CN107095906A - It is a kind of to treat psoriasis and Chinese medical extract and bathing instant granular with skin moistening and itch stopping effect - Google Patents
It is a kind of to treat psoriasis and Chinese medical extract and bathing instant granular with skin moistening and itch stopping effect Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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Abstract
The present invention is a kind of to treat psoriasis and Chinese medical extract and bathing instant granular with skin moistening and itch stopping effect, belongs to pharmaceutical preparations technology field.Chinese medical extract is that fresh goods Folium Fructus Broussonetiae is carried out to merge decoction after decocting twice, and it is 200~300 mesh of filtration acquisition after 1.10~1.16g/ml liquid extract to be concentrated into relative density at 60 DEG C.Bathing instant granular includes active component and pharmaceutically acceptable carrier, and active component is that fresh goods Folium Fructus Broussonetiae is carried out to merge decoction after decocting twice, and is concentrated into the liquid extract that relative density at 60 DEG C is 1.10~1.16g/ml, crosses 200~300 mesh;Dried, got dry extract with spray drying process after liquid extract is well mixed;Get dry extract and cross 100 mesh sieves and be ground into fine powder in crushing unit, produce active component.The present invention has advantages below:There is provided a kind of novel drugs, psoriasis can be effectively treated;Raw material are easily obtained in preparation method, the simple advantage of technical process.
Description
Technical field
The invention belongs to pharmaceutical preparations technology field, and in particular to a kind of to treat psoriasis and have skin moistening and itch stopping effect
Chinese medical extract and bathing instant granular.
Background technology
Psoriasis is a kind of chronic skin being characterized with hyperproliferative epidermal, with parakeratosis and corium lymphocytic infiltration
Skin disease.It is relevant with heredity, virus or streptococcal infection, immunologic dysfunction, epidermis dyspoiesis.China was carried out for 1984
Once national epidemiology survey, it is 0.12%, -2008 years 2007, the provinces and cities' psoriasis stream of China six as a result to show illness rate
Row disease learns investigation, it is found that psoriasis illness rate is improved to 0.47%, and China psoriatic is up to 2,000,000 people according to a preliminary estimate.Due to
The easy recurrent exerbation of psoriasis, the state of an illness is obstinate, is difficult radical cure, pachyderma, itch, furfur, cutaneous lesion bleeding, affected joints pain
The even disabled decline for causing patient's somatic function of pain, psychological pressure caused by the skin appearance of defect and is repelled by the public,
Hamper the human communication of patient so that patients ' life quality is substantially reduced, patients ' life quality and physical and mental health are caused
Serious puzzlement.
At present, the treatment of psoriasis is mainly drug therapy (being divided into externally applied drug and innerlich anwenden), physical treatment, biological agent
Treatment, psychotherapy and motherland's Chinese Traditional Medicine treatment.Generally give extensive complex treatment, locality is controlled with external used medicine
Based on treatment, the combination of Chinese tradiational and Western medicine has complementary advantages, and improves curative effect.But psoriasis still can't be thoroughly eradicated, can only be to a certain degree
The upper breaking-out for suppressing disease, and adverse drug reaction and cumulative toxicity easily cause potential risks, it is impossible to reach gratifying
Degree.
The senile pruritus traditional Chinese medical science is referred to as pruritus due to wind pathogen, and clinic is by only pruitus without primary cutaneous impairer
Referred to as pruritus.Belong to the category of the traditional Chinese medical science " pruritus ", be one of clinically common skin disease, be more common in the elderly, male's
The incidence of disease is higher than women.Skin is mainly shown as without fash, first because skin is itched, and it is more than to scratch, and grabs and more itches, typically to skin
Skin catches blood and itch could stop, therefore many scratch, scab, pigmentation, lichenification often occur on skin, and severe one can be with
Generation skin infection, very itches in paroxysmal more, and night is very, to have a strong impact on sleep quality.There is 30%-40% old age at present
People is tormented by pruritus, has a strong impact on their quality of life.Dry skin itch is a kind of performance of old regression, because of skin
Regression atrophy, the secretion of adipose gland sweat gland are reduced, dry skin, and the non-tip receptor regression of nerve of distribution is old in shrinkage skin in addition
Change.Conventional treatment method is generally:Antihistamine, injection sex hormone, external preparation etc., can not eradicate and long-term prescription produces poison more
Side reaction.Folium Fructus Broussonetiae extract and its instant granular use pure Chinese medicine security elements, the work(with skin moistening and itch stopping, raising immunity
Effect, can effectively alleviate skin itching symptom, and use for a long time, will not produce dependence and toxic side effect.
The content of the invention
For the above mentioned problem present in treatment psoriasis at present and senile pruritus, this invention address that providing one
Plant safely and effectively treatment psoriasis and the simple novel formulation of preparation technology with skin moistening and itch stopping effect.
Folium Fructus Broussonetiae is Moraceae paper mulberry Broussonetia papyrifera (L.) L ' Her.ex Vant. fresh leaf, summer
Harvesting, is distributed in all parts of the country, for treating dermatophytosis, senile pruritus.In Folium Fructus Broussonetiae extract chief active into
Point-flavone compound, the effects such as with anti-inflammatory and antalgic, immunological regulation, antibacterial anti-corrosion, anti-aging, its mechanism of action is as follows:It is logical
Cross on macrophage, T lymphocytes, bone-marrow-derived lymphocyte, NK, cell factor and influence thymus gland to be immunized
Adjustment effect, strengthens the nonspecific immunity function and humoral immune function of body;Acted on certain anti-superficial mycosis and anti-
Rotten effect, bacterio static itching-relieving;Acted on anti-oxidant, anti-aging, female estrogen sample, skin of moistening.
Vitexin (vitexin) is also known as Vitexina, is a kind of natural plants flavonoid glycoside chemical combination extracted from Folium Fructus Broussonetiae
Thing, property is stable.At present, many plant extract flavonoid glycoside compounds are referred to Vitexin (Vitexin) for active ingredient mostly
Mark is produced, detected.Therefore the Folium Fructus Broussonetiae extract and Folium Fructus Broussonetiae instant granular of this patent development are using Vitexin as effect composition
Index is detected.
Folium Fructus Broussonetiae resource extensively, as the anti-superficial mycosis Chinese herbal medicine of wide spectrum, can play effect of skin moistening and itch stopping, can be effective
Treatment psoriasis, senile pruritus.
It is an object of the invention to disclose a kind of Chinese medical extract treated psoriasis and have skin moistening and itch stopping effect.
Second object of the present invention is that disclosing a kind of bathing treated psoriasis and have skin moistening and itch stopping effect uses
Instant granular.
The purpose of the present invention is achieved through the following technical solutions:
It is a kind of to treat psoriasis and the Chinese medical extract with skin moistening and itch stopping effect, wherein, the Chinese medical extract passes through
Following methods prepare gained:
(1), take fresh goods Folium Fructus Broussonetiae, plus purified water is soaked 0.5 hour, makes medicinal material wetting complete, is decocted twice, for the first time plus
10 times are measured water refluxing extraction 1 hour, are crossed 120 mesh sieves, are taken extract solution, stand-by;Add 8 times for the second time and measure water refluxing extraction 0.5 hour,
120 mesh sieves are crossed, extract solution is taken, it is stand-by;Merge extract solution, stand 2 hours;300 mesh sieves are crossed, subsequent filtrate is taken, it is standby.
(2), by subsequent filtrate obtained by step (1) in inspissator, setting steam pressure is 0.04~0.1Mpa, vacuum
For -0.08~-0.04Mpa, thickening temperature is 65~75 DEG C;It is concentrated into the stream that relative density at 60 DEG C is 1.10~1.16g/ml
Medicinal extract, crosses 200~300 mesh sieves, produces Chinese medical extract.
It is a kind of to treat psoriasis and the bathing instant granular with skin moistening and itch stopping effect, wherein, the instant granular bag
Active component and pharmaceutically acceptable carrier are included, the active component is as obtained by prepared by following methods:
(1), take fresh goods Folium Fructus Broussonetiae, plus purified water is soaked 0.5 hour, makes medicinal material wetting complete, is decocted twice, for the first time plus
10 times are measured water refluxing extraction 1 hour, are crossed 120 mesh sieves, are taken extract solution, stand-by;Add 8 times for the second time and measure water refluxing extraction 0.5 hour,
120 mesh sieves are crossed, extract solution is taken, it is stand-by;Merge extract solution, stand 2 hours;300 mesh sieves are crossed, subsequent filtrate is taken, it is standby;
(2), by subsequent filtrate obtained by step (1) in inspissator, setting steam pressure is 0.04~0.1Mpa, vacuum
For -0.08~-0.04Mpa, thickening temperature is 65~75 DEG C;It is concentrated into the stream that relative density at 60 DEG C is 1.10~1.16g/ml
Medicinal extract, crosses 200~300 mesh sieves, standby;
(3), take the liquid extract in step (2), after mixing, dried with spray drying process, set EAT be 190~
200 DEG C, leaving air temp is 90~100 DEG C, after drying, is got dry extract;
(4), step (3) is got dry extract in crushing crushing in unit, 100 mesh sieves is crossed, produces active component.
A kind of bathing instant granular treated psoriasis and there is skin moistening and itch stopping effect described in above-mentioned technical proposal, its
In, the pharmaceutically acceptable carrier is spray powder.
Folium Fructus Broussonetiae extract and its instant granular prepared by the present invention, preparation technology are simple, easy.
The invention has the advantages that:
1st, the invention provides a kind of novel drugs treated psoriasis and there is skin moistening and itch stopping effect, can effectively it treat
Psoriasis and senile pruritus.
2nd, the present invention establishes the preparation method for the treatment of psoriasis and the novel drugs with skin moistening and itch stopping effect, and raw material are easy
In acquisition, technical process is simple.
Brief description of the drawings:
1st, Fig. 1 is thin layer identification result figure, and wherein row 1 are Vitexin reference substance, and row 2~4 are test sample, and row 5 are blank
Sample.
2nd, Fig. 2 is Vitexin reference substance chromatogram.
3rd, Fig. 3 is Folium Fructus Broussonetiae instant granular sample chromatogram figure.
4th, Fig. 4 is that solvent (methanol) compares chromatogram.
Embodiment:
To readily appreciate technical scheme, psoriasis is treated to one kind of the present invention below in conjunction with specific test example
And there is the Chinese medical extract of skin moistening and itch stopping effect and bathing to be further described with instant granular.
Embodiment 1:A kind of Chinese medical extract for treating psoriasis:
(1), take fresh goods Folium Fructus Broussonetiae, plus purified water is soaked 0.5 hour, makes medicinal material wetting complete, is decocted twice, for the first time plus
10 times are measured water refluxing extraction 1 hour, are crossed 120 mesh sieves, are taken extract solution, stand-by;Add 8 times for the second time and measure water refluxing extraction 0.5 hour,
120 mesh sieves are crossed, extract solution is taken, it is stand-by;Merge extract solution, stand 2 hours;300 mesh sieves are crossed, subsequent filtrate is taken, it is standby.
(2), by subsequent filtrate obtained by step (1) in inspissator, setting steam pressure is 0.04~0.1Mpa, vacuum
For -0.08~-0.04Mpa, thickening temperature is 65~75 DEG C;It is concentrated into the stream that relative density at 60 DEG C is 1.10~1.16g/ml
Medicinal extract, crosses 200~300 mesh sieves, produces Chinese medical extract.
Embodiment 2:A kind of bathing instant granular for treating psoriasis:
(1), take fresh goods Folium Fructus Broussonetiae, plus purified water is soaked 0.5 hour, makes medicinal material wetting complete, is decocted twice, for the first time plus
10 times are measured water refluxing extraction 1 hour, are crossed 120 mesh sieves, are taken extract solution, stand-by;Add 8 times for the second time and measure water refluxing extraction 0.5 hour,
120 mesh sieves are crossed, extract solution is taken, it is stand-by;Merge extract solution, stand 2 hours;300 mesh sieves are crossed, subsequent filtrate is taken, it is standby;
(2), by subsequent filtrate obtained by step (1) in inspissator, setting steam pressure is 0.04~0.1Mpa, vacuum
For -0.08~-0.04Mpa, thickening temperature is 65~75 DEG C;It is concentrated into the stream that relative density at 60 DEG C is 1.10~1.16g/ml
Medicinal extract, crosses 200~300 mesh sieves, standby;
(3), take the liquid extract in step (2), after mixing, dried with spray drying process, set EAT be 190~
200 DEG C, leaving air temp is 90~100 DEG C, after drying, is got dry extract;
(4), step (3) is got dry extract in crushing crushing in unit, 100 mesh sieves is crossed, produces active component;
(5), step (4) fine powder after crushed and the blended machine of spray powder are sufficiently mixed uniformly;Take mixed carry
Powder is taken, carrying out dry granulation according to following parameter obtains bathing instant granular:It is 5 revs/min~22 revs/min to extrude rotating speed
Clock, feeding rotating speed is 10 revs/min~60 revs/min, and extruding force is 5MPa~15Mpa, and lateral pressure is 2MPa~3Mpa.
The bathing granulated quickly dissolving external application of the present invention, every bag of 10g.
Illustrate bathing of the invention with instant granular (hereinafter referred to as below by way of specific test example:Folium Fructus Broussonetiae instant granular)
Quality control detection and had the advantage that.
Test example 1:Thin layer differentiates:
The preparation of need testing solution:Folium Fructus Broussonetiae instant granular (prepared by the method for embodiment 2) 0.5g is taken, 70% ethanol is added
50mL, ultrasonically treated 30min, filtration, filtrate is evaporated, and residue adds water 20mL dissolvings, and with extracting n-butyl alcohol 2 times, each 20mL is closed
And butanol solution, water bath method, residue add methanol 1mL dissolve, produce;
The preparation of reference substance solution:Vitexin reference substance (market purchase) is weighed, plus methanol dissolving is made into 0.1mg/mL's
Solution;
Test method:Above-mentioned each 5 μ L of three kinds of solution are drawn, are put respectively on same silica gel g thin-layer plate, with toluene-acetic acid
Ethyl ester-formic acid-water (1:8:1:1) upper solution is solvent, is deployed, and takes out, dries, and spray is tried with 1% alchlor ethanol
Liquid, puts and is inspected under uviol lamp (365nm).
As a result show:On position corresponding with reference substance or test sample chromatogram, show the spot or fluorescence of same color
Spot, blank sample is noiseless, sees that (Fig. 1 is thin layer identification result figure to Fig. 1, and wherein row 1 are Vitexin reference substance, and row 2~4 are
Test sample, row 5 are blank sample).
Test example 2:Assay:
1st, chromatographic condition:
Chromatographic column:Inertsil ODS-3 (260 × 4.6mm, 5 μm);Mobile phase:A. acetonitrile, B.0.5% glacial acetic acid;Stream
Dynamic phase gradient is as shown in table 1.Flow velocity:1mL/min;Detection wavelength:340nm;Sample size:10μL;
The eluent gradient table of table 1
2nd, the preparation of reference substance solution:
Precision weighs Vitexin reference substance (market purchase), plus methanol dissolving is made into 10 μ g/mL solution.
3rd, the preparation of need testing solution:
2g Folium Fructus Broussonetiae instant granulars are weighed, 50mL methanol eddies is added and extracts 2h, produce.
Take in solvent (methanol), reference substance solution and each 10 μ L of need testing solution, injection liquid chromatograph, determine in accordance with the law.
As a result show, in need testing solution chromatogram, detected on the corresponding position of reference substance solution chromatogram between chromatographic peak, each peak
Baseline separation, peak type is good, and solvent control is noiseless, sees that (wherein Fig. 2 is that Vitexin reference substance chromatogram, Fig. 3 are paper mulberry for Fig. 2~4
Peach leaf instant granular sample chromatogram figure, Fig. 4 are that solvent (methanol) compares chromatogram).
Test example 3:Cell experiment:
Psoriasis is a kind of chronic skin being characterized with hyperproliferative epidermal, with parakeratosis and corium lymphocytic infiltration
Skin disease, it has substantial connection with keratinocyte hyper-proliferative and abnormal differentiation.People immortalizes epidermal cell (HaCaT cells)
For a kind of the most frequently used keratinocyte cell line, the cell model of psoriasis is accordingly acted as.This experiment passes through Folium Fructus Broussonetiae fresh goods water
The research of extract, dry product water extract to HaCaT cyto-inhibitions, to inquire into Folium Fructus Broussonetiae water extract and Folium Fructus Broussonetiae instant granular
Treat the pharmacy in vitro of psoriasis.
Experiment content:With reference to the method in embodiment 1 " a kind of Chinese medical extract for treating psoriasis ", Folium Fructus Broussonetiae is prepared
Each five dosage groups of water extract of fresh goods, dry product (fresh goods drying) and dry product (purchase), are respectively acting on HaCaT cells, administration
After 24h, inhibiting rate of the medicine to HaCaT cells is determined by mtt assay, tests parallel three times, averages.As a result paper mulberry peach is shown
Leaf water extract and Folium Fructus Broussonetiae instant granular have inhibitory action to HaCaT cells in psoriasis forming process, are shown in Table 2.
The different type Folium Fructus Broussonetiae water extract of table 2 is to HaCaT cell inhibitory rates (%)
Experiment conclusion:The water extract of Folium Fructus Broussonetiae fresh goods and dry product has significant inhibitory action to HaCaT cells.In 19-
In 310mg/mL medicinal material concentration range, inhibiting rate increases with the increase of medicinal material concentration.Middle low dose group (<155.57mg/
ML fresh goods) is more stronger than dry product (purchase) inhibitory action, high dose group (>155.57mg/mL) then no significant difference.And fresh goods with
All the time without significant difference between dry product (fresh goods drying).
Test example 4:Treat the clinical test of senile pruritus:
Senile pruritus pathogenic factors is more complicated, including internal cause or external cause or haves both at the same time.Pruritus senilis
The cause of disease is more to be caused due to sebum hypoadenia, dry skin and degeneration atrophy factor.The traditional Chinese medical science think blood deficiency and sthenic liver-energy so that
Raw dry humorously, failure of skin and muscle to be nourished is formed.With Folium Fructus Broussonetiae instant granular of the present invention treat senile pruritus 60, achieve compared with
For satisfied curative effect, clinical testing data is as follows.
1st, clinical data:In 60 patients, man 34, female 26,51~76 years old age;The course of disease most short person 1 year, most elder
6 years.All cases itch is in paroxysmal, is attached most importance to night, and trunk, four limbs are shown in the scratch of varying degree, scab, and minority is with wet
Rash sample becomes and pigmentation.
2nd, treatment method:Folium Fructus Broussonetiae instant granular 10g is taken to be dissolved in 0.5L warm water, local bathing or become soaked with sweat deposited 1 times/day, 1-2
Packet/time, the course for the treatment of 1 month.
3rd, criterion of therapeutical effect:
Recovery from illness:Skin damaged disappears, and local skin recovers as usual, and pruritis disappears, and follow-up is not recurred for 1 year;
Effectively:Itch disappears substantially, and skin damaged disappears, and is indulged in excessive drinking in 1 year, overfeeding is pungent recurrence;
It is invalid:Without significant change before and after treatment.
4th, model case:Patient, man, 73 years old, retired cadre, whole body itch 2 years was attached most importance to winter, once for oral administration, external application west
Medicine, curative effect is little, and first visit in November, 2010, symptoms include four limbs stretch side, waist, the back of the body, abdominal skin scratch, has scab, with four limbs,
The back of the body, waist substantially, have a little eczema sample to become on the outside of both legs.Using Folium Fructus Broussonetiae instant granular bathing, all symptoms disappear, skin damaged
Recover as usual in place.Advise it to avoid eating beef, the stimulating food such as pungent, avoid to be scalded with hot water and washed with soap, follow-up 4 years is not recurred again.
5th, treatment results:
In this group of case, fully recover 38, account for 63.3%, effective 15 account for 25.0%, invalid 7, total effective rate 88.3%,
Good therapeutic effect is achieved using the Folium Fructus Broussonetiae Granules in Treating senile pruritus of the present invention.
It is described above, only presently preferred embodiments of the present invention, not the present invention is made it is any in form and substantial limit
System, all those skilled in the art, without departing from the scope of the present invention, when using disclosed above skill
Art content, and the equivalent variations for a little variation, modification and evolution made, are the equivalent embodiment of the present invention;Meanwhile, it is all according to
The variation, modification and evolution for any equivalent variations made according to the substantial technological of the present invention to above example, still fall within this
In the range of the technical scheme of invention.
Claims (3)
1. a kind of treat psoriasis and the Chinese medical extract with skin moistening and itch stopping effect, it is characterised in that:The Chinese medical extract
As obtained by prepared by following methods:
(1) fresh goods Folium Fructus Broussonetiae, is taken, plus purified water is soaked 0.5 hour, makes medicinal material wetting complete, is decocted twice, for the first time plus 10 times
Measure water refluxing extraction 1 hour, cross 120 mesh sieves, take extract solution, it is stand-by;Add 8 times for the second time and measure water refluxing extraction 0.5 hour, mistake
120 mesh sieves, take extract solution, stand-by;Merge extract solution, stand 2 hours;300 mesh sieves are crossed, subsequent filtrate is taken, it is standby.
(2), by subsequent filtrate obtained by step (1) in inspissator, settings steam pressure is 0.04~0.1Mpa, vacuum is-
0.08~-0.04Mpa, thickening temperature is 65~75 DEG C;Relative density at 60 DEG C is concentrated into soak for 1.10~1.16g/ml stream
Cream, crosses 200~300 mesh sieves, produces Chinese medical extract.
2. a kind of treat psoriasis and the bathing instant granular with skin moistening and itch stopping effect, it is characterised in that:Described instant
Grain includes active component and pharmaceutically acceptable carrier, and the active component is as obtained by prepared by following methods:
(1) fresh goods Folium Fructus Broussonetiae, is taken, plus purified water is soaked 0.5 hour, makes medicinal material wetting complete, is decocted twice, for the first time plus 10 times
Measure water refluxing extraction 1 hour, cross 120 mesh sieves, take extract solution, it is stand-by;Add 8 times for the second time and measure water refluxing extraction 0.5 hour, mistake
120 mesh sieves, take extract solution, stand-by;Merge extract solution, stand 2 hours;300 mesh sieves are crossed, subsequent filtrate is taken, it is standby;
(2), by subsequent filtrate obtained by step (1) in inspissator, settings steam pressure is 0.04~0.1Mpa, vacuum is-
0.08~-0.04Mpa, thickening temperature is 65~75 DEG C;Relative density at 60 DEG C is concentrated into soak for 1.10~1.16g/ml stream
Cream, crosses 200~300 mesh sieves, standby;
(3) liquid extract in step (2), is taken, after mixing, is dried with spray drying process, it is 190~200 DEG C to set EAT,
Leaving air temp is 90~100 DEG C, after drying, is got dry extract;
(4), step (3) is got dry extract in crushing crushing in unit, 100 mesh sieves is crossed, produces active component.
3. a kind of bathing instant granular treated psoriasis and there is skin moistening and itch stopping effect according to claim 2, its
It is characterised by:The pharmaceutically acceptable carrier is spray powder.
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CN113318069A (en) * | 2021-05-18 | 2021-08-31 | 南方医科大学皮肤病医院 | Anti-inflammatory topical cream for treating psoriasis and preparation method thereof |
CN113440475A (en) * | 2021-05-18 | 2021-09-28 | 南方医科大学皮肤病医院 | External cream for repairing skin barrier function and preparation method thereof |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113318069A (en) * | 2021-05-18 | 2021-08-31 | 南方医科大学皮肤病医院 | Anti-inflammatory topical cream for treating psoriasis and preparation method thereof |
CN113440475A (en) * | 2021-05-18 | 2021-09-28 | 南方医科大学皮肤病医院 | External cream for repairing skin barrier function and preparation method thereof |
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