CN113398223A - 一种治疗不孕不育的中药组合物、粉剂、丸剂及其制备方法和应用 - Google Patents
一种治疗不孕不育的中药组合物、粉剂、丸剂及其制备方法和应用 Download PDFInfo
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- CN113398223A CN113398223A CN202110905595.5A CN202110905595A CN113398223A CN 113398223 A CN113398223 A CN 113398223A CN 202110905595 A CN202110905595 A CN 202110905595A CN 113398223 A CN113398223 A CN 113398223A
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Abstract
本发明涉及一种制备简单、针对性强、疗效显著且无毒副作用的治疗不孕不育的组合物、粉剂、丸剂及其制备方法和应用,其活性成分由以下原料制成:当归,枸杞,杜仲,巴载天,仙茅,淫羊藿,山茱萸,淮山药,破故纸,菟丝子,牡蛎,锁阳,蛇床子,黄芪,白术,云苓,覆盆子,桂枝,党参,川断,寄生,砂仁,韭菜籽,肉苁蓉,五味子,鹿角霜,紫河车,甘草。本方剂系纯中剂,具有温补肾阳,调经赞育,益气生精,保胎之疗效,无毒副作用,服药方便,安全可靠,疗效显著,用药严谨,配伍合理,治愈率高等特点,具有很好的治疗作用和良好的市场前景。
Description
技术领域
本发明涉及一种中药组合物,特别涉及一种治疗不孕不育的中药组合物、粉剂、丸剂及其制备方法和应用。
背景技术
传统中医认为,肾为先天之本,肾藏精,主生殖,是人体活动的主要物质之一,但肾气肾精一衰,各个器官都受影响,尤其在生育方面影响最大,随着现代生活压力大和饮食习惯的改变,不孕不育的患者越来越多,主要表现为女子不孕,包括月经不调,闭经,宫胞虚寒和肿瘤等,男子表现为性功能障碍,包括阳痿,早泄,精少,精弱等症状,都与肾精有着密不可分的联系。现在西医治疗不孕不育的方法主要由人工试管婴儿和雌激素治疗两种方法,但这两种方法都存在较大弊端,人工试管婴儿方法对人体危害极大,成功率低,而且花费大,给患者造成较大的经济压力,雌激素治疗虽然经济成本较低,但是会在一定程度上造成内分泌功能紊乱和失调,容易造成再次不孕。
发明内容
为了弥补现有技术的不足,本发明提供了一种制备简单、针对性强、疗效显著且无毒副作用的治疗不孕不育的组合物、粉剂、丸剂及其制备方法和应用,本方剂系纯中剂,具有温补肾阳,调经赞育,益气生精,保胎之疗效,无毒副作用,服药方便,安全可靠,疗效显著,用药严谨,配伍合理,治愈率高等特点,具有很好的治疗作用和良好的市场前景,解决了不孕不育患者疾病带来的各种不适。
本发明是通过如下技术方案实现的:
一种治疗不孕不育的中药组合物,其活性成分由以下重量份数的原料制成:
熟地20-30份,当归5-15份,枸杞15-30份,杜仲10-15份,巴载天10-20份,仙茅10-15份,淫羊藿20-30份,山茱萸15-30份,淮山药10-20份,破故纸10-25份,菟丝子10-15份,牡蛎10-20份,锁阳10-15份,蛇床子10-15份,黄芪15-25份,白术10-25份,云苓10-20份,覆盆子10-15份,桂枝10-20份,党参10-15份,川断10-15份,寄生20-25份,砂仁5-10份,韭菜籽20-30份,肉苁蓉15-25份,五味子10-15份,鹿角霜15-20份,紫河车20-35份,甘草10-20份。
一种治疗不孕不育的中药组合物,其活性成分由以下重量份数的原料制成:
熟地25份,当归10份,枸杞20份,杜仲12份,巴载天15份,仙茅12份,淫羊藿25份,山茱萸23份,淮山药15份,破故纸18份,菟丝子12份,牡蛎15份,锁阳12份,蛇床子12份,黄芪20份,白术18份,云苓15份,覆盆子12份,桂枝15份,党参12份,川断12份,寄生22份,砂仁8份,韭菜籽25份,肉苁蓉20份,五味子12份,鹿角霜17份,紫河车28份,甘草15份。
一种治疗不孕不育的粉剂,包括由如上所述的中药组合物制成的干粉。
根据如上所述的治疗不孕不育的粉剂,所述干粉为150目以上的微粒粉。
根据如上所述的治疗不孕不育的粉剂,所述粉剂中水的质量百分含量为10%以下。
一种治疗不孕不育的丸剂,包括如上任一所述的粉剂和赋形剂。
根据如上所述的治疗不孕不育的丸剂,所述赋形剂为蜂蜜、凡士林、聚丙烯酸钠、香油中的至少一种。
一种如上所述的治疗不孕不育的粉剂的制备方法,包括以下步骤:
(1)按如上所述的比例称取熟地,当归,枸杞,杜仲,巴载天,仙茅,淫羊藿,山茱萸,淮山药,破故纸,菟丝子,牡蛎,锁阳,蛇床子,黄芪,白术,云苓,覆盆子,桂枝,党参,川断,寄生,砂仁,韭菜籽,肉苁蓉,五味子,鹿角霜,紫河车,甘草,去杂质、干燥后得混合物备用;
(2)将步骤(1)得到的混合物置于研磨器中,研磨为粉末,然后将研磨后的粉末过100-150目筛得混合粉末;
(3)将步骤(2)得到的混合粉末干燥、灭菌后用灌装轧盖机进行灌装,密封,得治疗不孕不育的中药组合物。
一种如上所述治疗不孕不育的丸剂的制备方法,包括以下步骤:
(1)按如上所述的比例称取熟地,当归,枸杞,杜仲,巴载天,仙茅,淫羊藿,山茱萸,淮山药,破故纸,菟丝子,牡蛎,锁阳,蛇床子,黄芪,白术,云苓,覆盆子,桂枝,党参,川断,寄生,砂仁,韭菜籽,肉苁蓉,五味子,鹿角霜,紫河车,甘草,去杂质、干燥后得混合物备用;
(2)将步骤(1)得到的混合物置于研磨器中,研磨为粉末,然后将研磨后的粉末过100-150目筛得混合粉末;
(3)将步骤(2)得到的混合粉末干燥、灭菌后得治疗不孕不育的粉剂;
(4)将步骤(3)得到的治疗不孕不育的粉剂与赋形剂混合,然后用纯净水起膜制成直径为0.5-1mm的丸模,向丸模上反复加水、撒粉制成丸芯,盖面处理后制得丸粒;
(5)对丸粒进行包衣、干燥、选丸,即得治疗不孕不育的丸剂。
本发明所述的粉剂可与医学上可接受的载体和/或赋形剂做成胶囊、片剂或颗粒剂等便于服用或便于药物发挥作用的剂型。
一种如上所述的中药组合物在制备不孕不育的药物中的应用。
本发明所采用的各活性成分的药理功效如下所示:
本发明以温补肾阳,调经赞育,益气生精为组方原则,其中,熟地,白术,当归,杜仲,仙茅,巴载天,山茱萸,淫羊藿,肉苁蓉,韭菜籽,蛇床子,砂仁,枸杞几种药物相互配伍,主治男子阳痿精衰,虚寒不育。各成分的功效如下,熟地:养血滋阴,补精益髓,用来治疗血虚萎黄、月经不调、崩漏及肾阴不足,遗精等证。白术:健脾益气,和胃,安胎,用于胎动不安。当归:当归气轻而辛,故又能行血,既可通经调经,又能活络止痛,特别适合月经不调、痛经、血虚闭经等病证,被古人称为“妇科圣药”。杜仲:补阳壮阳,养肾补肾,补气益气,滋阴补阴,肾气不固,胎动不安,用于安胎保胎。仙茅:温肾阳,壮筋骨,治阳萎精冷,阳虚冷泻。巴载天:补肾阳,子宫虚冷。山茱萸:补益肝肾,涩精固脱,用于防止阳痿遗精。淫羊藿:补肾壮阳,治阳痿不举。肉苁蓉:补肾阳,益精血,用于:阳痿,不孕。韭菜籽:阳痿、遗精、白带白淫等。蛇床子:温肾壮阳,用于阳痿、宫冷、寒湿带下。砂仁:具有化湿开胃、理气安胎的功效。枸杞:治肝肾阴亏,遗精。杜仲和肉苁蓉相互配伍,可用来治疗肝肾不足。而人参,白术,云苓,甘草,当归,熟地,菟丝子,杜仲,鹿角霜几种药物相互配伍,主治妇人气血俱虚,静脉不调或断续或带浊或腰酸腹痛或饮食不甘瘦弱不孕。党参,白术,云苓,甘草组成四君子汤,其四种药物相互配伍,主治脾胃气虚,可治疗因脾肾气虚而引起的先兆流产。仙茅,淫羊藿,当归,巴载天组成的二仙汤可用来主治温肾阳,补肾精,调冲任。枸杞子,五味子,覆盆子,菟丝子和韭菜籽组成的五子衍主治肾虚精少,阳痿早泄,遗精,精冷,永不生育。
另外,在本方剂中,紫河车为有血有肉之品,有大补元气,养血益精之功效,鹿角霜性温,有补肾阳,血弱精寒之效,淫羊藿,巴载天,补肾壮阳、益精,这几种药物相互配合,同为大补之品,共为君药;仙茅,杜仲,破故纸,菟丝子,川断,寄生,覆盆子,锁阳,肉苁蓉,韭菜籽,蛇床子,同为温补肾阳,补益精,共为臣药;熟地,当归,调经补血,山芋肉,枸杞,五味子,滋阳壮阳,黄芪,党参,白术,云苓,补中益气;牡蛎,涩精,止遗,砂仁健脾,和胃,安胎,补而不滞,共为佐药;桂枝温经散寒,甘草补中调和药性,共为使药。
本配方中诸药配伍,制备简单、针对性强、疗效显著且无毒副作用,本方剂系纯中剂,具有温补肾阳,调经赞育,益气生精,保胎之疗效,无毒副作用,服药方便,安全可靠,疗效显著,用药严谨,配伍合理,治愈率高等特点,具有很好的治疗作用和良好的市场前景。
具体实施方式
下面结合实施例对本发明作进一步说明,但本发明并不局限于此。
实施例1:
一种治疗不孕不育的中药组合物,由下列药物组成,每份按1斤计,采用如下步骤:
熟地20份,当归5份,枸杞15份,杜仲10份,巴载天10份,仙茅10份,淫羊藿20份,山茱萸15份,淮山药10份,破故纸10份,菟丝子10份,牡蛎10份,锁阳10份,蛇床子10份,黄芪15份,白术10份,云苓10份,覆盆子10份,桂枝10份,党参10份,川断10份,寄生20份,砂仁5份,韭菜籽20份,肉苁蓉15份,五味子10份,鹿角霜15份,紫河车20份,甘草10份。
一种治疗不孕不育的粉剂,包括由如上所述的中药组合物制成的干粉。
根据如上所述的治疗不孕不育的粉剂,所述干粉为150目以上的微粒粉。
根据如上所述的治疗不孕不育的粉剂,所述粉剂中水的质量百分含量为10%以下。
一种治疗不孕不育的丸剂,包括如上所述的粉剂和赋形剂。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗各种情况引起的不孕不育症患者,男方女方均可服用。
根据如上所述的治疗不孕不育的丸剂,所述赋形剂为蜂蜜、凡士林、聚丙烯酸钠、香油中的至少一种。
一种如上所述的治疗不孕不育的粉剂的制备方法,包括以下步骤:
(1)按如上所述的比例称取熟地,当归,枸杞,杜仲,巴载天,仙茅,淫羊藿,山茱萸,淮山药,破故纸,菟丝子,牡蛎,锁阳,蛇床子,黄芪,白术,云苓,覆盆子,桂枝,党参,川断,寄生,砂仁,韭菜籽,肉苁蓉,五味子,鹿角霜,紫河车,甘草,去杂质、干燥后得混合物备用;
(2)将步骤(1)得到的混合物置于研磨器中,研磨为粉末,然后将研磨后的粉末过100-150目筛得混合粉末;
(3)将步骤(2)得到的混合粉末干燥、灭菌后用灌装轧盖机进行灌装,密封,得治疗不孕不育的中药组合物。
一种如上所述治疗不孕不育的丸剂的制备方法,包括以下步骤:
(1)按如上所述的比例称取熟地,当归,枸杞,杜仲,巴载天,仙茅,淫羊藿,山茱萸,淮山药,破故纸,菟丝子,牡蛎,锁阳,蛇床子,黄芪,白术,云苓,覆盆子,桂枝,党参,川断,寄生,砂仁,韭菜籽,肉苁蓉,五味子,鹿角霜,紫河车,甘草,去杂质、干燥后得混合物备用;
(2)将步骤(1)得到的混合物置于研磨器中,研磨为粉末,然后将研磨后的粉末过100-150目筛得混合粉末;
(3)将步骤(2)得到的混合粉末干燥、灭菌后得治疗不孕不育的粉剂;
(4)将步骤(3)得到的治疗不孕不育的粉剂与赋形剂混合,然后用纯净水起膜制成直径为0.5-1mm的丸模,向丸模上反复加水、撒粉制成丸芯,盖面处理后制得丸粒;
(5)对丸粒进行包衣、干燥、选丸,即得治疗不孕不育的丸剂。
用法用量:
粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。
丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。
适应范围:各种不孕不育症。本实施例所述的中药组合物的各种剂型均为内服药,用于治疗各种原因引起的不孕不育症,需夫妻双方同时服用。
注意事项:阴虚內热者慎用。
禁忌:服药期间忌辛辣。
因个体差异,服药时间长短不一,通常服药2-6个月左右可受孕。
实施例2:
一种治疗不孕不育的中药组合物,由下列药物组成,每份按1斤计,采用如下步骤:
熟地25份,当归10份,枸杞20份,杜仲12份,巴载天15份,仙茅12份,淫羊藿25份,山茱萸23份,淮山药15份,破故纸18份,菟丝子12份,牡蛎15份,锁阳12份,蛇床子12份,黄芪20份,白术18份,云苓15份,覆盆子12份,桂枝15份,党参12份,川断12份,寄生22份,砂仁8份,韭菜籽25份,肉苁蓉20份,五味子12份,鹿角霜17份,紫河车28份,甘草15份。
其制备方法和服用方法等同实施例1。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗各种情况引起的不孕不育症患者,男方女方均可服用。
实施例3:
熟地30份,当归15份,枸杞30份,杜仲15份,巴载天20份,仙茅15份,淫羊藿30份,山茱萸30份,淮山药20份,破故纸25份,菟丝子15份,牡蛎20份,锁阳15份,蛇床子15份,黄芪25份,白术25份,云苓20份,覆盆子15份,桂枝20份,党参15份,川断15份,寄生25份,砂仁10份,韭菜籽30份,肉苁蓉25份,五味子15份,鹿角霜20份,紫河车35份,甘草20份。
其制备方法和服用方法等同实施例1。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗各种情况引起的不孕不育症患者,男方女方均可服用。
实施例4:
熟地20份,当归5份,枸杞15份,杜仲10份,巴载天10份,仙茅10份,淫羊藿20份,山茱萸15份,蛇床子10份,白术10份,覆盆子10份,砂仁5份,韭菜籽20份,肉苁蓉15份。
其制备方法和服用方法等同实施例1。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗男子阳痿精縗,虚寒不育引起的不孕不育症患者,治疗的夫妇,男子服用该药物时,女方可服用实施例1-3或实施例5-6任一实施例对应的药物组合物的粉剂或丸剂用来辅助受孕,提高受孕概率。
实施例5:
熟地30份,当归15份,杜仲15份,菟丝子15份,白术25份,云苓20份,党参15份,川断15份,鹿角霜20份,甘草20份。
其制备方法和服用方法等同实施例1。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗女子气血俱虚,静脉不调或断续或带浊或腰酸腹痛或饮食不甘或瘦弱不孕等情况引起的不孕不育症患者,治疗的夫妇,女子服用该药物时,男方可服用实施例1-3或实施例4或实施例7-8任一实施例对应的药物组合物的粉剂或丸剂用来辅助受孕,提高受孕概率。
实施例6:
党参15份,白术25份,云苓20份,甘草20份。
其制备方法和服用方法等同实施例1。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗女子脾胃气虚,引起的不孕不育症患者,治疗的夫妇,女子服用该药物时,男方可服用实施例1-3或实施例4或实施例7-8任一实施例对应的药物组合物的粉剂或丸剂用来辅助受孕,提高受孕概率。
实施例7:
仙茅10份,淫羊藿20份,当归15份,巴载天10份。
其制备方法和服用方法等同实施例1。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗男子肾虚阳縗,虚寒不育引起的不孕不育症患者,治疗的夫妇,男子服用该药物时,女方可服用实施例1-3或实施例5-6任一实施例对应的药物组合物的粉剂或丸剂用来辅助受孕,提高受孕概率。
实施例8:
枸杞15份,五味子15份,覆盆子15份,菟丝子15份,韭菜籽20份。
其制备方法和服用方法等同实施例1。
本实施例所述的药物组合物的粉剂或者丸剂,主要用来治疗男子肾虚精少,阳痿早泄,遗精,精冷,不宜生育引起的不孕不育症患者,治疗的夫妇,男子服用该药物时,女方可服用实施例1-3或实施例5-6任一实施例对应的药物组合物的粉剂或丸剂用来辅助受孕,提高受孕概率。
临床疗效观察:
病例选择:
选取2012年1月--2020年1月在山东省济南市历城区彩石镇虎门村虎门中医诊所就诊的不孕不育患者夫妻150例,男性年龄25-45;女性26-46;
诊断依据:
根据《妇科学》(全国高等医学院教材)诊断。
有正常性生活未经避孕1年未妊娠者称为不孕症。
婚后一年未避孕而从未妊娠者称为原发不孕症。
曾有过妊娠而后未避孕连续1年不孕者称为继发性不孕症。
疗效评定标准:
临床治愈:纠正原发病,正常妊娠至足月分娩。
未愈:经过以上药物治疗仍未妊娠。
服用方法:
口服,夫妻双方可同时服用。
粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。
丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。
该150例夫妇中,有些是夫妻双方都患有不孕不育症,有的是男方患有不孕不育症,有的是女方患有不孕不育症,虽然有的夫妇是一方患病,但是在治疗期间为了提高受孕成功率和缩短受孕时间,仍需夫妇双方共同服用该药物,患不孕不育病患者的一方在服用期间可用来治疗不孕不育症,而未患不孕不育症的一方在服用此药时可用来为受孕做准备,夫妇同用,可提高受孕率。
该150例夫妇中,有的精子量少,有的精子活动力弱,有的肾气亏虚,有的宫胞虚寒,有的气血不足,有的下焦湿寒,有的寒邪盘踞等各种影响受孕的因素。在这150例患者夫妇中,大概有15例是属于精子量少的,大概有20例是属于精子活动力弱的,大概有28例是属于肾气亏虚的,大概有23例是属于宫胞虚寒的,大概有16例是属于气血不足的,大概有12例是属于下焦湿寒的,大概有19例是属于寒邪盘踞的,另外,大概有17例属于其他情况的不孕不育症患者。
就诊的15例精子量少的,男方服用实施例8所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,女方服用实施例5所述的药物组合物的粉剂或丸剂。服用方法和时长同男方。
就诊的20例精力活动力弱的,男方服用实施例4所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,女方服用实施例5所述的药物组合物的粉剂或丸剂。服用方法和时长同男方。
就诊的28例肾气亏虚的,男方服用实施例8所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,女方服用实施例5所述的药物组合物的粉剂或丸剂。服用方法和时长同男方。
就诊的23例宫胞虚寒的,女方服用实施例5所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,男方服用实施例4所述的药物组合物的粉剂或丸剂。服用方法和时长同女方。
就诊的16例气血不足的,女方服用实施例5所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,男方服用实施例4所述的药物组合物的粉剂或丸剂。服用方法和时长同女方。
就诊的12例下焦湿寒的,女方服用实施例5所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,男方服用实施例7所述的药物组合物的粉剂或丸剂。服用方法和时长同女方。
就诊的19例寒邪盘踞的,女方服用实施例1-3所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,男方服用实施例8所述的药物组合物的粉剂或丸剂。服用方法和时长同女方。
就诊的17例其他情况的不孕不育症患者,女方服用实施例1-3所述的药物组合物的粉剂或丸剂,粉剂:每日2次,每次3-5克,开水冲泡,温水送服,饭前或饭后半小时服用,十天一个疗程。丸剂:每日2次,每次1粒,一粒3-5克,温水送服,饭前或饭后半小时服用,十天一个疗程。连续服用三到六个月。同时,男方服用实施例1-4或实施例7-8所述的药物组合物的粉剂或丸剂。服用方法和时长同女方。
治疗效果:
经过三到六个月的服药治疗,这150对夫妇中,15例精子量少的患者中有13例得到治愈;20例精子活动力弱的患者中有18例得到治愈;28例肾气亏虚的患者中有25例得到治愈;23例宫胞虚寒的患者中有20例得到治愈;16例气血不足的患者中有13例得到治愈;12例下焦湿寒的患者中有10例得到治愈;19例寒邪盘踞的患者中有18例得到治愈;17例其他情况的不孕不育的患者中有13例得到治愈。被治愈的130对患者均在6个月之内成功受孕,其中有1对肾气亏虚的夫妇治愈后受孕,但该女子受孕后在两个月的时候因外力置其意外流产;有1对精子活动力弱患者治愈后受孕,但该女子受孕后在三个月的时候因不小心摔倒后置其流产,其他128例均足月分娩,成功治愈率达到86.7%。详情见下表所示:
从上表可以看出,本发明所制的中药组合物对确诊为不孕不育的患者有良好的治疗作用,具有温补肾阳,调经赞育,益气生精,保胎之疗效,无毒副作用,服药方便,安全可靠,疗效显著,用药严谨,配伍合理,治愈率高等特点,具有很好的治疗作用和良好的市场前景。
典型病历分析:
患者刘某夫妇,刘某,女,33岁,结婚六年未孕,做过试管婴儿,未成功。一年多未来月经,带白而多,体寒,怕冷,尤为腹部和腰部为甚,身体偏胖,苔白而厚,脉沉而紧数,西医诊断未多囊卵巢综合征,并告知没有怀孕的可能,并作试管婴儿一次未成功受孕,遂求中医治疗,给刘某服用实施例5所述的药物组合物的粉剂三个月,其夫服用实施例7所述的药物组合物的粉剂三个月,经过三个月治疗之后又用实施例1所述的药物组合物的丸剂中药加强剂治疗一个月,一个月后月经初潮,夫妇又同时服用实施例1所述的药物组合物的粉剂调理了一个月后怀孕,足月顺产一健康女婴。
患者刘某,女,30岁,结婚3年未孕,西医检查均正常,中医诊断月经后期量少,质暗红,腹凉,腰酸胀,给刘某服用实施例5所述的药物组合物的粉剂两个月,其夫服用实施例8所述的药物组合物的粉剂两个月,经过两个月治疗之后又用实施例2所述的药物组合物的丸剂中药加强剂治疗两个月后怀孕,足月刨妇产一健康男婴。
患者谢某,女,40岁,患子宫肌瘤多年,其他医院检查需手术切除,并预测没有怀孕的可能,因患者多方面的原因不愿意做手术,遂求中医治疗,采用活血化瘀软坚散结两个月,子宫肌瘤消失,又以实施例4所述的药物组合物的丸剂给其夫服用两个月,以实施例1所述是药物组合物的丸剂给其服用两个月,一个月侯受孕,足月生下一健康男婴。
李某某,女,25岁,结婚一年半未孕,月经不调,经医院检查闭经,经实施例3所述的中药方剂服用3各疗程后怀孕,服药期间其夫未服用,足月生下一健康男婴。
黄某某,女,34岁,怀孕十周时运动不当引起先兆流程,开始流血,小腹痛,腰部酸胀,遂来就诊,红药治疗七天后痊愈,足月生下一健康男婴。
含某某,女,28岁,怀孕七周时出现流血现象,有流产迹象,去医院检查为孕酮低,患者不愿意接受雌激素疗法,遂来就诊,服用实施例2所述的药物组合物的丸剂一个疗程后症状消失,足月顺产一健康男婴。
张某,男,28岁,结婚三年未育,因工作压力大,经常熬夜,出现腰膝酸软,脱发,健忘,早泄等症状,服用实施例4所述的中药组合物的粉剂两个月后,症状明显改善,又继续服用一个月后妻子怀孕,足月生产一健康男婴。
王某,男,27岁,结婚两年未育,医院检查为精少,精子成活率低,因不愿意接受性激素疗法,遂来就诊,经服用实施例8所述的中药组合物的粉剂一个月后,症状明细消失,连续服用两个疗程后其妻子怀孕,足月生产一健康女婴。
赵某,女,46岁,已育有一子,现因为生育政策调整,遂想要二胎,但42岁以后出现闭经,卵巢早衰,经过黄体酮多次无效,并作试管婴儿一次未成功,经服用实施例1所述的中药组合物的丸剂三个月后,月经初潮,随后怀孕,足月生产一健康女婴。
上述具体实施方式不能作为对本发明保护范围的限制,对于本技术领域的技术人员来说,对本发明实施方式所做出的任何替代改进或变换均落在本发明的保护范围内。
本发明未详述之处,均为本技术领域技术人员的公知技术。
Claims (10)
1.一种治疗不孕不育的中药组合物,其特征在于:其活性成分由以下重量份数的原料制成:
熟地20-30份,当归5-15份,枸杞15-30份,杜仲10-15份,巴载天10-20份,仙茅10-15份,淫羊藿20-30份,山茱萸15-30份,淮山药10-20份,破故纸10-25份,菟丝子10-15份,牡蛎10-20份,锁阳10-15份,蛇床子10-15份,黄芪15-25份,白术10-25份,云苓10-20份,覆盆子10-15份,桂枝10-20份,党参10-15份,川断10-15份,寄生20-25份,砂仁5-10份,韭菜籽20-30份,肉苁蓉15-25份,五味子10-15份,鹿角霜15-20份,紫河车20-35份,甘草10-20份。
2.根据权利要求1所述的治疗不孕不育的中药组合物,其特征在于:其活性成分由以下重量份数的原料制成:
熟地25份,当归10份,枸杞20份,杜仲12份,巴载天15份,仙茅12份,淫羊藿25份,山茱萸23份,淮山药15份,破故纸18份,菟丝子12份,牡蛎15份,锁阳12份,蛇床子12份,黄芪20份,白术18份,云苓15份,覆盆子12份,桂枝15份,党参12份,川断12份,寄生22份,砂仁8份,韭菜籽25份,肉苁蓉20份,五味子12份,鹿角霜17份,紫河车28份,甘草15份。
3.一种治疗不孕不育的粉剂,其特征在于:包括由权利要求1或2所述的中药组合物制成的干粉。
4.根据权利要求3所述的治疗不孕不育的粉剂,其特征在于:所述干粉为150目以上的微粒粉。
5.根据权利要求3或4所述治疗不孕不育的粉剂,其特征在于:所述粉剂中水的质量百分含量为10%以下。
6.一种治疗不孕不育的丸剂,其特征在于:包括如权利要求3--5任一所述的粉剂和赋形剂。
7.根据权利要求6所述的治疗不孕不育的丸剂,其特征在于:所述赋形剂为蜂蜜、凡士林、聚丙烯酸钠、香油中的至少一种。
8.一种如权利要求3-5任一一项权利要求所述的治疗不孕不育的粉剂的制备方法,其特征在于:包括以下步骤:
(1)按权利要求1或2所述的比例称取熟地,当归,枸杞,杜仲,巴载天,仙茅,淫羊藿,山茱萸,淮山药,破故纸,菟丝子,牡蛎,锁阳,蛇床子,黄芪,白术,云苓,覆盆子,桂枝,党参,川断,寄生,砂仁,韭菜籽,肉苁蓉,五味子,鹿角霜,紫河车,甘草,去杂质、干燥后得混合物备用;
(2)将步骤(1)得到的混合物置于研磨器中,研磨为粉末,然后将研磨后的粉末过100-150目筛得混合粉末;
(3)将步骤(2)得到的混合粉末干燥、灭菌后用灌装轧盖机进行灌装,密封,得治疗不孕不育的中药组合物。
9.一种如权利要求6或7治疗不孕不育的丸剂的制备方法,其特征在于:包括以下步骤:
(1)按权利要求1或2所述的比例称取熟地,当归,枸杞,杜仲,巴载天,仙茅,淫羊藿,山茱萸,淮山药,破故纸,菟丝子,牡蛎,锁阳,蛇床子,黄芪,白术,云苓,覆盆子,桂枝,党参,川断,寄生,砂仁,韭菜籽,肉苁蓉,五味子,鹿角霜,紫河车,甘草,去杂质、干燥后得混合物备用;
(2)将步骤(1)得到的混合物置于研磨器中,研磨为粉末,然后将研磨后的粉末过100-150目筛得混合粉末;
(3)将步骤(2)得到的混合粉末干燥、灭菌后得治疗不孕不育的粉剂;
(4)将步骤(3)得到的治疗不孕不育的粉剂与赋形剂混合,然后用纯净水起膜制成直径为0.5-1mm的丸模,向丸模上反复加水、撒粉制成丸芯,盖面处理后制得丸粒;
(5)对丸粒进行包衣、干燥、选丸,即得治疗不孕不育的丸剂。
10.一种如权利要求1--2所述的中药组合物在制备不孕不育的药物中的应用。
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