CN113384559A - 一种含生物活性成分的硅酮凝胶贴及其制作方法 - Google Patents
一种含生物活性成分的硅酮凝胶贴及其制作方法 Download PDFInfo
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- CN113384559A CN113384559A CN202110499703.3A CN202110499703A CN113384559A CN 113384559 A CN113384559 A CN 113384559A CN 202110499703 A CN202110499703 A CN 202110499703A CN 113384559 A CN113384559 A CN 113384559A
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- silicone gel
- bioactive
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- patch containing
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Abstract
本发明公开了一种含生物活性成分的硅酮凝胶贴及其制作方法,属于医疗用品技术领域。其成分包括乙烯基聚硅氧烷、交联剂、催化剂、增粘剂、二氧化硅、生物活性成分。其制备方法为涂布交联成型。本发明制备的硅酮凝胶贴能够在发挥硅酮凝胶自身保湿、缓释、良好生物相容性的前提下,能够使其内部带有的生物活性成分以缓释的方式释放出来直达病灶;同时缓释时间和速度都能够长时间保持稳定。本发明的制备方法条件温和、步骤简单,适合大规模生产。
Description
技术领域
本发明涉及医疗、日化用品技术领域,具体涉及一种含生物活性成分的硅酮凝胶贴及其制作方法。
背景技术
硅酮凝胶是由聚硅氧烷为主体的医疗、日化保健用敷料。由于聚硅氧烷具有良好的缓释性、生物相容性,在上世界80年代起就有以外敷的形式治疗、改善或软化由于烧伤、烫伤、伤口增生形成疤痕的应用记录。由于硅酮凝胶能在目标区域保持一定的温度、压力、氧气含量、含水量,除了用于淡化疤痕外,还可以用于防止术后伤口感染、保湿等多种用途,但是目前关于硅酮凝胶除了改善疤痕以外功能的开发相对不足,有很大的发展潜力。
发明内容
本发明的第一个目的是提供一种含生物活性成分的硅酮凝胶贴,此硅酮凝胶贴能够利用硅酮凝胶的缓释作用将含有的生物活性成分长期稳定的直接到达病灶和肌肤,达到所需的治疗或美容目的,扩展了硅酮凝胶贴的应用范围
本发明的第二个目的是提供上述含生物活性成分的硅酮凝胶贴制作方法。
本发明的第一个目的,通过以下技术方案予以实现:
一种含生物活性成分的硅酮凝胶贴,以质量份计算包括以下组分:
进一步地,所述生物活性成分包括以下成分中至少一种:
胶原蛋白、透明质酸钠、神经酰胺、辅酶Q10、虾青素、维生素C、左旋肉碱、咖啡因硅烷醇C、银离子、肝素钠、氨甲环酸、谷胱甘肽,羟丙基四氢吡喃醇,重组人胶原蛋白、生物多肽、葡聚糖、类肉毒素、抗菌肽、维生素E、水杨酸、水杨酸衍生物、伞花烃、伞花烃-5-醇,光甘草定、烟酰胺丁基间苯二酚、苯乙基间苯二酚、辣椒素、光甘草定、烟酰胺。
生物活性成分的物理形态为液体或粉状。
生物活性成分粉体粒径范围在10-3-10-9m。
进一步地,所述交联剂为含氢硅油、所述催化剂为氯铂酸、增粘剂为MQ硅树脂。
进一步地,所述二氧化硅的粒径范围在10-3-10-9m。
进一步地,所述乙烯基聚硅氧烷的粘度范围在100-300000cps。
本发明的第二个目的,通过以下技术方案予以实现:
一种含生物活性成分的硅酮凝胶贴的制备方法,所述生物活性成分的粉体经过粉碎后加入硅酮凝胶基料中;生物活性成分的液体直接加入硅酮凝胶基料中,或通过二氧化硅作为载体加入硅酮凝胶基料中;然后涂布交联成型。
进一步地,当生物活性成分通过二氧化硅作为载体加入硅酮凝胶基料中时,将生物活性成分用水溶解,然后加入至二氧化硅中通过溶剂萃取,再通过低温干燥或低温减压抽滤的方法除去溶剂,获得吸附有生物活性成分的二氧化硅;所述溶剂为乙醇、石油醚和二甲基亚砜中的至少一种。
所述减压的压力范围为<101.325kPa,所述低温的温度范围为-10至80℃。
进一步地,所述涂布的温度为-10℃至100℃。
本发明中,MQ硅树脂是由单官能团Si-O单元与四官能团Si-O单元)组成的一种有机硅树脂。
本发明具有以下有益效果:
1.本发明制备的硅酮凝胶贴能够在发挥硅酮凝胶自身保湿、温和、良好生物相容性的前提下,能够使其内部带有的生物活性成分以缓释的方式释放出来直达病灶;同时缓释时间和速度都能够长时间保持稳定。
2.本发明制备的硅酮凝胶贴的保湿性、保水性、温和性,可以长时间貼敷,软化肌肤,同时硅酮凝胶贴持续稳定的缓释活性成分,使生物活性成分能够深入的渗透到肌肤底层。
3.本发明制备的硅酮凝胶贴的能够承载多种不同的生物活性成分,能够根据不同的需求制成具有不同效果的硅酮凝胶贴,适用范围广。
4.本发明制备的硅酮凝胶贴能够重复使用,一般而言可以至少重复使用10次以上,且每次使用的缓释效果衰减相对稳定。
5.本发明充分发挥硅酮凝胶温和无刺激、柔软贴敷,软化肌肤,超强稳定缓释作用。扩展了硅酮凝胶贴的使用范围。
6.本发明的制备方法条件温和、步骤简单,适合大规模生产。
具体实施方式
下面具体实施例对本发明作进一步说明,以使本领域技术人员可以更好的理解本发明并能予以实施,但所举实施例不作为对本发明的限定。按照本领域的普通技术知识和惯用手段,在不脱离本发明上述基本技术思想前提下,对本发明上述结构做出的其它多种形式的修改、替换或变更,均应落在本发明的保护范围。
本发明制备方法:
第一步:
方法一,称取各组分,将生物活性成分用水和溶剂进行溶解和萃取,然后加入二氧化硅粉料,然后通过低温干燥或低温减压抽滤,除去溶剂,得到含有生物活性成分的二氧化硅粉体。
溶剂为乙醇、石油醚和二甲基亚砜中的至少一种。
减压的压力范围为<101.325kPa,低温的温度范围为-10至80℃。
方法二,称取各组分,将粉状生物活性成分粉碎成0.1mm-10nm的粉状后加入硅酮凝胶基料,液体生物活性成分直接加入硅酮凝胶基料。
第二步:将乙烯基聚硅氧烷、交联剂、催化剂、增粘剂混合均匀制成硅酮凝胶基料。硅酮凝胶基料和生物活性成分,含有生物活性成分的二氧化硅粉体混合涂布成型。
按下表1称量硅酮凝胶体系的原料,按下表2称量活性成分的原料。
表1
序号 | 乙烯基聚硅氧烷 | 含氢硅油 | 氯铂酸 | MQ硅树脂 | 二氧化硅 |
实施例1 | 100 | 0.01 | 0.0001 | 0.0001 | 0.01 |
实施例2 | 100 | 0.03 | 0.0005 | 0.001 | 5 |
实施例3 | 100 | 0.06 | 0.001 | 0.1 | 5 |
实施例4 | 100 | 0.08 | 0.005 | 1 | 0 |
实施例5 | 100 | 0.10 | 0.01 | 5 | 10 |
实施例6 | 100 | 0.12 | 0.05 | 10 | 20 |
实施例7 | 100 | 0.14 | 0.1 | 15 | 15 |
实施例8 | 100 | 0.16 | 0.3 | 20 | 15 |
实施例9 | 100 | 0.18 | 0.6 | 25 | 15 |
实施例10 | 100 | 0.20 | 1 | 30 | 12 |
实施例11 | 100 | 0.20 | 1 | 30 | 12 |
实施例12 | 100 | 0.20 | 1 | 30 | 12 |
表1中,实施例1-3的乙烯基聚硅氧烷分子量为1000cps,实施例4-6的乙烯基聚硅氧烷分子量为5000cps,实施例7、8的乙烯基聚硅氧烷分子量为12000cps,实施例9-12的乙烯基聚硅氧烷分子量为50000cps。
第三步,将第一步中制成的生物活性成分加入第二步中制成的硅酮凝胶基料中,混合均匀后涂布交联成含生物活性成份的硅酮凝胶贴。
表2
实施例1,将胶原蛋白0.8g、透明质酸钠0.8g、神经酰胺1.0g直接加入100g硅酮凝胶基料中,混合均匀,涂布交联成保湿抗皱修复屏障功能的硅酮凝胶贴,
实施例1,将胶原蛋白0.8g、透明质酸钠0.8g、神经酰胺1.0g溶解在水中,加入5克二氧化硅,再通过减压蒸馏干燥后制成含有活性成分的二氧化硅,再将其加入100g硅酮凝胶基料中,混合均匀,涂布交联成保湿抗皱修复屏障功能的硅酮凝胶贴,
实施例2将透明质酸钠0.6g、神经酰胺1.0g、辅酶Q10,1.5g粉碎成0.001mm的粉状,直接加入100g硅酮凝胶基料中,混合均匀,涂布交联成保湿抗皱修复屏障功能的硅酮凝胶贴,以制成保湿抗衰修复屏障功能的硅酮凝胶贴
实施例3,4,5,可以制成发热廋身硅酮凝胶贴,可用于局部减肥瘦身贴。
实施例6可以制成抗菌祛疤硅酮凝胶贴,可治疗青春痘、闭口炎症创面。
实施例7可以制成抗菌硅酮凝胶贴,用于炎症创面貼敷治疗
实施例8可以制成保湿减脂硅酮凝胶贴,用于眼袋、黑眼圈的治疗。
实施例9,10可以制成美白廋身硅酮凝胶贴。
实施例11,12可以制成美白祛斑硅酮凝胶贴,用于治疗黄褐斑、雀斑、老年斑、妊娠斑的硅酮凝胶贴。
缓释测试:以透明质酸钠为指标物,含有透明质酸钠的的实施例1、2、3、4、6,测试缓释性能。将硅酮凝胶贴浸泡在纯化水中,每隔3小时换一次水,测定对应时间内溶液中透明质酸钠含量,结果如表5所示。
表4
根据表4中溶液中透明质酸钠分析,硅酮凝胶贴具有缓慢释放生物活性成份的效果,缓释效果稳定,硅酮凝胶贴通过和肌肤长时间接触,生物活性成分不断缓慢释放,作用于肌肤,渗透到肌肤底层,达到预期美容、治疗效果。
Claims (10)
2.根据权利要求1所述的含生物活性成分的硅酮凝胶贴,其特征在于,所述生物活性成分包括以下成分中至少一种:
胶原蛋白、透明质酸钠、神经酰胺、辅酶Q10、虾青素、维生素C、左旋肉碱、咖啡因硅烷醇C、银离子、肝素钠、氨甲环酸、谷胱甘肽,羟丙基四氢吡喃醇,重组人胶原蛋白、生物多肽、葡聚糖、类肉毒素、抗菌肽、维生素E、水杨酸、水杨酸衍生物、伞花烃、伞花烃-5-醇,光甘草定、烟酰胺、丁基间苯二酚、苯乙基间苯二酚、辣椒素、光甘草定、烟酰胺。
3.根据权利要求2所述的含生物活性成分的硅酮凝胶贴,其特征在于,生物活性成分的物理形态为液体或粉状。
4.根据权利要求3所述的含生物活性成分的硅酮凝胶贴,其特征在于,生物活性成分粉体粒径范围在10-3-10-9m。
5.根据权利要求1所述的含生物活性成分的硅酮凝胶贴,其特征在于,所述交联剂为含氢硅油、所述催化剂为氯铂酸、增粘剂为MQ硅树脂。
6.根据权利要求1所述的含生物活性成分的硅酮凝胶贴的制备方法,其特征在于,所述二氧化硅的粒径范围在10-3-10-9m。
7.权利要求1-6任一所述的含生物活性成分的硅酮凝胶贴的制备方法,其特征在于,所述生物活性成分的粉体经过粉碎后加入硅酮凝胶基料中;生物活性成分的液体直接加入硅酮凝胶基料中,或通过二氧化硅作为载体加入硅酮凝胶基料中;然后涂布成型。
8.根据权利要求7所述的含生物活性成分的硅酮凝胶贴的制备方法,其特征在于,当生物活性成分通过二氧化硅作为载体加入硅酮凝胶基料中时,将生物活性成分用水溶解,然后加入至二氧化硅中通过溶剂萃取,然后通过低温干燥或低温减压抽滤的方法除去溶剂,获得吸附有生物活性成分的二氧化硅;所述溶剂为乙醇、石油醚和二甲基亚砜中的至少一种。
9.根据权利要求8所述的含生物活性成分的硅酮凝胶贴的制备方法,其特征在于,所述减压的压力范围为<101.325kPa,所述低温的温度范围为-10至80℃。
10.根据权利要求7所述的含生物活性成分的硅酮凝胶贴的制备方法,其特征在于,所述涂布的温度为-10℃至100℃。
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