CN113440475A - External cream for repairing skin barrier function and preparation method thereof - Google Patents
External cream for repairing skin barrier function and preparation method thereof Download PDFInfo
- Publication number
- CN113440475A CN113440475A CN202110540257.6A CN202110540257A CN113440475A CN 113440475 A CN113440475 A CN 113440475A CN 202110540257 A CN202110540257 A CN 202110540257A CN 113440475 A CN113440475 A CN 113440475A
- Authority
- CN
- China
- Prior art keywords
- papermulberry
- parts
- cream
- skin barrier
- leaf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006071 cream Substances 0.000 title claims abstract description 63
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 241000933832 Broussonetia Species 0.000 claims abstract description 85
- 230000008439 repair process Effects 0.000 claims abstract description 28
- 239000000284 extract Substances 0.000 claims abstract description 26
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 25
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 25
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000203 mixture Substances 0.000 claims abstract description 16
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 15
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims abstract description 15
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 15
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 15
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 15
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 15
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 15
- 229950004959 sorbitan oleate Drugs 0.000 claims abstract description 15
- 239000008117 stearic acid Substances 0.000 claims abstract description 15
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 13
- 229950008882 polysorbate Drugs 0.000 claims abstract description 13
- 229920000136 polysorbate Polymers 0.000 claims abstract description 13
- 239000003871 white petrolatum Substances 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 8
- 229960004274 stearic acid Drugs 0.000 claims abstract description 8
- 238000000605 extraction Methods 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims description 18
- 238000005303 weighing Methods 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 13
- 239000012154 double-distilled water Substances 0.000 claims description 9
- 238000003860 storage Methods 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 229940100611 topical cream Drugs 0.000 claims description 4
- 230000032683 aging Effects 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000002386 leaching Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 13
- 239000003814 drug Substances 0.000 abstract description 12
- 229940079593 drug Drugs 0.000 abstract description 8
- 238000000746 purification Methods 0.000 abstract description 3
- 230000004888 barrier function Effects 0.000 description 47
- 239000000306 component Substances 0.000 description 21
- 238000012360 testing method Methods 0.000 description 15
- 238000002474 experimental method Methods 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 7
- 244000144730 Amygdalus persica Species 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 235000006040 Prunus persica var persica Nutrition 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000003674 animal food additive Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 239000008358 core component Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 231100000021 irritant Toxicity 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000009021 pien tze huang Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000705930 Broussonetia papyrifera Species 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 241000735527 Eupatorium Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010041303 Solar dermatitis Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037365 barrier function of the epidermis Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 206010021198 ichthyosis Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000011120 smear test Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external cream for repairing skin barrier function, which comprises the following components in part by weight: comprises a papermulberry leaf extract, an oil phase component and a water phase component except the papermulberry leaf extract. The papermulberry fruit leaf extract is extracted from papermulberry fruit leaf dry products or papermulberry fruit leaf fresh products; the oil phase component combination comprises white vaseline, light liquid paraffin, stearic acid, polysorbate and sorbitan oleate; the water phase component composition except the papermulberry leaf extract comprises hyaluronic acid and potassium sorbate. The invention also provides a preparation method of the external cream for repairing the skin barrier function, and part of the external cream is the extraction and purification of the effective components of the papermulberry leaf cream; the other part is the preparation of cream. The invention effectively solves the technical problems of insufficient skin barrier repair function and high medication cost of the emulsifiable paste in the prior art, and further realizes the technical effects of effectively improving the skin barrier repair function and reducing the medication cost.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an external cream for repairing skin barrier function and a preparation method thereof.
Background
Skin barrier broadly includes physical barrier, pigment barrier, nerve barrier, and immune barrier. The skin barrier is mainly defined as a physical barrier, and the skin barrier is usually said to be a physical barrier. The physical barrier is composed of a sebum membrane, horny layer keratin, lipid, a sandwich structure, a brick wall structure, dermal mucopolysaccharide, mucopolysaccharide and the like, resists the entrance of external harmful substances, irritants and sunlight, and has the functions of moisturizing, regulating and resisting inflammation. The damage of skin physical barrier can cause skin dryness, skin aging, pigmentation atopic dermatitis, eczema, psoriasis, ichthyosis, solar dermatitis, skin greasiness, irritant dermatitis, hormone dependent dermatitis, and seborrheic diseases such as acne, rosacea, and seborrheic dermatitis.
The best method for keeping skin healthy is to protect the skin barrier function, and the skin barrier repairing liquid is usually smeared on the skin barrier repairing liquid, so that the immunity of the skin can be effectively improved, and the skin becomes firm. However, in the process of implementing the technical solution in the prior art, the applicant finds that the following technical problems exist in the technical solution in the prior art:
at present, skin care products containing words with skin barrier repair functions are manufactured by a plurality of brands of cosmetics at home and abroad. But there is no national established evaluation standard for skin barrier repair efficacy. Resulting in the fact that many brands of barrier repair products fail to perform effectively, and such skin care products are relatively expensive.
Disclosure of Invention
On one hand, the technical problem to be solved by the invention is to provide the external cream for repairing the skin barrier function, the technical problems of insufficient skin barrier repairing function and high medication cost of the cream in the prior art are solved, and the technical effects of effectively improving the skin barrier repairing function and reducing the medication cost are achieved.
In order to solve the technical problems, the technical scheme of the invention is as follows:
an external cream for repairing skin barrier function: comprises a papermulberry leaf extract, an oil phase component and a water phase component except the papermulberry leaf extract.
Preferably, the papermulberry leaf extract is extracted from papermulberry leaf dry products or papermulberry leaf fresh products; the oil phase component combination comprises white vaseline, light liquid paraffin, stearic acid, polysorbate and sorbitan oleate; the water phase component composition except the papermulberry leaf extract comprises hyaluronic acid and potassium sorbate.
Preferably, the feed additive is prepared from the following raw materials in parts by weight:
90-110 parts of dry papermulberry leaf, 118 parts of hyaluronic acid 105-containing materials, 130 parts of white vaseline 110-containing materials, 170 parts of light liquid paraffin 150-containing materials, 125 parts of stearic acid 115-containing materials, 85-90 parts of polysorbate, 30-35 parts of sorbitan oleate, 1-6 parts of potassium sorbate and 1500 parts of water 1000-containing materials.
Preferably, the feed additive is prepared from the following raw materials in parts by weight:
90-95 parts of dry papermulberry leaf, 113 parts of hyaluronic acid 105-.
More preferably, the feed additive is prepared from the following raw materials in parts by weight:
95-110 parts of dry papermulberry leaf, 118 parts of hyaluronic acid 113-.
Particularly preferably, the compound is prepared from the following raw materials in parts by weight:
40-60g of dry papermulberry leaf, 50g of hyaluronic acid, 60g of white vaseline, 80g of light liquid paraffin, 60g of stearic acid, 44g of polysorbate, 16g of sorbitan oleate, 1.5g of potassium sorbate and 600g of water 500-.
Particularly preferably, the preparation method of the papermulberry leaf extract comprises the following steps:
(A1) leaching raw materials: weighing 50g of dry papermulberry leaf, adding 500ml of 75% ethanol, and soaking for 12 hours;
(A2) reflux extraction: reflux-extracting in 85 deg.C water bath for 60 min;
(A3) preparing a cleaning paste: adding the extractive solution into a rotary evaporator, recovering under reduced pressure, collecting concentrated paste, weighing, and dissolving in double distilled water for storage.
The problem to be solved by the other aspect of the invention is to provide a preparation method of the external cream for repairing the skin barrier function, which comprises the following steps:
(S1): weighing hyaluronic acid, adding 50ml of double distilled water, and sealing for overnight storage after the hyaluronic acid is dissolved in the water;
(S2): weighing white vaseline, light liquid paraffin, stearic acid, polysorbate and sorbitan oleate as oil phase components on the next day, mixing, and heating to 85 deg.C to obtain mixture A;
(S3): weighing double distilled water, adding the papermulberry leaf extract, potassium sorbate and hyaluronic acid as water phase components, and heating to 85 ℃ to obtain a mixture B;
(S4): mixing the mixture A and the mixture B, and stirring for 30 minutes by using an electronic stirrer until all components are uniformly stirred to obtain a mixed solution C;
(S5): aging the mixed solution C in a water bath at 50 ℃ for 72 hours to prepare cream A;
(S6): storing cream A in cold storage room at 4 deg.C for 18 hr, and packaging to obtain topical cream for repairing skin barrier.
One or more technical solutions provided by the present application have at least the following technical effects or advantages:
according to the technical scheme, the papermulberry fruit leaf extract is used as a core component and combined in the substrate of the emulsifiable paste, and a series of technical means such as hyaluronic acid, stearic acid, sorbitan oleate, potassium sorbate and the like are included, so that animal and human experiments prove that the papermulberry fruit leaf extract with high safety avoids skin irritation. The technical problems that the skin barrier repair function of the emulsifiable paste in the prior art is insufficient and the medication cost is high are effectively solved, and the technical effects of effectively improving the skin barrier repair function and reducing the medication cost are further realized.
Drawings
FIG. 1 is a comparison graph of efficacy indexes of the paper mulberry leaf repairing barrier cream and the substrate;
FIG. 2 is a comparison graph of repairing speed indexes of the papermulberry leaf repairing barrier cream and the substrate barrier;
fig. 3 is a graph comparing the efficacy of papermulberry leaf with other barrier repair products.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The healthy skin barrier can resist the entrance of external harmful substances, irritants and sunlight, and has the effects of moisturizing and regulating. Having a healthy skin barrier is equivalent to having beautiful natural skin. However, the skin barrier is damaged due to environmental, dietary and wrong skin care, so that the self-defense ability of the skin is insufficient and the skin is extremely sensitive and damaged. The best way to maintain skin health is to preserve the skin barrier function. Skin care products containing words with skin barrier repair functions are manufactured by various brands of cosmetics at home and abroad, but actually, the barrier repair products of various brands cannot achieve effective effects and are high in price.
According to the technical scheme of the embodiment of the application, the skin barrier repairing function external cream and the preparation method thereof are provided, the problems that the skin barrier repairing function of the cream is insufficient and the medication cost is high in the prior art are solved, and the beneficial effects of effectively improving the skin barrier repairing function and reducing the medication cost are achieved under the condition that the papermulberry leaf extract is used as a core component.
The general idea of the embodiment of the invention for solving the technical problems is as follows:
an external cream for repairing skin barrier function: comprises a papermulberry leaf extract, an oil phase component and a water phase component except the papermulberry leaf extract.
Wherein the papermulberry leaf extract is extracted from papermulberry leaf dry products or papermulberry leaf fresh products; the oil phase component combination comprises white vaseline, light liquid paraffin, stearic acid, polysorbate and sorbitan oleate; the water phase component composition except the papermulberry leaf extract comprises hyaluronic acid and potassium sorbate.
The feed is prepared from the following raw materials in parts by weight:
90-110 parts of dry papermulberry leaf, 118 parts of hyaluronic acid 105-containing materials, 130 parts of white vaseline 110-containing materials, 170 parts of light liquid paraffin 150-containing materials, 125 parts of stearic acid 115-containing materials, 85-90 parts of polysorbate, 30-35 parts of sorbitan oleate, 1-6 parts of potassium sorbate and 1500 parts of water 1000-containing materials.
The main effective component of the formula is the extract of traditional Chinese medicine papermulberry leaf. The papermulberry leaf has the effect of moistening the skin recorded in ancient traditional Chinese medicine books. In recent times, Mr. Zhao Zhan nan, a Chinese medicine dermatology department, is used as a medicated bath raw material for treating psoriasis. The papermulberry leaf is the leaf of papermulberry, is a natural product in nature, has good safety and does not have strong irritation to human body, and the papermulberry leaf is also the main effective component source of the invention. The matrix of the cream contains multiple components such as hyaluronic acid, stearic acid, sorbitan oleate, potassium sorbate and the like, so that the barrier repairing effect of the papermulberry peach leaves can be better exerted.
In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.
Example 1
An external cream for repairing skin barrier function:
the feed is prepared from the following raw materials in parts by weight:
50g of dry papermulberry leaf, 50g of hyaluronic acid, 60g of white vaseline, 80g of light liquid paraffin, 60g of stearic acid, 44g of polysorbate, 16g of sorbitan oleate and 1.5g of potassium sorbate.
The production process of the skin barrier repair cream of the embodiment is divided into two parts: one part is the extraction and purification of the effective components of the papermulberry leaf emulsifiable paste; the other part is the preparation of cream.
The separation, extraction and purification process of the effective components for repairing the paper mulberry leaf barrier comprises the following steps:
step 1: weighing 50g of dry papermulberry leaf, adding 500ml of 75% ethanol, and soaking for 12 hours;
step 2: reflux-extracting in 85 deg.C water bath for 60 min;
and step 3: adding the extract into a rotary evaporator, recovering under reduced pressure, collecting concentrated paste, and weighing;
and dissolving the collected and weighed pure paste in double distilled water for storage.
Preparing the papermulberry leaf skin barrier repairing cream:
step 01: weighing 2g of hyaluronic acid, adding 50ml of double distilled water, and sealing for overnight storage after the hyaluronic acid is dissolved in the water.
Step 02: weighing 60g of white vaseline, 80g of light liquid paraffin, 60g of stearic acid, 44g of polysorbate and 16g of sorbitan oleate as oil phase components on the next day, mixing, and heating to 85 ℃ to obtain a mixture A.
Step 03: weighing 566.5g of double distilled water, adding 20g of papermulberry leaf extract, 1.5g of potassium sorbate and 50g of hyaluronic acid as water phase components, and heating to 85 ℃ to obtain a mixture B.
Step 04: and mixing the mixture A and the mixture B, and stirring for 30 minutes by using an electronic stirrer until all components are uniformly stirred to obtain a mixed solution C.
Step 05: aging the mixed solution C in a water bath at 50 ℃ for 72 hours to prepare cream A;
step 06: storing cream A in cold storage room at 4 deg.C for 18 hr, and packaging to obtain topical cream for repairing skin barrier.
Example 2
The dry papermulberry leaf in the example 1 is replaced by the fresh papermulberry leaf.
The procedure was the same as in example 1.
The test details of the examples are as follows:
the test data for example 1 mainly included safety and efficacy in repairing skin barrier in both directions, and animal experiments and human experiments were performed, respectively.
Specifically, the safety test of the papermulberry leaf repairing barrier cream and the safety animal test of the papermulberry leaf repairing barrier cream are carried out.
Step 1: subpackaging the papermulberry leaf repairing barrier cream according to the steps. C57B/6J mice were purchased and shaved on the back.
Step 2: the papermulberry leaf repairing barrier cream prepared by daubing the back of a mouse every day is 2 times, and the daubing amount is 2mg +/-0.1 mg/cm 2. The rub lasted 7 days.
And step 3: the observation result shows that the papermulberry leaf barrier repair cream has no relevant irritation to mice.
Safety human body test of the papermulberry leaf repairing barrier cream:
repetitive open smear test
Step 1: the participants were selected according to the subject's inclusion criteria, 20.
Step 2: the area of the forearm flexor is 3X 3cm2, and the test part should be kept dry to avoid contact with other external preparations.
And step 3: the paper mulberry leaf barrier repair cream is uniformly applied to the tested part for 7 days at a dose of about 0.050 +/-0.005 g (mL) per time and 2 times per day, and skin reaction is observed at the same time.
And 4, step 4: and observing according to the skin reaction judgment standard of the repetitive open smearing test, wherein the testee does not find obvious irritation reaction.
In order to evaluate the efficacy of the paper mulberry leaf repairing barrier cream, a human test of efficacy evaluation is carried out:
step 1: in order to prove the barrier repairing efficacy of the papermulberry leaf, the matrix emulsifiable paste of the papermulberry leaf barrier repairing emulsifiable paste is required to be prepared as a contrast, and the preparation method is the same as the above.
Step 2: the participants were selected according to the subject's inclusion criteria, 20.
Step 2: the area of the test part is 3X 3cm2, and the test part should be kept dry to avoid contact with other external preparations.
And step 3: uniformly applying the paper mulberry leaf barrier repair cream to the right arm part of a subject for 2 times a day according to the dosage of 2mg +/-0.1 mg/cm2, and uniformly applying the cream matrix to the left arm part of the subject for 2 times a day according to the dosage of 2mg +/-0.1 mg/cm2 for 7 days.
And 4, step 4: the basic TEWL values and barrier function recovery rate indices of both arms were measured by the TEWL probe of the skin barrier function measuring instrument MPA580 of CK, Germany.
And 5: the test results show that the basic skin barrier function indexes of the papermulberry leaf barrier repair cream group and the matrix cream control group have no statistical difference through analysis, but the papermulberry leaf barrier repair cream group in the skin barrier function repair indexes is obviously superior to the matrix cream group, and the test results show in fig. 1 and 2.
The efficacy evaluation animal test of the papermulberry leaf repairing barrier cream comprises the following steps:
in order to evaluate the efficacy of the paper mulberry leaf barrier repairing cream, a plurality of skin barrier repairing products which are currently sold are selected for efficacy evaluation comparison. The skin barrier repair cream comprises 4 similar products such as American manicure skin barrier repair cream, jade eupatorium skin barrier repair cream, pien Tze Huang skin barrier repair cream, Binxi skin barrier repair cream and the like.
Step 1: animal models were constructed using C57B/6J mice divided into 6 groups of 8 mice each, shaved back. Respectively as a control non-intervention group, a Yuze repairing group, a repair repairing group, a pien Tze Huang repairing group, a Bingxi repairing group and a Broussonetia papyrifera leaf repairing group.
Step 2: the back of mice of different groups is rubbed with the corresponding barrier repair product 2 times a day, and the amount of the rubbing is 2mg +/-0.1 mg/cm 2. The rub lasted 7 days.
And step 3: the basic TEWL values and barrier function recovery rate indices of both arms were measured by the TEWL probe of the skin barrier function measuring instrument MPA580 of CK, Germany.
And 4, step 4: the test results show that the basic skin barrier function indexes of the papermulberry leaf barrier repairing cream group and other barrier repairing groups have no statistical difference through analysis, but the papermulberry leaf barrier repairing cream group in the skin barrier function repairing indexes is obviously superior to other barrier function repairing groups, and the test results are shown in figure 3.
And (3) analyzing test results:
firstly, the main effective components of the papermulberry leaf barrier repairing emulsifiable paste come from papermulberry leaves which are sweet, cool and nontoxic and have the effects of dispelling wind and removing dampness, clearing heat and killing insects, moistening skin and relieving itching and the like. The effective components in the papermulberry peach leaves can be considered to have the effect of repairing skin barriers, so that related animal and human body experiments are developed. After the papermulberry leaf barrier repairing cream is prepared, a human body safety experiment is firstly carried out, and all subjects are negative through a patch experiment, so that the safety of the prepared cream is proved. After being reviewed by ethical committee of southern medical university dermatologic hospital, a human body efficacy evaluation experiment is carried out, healthy people are recruited as subjects in a self-contrast mode, and the papermulberry peach leaf barrier repair cream and the contrast matrix cream are respectively smeared on arms at two sides, so that the result proves that the epidermal barrier repair effect of the papermulberry peach leaf barrier repair cream is obviously better than that of a contrast matrix group. Then, in the animal experiments, the repairing effects of 4 skin barrier function repairing products on sale and the researched and developed papermulberry peach leaf barrier repairing emulsifiable paste are compared, and the result proves that the researched and developed papermulberry peach leaf barrier repairing emulsifiable paste is slightly superior to different brands on sale, and the advantages and effects of the researched and developed barrier repairing skin care product are proved.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (8)
1. An external cream for repairing skin barrier function, which is characterized in that: comprises a papermulberry leaf extract, an oil phase component and a water phase component except the papermulberry leaf extract.
2. The external cream for repairing skin barrier function according to claim 1, characterized in that: the papermulberry fruit leaf extract is extracted from papermulberry fruit leaf dry products or papermulberry fruit leaf fresh products; the oil phase component combination comprises white vaseline, light liquid paraffin, stearic acid, polysorbate and sorbitan oleate; the water phase component composition except the papermulberry leaf extract comprises hyaluronic acid and potassium sorbate.
3. The external cream for repairing skin barrier function according to claim 1, characterized in that: the material is prepared from the following raw materials in parts by weight:
90-110 parts of dry papermulberry leaf, 118 parts of hyaluronic acid 105-containing materials, 130 parts of white vaseline 110-containing materials, 170 parts of light liquid paraffin 150-containing materials, 125 parts of stearic acid 115-containing materials, 85-90 parts of polysorbate, 30-35 parts of sorbitan oleate, 1-6 parts of potassium sorbate and 1500 parts of water 1000-containing materials.
4. The external cream for repairing skin barrier function according to claim 3, characterized in that: the material is prepared from the following raw materials in parts by weight:
90-95 parts of dry papermulberry leaf, 113 parts of hyaluronic acid 105-.
5. The external cream for repairing skin barrier function according to claim 3, characterized in that: the material is prepared from the following raw materials in parts by weight:
95-110 parts of dry papermulberry leaf, 118 parts of hyaluronic acid 113-.
6. The external cream for repairing skin barrier function according to claim 3, characterized in that: the feed is prepared from the following raw materials in parts by weight:
40-60g of dry papermulberry leaf, 50g of hyaluronic acid, 60g of white vaseline, 80g of light liquid paraffin, 60g of stearic acid, 44g of polysorbate, 16g of sorbitan oleate, 1.5g of potassium sorbate and 600g of water 500-.
7. Topical cream for the repair of skin barrier function according to any one of claims 1 to 6, characterized in that: the preparation method of the papermulberry leaf extract comprises the following steps:
(A1) leaching raw materials: weighing 50g of dry papermulberry leaf, adding 500ml of 75% ethanol, and soaking for 12 hours;
(A2) reflux extraction: reflux-extracting in 85 deg.C water bath for 60 min;
(A3) preparing a cleaning paste: adding the extractive solution into a rotary evaporator, recovering under reduced pressure, collecting concentrated paste, weighing, and dissolving in double distilled water for storage.
8. A process for preparing an external cream for repairing skin barrier function according to any one of claims 1 to 7, characterized in that: the method comprises the following steps:
(S1): weighing hyaluronic acid, adding 50ml of double distilled water, and sealing for overnight storage after the hyaluronic acid is dissolved in the water;
(S2): weighing white vaseline, light liquid paraffin, stearic acid, polysorbate and sorbitan oleate as oil phase components on the next day, mixing, and heating to 85 deg.C to obtain mixture A;
(S3): weighing double distilled water, adding the papermulberry leaf extract, potassium sorbate and hyaluronic acid as water phase components, and heating to 85 ℃ to obtain a mixture B;
(S4): mixing the mixture A and the mixture B, and stirring for 30 minutes by using an electronic stirrer until all components are uniformly stirred to obtain a mixed solution C;
(S5): aging the mixed solution C in a water bath at 50 ℃ for 72 hours to prepare cream A;
(S6): storing cream A in cold storage room at 4 deg.C for 18 hr, and packaging to obtain topical cream for repairing skin barrier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110540257.6A CN113440475A (en) | 2021-05-18 | 2021-05-18 | External cream for repairing skin barrier function and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110540257.6A CN113440475A (en) | 2021-05-18 | 2021-05-18 | External cream for repairing skin barrier function and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113440475A true CN113440475A (en) | 2021-09-28 |
Family
ID=77810075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110540257.6A Pending CN113440475A (en) | 2021-05-18 | 2021-05-18 | External cream for repairing skin barrier function and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113440475A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902658A (en) * | 2014-09-16 | 2016-08-31 | 李�浩 | Traditional Chinese medicine bath liquid for treating pruritic scrotal eczema |
| CN107095906A (en) * | 2017-03-24 | 2017-08-29 | 蔡瑞康 | It is a kind of to treat psoriasis and Chinese medical extract and bathing instant granular with skin moistening and itch stopping effect |
| CN107669935A (en) * | 2017-11-16 | 2018-02-09 | 柴为智 | A kind of Chinese medicine antiallergy beauty mask and preparation method thereof |
| CN109745361A (en) * | 2018-11-08 | 2019-05-14 | 戴博 | It is a kind of to alleviate senile skin itch and the compound skin cream and its preparation method and application with moisturizing effect |
| CN112516250A (en) * | 2020-12-22 | 2021-03-19 | 黑龙江中医药大学附属第一医院（黑龙江中医药大学第一临床医学院） | Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof |
-
2021
- 2021-05-18 CN CN202110540257.6A patent/CN113440475A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902658A (en) * | 2014-09-16 | 2016-08-31 | 李�浩 | Traditional Chinese medicine bath liquid for treating pruritic scrotal eczema |
| CN107095906A (en) * | 2017-03-24 | 2017-08-29 | 蔡瑞康 | It is a kind of to treat psoriasis and Chinese medical extract and bathing instant granular with skin moistening and itch stopping effect |
| CN107669935A (en) * | 2017-11-16 | 2018-02-09 | 柴为智 | A kind of Chinese medicine antiallergy beauty mask and preparation method thereof |
| CN109745361A (en) * | 2018-11-08 | 2019-05-14 | 戴博 | It is a kind of to alleviate senile skin itch and the compound skin cream and its preparation method and application with moisturizing effect |
| CN112516250A (en) * | 2020-12-22 | 2021-03-19 | 黑龙江中医药大学附属第一医院（黑龙江中医药大学第一临床医学院） | Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘素兰，王萍主编: "《药剂学 第3版》", 30 November 2020, 西安：西安交通大学出版社, pages: 189 - 195 * |
| 杨明，李小芳主编: "《药剂学 第2版》", vol. 2018, 30 August 2018, 北京：中国医药科技出版社, pages: 165 - 168 * |
| 马振友等主编: "《皮肤美容化妆品制剂手册 第2版》", vol. 2015, 31 January 2015, 北京：中医古籍出版社, pages: 85 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107854367B (en) | Essence for repairing sensitive skin | |
| CN107334726B (en) | Acne-removing composition and preparation method and application thereof | |
| US8845600B2 (en) | Skin care compositions and uses thereof | |
| CN111973641B (en) | Antidandruff compositions and methods of use thereof | |
| AT507845B1 (en) | COSMETIC PREPARATION FOR SKIN CARE | |
| CN104254318A (en) | Cosmetic composition containing the slime of snails fed with red ginseng and method for manufacturing same | |
| CN113456568A (en) | Composition for soothing, repairing and moisturizing skin and preparation method and application thereof | |
| JP2010520232A (en) | External preparation composition containing ginseng extract and its use as a skin moisturizing cosmetic | |
| CN108721154B (en) | Skin care product for skin moisturizing and barrier repair and preparation method thereof | |
| CN116672296B (en) | Compound plant extract with soothing and repairing effects, and preparation method and application thereof | |
| CN116139060B (en) | Composition with anti-inflammatory and anti-aging effects and preparation method and application thereof | |
| CN103845280B (en) | 20(R)-ginsenoside Rg3 preparation for external use, preparing method thereof and applications thereof | |
| CN115054566B (en) | Scalp aging resisting composition and preparation method thereof | |
| CN113440475A (en) | External cream for repairing skin barrier function and preparation method thereof | |
| CN110403873A (en) | A kind of anti-wrinkle cream and preparation method thereof | |
| CN116407486A (en) | Active composition, cosmetic composition, application of active composition, repairing essence and preparation method of repairing essence | |
| JPH08127511A (en) | Multifunctional substance derived from plant | |
| KR20170010499A (en) | Cosmetic Compositions comprising Snail mucus fermentation filtrate for improving skin barrier function and having high skin absorption and Functional Cosmetic using this | |
| CN108938929A (en) | A kind of Chinese medicine composition and its preparation method and application having both moisturizing and anti-aging effects | |
| EP1458334B1 (en) | Yeast-based curative and care product and method for making same | |
| CN110711147B (en) | Facial mask with acne removing and acne mark repairing functions | |
| KR101822558B1 (en) | Cosmetic composition for alleviating skin irritation with apple extract and α-hydroxy acid | |
| JP5855949B2 (en) | Keratin production promoter, hair dye and nail polish | |
| KR20110094859A (en) | Composition for promoting collagen synthesis having kava extract | |
| CN109091619A (en) | For the Chinese medicine external emulsifiable paste and preparation method thereof of skin health |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 510000 Lujing Road, Guangzhou, Guangdong Applicant after: DERMATOLOGY HOSPITAL OF SOUTHERN MEDICAL University (GUANGDONG PROVINCIAL DERMATOLOGY HOSPITAL GUANGDONG SKIN DISEASE PREVENTION CENTER CHINA LEPROSY CONTROL RESEARCH CENTER) Address before: 510091 skin physiology and topical preparation R & D and evaluation center, 10th floor, Dermatology Hospital, Southern Medical University, No. 2 Lujing Road, Yuexiu District, Guangzhou, Guangdong Province Applicant before: DERMATOLOGY HOSPITAL OF SOUTHERN MEDICAL University |
|
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |