CN113383860A - Vomitoxin antidote and preparation process thereof - Google Patents
Vomitoxin antidote and preparation process thereof Download PDFInfo
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- CN113383860A CN113383860A CN202010164233.0A CN202010164233A CN113383860A CN 113383860 A CN113383860 A CN 113383860A CN 202010164233 A CN202010164233 A CN 202010164233A CN 113383860 A CN113383860 A CN 113383860A
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- vomitoxin
- antidote
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- feed
- extract
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- LINOMUASTDIRTM-QGRHZQQGSA-N deoxynivalenol Chemical compound C([C@@]12[C@@]3(C[C@@H](O)[C@H]1O[C@@H]1C=C(C([C@@H](O)[C@@]13CO)=O)C)C)O2 LINOMUASTDIRTM-QGRHZQQGSA-N 0.000 title claims abstract description 47
- LINOMUASTDIRTM-UHFFFAOYSA-N vomitoxin hydrate Natural products OCC12C(O)C(=O)C(C)=CC1OC1C(O)CC2(C)C11CO1 LINOMUASTDIRTM-UHFFFAOYSA-N 0.000 title claims abstract description 47
- 239000000729 antidote Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 10
- 239000000419 plant extract Substances 0.000 claims description 10
- 244000063299 Bacillus subtilis Species 0.000 claims description 6
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 6
- 210000005253 yeast cell Anatomy 0.000 claims description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 229940110280 zinc methionine Drugs 0.000 claims description 5
- CNMFGFBWPBBGKX-SCGRZTRASA-L zinc;(2s)-2-amino-4-methylsulfanylbutanoate Chemical compound [Zn+2].CSCC[C@H](N)C([O-])=O.CSCC[C@H](N)C([O-])=O CNMFGFBWPBBGKX-SCGRZTRASA-L 0.000 claims description 5
- 241000205585 Aquilegia canadensis Species 0.000 claims description 4
- 241000207929 Scutellaria Species 0.000 claims description 4
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 3
- 244000179560 Prunella vulgaris Species 0.000 claims description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 3
- 235000011477 liquorice Nutrition 0.000 claims description 3
- 235000010674 Prunella vulgaris Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 238000009395 breeding Methods 0.000 abstract description 7
- 230000001488 breeding effect Effects 0.000 abstract description 7
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 231100000678 Mycotoxin Toxicity 0.000 description 18
- 239000002636 mycotoxin Substances 0.000 description 18
- 244000144972 livestock Species 0.000 description 12
- 239000003463 adsorbent Substances 0.000 description 9
- 238000001784 detoxification Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 244000144977 poultry Species 0.000 description 9
- 239000002994 raw material Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000002354 daily effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 108700012359 toxins Proteins 0.000 description 4
- 229930195730 Aflatoxin Natural products 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000005409 aflatoxin Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 235000007516 Chrysanthemum Nutrition 0.000 description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 229930000044 secondary metabolite Natural products 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229930013292 trichothecene Natural products 0.000 description 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241000228230 Aspergillus parasiticus Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000000433 anti-nutritional effect Effects 0.000 description 1
- FIVPIPIDMRVLAY-UHFFFAOYSA-N aspergillin Natural products C1C2=CC=CC(O)C2N2C1(SS1)C(=O)N(C)C1(CO)C2=O FIVPIPIDMRVLAY-UHFFFAOYSA-N 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 239000003008 fumonisin Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- FIVPIPIDMRVLAY-RBJBARPLSA-N gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229930183344 ochratoxin Natural products 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 235000008113 selfheal Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- MBMQEIFVQACCCH-UHFFFAOYSA-N trans-Zearalenon Natural products O=C1OC(C)CCCC(=O)CCCC=CC2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-UHFFFAOYSA-N 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- LZAJKCZTKKKZNT-PMNGPLLRSA-N trichothecene Chemical compound C12([C@@]3(CC[C@H]2OC2C=C(CCC23C)C)C)CO1 LZAJKCZTKKKZNT-PMNGPLLRSA-N 0.000 description 1
- 150000003327 trichothecene derivatives Chemical class 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- -1 yeast cell walls Substances 0.000 description 1
- MBMQEIFVQACCCH-QBODLPLBSA-N zearalenone Chemical compound O=C1O[C@@H](C)CCCC(=O)CCC\C=C\C2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-QBODLPLBSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
- A23L5/273—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption using adsorption or absorption agents, resins, synthetic polymers, or ion exchangers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/28—Removal of unwanted matter, e.g. deodorisation or detoxification using microorganisms
Abstract
The invention discloses a vomitoxin antidote and a preparation process thereof. The vomitoxin antidote provided by the invention has an obvious effect on vomitoxin, and meanwhile, the product can improve the conversion rate of feed, and has good application value to feed and breeding industries.
Description
Technical Field
The invention belongs to the technical field of feed additive mycotoxin degradation, and mainly relates to a vomitoxin antidote and a preparation process thereof.
Background
Mycotoxin is a secondary metabolite generated by fungal metabolism, is an anti-nutritional factor existing in feed and feed raw materials, and the problem of mycotoxin pollution in the feed and the feed raw materials is a global problem facing feed enterprises and breeding enterprises, and the mycotoxin are easy to breed under the condition of high humidity generally. Is a secondary metabolite produced by aspergillin, penicillins and fusarium under a certain temperature and humidity condition, and has great harm in the production process: aflatoxins, trichothecenes, zearalenone, fumonisins, ochratoxins, and the like. The aflatoxin is a strong biological alkaline compound generated by aspergillus flavus and aspergillus parasiticus, and is also the strongest carcinogenic substance so far, and the crops which are mainly harmful to the aflatoxin comprise crops such as peanuts, rice, beans and the like.
Mycotoxin almost affects various organs of livestock and poultry, particularly liver, kidney, oral cavity, gastrointestinal tract, nervous system and reproductive system, and is directly expressed in the appearance that the feed intake of livestock and poultry is reduced, the weight is slowly increased, vomit and the like, so that the conversion rate of feed is reduced. Trichothecene toxins present strong alkalinity, and poisoning of the toxins mainly damages oral cavity, gastrointestinal tract and the like and plays a toxic role by influencing protein synthesis and organism immunity.
Generally, vomitoxin has stable chemical properties, is not easy to be reprocessed and damaged in the storage process, and currently, mycotoxin detoxification treatment mainly comprises the following steps: mechanical detoxification, biological detoxification, chemical detoxification, physical adsorption detoxification and the like. Wherein, the physical detoxification operation is complicated, the cost is high, and the like, and the chemical detoxification can not be effectively used in the production practice due to the problem of chemical residue; the adsorbent detoxification method is mainly characterized in that various adsorbents are added into feed or grains, so that mycotoxin substances can be adsorbed, and the mycotoxin is not absorbed by animals when passing through intestinal tracts of the animals and is directly discharged out of the bodies of the animals. The invention relates to a vomitoxin antidote and a preparation process thereof, in view of the fact that a mature and feasible mycotoxin detoxification method is available in the feed market at present, but a conventional adsorbent with a diverse mycotoxin structure cannot effectively solve the problems of pollution and harm of various mycotoxins.
Disclosure of Invention
Aiming at the problems of the prior mold remover product, the invention provides a mold toxin adsorbent which solves the problem of mold toxin pollution of livestock and poultry breeding feed and raw materials by inhibiting the breeding, degrading and adsorbing of vomitoxin-producing bacteria, and the like, and can promote the balance of livestock and poultry intestinal flora and improve the immunity of livestock and poultry, and a preparation process thereof.
The technical scheme of the vomitoxin antidote and the preparation process provided by the invention is as follows:
the mycotoxin adsorbent provided by the invention is characterized in that the main components of the mycotoxin adsorbent are composed of bacillus subtilis, vitamin C, montmorillonite, yeast cell walls, plant extracts and zinc methionine.
The natural plant extract is composed of honeysuckle extract, licorice extract, scutellaria extract and prunella vulgaris.
An antidote for vomitoxin and a preparation process thereof are characterized in that: the vomitoxin antidote disclosed by the invention comprises 30% of montmorillonite by mass, 65% of yeast cell wall by mass, 1% of vitamin C by mass, 2.7% of bacillus subtilis by mass, 1% of plant extract by mass and 0.3% of zinc methionine by mass.
The plant extract is prepared by mixing honeysuckle extract, liquorice extract, scutellaria extract, selfheal chrysanthemum and the like according to a mass ratio.
The montmorillonite is high-purity nano montmorillonite with the purity of 99.5 percent.
The prepared vomitoxin antidote and the preparation process thereof can be applied to the aspect of livestock and poultry feed, and the mycotoxin adsorbent can be added into the livestock and poultry breeding feed to be suitable for various livestock and poultry breeding feeds.
The invention provides a vomitoxin antidote and a preparation process thereof, and the preparation process has the following advantages:
the preparation process of the livestock and poultry mycotoxin adsorbent is simple and easy to obtain, and the required raw materials are uniformly mixed and vacuum-packaged according to the formula proportion during large-scale production.
The vomitoxin antidote provided by the invention can effectively adsorb and degrade mycotoxin and reduce the harm of mycotoxin to cultivation and livestock growth.
Regulating intestinal environment of livestock and fowl, enhancing digestion and absorption ability and immunity of livestock and fowl, increasing feed conversion rate, and inhibiting harmful bacteria.
The vomitoxin antidote provided by the invention adopts montmorillonite which has little adsorption on amino acid, vitamin and other nutrient substances.
The raw materials of the components can cooperate with each other, the absorption and degradation effects of the vomitoxin can be effectively exerted, and the problems of mould pollution and vomitoxin pollution in the feed and the raw materials can be effectively reduced.
The vomitoxin antidote and the preparation process thereof provided by the invention have good stability in the processing and storage processes, are not easy to agglomerate, and have good application value for feed and breeding enterprises.
Detailed Description
The above description of the present invention is further described below with reference to embodiments, and all the application technologies realized based on the above description of the present invention are within the scope of the present invention.
The specific process disclosed by the invention comprises the following steps:
according to the vomitoxin antidote and the preparation process thereof, montmorillonite, bacillus subtilis, yeast cell walls, plant extracts, vitamin C and zinc methionine are respectively weighed according to the proportion of each formula.
The natural plant extract is added by honeysuckle extract, liquorice extract, scutellaria extract, summer mulberry chrysanthemum and the like according to the mass ratio.
Adding yeast cells, bacillus subtilis, plant extract, zinc methionine and montmorillonite into an automatic mixer with the batch mixing amount of 500kg, and controlling the environmental temperature to be 25 +/-2 ℃ and the environmental humidity to be 45 +/-5% during mixing.
Example of the implementation
The formula of the vomitoxin antidote in the embodiment is as follows:
the mass proportion is respectively as follows: weighing 150Kg of modified montmorillonite, 325Kg of yeast cell wall, 5Kg of vitamin C, 13.5 Kg of Bacillus subtilis, 5Kg of plant extract and 1.5Kg of methionine zinc.
The preparation method comprises the following steps: under the conditions of the ambient temperature of 25 +/-2 ℃ and the ambient humidity of 45 +/-5%, mixing and uniformly mixing the raw materials according to the formula proportion, and finally carrying out vacuum packaging.
The using method comprises the following steps: the mycotoxin adsorbent prepared by the invention is added into complete feed according to the proportion of 1% (namely 10Kg of the product of the invention is added to each ton of feed).
The product of the invention has the same effect application, preparation method and use method as the embodiment 1.
Through a large number of experiments and verification experiments, the applicant prepares the vomitoxin antidote according to the formula provided by the invention, and the experimental result shows that the vomitoxin antidote disclosed by the invention has good adsorption and degradation effects on vomitoxin. Meanwhile, the piglet feeding experiment has good productivity effect, reduces morbidity, improves daily gain and reduces feed ratio by being linked with a culture base memorial feeding experiment cooperated by a company, and the following data can be used as data support for effect description.
The first experimental protocol is as follows:
the applicant carried out 90-day feeding experiments in the pig farm in 6 months of 2019, and the 30-day-old piglets were randomly divided into 3 experimental groups and 1 control group in the experiments, and each group included 30 piglets. Feeding basal diet for the control group; the prepared vomitoxin antidote is added in the first basic daily ration embodiment fed by the experimental group, daily gain, feed conversion ratio, morbidity and mortality of piglets in the feeding process are recorded every day, statistics is carried out from 30 days of age to 120 days of age, and experimental results are compared by adopting a statistical method.
Influence of vomitoxin antidote on piglet production performance
| Experimental groups | Incidence of disease | Mortality rate | Daily gain (g/d) | Meat ratio of materials |
| Example 1 | 1.74% | 0 | 423.74±10 | 1.97 |
| Control | 38.33% | 5.8% | 280.66±10 | 2.80 |
Compared with an experimental group and a control group, the vomitoxin antidote disclosed by the invention is obvious in action effect, good in piglet production performance action effect, low in morbidity, obvious in increase of daily gain compared with the control group, capable of obviously reducing the feed ratio and improving the feed conversion rate.
The second experimental protocol was as follows:
preparing 1ppm vomitoxin solution, subpackaging in 200mL triangular flasks, bottling 1ppm vomitoxin solution 50mL each, adding 2g, 3g and 4g of vomitoxin antidote in an experimental group, not adding any control group, respectively numbering 1,2,3 and 4, performing 3 parallel tests in each group, measuring the content of vomitoxin by using enzyme-linked immunosorbent assay, and counting test results to perform data analysis.
The effect of the antidote for vomitoxin on vomitoxin is compared
| Experimental groups | Content of vomitoxin |
| 1 | 0.487ppm |
| 2 | 0.200ppm |
| 3 | 0.025ppm |
| 4 | 0.983ppm |
Tests show that 2g of vomitoxin antidote of the product is added into 50mL of 1ppm vomitoxin solution, the reduction of vomitoxin is 50.46%, 3g of vomitoxin antidote of the product is added into 50mL of 1ppm vomitoxin solution, the reduction of vomitoxin is 79.65%, 3g of vomitoxin antidote of the product is added into 50mL of 1ppm vomitoxin solution, the reduction of vomitoxin is 97.46%, and test results show that the product has an obvious effect on vomitoxin.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art of the present invention, the product process formula can be simply replaced without departing from the spirit of the present invention, and all such changes should be considered as falling within the scope of the present invention.
Claims (3)
1. An antidote for vomitoxin and a preparation process thereof are characterized in that: 30 percent of montmorillonite, 65 percent of yeast cell wall, 1 percent of vitamin C, 2.7 percent of bacillus subtilis, 1 percent of plant extract and 0.3 percent of zinc methionine.
2. The vomitoxin antidote and the preparation process thereof according to claim 1, wherein the plant extract is prepared by mixing honeysuckle extract, liquorice extract, scutellaria extract and prunella vulgaris in equal proportion by mass.
3. The vomitoxin antidote and the preparation process according to claim 1, wherein the montmorillonite is high purity nano montmorillonite with purity of 99.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010164233.0A CN113383860A (en) | 2020-03-11 | 2020-03-11 | Vomitoxin antidote and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010164233.0A CN113383860A (en) | 2020-03-11 | 2020-03-11 | Vomitoxin antidote and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113383860A true CN113383860A (en) | 2021-09-14 |
Family
ID=77615216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010164233.0A Withdrawn CN113383860A (en) | 2020-03-11 | 2020-03-11 | Vomitoxin antidote and preparation process thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766519A (en) * | 2022-04-28 | 2022-07-22 | 上海市农业科学院 | Use of Scutellariae radix extract as deoxynivalenol production inhibitor |
| CN114766519B (en) * | 2022-04-28 | 2024-05-17 | 上海市农业科学院 | Use of Scutellariae radix extract as deoxynivalenol production inhibitor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105309777A (en) * | 2015-12-07 | 2016-02-10 | 山东润牧生物科技有限公司 | Mycotoxin toxin adsorbent of livestock and poultry feed and preparation process |
| CN109938244A (en) * | 2019-04-04 | 2019-06-28 | 浙江启润生物科技有限公司 | A kind of high-efficiency feed mold toxin sorbent preparation process |
| CN113558171A (en) * | 2020-04-28 | 2021-10-29 | 浙江启润生物科技有限公司 | Preparation method of antibacterial mycotoxin adsorbing nano montmorillonite feed additive |
-
2020
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105309777A (en) * | 2015-12-07 | 2016-02-10 | 山东润牧生物科技有限公司 | Mycotoxin toxin adsorbent of livestock and poultry feed and preparation process |
| CN109938244A (en) * | 2019-04-04 | 2019-06-28 | 浙江启润生物科技有限公司 | A kind of high-efficiency feed mold toxin sorbent preparation process |
| CN113558171A (en) * | 2020-04-28 | 2021-10-29 | 浙江启润生物科技有限公司 | Preparation method of antibacterial mycotoxin adsorbing nano montmorillonite feed additive |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766519A (en) * | 2022-04-28 | 2022-07-22 | 上海市农业科学院 | Use of Scutellariae radix extract as deoxynivalenol production inhibitor |
| CN114766519B (en) * | 2022-04-28 | 2024-05-17 | 上海市农业科学院 | Use of Scutellariae radix extract as deoxynivalenol production inhibitor |
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Application publication date: 20210914 |