CN113384665A - 一种降尿酸天然药物组合 - Google Patents

一种降尿酸天然药物组合 Download PDF

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CN113384665A
CN113384665A CN202110794746.4A CN202110794746A CN113384665A CN 113384665 A CN113384665 A CN 113384665A CN 202110794746 A CN202110794746 A CN 202110794746A CN 113384665 A CN113384665 A CN 113384665A
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uric acid
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蒋勇
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Chongqing Senkangdao Life And Health Research Institute Co ltd
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Abstract

一种降尿酸天然药物组合，具体组分包括枸杞提取物，葛根提取物，白术提取物，西洋参提取物，三七提取物，肉苁蓉提取物，车前草提取物，红景天提取物，薏仁提取物。本发明能快速安全降低血尿酸浓度，预防痛风及缓解痛风发作期的不适症状；保护肾功，预防高尿酸所导致的尿毒症发生及尿毒症前期症状(肌酐值<600)的逆转。

Description

一种降尿酸天然药物组合
技术领域
本发明涉及尿酸药物领域，具体涉及一种降尿酸天然药物组合。
背景技术
高尿酸血症(hyperuricemia，HUA)是指由于嘌呤代谢紊乱和/或尿酸排泄障碍所致的一种异质性疾病，以血尿酸升高为主要特征。近年来，随着人民生活水平的提高和饮食结构的改变，我国高尿酸血症的患病率有非常明显的上升趋势。
当前，国内外降尿酸产品主要以西药为主，市场上治疗高尿酸血症的主要药物包括：非布司他、丙舒磺、苯溴马隆、别嘌醇、秋水仙碱。其中非布司他、别嘌醇为黄嘌呤氧化酶抑制剂，降低体内的尿酸产生而达到降尿酸的目的，副作用为对心脑血管存在明显损伤，导致心脑血管疾病的发生；苯溴马隆的作用原理为通过扩张肾小球达到排泄尿酸而降低血尿酸浓度，副作用大，易导致尿毒症的发生；丙舒磺及秋水仙碱为痛风急发期的用药，副作用特别明显。
发明内容
本发明针对现有技术的不足，提出一种利用食药两用天然产物为原料，经提取、分离纯化等操作，获得活性成分，科学配方组合的降尿酸天然药物组合，具体技术方案如下：
一种降尿酸天然药物组合，具体组分包括枸杞提取物，葛根提取物，白术提取物，西洋参提取物，三七提取物，肉苁蓉提取物，车前草提取物，红景天提取物，薏仁提取物，菖蒲提取物。
作为优化：所述枸杞提取物，葛根提取物，白术提取物，西洋参提取物，三七提取物，肉苁蓉提取物，车前草提取物，红景天提取物，薏仁提取物和菖蒲提取物的比例为5-10：1-2：1-2：1：1-5：2-6：5-10：1-2：1：0.5。
中医观点认为，高尿酸血症一般为湿热痹症。高尿酸对人体肝脏、肾脏、脾脏损伤作用明显。本配方中：枸杞具有滋补肝肾、润肺明目的功效；葛根具有疏风解热、生津止渴、生发清阳的功效；白术具有健脾益气、燥湿利水止汗等功效；西洋参具有补气养阴、清火生津的功效；三七具有化瘀止血、活血定痛的功效；肉苁蓉具有补肾阳、益精血、润肠通便的功效；车前草具有清热解毒、利水通淋的功效；红景天具有益气活血、通肺平喘的功效；薏仁具有健脾利水、利湿除痹、清热排脓的功效；菖蒲具有开窍豁痰、理气活血、散风祛湿的功效。
本发明的有益效果为：1、快速安全降低血尿酸浓度，预防痛风及缓解痛风发作期的不适症状；2、保护肾功，预防高尿酸所导致的尿毒症发生及尿毒症前期症状(肌酐值<600)的逆转。
具体实施方式
下面本发明的较佳实施例进行详细阐述，以使本发明的优点和特征能更易于被本领域技术人员理解，从而对本发明的保护范围做出更为清楚明确的界定。
一种降尿酸天然药物组合，具体组分为枸杞提取物，葛根提取物，白术提取物，西洋参提取物，三七提取物，肉苁蓉提取物，车前草提取物，红景天提取物，薏仁提取物。其中枸杞提取物，葛根提取物，白术提取物，西洋参提取物，三七提取物，肉苁蓉提取物，车前草提取物，红景天提取物，薏仁提取物和菖蒲提取物的按照质量比例为5-10：1-2：1-2：1：1-5：2-6：5-10：1-2：1：0.5。
经30余位血尿酸为580-730的患者使用，均在一个月血尿酸浓度降至390以下。达到了理想的降尿酸效果，经1年以上跟踪随访，没有出现痛风状况，血尿酸浓度保持相对稳定。
案例1：杨某，男，48岁，血尿酸浓度630左右，痛风发作频率2-3次/月，肌酐值约500。服用苯溴马隆、别嘌醇片一年以上，血尿酸浓度没有降低。使用本发明组合物一个月后，医院检验结果显示：血尿酸浓度<360，肌酐85，达到了较好的效果。

Claims (2)

1.一种降尿酸天然药物组合，其特征在于：具体组分包括枸杞提取物，葛根提取物，白术提取物，西洋参提取物，三七提取物，肉苁蓉提取物，车前草提取物，红景天提取物，薏仁提取物，菖蒲提取物。
2.根据权利要求1所述降尿酸天然药物组合，其特征在于：所述枸杞提取物，葛根提取物，白术提取物，西洋参提取物，三七提取物，肉苁蓉提取物，车前草提取物，红景天提取物和薏仁提取物的比例为5-10：1-2：1-2：1：1-5：2-6：5-10：1-2：1：0.5。
CN202110794746.4A 2021-07-14 2021-07-14 一种降尿酸天然药物组合 Pending CN113384665A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103536811A (zh) * 2012-07-10 2014-01-29 罗文礼 一种预防和治疗痛风的中药冲剂及其制备方法
CN104524342A (zh) * 2015-01-16 2015-04-22 邓运明 一种四降保元中药制剂及其膏剂的制备方法
CN110960638A (zh) * 2019-12-30 2020-04-07 李刚 一种降尿酸的组合物及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103536811A (zh) * 2012-07-10 2014-01-29 罗文礼 一种预防和治疗痛风的中药冲剂及其制备方法
CN104524342A (zh) * 2015-01-16 2015-04-22 邓运明 一种四降保元中药制剂及其膏剂的制备方法
CN110960638A (zh) * 2019-12-30 2020-04-07 李刚 一种降尿酸的组合物及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陆再华等: "三七总皂苷对痛风的干预", 《中国药物经济学》 *

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