixedly connected with a magnetic seal (12), the magnetic seal (12) can be adsorbed with the sealing plate (4) in a sealing way, and the side walls, in abutting contact, of the two sealing plates (4) are fixedly connected with a sealing seal (13);
a hole (20) for the passage of the multi-section electric telescopic rod (7) is reserved on the airtight seal (13), and the hole (20) can be tightly attached to the outer wall of the multi-section electric telescopic rod (7);
the egg box comprises a box body (1), wherein guide rails (14) are fixedly connected to two symmetrical vertical side walls in the box body (1), a supporting plate (15) capable of horizontally sliding is arranged between the two guide rails (14), a round hole (16) for placing eggs is formed in the supporting plate (15), an egg tray (8) can penetrate through the round hole (16), square holes (17) for a connecting piece (11) and a hook (9) to pass through are formed in the edge of the round hole (16), a door opening (18) for the supporting plate (15) to pass through is formed in the side wall of the box body (1), and a sealing door plate (19) is installed on the outer side wall of the box body (1) where the door opening (18) is formed in a matched mode;
egg holds in palm (8) including cylinder piece (21) and a plurality of support piece (22), round groove (23) have been seted up on the plane lateral wall of cylinder piece (21), a plurality of support piece (22) fixed connection is in the edge of round groove (23), support piece (22) evenly distributed around the axis of cylinder piece (21), support piece (22) are in the whole cylinder piece (21) that falls of projection on vertical direction, support piece (22) are made by rubber material.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110566736.5A CN113444643B (en) | 2021-05-24 | 2021-05-24 | Clinical laboratory is with bacterin research and development virus culture apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110566736.5A CN113444643B (en) | 2021-05-24 | 2021-05-24 | Clinical laboratory is with bacterin research and development virus culture apparatus |
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| Publication Number | Publication Date |
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| CN113444643A CN113444643A (en) | 2021-09-28 |
| CN113444643B true CN113444643B (en) | 2023-12-01 |
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| CN114752497A (en) * | 2022-06-16 | 2022-07-15 | 江苏中慧元通生物科技股份有限公司 | Sterile culture device for preparing influenza vaccine |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6286455B1 (en) * | 1998-01-12 | 2001-09-11 | Embrex, Inc. | Automated in ovo injection apparatus |
| CN207646224U (en) * | 2017-10-22 | 2018-07-24 | 徐宇环 | A kind of biochemical industry microculture experimental bench |
| CN208545434U (en) * | 2018-05-15 | 2019-02-26 | 李国英 | A kind of clinical laboratory's anti-pollution type germ culturing device |
| JP2020000195A (en) * | 2018-06-29 | 2020-01-09 | 国立大学法人大阪大学 | Storage body of culture vessel and culture processing system |
| CN111269797A (en) * | 2018-12-05 | 2020-06-12 | 上海清强健康科技有限公司 | Constant temperature incubator |
| CN211005324U (en) * | 2019-09-05 | 2020-07-14 | 苏维娜 | Clinical laboratory uses microbial cultivation ware |
| CN111635857A (en) * | 2020-06-19 | 2020-09-08 | 黑龙江省农业科学院土壤肥料与环境资源研究所 | Integrated equipment for avoiding contamination based on microbial cultivation |
| CN211771238U (en) * | 2020-01-14 | 2020-10-27 | 河北医科大学第一医院 | Germ culture apparatus is used in medical treatment |
| CN212640459U (en) * | 2020-06-29 | 2021-03-02 | 范玉梅 | Bacterial culture device for clinical laboratory |
| CN213060841U (en) * | 2020-05-28 | 2021-04-27 | 许京波 | Cytoplasm separator is used in bacterin production |
-
2021
- 2021-05-24 CN CN202110566736.5A patent/CN113444643B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6286455B1 (en) * | 1998-01-12 | 2001-09-11 | Embrex, Inc. | Automated in ovo injection apparatus |
| CN207646224U (en) * | 2017-10-22 | 2018-07-24 | 徐宇环 | A kind of biochemical industry microculture experimental bench |
| CN208545434U (en) * | 2018-05-15 | 2019-02-26 | 李国英 | A kind of clinical laboratory's anti-pollution type germ culturing device |
| JP2020000195A (en) * | 2018-06-29 | 2020-01-09 | 国立大学法人大阪大学 | Storage body of culture vessel and culture processing system |
| CN111269797A (en) * | 2018-12-05 | 2020-06-12 | 上海清强健康科技有限公司 | Constant temperature incubator |
| CN211005324U (en) * | 2019-09-05 | 2020-07-14 | 苏维娜 | Clinical laboratory uses microbial cultivation ware |
| CN211771238U (en) * | 2020-01-14 | 2020-10-27 | 河北医科大学第一医院 | Germ culture apparatus is used in medical treatment |
| CN213060841U (en) * | 2020-05-28 | 2021-04-27 | 许京波 | Cytoplasm separator is used in bacterin production |
| CN111635857A (en) * | 2020-06-19 | 2020-09-08 | 黑龙江省农业科学院土壤肥料与环境资源研究所 | Integrated equipment for avoiding contamination based on microbial cultivation |
| CN212640459U (en) * | 2020-06-29 | 2021-03-02 | 范玉梅 | Bacterial culture device for clinical laboratory |
Non-Patent Citations (1)
| Title |
|---|
| 大型生物制药厂的病毒鸡胚培养;孙爱喜;;当代畜禽养殖业(第10期);第4-6页 * |
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