CN113383013A - 一种人白细胞介素2变体或其衍生物 - Google Patents

一种人白细胞介素2变体或其衍生物 Download PDF

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CN113383013A
CN113383013A CN201980072296.9A CN201980072296A CN113383013A CN 113383013 A CN113383013 A CN 113383013A CN 201980072296 A CN201980072296 A CN 201980072296A CN 113383013 A CN113383013 A CN 113383013A
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variant
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cells
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CN113383013B (zh
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陈磊
胡齐悦
葛虎
林�源
王宏伟
欧阳超
孔祥林
廖成
张连山
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Shanghai Shengdi Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Shanghai Shengdi Pharmaceutical Co Ltd
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Abstract

提供了具有一个或多个氨基酸突变的人白细胞介素‑2(IL‑2)变体或其衍生物，所述IL‑2变体或其衍生物与野生型IL‑2相比，具有增加的稳定性，并具有用作免疫治疗剂的改善特性。还公开了包含所述人IL‑2变体或其衍生物的免疫缀合物、药物组合物、编码其的多核苷酸分子、载体、宿主细胞和制备方法，以及所述IL‑2变体或其衍生物、包含其的免疫缀合物或药物组合物的制药用途。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201980072296.9A 2018-12-21 2019-12-20 一种人白细胞介素2变体或其衍生物 Active CN113383013B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2018115709305 2018-12-21
CN201811570930 2018-12-21
CN201910158957 2019-03-04
CN2019101589571 2019-03-04
PCT/CN2019/126901 WO2020125743A1 (zh) 2018-12-21 2019-12-20 一种人白细胞介素2变体或其衍生物

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CN113383013A true CN113383013A (zh) 2021-09-10
CN113383013B CN113383013B (zh) 2022-11-04

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US (1) US20220056094A1 (zh)
EP (1) EP3875475A4 (zh)
JP (1) JP2022513265A (zh)
KR (1) KR20210107714A (zh)
CN (1) CN113383013B (zh)
AU (1) AU2019409196A1 (zh)
BR (1) BR112021010983A2 (zh)
CA (1) CA3123471A1 (zh)
MX (1) MX2021007085A (zh)
TW (1) TW202034945A (zh)
WO (1) WO2020125743A1 (zh)
ZA (1) ZA202103785B (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023046156A1 (en) * 2021-09-26 2023-03-30 Wuxi Biologics (Shanghai) Co. Ltd. Il-2 variants and fusion proteins thereof
CN116041539A (zh) * 2022-10-31 2023-05-02 山东博安生物技术股份有限公司 Il-2突变体免疫缀合物
WO2024083097A1 (zh) * 2022-10-19 2024-04-25 北京志道生物科技有限公司 一种il-2突变体

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TW202128961A (zh) 2019-11-20 2021-08-01 美商安維塔生物科學股份有限公司 細胞激素融合蛋白及其醫藥組合物及治療應用
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
CN114380919B (zh) * 2020-10-18 2024-06-25 北京志道生物科技有限公司 经修饰的il-2分子及其用途
CA3201446A1 (en) * 2020-11-13 2022-05-19 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising human interleukin 2 variant or derivative thereof and use thereof
CN113831402A (zh) * 2021-07-30 2021-12-24 西安龙腾景云生物科技有限公司 一种人白细胞介素2变体及其用途
KR20240036511A (ko) * 2021-07-30 2024-03-20 윈취안 바이오테크놀로지 (베이징) 씨오., 엘티디. 인간 인터루킨-2 변이체 및 이의 용도
WO2023180527A1 (en) 2022-03-25 2023-09-28 Universität Zürich Adenoviral mediated targeting of activated immune cells
WO2024037572A1 (en) * 2022-08-16 2024-02-22 Kine Biotech Co., Ltd. Interleukin-2 variants and their uses in treating cancers

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WO2005007121A2 (en) * 2003-07-18 2005-01-27 Massachusetts Institute Of Technology Mutant interleukin-2(il-2) polypeptides
CN1599867A (zh) * 2001-12-04 2005-03-23 默克专利有限公司 具有调节的选择性的免疫细胞因子
CN103492411A (zh) * 2011-02-10 2014-01-01 罗切格利卡特公司 突变体白介素-2多肽

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US7371371B2 (en) 2001-08-13 2008-05-13 University Of Southern California Interleukin-2 mutants with reduced toxicity
EP1723251A4 (en) * 2004-03-05 2008-04-23 Novartis Vaccines & Diagnostic IN VITRO TESTING SYSTEM FOR PREDICTING THE TOLERABILITY OF THERAPEUTIC AGENTS IN PATIENTS
GB2415904B (en) * 2005-02-07 2006-10-25 Chiron Corp Preparing aldesleukin for pharmaceutical use
WO2009061853A2 (en) 2007-11-05 2009-05-14 Massachusetts Institute Of Technology Mutant interleukin-2 (il-2) polypeptides
DE102008023820A1 (de) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
CA2749539C (en) 2009-01-21 2022-07-19 Amgen Inc. Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases
CU23923B1 (es) 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
KR102493543B1 (ko) * 2014-07-21 2023-01-30 데리니아, 인크. 자가면역 질환의 치료를 위한 조절 t 세포를 선택적으로 활성화시키는 분자
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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN1599867A (zh) * 2001-12-04 2005-03-23 默克专利有限公司 具有调节的选择性的免疫细胞因子
WO2005007121A2 (en) * 2003-07-18 2005-01-27 Massachusetts Institute Of Technology Mutant interleukin-2(il-2) polypeptides
CN103492411A (zh) * 2011-02-10 2014-01-01 罗切格利卡特公司 突变体白介素-2多肽

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023046156A1 (en) * 2021-09-26 2023-03-30 Wuxi Biologics (Shanghai) Co. Ltd. Il-2 variants and fusion proteins thereof
WO2024083097A1 (zh) * 2022-10-19 2024-04-25 北京志道生物科技有限公司 一种il-2突变体
CN116041539A (zh) * 2022-10-31 2023-05-02 山东博安生物技术股份有限公司 Il-2突变体免疫缀合物

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JP2022513265A (ja) 2022-02-07
EP3875475A4 (en) 2022-12-07
BR112021010983A2 (pt) 2021-08-31
AU2019409196A1 (en) 2021-06-17
TW202034945A (zh) 2020-10-01
ZA202103785B (en) 2022-07-27
CN113383013B (zh) 2022-11-04
MX2021007085A (es) 2021-08-11
US20220056094A1 (en) 2022-02-24
EP3875475A1 (en) 2021-09-08
WO2020125743A1 (zh) 2020-06-25
CA3123471A1 (en) 2020-06-25
KR20210107714A (ko) 2021-09-01

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