CN113383014A - 双受体重激动剂化合物及其药物组合物 - Google Patents
双受体重激动剂化合物及其药物组合物 Download PDFInfo
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- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
提供了一系列多肽双重激动剂化合物及其可药用盐及其药物组合物，其对人类胰高血糖素样肽‑1(Glucagon‑like peptide‑1，GLP‑1)受体和人类血糖依赖性促胰岛素多肽(Glucose‑dependent insulinotropic poly peptide，GIP)受体具有双重激动剂作用，并可以用于非胰岛素依赖性糖尿病、胰岛素依赖性糖尿病和肥胖症等相关疾病的治疗。
Description
PCT国内申请，说明书已公开。
Claims (43)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019111209066 | 2019-11-15 | ||
| CN201911120906 | 2019-11-15 | ||
| CN2020108177908 | 2020-08-14 | ||
| CN202010817790 | 2020-08-14 | ||
| PCT/CN2020/129071 WO2021093883A1 (zh) | 2019-11-15 | 2020-11-16 | 双受体重激动剂化合物及其药物组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113383014A true CN113383014A (zh) | 2021-09-10 |
| CN113383014B CN113383014B (zh) | 2024-06-18 |
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| CN202080006382.2A Active CN113383014B (zh) | 2019-11-15 | 2020-11-16 | 双受体重激动剂化合物及其药物组合物 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN113383014B (zh) |
| TW (1) | TW202120535A (zh) |
| WO (1) | WO2021093883A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114958883A (zh) * | 2022-04-12 | 2022-08-30 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117794946A (zh) * | 2021-06-09 | 2024-03-29 | 斯克利普斯研究所 | 长效双重gip/glp-1肽缀合物及使用方法 |
| CA3239474A1 (en) * | 2021-12-01 | 2023-06-08 | Hua He | Pharmaceutical composition of glp-1 and gip receptor dual agonist and use thereof |
| WO2023131325A1 (zh) * | 2022-01-10 | 2023-07-13 | 江苏豪森药业集团有限公司 | 一种稳定的受体激动剂的药物组合物、制备方法及其应用 |
| CN117402219A (zh) * | 2022-07-13 | 2024-01-16 | 杭州中美华东制药有限公司 | Glp-1/gip双激动剂及其制备方法和用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103764673A (zh) * | 2011-06-10 | 2014-04-30 | 北京韩美药品有限公司 | 葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用 |
| WO2015035419A1 (en) * | 2013-09-09 | 2015-03-12 | Hoffmann-La Roche Inc. | Dosages of gip/glp-1 co-agonist peptides for human administration |
| CN107001439A (zh) * | 2014-10-29 | 2017-08-01 | 西兰制药公司 | Gip激动剂化合物及方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104470948B (zh) * | 2012-05-03 | 2018-06-15 | 西兰制药公司 | Gip-glp-1双激动剂化合物及方法 |
| TWI670281B (zh) * | 2013-11-06 | 2019-09-01 | 西蘭製藥公司 | Ｇｉｐ－ｇｌｐ－１雙重促效劑化合物及方法 |
-
2020
- 2020-11-16 WO PCT/CN2020/129071 patent/WO2021093883A1/zh active Application Filing
- 2020-11-16 TW TW109140201A patent/TW202120535A/zh unknown
- 2020-11-16 CN CN202080006382.2A patent/CN113383014B/zh active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103764673A (zh) * | 2011-06-10 | 2014-04-30 | 北京韩美药品有限公司 | 葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用 |
| WO2015035419A1 (en) * | 2013-09-09 | 2015-03-12 | Hoffmann-La Roche Inc. | Dosages of gip/glp-1 co-agonist peptides for human administration |
| CN107001439A (zh) * | 2014-10-29 | 2017-08-01 | 西兰制药公司 | Gip激动剂化合物及方法 |
Non-Patent Citations (1)
| Title |
|---|
| 李磊;李立安;: "胰高血糖素样肽-1的生物学及相关药物研究" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114958883A (zh) * | 2022-04-12 | 2022-08-30 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021093883A1 (zh) | 2021-05-20 |
| TW202120535A (zh) | 2021-06-01 |
| CN113383014B (zh) | 2024-06-18 |
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