CN113413437A - Ganoderma lucidum spore sleep-aiding composition and preparation method and application thereof - Google Patents

Ganoderma lucidum spore sleep-aiding composition and preparation method and application thereof Download PDF

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CN113413437A
CN113413437A CN202110794358.6A CN202110794358A CN113413437A CN 113413437 A CN113413437 A CN 113413437A CN 202110794358 A CN202110794358 A CN 202110794358A CN 113413437 A CN113413437 A CN 113413437A
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sleep
ganoderma lucidum
lucidum spore
aiding
raw materials
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唐林志
杨惠华
吕思敏
文芳
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Guangdong Runcell Biotechnology Co ltd
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Guangdong Runcell Biotechnology Co ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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Abstract

The invention relates to the technical field of ganoderma spore powder, in particular to a ganoderma spore sleep-aiding composition and a preparation method and application thereof. Through reasonable compatibility of the medicines, the traditional Chinese medicine composition has the effects of tonifying qi, nourishing liver, calming heart and helping sleep, combines cold and heat, gives consideration to yin and yang, releases heat without damaging stomach, regulates qi without damaging yin, treats deficiency and excess, soothes liver and regulates spleen, and can effectively treat most insomnia.

Description

Ganoderma lucidum spore sleep-aiding composition and preparation method and application thereof
Technical Field
The invention relates to the technical field of ganoderma lucidum spore powder, and in particular relates to a ganoderma lucidum spore sleep-aiding composition and a preparation method and application thereof.
Background
Sleep is an indispensable physiological function of the human body and is closely related to the health of people. The understanding of insomnia by clinical medicine science is limited at present, but clinical doctors begin to define insomnia according to clinical research, and a sleep disorder department of the neurology conference of the Chinese medical society in 2012 sets up a Chinese adult insomnia diagnosis and treatment guideline according to the existing evidence of evidence, wherein insomnia refers to subjective experience of patients on the condition that sleep time and/or quality are not satisfied and daily social functions are affected.
Ganoderma lucidum is a fungus belonging to the genus Ganoderma of the class Basidiomycetes, and has high edible and medicinal values. The Donghai's book of Shennong Ben Cao Jing listed Ganoderma as the top grade, the 2000 edition of pharmacopoeia of the people's republic of China collected Ganoderma (Ganoderma lucidum, Ganoderma sinensis) fruiting body as legal Chinese medicinal material, and the 2000 edition of pharmacopoeia of American herbal medicine and treatment summary also collected Ganoderma, which shows that the research of Ganoderma has been highly regarded by the medical and pharmaceutical field of America. Modern medicine proves that: ganoderma contains multiple physiologically active substances, and has tranquilizing effect on central nervous system.
The ganoderma lucidum spores are adopted as sleep-aiding medicines, so that the application prospect is better, but related research reports are few at present.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide a ganoderma lucidum spore sleep-aiding composition and a preparation method and application thereof.
The purpose of the invention is realized by the following technical scheme:
a ganoderma lucidum spore sleep-aiding composition comprises the following raw materials in parts by weight:
Figure BDA0003162313680000011
Figure BDA0003162313680000021
the pharmacodynamic mechanism of each raw material of the invention is as follows:
breaking the wall of ganoderma lucidum spores: the ganoderma lucidum crude polysaccharide has wide pharmacological activity, can provide organism immunity, improve the oxygen resistance of the organism, eliminate free radicals, resist radiation, detoxify, improve the capability of synthesizing DHA, RHA and protein by liver, bone marrow and blood, prolong the service life, inhibit tumors and the like; ganoderic acid has strong pharmacological activity, and has effects of relieving pain, tranquilizing, inhibiting histamine release, removing toxic substance, protecting liver, and killing tumor cells; the invention adopts the wall-broken ganoderma lucidum spores as the main medicine, has mild medicine property and no side effect, and can nourish the heart and tonify the liver, thereby playing the role of helping sleep.
Astragalus root: sweet taste, warm nature, entering lung and spleen channels, has the efficacy of replenishing qi to invigorate the spleen.
Wolfberry fruit: sweet in taste, neutral in nature, capable of nourishing kidney, moistening lung, tonifying liver and improving eyesight. For treating liver and kidney yin deficiency, soreness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea; the carotene rich in the extract has outstanding antioxidation effect, can improve the immunity of the organism and has the effect of relieving fatigue.
Acanthopanax root: acanthopanax senticosus has a long history of being widely applied as a medicament in Chinese medicine and pharmacology, has the effects of tonifying middle-jiao and replenishing essence, strengthening muscles and bones and strengthening will, and is light and durable after being taken for a long time; modern medicine shows that saponin and polysaccharide which are rich in acanthopanax can relieve liver pathological tissue damage, and chlorogenic acid methyl ester, daucosterol, flavonoid and the like can play a role in resisting fatigue.
Caulis polygoni multiflori: sweet taste, slight bitter taste, mild nature, heart and liver meridian entered, used for insomnia, dreaminess, blood deficiency and body pain, skin numbness, rheumatic arthralgia, rubella and pruritus; modern medicine shows that the anthraquinone compounds and the beta-sitosterol contained in the compound have obvious effects of calming and helping sleep.
Rhizoma anemarrhenae: bitter and cold taste, entering lung, stomach and kidney channels, and can be used for treating fever polydipsia, lung heat dry cough, bone steaming hectic fever, internal heat diabetes, intestinal dryness and constipation; the compatibility of Zhi mu and Huang Qi can neutralize the property of herbs and avoid the warm-heat and typhoid fever of Huang Qi.
Schisandra chinensis: sour and sweet in taste, warm in nature, entering lung, heart and kidney meridians, and used for treating chronic cough, asthma, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, internal heat, diabetes, palpitation; modern medicine shows that schisandra fruit can inhibit the release of aminotransferase, lower ALT activity, and has the functions of relieving pain and relaxing muscle.
Costustoot: pungent, bitter and warm in flavor, it enters spleen, stomach, large intestine, triple energizer and gallbladder meridians, and is indicated for distending pain in chest and hypochondrium and stomach, abdominal distention and pain, diarrhea and dysentery with tenesmus, indigestion and indigestion, poor appetite. Roasted Aucklandia lappa Decne, radix aucklandiae and Cornus Sessima to relieve diarrhea. Can be used for treating diarrhea and abdominal pain; harmonize stomach qi, purge lung qi, and move liver qi.
Through reasonable compatibility of the medicines, the traditional Chinese medicine composition has the effects of tonifying qi, nourishing liver, calming heart and helping sleep, combines cold and heat, gives consideration to yin and yang, releases heat without damaging stomach, regulates qi without damaging yin, treats deficiency and excess, soothes liver and regulates spleen, and can effectively treat most insomnia.
Preferably, the raw materials comprise the following weight fractions:
Figure BDA0003162313680000031
preferably, the raw materials comprise the following weight fractions:
Figure BDA0003162313680000032
Figure BDA0003162313680000041
preferably, the raw materials comprise the following weight fractions:
Figure BDA0003162313680000042
the wall-broken ganoderma lucidum spores are prepared by a method for breaking walls by freezing under high pressure through acid leaching, and particularly the method disclosed by CN109157550A records.
The preparation method of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: weighing the raw materials according to the formula ratio and mixing.
The application of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: the ganoderma lucidum spore sleep-aiding composition is prepared into one of pills, powder, granules, tablets and capsules.
The invention has the beneficial effects that: through reasonable compatibility of the medicines, the traditional Chinese medicine composition has the effects of tonifying qi, nourishing liver, calming heart and helping sleep, combines cold and heat, gives consideration to yin and yang, releases heat without damaging stomach, regulates qi without damaging yin, treats deficiency and excess, soothes liver and regulates spleen, and can effectively treat most insomnia.
Detailed Description
The present invention will be further described with reference to the following examples for facilitating understanding of those skilled in the art, and the description of the embodiments is not intended to limit the present invention.
Example 1
A ganoderma lucidum spore sleep-aiding composition comprises the following raw materials in parts by weight:
Figure BDA0003162313680000051
wherein the wall-broken ganoderma lucidum spores are prepared by a method of performing acid powder permeation and high-pressure freezing to break the walls.
Wherein, in the step (4), the drying method is spray drying, vacuum freeze drying or heating concentration drying.
The preparation method of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: weighing the raw materials according to the formula ratio and mixing.
The application of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: the ganoderma lucidum spore sleep-aiding composition is prepared into capsules.
Example 2
A ganoderma lucidum spore sleep-aiding composition comprises the following raw materials in parts by weight:
Figure BDA0003162313680000052
Figure BDA0003162313680000061
wherein the wall-broken ganoderma lucidum spores are prepared by a method of performing acid powder permeation and high-pressure freezing to break the walls.
The preparation method of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: weighing the raw materials according to the formula ratio and mixing.
The application of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: the ganoderma lucidum spore sleep-aiding composition is prepared into pills.
Example 3
A ganoderma lucidum spore sleep-aiding composition comprises the following raw materials in parts by weight:
Figure BDA0003162313680000062
wherein the wall-broken ganoderma lucidum spores are prepared by a method of performing acid powder permeation and high-pressure freezing to break the walls.
The preparation method of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: weighing the raw materials according to the formula ratio and mixing.
The application of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: the ganoderma lucidum spore sleep-aiding composition is prepared into powder.
Example 4
A ganoderma lucidum spore sleep-aiding composition comprises the following raw materials in parts by weight:
Figure BDA0003162313680000063
Figure BDA0003162313680000071
wherein the wall-broken ganoderma lucidum spores are prepared by a method of performing acid powder permeation and high-pressure freezing to break the walls.
The preparation method of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: weighing the raw materials according to the formula ratio and mixing.
The application of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: the ganoderma lucidum spore sleep-aiding composition is prepared into granules.
Example 5
A ganoderma lucidum spore sleep-aiding composition comprises the following raw materials in parts by weight:
Figure BDA0003162313680000072
wherein the wall-broken ganoderma lucidum spores are prepared by a method of performing acid powder permeation and high-pressure freezing to break the walls.
The preparation method of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: weighing the raw materials according to the formula ratio and mixing.
The application of the ganoderma lucidum spore sleep-aiding composition comprises the following steps: the ganoderma lucidum spore sleep-aiding composition is prepared into tablets.
Through clinical tests, the ganoderma lucidum spore sleep-aiding composition disclosed by the embodiment 1 of the invention has the advantages that 9 cases are cured, 38 cases are obviously effective, 6 cases are effective, 7 cases are ineffective and the effective rate of treatment is 88.3% in 60 cases of insomnia.
The above-described embodiments are preferred implementations of the present invention, and the present invention may be implemented in other ways without departing from the spirit of the present invention.

Claims (7)

1. A ganoderma lucidum spore sleep-aiding composition is characterized in that: comprises the following raw materials in parts by weight:
Figure FDA0003162313670000011
2. the ganoderma lucidum spore sleep aid composition according to claim 1, wherein: comprises the following raw materials in parts by weight:
Figure FDA0003162313670000012
3. the ganoderma lucidum spore sleep aid composition according to claim 2, wherein: comprises the following raw materials in parts by weight:
Figure FDA0003162313670000013
Figure FDA0003162313670000021
4. the sleep-aiding composition of ganoderma lucidum spores as claimed in claim 3, wherein: comprises the following raw materials in parts by weight:
Figure FDA0003162313670000022
5. the ganoderma lucidum spore sleep aid composition according to claim 1, wherein: the wall-broken ganoderma lucidum spore is prepared by a method of freezing and breaking the wall by permeating acid and high pressure.
6. A method for preparing a sleep-aiding composition containing Ganoderma lucidum spores as claimed in any one of claims 1 to 5, wherein: weighing the raw materials according to the formula ratio and mixing.
7. The application of the ganoderma lucidum spore sleep-aiding composition is characterized in that: the ganoderma lucidum spore sleep-aiding composition of any one of claims 1 to 5 is formulated into one of pills, powders, granules, tablets and capsules.
CN202110794358.6A 2021-07-14 2021-07-14 Ganoderma lucidum spore sleep-aiding composition and preparation method and application thereof Pending CN113413437A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王守东等: "《灵芝百问（修订版）》", 30 April 2015, 中国中医药出版社 *

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Application publication date: 20210921