CN113368210B - A topical Chinese medicinal composition for treating children tic disorder and preparation method thereof - Google Patents
A topical Chinese medicinal composition for treating children tic disorder and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external traditional Chinese medicine composition for treating children's tic disorders and a preparation method thereof. The external traditional Chinese medicine composition comprises the following raw materials in parts by weight: 6-12 parts of radix bupleuri, 6-12 parts of rhizoma acori graminei, 6-12 parts of polygala tenuifolia and 3-5 parts of scorpion; 6-15 parts of white paeony root, 6-15 parts of radix curcumae, 4-8 parts of albizia julibrissin, 4-8 parts of poria cocos, 3-5 parts of stiff silkworm, 6-9 parts of uncaria, 9-12 parts of feather cockscomb seed, 9-12 parts of fructus viticis, 3-5 parts of magnolia flower, 9-12 parts of radix puerariae, 9-12 parts of mulberry twig, 3-5 parts of earthworm and 3-5 parts of borneol. The invention has simple formula, quick response, good curative effect and no toxic or side effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external traditional Chinese medicine composition for treating children's tic disorders and a preparation method thereof.
Background
The child Tourette Syndrome (also called Tourette Syndrome), which is more than the onset of children and adolescents, is mainly characterized by involuntary, rapid and purposeless one or more parts of the disease such as meat movement or phonation twitch, which can be accompanied by hyperactivity, attention to lack of concentration, compulsive action and thinking or other behavioral symptoms, but has normal intelligence, and is a neuropsychiatric disease with obvious genetic tendency. The onset age of TD is 2-21 years, men are obviously more than women, the prevalence rate of boys is about 1.06%, the prevalence rate of girls is about 0.25%, most of the TD is seen in early school age and school age children, most of the TD is 5-10 years, and if the TD is not diagnosed and treated in time, the disease condition is usually the most serious in 10-12 years. Meanwhile, tic disorder can often be combined with various diseases, such as 36% of comorbid attention deficit hyperactivity disorder, 27% of self-disabling behavior and 18% of compulsive behavior.
Ancient books of traditional Chinese medicine do not record completely corresponding to the disease, and are mostly classified into syndrome differentiation ranges of chronic infantile convulsion, convulsive limbs, convulsion and spasm, liver wind syndrome, wind disease and other diseases according to clinical manifestations. Its occurrence is related to both internal and external factors. The occurrence of this disease has many factors, but there are no external or internal factors. Clinically, the occurrence of this disease is usually related to two major aspects of the disease. Congenital deficiency, which can cause weak fetal qi, or birth injury, asphyxia and anoxia to cause infantile congenital deficiency without the history of illness in the period of pregnancy; the onset of diseases can be caused by acquired malnutrition, such as recovery from exogenous pathogenic factors or improper nursing. The emotional disorder of the children can also cause the delicate viscera and incomplete qi of the children, which are easily disturbed by the transformation boundary, for example, the study pressure is large, the parent's education is too strict, and the long-term emotional disorder leads to the clinical manifestations of liver loss, diarrhea and qi movement disorder, which is caused by the wind-evil in TCM. Wind is yang pathogen, which is good at moving and changing rapidly, and its nature changes rapidly, or up or down, without fixed time, and irregular. The disease is located in the five zang organs, and the disorder of emotion and body behavior occurs due to the imbalance of yin and yang in the five zang organs, and the wind-cold falling into the string belongs to the liver, which is mainly responsible for the liver. The western medicine treatment of the disease is mainly drug treatment and psychological behavior treatment. The medicine mainly comprises dopamine receptor blocker, a2 receptor agonist and other medicines. The medicines have certain side effects after long-term application and lack the function of integral adjustment. The traditional Chinese medicine has the characteristics of multi-target effect and has better advantages in the aspect of treating the children tic disorder. Therefore, the development of the traditional Chinese medicine external gel patch for treating the children tic disorder has important significance.
Disclosure of Invention
Aiming at the above purposes, the invention aims to provide an external traditional Chinese medicine composition for treating children tic disorder and a preparation method thereof. Simple formula, quick response, good curative effect and no toxic or side effect.
In order to achieve the purpose, the invention provides an external traditional Chinese medicine composition for treating children tic disorder, which comprises the following raw materials in parts by weight: 6-12 parts of radix bupleuri, 6-12 parts of rhizoma acori graminei, 6-12 parts of polygala tenuifolia and 3-5 parts of scorpion; 6-15 parts of white paeony root, 6-15 parts of radix curcumae, 4-8 parts of albizia julibrissin, 4-8 parts of poria cocos, 3-5 parts of stiff silkworm, 6-9 parts of uncaria, 9-12 parts of feather cockscomb seed, 9-12 parts of fructus viticis, 3-5 parts of magnolia flower, 9-12 parts of radix puerariae, 9-12 parts of mulberry twig, 3-5 parts of earthworm and 3-5 parts of borneol.
A preparation method of an external traditional Chinese medicine composition for treating children tic disorder specifically comprises the following steps: extracting the raw materials with 60-80% ethanol under reflux for 2-3 times, each for 2-3 hr, distilling the extractive solutions under reduced pressure respectively to recover ethanol, extracting and concentrating to relative density of 1.5-1.8(50 deg.C), and vacuum drying to obtain extract powder; grinding Borneolum Syntheticum, adding into the above dry extract powder, and mixing; adding appropriate amount of glycerol into the mixture, and making into ointment with thickness of 0.5-0.7cm and diameter of 2-3cm to obtain topical Chinese medicinal composition.
Analyzing the drug properties of the raw materials.
Bupleurum root, radix bupleuri, pungent and bitter in flavor, slightly cold in nature. It enters liver, gallbladder and lung meridians. Harmonize exterior and interior, soothe liver, relieve depression, raise yang, lift sinking, allay fever and check malaria. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis. Yunnan materia Medica (Yunnan province) says: radix bupleuri for typhoid fever and sweating can be used after four days: if it is used first, yang syndrome will lead to yin meridian, and it should not be used. "this meridian origin" is: bupleuri radix, children's five malnutrition with the symptoms of shortness of breath, cold and heat, all malaria, it is used with salty. Cold and heat, or pain and heat in the hypochondrium, are seen after the pimple is seen, and when it is used internally, it is indicated for exterior-penetrating herbs, so it will not cause heat to stay in the shaoyang meridian, and there will be no bite in the future. "
Grassleaf sweelflag rhizome, rhizoma Acori Graminei, pungent and bitter, warm in nature, enters heart and stomach meridians. Inducing resuscitation and eliminating phlegm, refreshing mind and improving intelligence, and eliminating dampness and promoting appetite. Can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness. The book Jing (Ben) is characterized in that: it can be used for treating arthralgia due to wind-cold-dampness, cough, adverse rising of qi, opening heart-qi, tonifying five internal organs, dredging nine orifices, improving eyesight and hearing, and producing voice. "the bibliographic" is listed: "mainly deafness, carbuncle and sore, warming intestines and stomach, stopping small and convenient, damp arthralgia of limbs, no flexing and stretching, warm malaria in children, no decomposition of heat in body, can be used as bath soup. Improve hearing and eyes, and benefit heart and intelligence. "
Yuan Zhi is bitter, pungent and warm. It enters heart, kidney and lung meridians. Induce tranquilization, improve intelligence and relieve depression. It is indicated for palpitation, amnesia, nocturnal emission, insomnia, cough with excessive phlegm, abscess, deep-rooted carbuncle, sore and swelling. The book Jing (Ben) is characterized in that: mainly cough and dyspnea impairs the middle-jiao, tonifies deficiency, removes pathogenic qi, benefits nine orifices, benefits wisdom, improves hearing and eyesight, does not forget, and strengthens strength. "the bibliographic" is listed: to calm heart qi, stop palpitation, replenish vital essence, remove heart qi, heat in skin and yellow complexion. "
Bai Shao is bitter and sour in taste and slightly cold in nature. It enters liver and spleen meridians. Nourish blood and regulate menstruation, astringe yin and check sweating, soften liver and relieve pain, and calm liver yang. Can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, and vertigo. The book Jing (Ben) is characterized in that: the Chinese medicinal composition has the effects of treating abdominal pain due to pathogenic factors, removing blood stagnation, breaking hard mass, treating hernia due to cold and heat, relieving pain, promoting urination and tonifying qi. "the bibliographic" is listed: promoting blood circulation, relieving epigastric distention, dispersing blood stasis, expelling blood stasis, removing water and qi, benefiting bladder, large intestine and small intestine, and eliminating carbuncle and swelling. "
Yu jin is pungent, bitter and cold. It enters liver, heart and lung meridians. Promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice. Can be used for treating pricking pain in chest and hypochondrium, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, breast pain, coma due to fever, epilepsy, hematemesis, hemorrhage, jaundice, and dark urine. The compendium of materia Medica (Ben Cao gang mu) is characterized in that: for blood-qi-heart-abdominal pain, postpartum septicemia, heart-attacking and dying, heart-fire loss, mania and venomous poison. "this meridian origin" is: yu jin is pungent and slow in flavor, ascending first and descending second, entering heart and enveloping. It is indicated for hematemesis, epistaxis, salivation, and hematochezia. Stranguria with blood, hematuria, retrograde menstruation of women, postpartum septicemia and heart attack, and persistent blood and heartache, it is advisable to take Yu jin powder with ginger juice and urina hominis together, so that the blood is clear. The 'materia medica truth seeking' is recorded in the book: "the qi ascends first and slightly descends. There is blood stagnation. And substances with blood-evil. The qi goes ahead of the upper one. If it makes qi and blood of the pathogenic factors difficult to disappear because they are located on the diaphragm. Should be warm and cool. The same as other flavors. It is also used for regulation and treatment. "
Albizzia julibrissin (flower), sweet and neutral. Soothing depression, regulating qi, soothing nerves and activating collaterals. It is used to treat chest distress, insomnia, amnesia, eye diseases due to wind-fire, blurred vision, pharyngalgia, carbuncle, swelling, and pain due to traumatic injury. The book Ben Cao just reads (Ben Cao just reads) is in the name: "can nourish blood". The 'classified herb properties' is recorded in the book: it can clear heart fire and improve vision. The expression of the Chinese materia medica of Sichuan is as follows: it has the functions of regulating heart, stimulating appetite, regulating vital energy, dispelling wind, improving eyesight and relieving depression. It is indicated for insomnia due to heart deficiency. "
Poria cocos, sweet and bland in flavor, mild in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. The compendium of materia Medica (Ben Cao gang mu) is characterized in that: poria cocos, Poria cocos, Poria, belongs to yang, and belongs to the yang, and also refers to the property of nature, nourishing water, promoting urination, and inducing diuresis; dongyuan means that it is the yin in yang and descending, so it is also called the action. The 'Ben Cao Yan Yi' has the main points: poria cocos, Poria cocos wolf and Poria cocos wolf have the action of moving water, and can tonify heart and spleen, and do not reach the limit. The 'materia medica Zheng' is recorded: the Chinese medicinal composition has the effects of inducing resuscitation and removing dampness, and inducing resuscitation and restoring heart and intelligence, and promoting the production of body fluid; removing dampness can expel water and dry spleen, strengthen middle-jiao and invigorate stomach; to treat epilepsy due to fright and thick intestine, it is indicated for phlegm and helps to descend. Because its taste is slightly sweet, it is said to tonify yang. But with less benefit and more profit. "
Quan Xie, pungent and Ping. It enters liver meridian. Extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation. Can be used for treating liver wind stirring, spasm, convulsion, infantile convulsion, and apoplexy
Hemiplegia, tetanus, stubborn rheumatism, migraine, sore and ulcer, scrofula. The compendium of materia Medica (Ben Cao gang mu) is characterized in that: the infantile convulsion and convulsion are ground and taken after being roasted by the mint; radix seu caulis Parthenocissi Tricuspidatae, Cinnabaris, Moschus, or pill; epilepsy and chronic convulsion, taking the mixture with pomegranate in the last dose; for chronic convulsion, it is taken with Bai Zhu and Ma Huang powder; it is administered together with she Xiang. The 'materia medica truth seeking' is recorded in the book: scorpio (Special for liver). Pungent and sweet in flavor. The temperature is toxic. The cyanine belongs to wood. So it is specially used for liver to dispel wind. "
Jiang Can, salty and pungent in flavor and neutral in nature. It enters liver, lung and stomach meridians. Extinguish wind and stop spasm, dispel wind and alleviate pain, resolve phlegm and dissipate nodulation. Can be used for treating liver wind with phlegm, epilepsy and convulsion, infantile acute convulsion, tetanus and apoplexy
Headache due to wind-heat, conjunctival congestion, pharyngalgia, pruritus due to rubella, and parotitis. The Shennong Bencao Jing records that the traditional Chinese medicine composition has the effects of treating infantile convulsion and night cry, removing three insects, blackening the skin, and improving the complexion and male yin and external diseases. The compendium of materia medica records that wind-phlegm-dispersing tuberculosis, scrofula, wind-damp, wind-worm toothache, skin wind-sores, erysipelas itching, … … all incised sores, furuncle and swelling wind-hemorrhoids. "
Uncaria rhynchophylla is sweet in taste and cold in nature. It enters liver and pericardium meridians. Stop convulsion, clear heat and pacify liver. Can be used for treating stirring of liver-wind, convulsion, febrile convulsion, common cold with convulsion, infantile cry, eclampsia in pregnancy, headache, and vertigo. Bibliographic (r) is as follows: it is indicated for cold and heat in children and fright epilepsy. "compendium" is listed: big head dizziness, liver wind pacifying, heart heat removing, abdominal pain in children fishing, macula eruption. The 'new compilation of materia medica' is recorded: uncaria rhynchophylla is suitable for patients with wind syndrome because of its rapid wind-dispelling effect. However, the generation of wind-fire is mostly due to kidney water deficiency, which causes wood dryness fire, in yin tonics, less hooked uncaria is easy to disperse, if not all yin tonics, pure hooked uncaria is used to dispel wind and dissipate fire, which makes wind unable to extinguish, and fire is cured . "
Feather cockscomb seed, bitter and slightly cold. It enters liver meridian. Clearing liver-fire, improving vision, removing nebula, and can be used for treating liver heat with conjunctival congestion, nebula membrane, blurred vision, and liver fire vertigo. The compendium of materia Medica (Ben Cao gang mu) is characterized in that: although the Shennong Ben Cao Jing (Shen nong's herbal classic) does not say that Qing Zi has the same effect of treating eyes, Yun Yi Cao Jue Ming and Zhun kou Qing have the same effect of improving eyesight . The liver orifice of eye, the lip mouth is blue, the syndrome of reverting yin meridian of foot is also commonly indicated by heat-clearing from ancient recipe, and celosia seeds are the reverting yin herb, , which is often indicated for eyes under the condition of treating eyes. "this meridian origin" is: qing Xiang Zi has the same action as Jue Ming Zi … … in treating wind-heat eye diseases, wind-itching, body-heat in skin, so it can also dissipate wind-heat in blood vessels of Jueyin channel. The 'materia medica justice' is recorded: feather cockscomb, the same family of cockscomb. It is bitter, cold and slippery, and good at clearing stagnated heat, so it is indicated for wind-heat and liver-fire in ophthalmology. "
Man Jing Zi is pungent, bitter and slightly cold in nature. It enters lung, bladder and liver meridians. Disperse wind-heat, clear head and eyes, and remove dampness from joints. Can be used for treating headache due to exogenous pathogenic factors, dizziness, blurred vision, hyperdacryosis, eye pain, gingival swelling and pain, and spasm due to damp arthralgia. The compendium of materia Medica (Ben Cao gang mu) is characterized in that: man Jing Shi has light smell and pungent flavor, light and superficial body, ascending and dispersing, so it is mainly indicated for wind deficiency of head and face. The book "the summary of materia Medica" says: man Jing Zi is also indicated for wind diseases of the head and face. The former ancient method mainly promotes nine orifices, activates joints, improves eyesight, strengthens teeth, and dispels wind-cold and wind-heat evil. It is pungent and warm with mild property, floating and ascending, so it is mainly indicated for various syndromes of head and face deficiency wind. Tui Jiuqiao and benefit the joints, so it is often used in decoction powder to treat spasm due to damp arthralgia, cold hernia and beriberi, and it is not confined to the upper part of the head and face. The 'new compilation of materia medica' is recorded: "Chastetree fruit, Zi Bu Chinese medicine is the most effective for headache because of its thinness and lightness, so that if a single effect is exceeded, it cannot. "
Xin Yi, pungent and warm in flavor, enters lung and stomach meridians. Disperse wind-cold and unblock nasal orifices. It can be used for treating wind-cold type common cold, nasal obstruction, and nasosinusitis. The compendium of materia Medica (Ben Cao gang mu) is characterized in that: the lung opens into the nose, while the yangming stomach pulse goes upward around the nose, the brain is the house of spirit, and the nose is the orifice of the gate of life; when the middle-qi is deficient and the clear-yang is not ascending, the head is inclined and nine orifices are obstructed. The pungent flavor of Xin Yi can warm the middle energizer and treat head, face, eyes and nose diseases because it can help the stomach clear yang to move upward and go through the sky. The 'new compilation of materia medica' is recorded: flos Magnoliae, with its orifices opening and ascending in the brain house, is used for treating nasal obstruction and nasosinusitis, and is not used by others, and is reserved for use in ears. In addition, the pungent and scattered substances are often used, which can damage the true qi and can be used temporarily but not for a long time. The 'Shennong Ben Cao Jing' has a name: "the five internal organs are cold and hot, and headache and brain pain are mainly caused. "
Burdock fruit, pungent, bitter and cold. It enters lung and stomach meridians. Disperse wind-heat, ventilate lung and relieve sore throat, remove toxicity and promote eruption, and relieve swelling and cure sore. Can be used for treating wind-heat type common cold, early stage of epidemic febrile disease, measles without adequate eruption, carbuncle, swelling and sore. The book Ben Cao Jing Shu (Ben Cao Jing Shu) says: the malignant excess is the essential herb for dispelling wind, removing heat and removing toxicity. Pungent flavor can dissipate nodulation, bitter flavor can discharge heat, and heat accumulation can clear and improve the visceral qi, so it can improve vision and tonify middle energizer. Wind hurts defensive qi, while heat is produced when it stagnates, while exterior qi is harmonized when it is relieved by pungent-cool wind, is not retained. The zang organs dominate wind-toxin swelling and flaccidity; elements are mainly used for moistening lung, dissipating stagnation of qi, relieving sore throat, removing skin wind, and dredging twelve meridians, which is known as this. So it is indicated for urticaria, acne and sore, especially for strange inspection. The 'medical treatise on herb properties' is characterized in that: to remove wind, erysipelas, improve vision, benefit waist and feet, and disperse tubercle, muscles and bones vexation and heat-toxin. "
Kudzuvine root, sweet and pungent in flavor, cool in nature. It enters lung and stomach meridians. Expelling pathogenic factors from muscles and skin, bringing down fever, promoting eruption, promoting the production of body fluid, quenching thirst, invigorating yang, and relieving diarrhea. Can be used for treating fever due to exterior syndrome, pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging, and diarrhea due to spleen deficiency. The book Ben Cao Jing Shu (Ben Cao Jing Shu) says: kudzuvine root, radix Puerariae, also has the main action of resolving heat pathogen of yangming-warm disease, so it is indicated for diabetes, fever, heat accumulation in chest and diaphragm and vomiting. It is also indicated for arthralgia due to its divergent and ascending nature and wind-herbs property. For cold-induced headache, neck-strong and back-pain, and general bone-pain, the pathogenic factors will not enter into yangming state even if the foot is sunny, so it is not suitable for taking. The book Jing is recorded in the book: diabetes, fever, vomiting, arthralgia, qi of the yin and toxicity. "
Di Long is cold in nature and salty in taste. Clearing heat, arresting convulsion, dredging collaterals, relieving asthma, and promoting urination, and can be used for treating hyperpyrexia, mania, convulsion, headache due to wind-heat, conjunctival congestion, hemiplegia, etc.
Mulberry twig, slightly bitter in taste, mild in nature. It enters liver meridian. Dispel wind-damp and benefit joints, and can be used for treating wind-damp arthralgia, soreness and numbness of shoulder, arm and joints. The "Ben Cao Tu Jing" is in the name of: "treat wind itching and dryness, beriberi and wind qi, spasm of limbs. The book' materia medica preparation is recorded: benefiting joints, nourishing body fluid, moving water and dispelling wind. The 'materia medica scooping essences' say: ramulus mori, a special purpose of removing rheumatism and spasm, is to obtain ramulus cinnamomi for treating shoulder and arm arthralgia; the sophora japonica branch, the willow branch and the peach branch can be washed for itching. "
Borneol, pungent and bitter with a cool taste. It enters heart and lung meridians. Unblocking orifices, dispelling stagnated fire, removing nebula, improving eyesight, relieving swelling and alleviating pain. It is indicated for wind stroke, vomiting, coma due to febrile disease, epilepsy due to convulsion, phlegm-phlegm, qi block, deafness, sore throat, aphtha, otitis media, carbuncle, swelling, hemorrhoid, nebula, and enterobiasis. Tang Ben Cao (materia Medica of Tang Dynasty): "governing pathogenic factors in heart and abdomen, accumulation of wind-dampness and deafness". Improve vision, remove blood-shot eyes and nebula. "(materia Medica of sea medicine): "governing eyes obstruction, three worms, five hemorrhoids, improving vision, relieving palpitation and secret essence. "compendium" (compendium): treating pharyngitis, encephalodynia, nasal obstruction, toothache, typhoid fever, tongue protrusion and infantile pox. Unblock orifices and dissipate stagnated fire. "
The prescription of the invention is compatible and release: tic disorder belongs to common diseases in pediatrics. Plain Wenyang original disease formula: wind falling and dizziness falling belong to the liver, and storm with strong and direct wind belongs to wind. The disease is mainly in the liver, children have frequent insufficiency of the spleen, and the liver is vigorous and can restrict the spleen. The ancient and modern medical science records that the spleen-earth is weak and the liver-wood is dominated by the weak spleen-earth, so the tendons are contracted to produce convulsion. "spleen is the source of phlegm generation, and spleen deficiency causes water-dampness to stop transportation and the generation of phlegm pathogen, which is brought into play in the infant section: after convulsions, qi does not disperse, stagnation of qi generates phlegm, phlegm generates heat, heat generates wind, and so on. "Su Wen & Gu kong Lun" is a cloud of all kinds of diseases caused by wind. Wan ' ang ' Tang Tou Ming ' is mostly worried about phlegm in the recipe. Cloud of Danxi Heart method: phlegm, which is the object, goes up and down with qi and is everywhere. Phlegm pathogen attaches to liver wind, externally reaches the skin and hair orifices, and internally reaches the viscera and meridians, causing a series of twitching symptoms. Wind-phlegm disturbing the interior, and moving through the meridians and collaterals can cause the facial, limbs and abdomen twitching; phlegm obstructing the throat can lead to itching throat, intercropping voice in the throat and foul speech in the mouth. The mutual combination of liver wind and phlegm can lead to the clinical manifestations of the infant's convulsion, accompanied by dizziness, easy fright, uneasy sleep, irritability and other mixed symptoms of deficiency and excess. Therefore, the basic therapeutic principles of calming liver wind and stopping, invigorating spleen and resolving phlegm for resuscitation should be applied.
The formula analysis in the formula: in the formula, the bupleurum root calms the liver, the grassleaf sweelflag rhizome and the thinleaf milkwort root-bark reduce phlegm and induce resuscitation, and the scorpion stops endogenous wind and stops functioning as monarch drug; radix Paeoniae alba, radix Curcumae, and herba Albiziae help radix bupleuri to calm liver, Poria strengthens spleen and reduces phlegm and helps rhizoma Acori Tatarinowii and radix Polygalae strengthen spleen and reduce phlegm; bombyx Batryticatus and ramulus Uncariae cum uncis have effects of calming endogenous wind and relieving spasm to help Scorpio stop; semen Celosiae and fructus Vitics Simplicifoliae stop vision, flos Magnoliae is effective in dredging nasal orifice, radix Puerariae and ramulus Mori are effective in relieving muscles and joints, and Lumbricus is effective in calming endogenous wind and relieving spasm as adjuvant drugs; the borneol is used for treating convulsion of children by dredging nine orifices and dissipating stagnated fire, and the whole formula is combined with the traditional Chinese medicine composition for calming liver wind and stopping convulsion, strengthening spleen and reducing phlegm for resuscitation.
Compared with the prior art, the invention has the beneficial effects of.
The viscera of children are delicate, the body shape and qi are not sufficient, and the metabolism function of the body to the medicine is weak, so the raw materials used by the medicine formula are safe and nontoxic, can effectively make up the efficacy limitation of single-component food, has more obvious effect on children's tic disorder clinically, and has potential social benefit and economic benefit.
Detailed Description
The present invention will be described in further detail with reference to the following embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1.
A traditional Chinese medicine composition for external use for treating children tic disorder is composed of the following raw materials in parts by weight: 6 parts of radix bupleuri, 6 parts of rhizoma acori graminei, 6 parts of polygala tenuifolia and 3 parts of scorpion; 6 parts of white paeony root, 15 parts of turmeric root-tuber, 8 parts of albizia julibrissin, 8 parts of poria cocos, 5 parts of stiff silkworm, 6 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 3 parts of biond magnolia flower, 12 parts of radix puerariae, 12 parts of mulberry twig, 5 parts of earthworm and 3 parts of borneol.
A method for preparing an external Chinese medicinal composition for treating children tic disorder comprises: extracting bupleuri radix, rhizoma Acori Graminei, cortex et radix Polygalae, Scorpio, radix Paeoniae alba, radix Curcumae, herba Albiziae, Poria, Bombyx Batryticatus, ramulus Uncariae cum uncis, semen Celosiae, fructus Vitics Simplicifoliae, flos Magnoliae, radix Puerariae, ramulus Mori and Lumbricus with 80% ethanol under reflux for 3 times, each time for 2 hr, distilling the extractive solutions under reduced pressure to recover ethanol, extracting and concentrating to relative density of 1.5(50 deg.C), and vacuum drying to obtain extract powder; grinding 3 parts of borneol, adding the ground borneol into the dry paste powder and mixing the ground borneol and the dry paste powder uniformly; adding appropriate amount of glycerol into the mixture, and making into ointment with thickness of 0.5cm and diameter of 3 cm.
Example 2.
A traditional Chinese medicine composition for external use for treating children tic disorder is composed of the following raw materials in parts by weight: 10 parts of radix bupleuri, 10 parts of rhizoma acori graminei, 10 parts of polygala tenuifolia and 3 parts of scorpion; 9 parts of white paeony root, 9 parts of radix curcumae, 8 parts of albizia julibrissin, 8 parts of poria cocos, 3 parts of stiff silkworm, 9 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 5 parts of biond magnolia flower, 9 parts of radix puerariae, 9 parts of mulberry twig, 3 parts of earthworm and 3 parts of borneol.
The preparation method is the same as that of example 1.
Example 3.
A traditional Chinese medicine composition for external use for treating children tic disorder is composed of the following raw materials in parts by weight: 12 parts of radix bupleuri, 12 parts of rhizoma acori graminei, 12 parts of polygala tenuifolia and 5 parts of scorpion; 15 parts of white paeony root, 15 parts of radix curcumae, 8 parts of albizia julibrissin, 8 parts of poria cocos, 5 parts of stiff silkworm, 9 parts of uncaria, 12 parts of feather cockscomb seed, 12 parts of fructus viticis, 5 parts of biond magnolia flower, 12 parts of radix puerariae, 12 parts of mulberry twig, 5 parts of earthworm and 5 parts of borneol.
The preparation method is the same as that of example 1.
Example 4.
A traditional Chinese medicine composition for external use for treating children tic disorder is composed of the following raw materials in parts by weight: 9 parts of radix bupleuri, 9 parts of rhizoma acori graminei, 9 parts of polygala tenuifolia and 4 parts of scorpion; 8 parts of white paeony root, 8 parts of radix curcumae, 8 parts of albizia julibrissin, 8 parts of poria cocos, 4 parts of stiff silkworm, 6 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 4 parts of biond magnolia flower, 9 parts of radix puerariae, 9 parts of mulberry twig, 4 parts of earthworm and 4 parts of borneol.
The preparation method is the same as that of example 1.
Example 5.
A traditional Chinese medicine composition for external use for treating children tic disorder is composed of the following raw materials in parts by weight: 11 parts of radix bupleuri, 11 parts of rhizoma acori graminei, 11 parts of polygala tenuifolia and 3 parts of scorpion; 10 parts of white paeony root, 10 parts of radix curcumae, 6 parts of albizia julibrissin, 6 parts of poria cocos, 5 parts of stiff silkworm, 7 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 4 parts of biond magnolia flower, 11 parts of radix puerariae, 11 parts of mulberry twig, 4 parts of earthworm and 3 parts of borneol.
The preparation method is the same as that of example 1.
1. Clinical data.
1.1 data and methods.
1.1.1 general data.
The pediatric outpatient clinic of the Liaoning traditional Chinese medicine university affiliated hospital in 1 month to 2017 months in 2013 meets the TD diagnosis standard of the revision (DSM-V-TR) of the American mental disease diagnosis and statistics manual 4 th edition, and 32 cases are included in the pediatric clinic.
1.1.2 Western diagnostic standards.
The diagnostic criteria for TD were adopted as revision American Manual for mental disorders, version 4 (DSM-IV-TR).
Diagnostic criteria for transient TD.
(1)1 or more motor tics and/or phonetics.
(2) The episodes are taken many times a day, almost daily, for a period of at least 4 weeks, but not more than one year.
(3) There has been no history of chronic exercise or vocal TD or TS.
(4) The disease starts before the age of 18 years.
(5) TD symptoms are not directly caused by certain drugs (e.g., stimulants) or medical conditions (e.g., huntington's disease or encephalitis following viral infection).
Diagnostic criteria for chronic exercise or vocalization TD.
(1)1 or more motor or vocal tic movements, but not simultaneously during the course of the disease.
(2) The twitching is performed for many times per day, and can be performed for each day or intermittently, but the intermittent period lasts for no more than 3 months, and the course of disease exceeds 1 year.
(3) The disease starts before the age of 18 years.
(4) TD symptoms are not caused by certain drugs (e.g., stimulants) or medical conditions (e.g., Huntington's chorea or encephalitis following viral infection).
The diagnostic criteria for TS were.
(1) There are multiple motor tics and 1 or more phonic tics in the course of the disease, but not necessarily occurring at the same time.
(2) The twitching may occur multiple times per day (usually in clusters) or intermittently, but the intermittent time does not exceed 3 months and the course of the twitching is more than 1 year.
(3) The location, number, frequency, intensity and complexity of twitches varies with time.
(4) The disease starts before the age of 18 years.
(5) Tic symptoms are not directly caused by certain drugs (e.g., stimulants) or medical conditions (e.g., huntington's disease or post viral infection encephalitis).
1.1.3 Chinese medicine diagnosis standard.
The syndrome of phlegm stirring in the liver-wind is formulated according to the traditional Chinese medicine syndrome differentiation of the multiple tic disorder of children in the second edition of 'practical traditional Chinese medicine' published by Shanghai science and technology publishing society in 2005 and the seven-year planning teaching material 'TCM' in the 'TCM' made by the Shanghai science and technology.
(1) And (3) master certificate: involuntary spontaneous twitching, at least the following 1 is satisfied.
Face twitching occurs at odds with glaring and blinking, crumpled and snout, oral twitching, mouth opening and tongue biting, grinning, etc.
Secondly, involuntary actions such as head shaking, head twisting and neck stretching, neck tilting and head shrinking, shoulder shrugging and head shrinking, and the like are performed when the neck and the shoulders are drawn.
And the limbs draw a chest support and twist waist, rub hands and make a fist, swing upper limbs, shake legs and roll feet, and even the gait is abnormal.
Sound-producing twitching a abnormal sound produced by twitching throat muscles, such as voice, nasal sound, dry cough, screaming sound, repeated language, imitation language, foul language, etc.
(2) The secondary syndrome is restless sleep; is easy to be irritative.
(3) Tongue pulse: a red tongue with white or yellow greasy coating and a wiry and slippery pulse.
The principal syndrome is essential, at least 1 of the secondary syndromes is provided, and the diagnosis of the principal syndrome can be established by referring to the typical tongue pulse.
1.1.4 inclusion criteria.
(1) The kit is in accordance with TD Western medicine diagnosis and eliminates organic diseases.
(2) According with the syndrome differentiation standard of liver wind with phlegm syndrome in traditional Chinese medicine.
(3) The age is between 4 and 18 years.
(4) The time of the consultation can be fixed for follow-up.
1.1.5 exclusion criteria (supplementary).
(1) Age <4 years or >18 years.
(2) Tic symptoms are caused by other diseases such as rheumatic chorea, Huntington's chorea, hepatolenticular degeneration, athetosis, myoclonus, acute dyskinesia, hysteria, epilepsy, etc.
(3) Combined with other visceral diseases.
1.1.6 methods of treatment.
The patient children who meet the diagnosis standard are provided with the stop plaster, the application parts are twitching parts and Shenque acupoint, and western medicines cannot be taken during the treatment period. The preparation is administered 2 times a day for 1 hr, and 4 weeks is 1 course of treatment. The treatment course is 1.
1.2 Observation of therapeutic effect.
First, the symptoms of 1 week before the first diagnosis and 4 weeks are thoroughly interrogated, and the number of attacks, frequency, intensity, complexity and interference of motor tic and vocal tic are scored.
② scoring according to the traditional Chinese medicine principal and secondary symptoms and the diet and the tongue pulse condition of the patient.
1.3 evaluation of therapeutic effect.
1.3.1 disease efficacy assessment.
The improvement of the twitch severity before and after treatment of the infant patients was evaluated comprehensively according to the YGTSS scale. The evaluation standards of clinical control, obvious effect, effective and ineffective 4-grade curative effects are formulated according to the integral value of the scale before and after treatment. The treatment effect was evaluated for motor twitches and vocal twitches, respectively.
The efficacy index ═ X100%
(1) The clinical control is that the curative effect index (the integral value is reduced) is more than or equal to 90 percent
(2) Has obvious effect, the curative effect index (the integral value is reduced) is more than 60 percent and less than 90 percent
(3) Effective that the curative effect index (the integral value is reduced) is more than or equal to 30 percent and less than 60 percent
(4) The ineffective rate is that the curative effect index (the integral value is reduced) is less than 30 percent.
1.3.2 evaluation of the curative effect of the traditional Chinese medicine syndrome.
According to the integral value of the observation indexes of the primary syndrome and the secondary syndrome before and after the administration of the medicine, 4 levels of curative effect evaluation standards of clinical control, obvious effect, effective effect and ineffective effect are formulated.
The efficacy index ═ X100%
(1) Clinical control, namely, the twitch symptom disappears, and the Chinese medicine symptom integral is reduced by more than or equal to 90 percent compared with that before the medicine is taken;
(2) has obvious effects that the twitching symptom is more than or equal to 60 percent, the traditional Chinese medicine symptom is obviously relieved, and the integral is reduced by less than 90 percent compared with that before the medicine is taken;
(3) has the advantages that the twitching symptom is more than or equal to 30 percent, the traditional Chinese medicine symptom is relieved, and the integral is reduced by less than 60 percent compared with the integral before the medicine is taken;
(4) the drug has no effect, the twitch symptom and the traditional Chinese medicine symptom are not obviously relieved or are not improved, and the integral is reduced by less than 30 percent compared with the integral before the drug is taken.
1.4 adverse reactions to the drug.
Comprises uncomfortable symptoms and general physical examination items, hematuria routine, liver and kidney functions and other test indexes which appear in the medicine taking process of the children patients.
1.5 statistical analysis.
Adopting SPSS19.0 software package for statistics, and adopting X for counting data2And (4) testing, wherein the curative effect index is processed by a t-test statistical method.
1.6 results.
1.6.1 comparison of therapeutic effects.
The score variable of the curative effect before and after treatment is analyzed, P is 0.061 to 0.05, the integral difference value of the curative effect accords with normal distribution, and the difference has statistical significance by t test of two matched samples, wherein P is less than 0.05, so that the treatment effect is shown.
Table 1 comparison before and after twitching.
1.6.2 treatment Forward and Backward motion twitches the integral change of each dimension.
The scores of times, frequency, intensity, complexity and interference of exercise tics before and after treatment are all reduced compared with the scores before treatment, P is less than 0.05 through t test, and the difference has statistical significance, which shows that the traditional Chinese medicine can improve exercise tics from different aspects such as times, frequency, intensity, complexity and the like.
Table 2 motility twitch integral change for each dimension.
1.6.3 integral changes of twitch in each dimension occur before and after treatment.
As can be seen from Table 3, the scores of the frequency, intensity, complexity and interference of the phonic tic twitching before and after treatment are all reduced compared with those before treatment, P is less than 0.05 through t test, and the difference has statistical significance, which indicates that the traditional Chinese medicine can improve the phonic twitching from different aspects such as frequency, intensity, complexity and the like.
Table 3 voicing twitch the integral change for each dimension.
1.6.4 and has therapeutic effect on symptoms of Chinese medicinal materials.
The Chinese medicine symptom score variables before and after treatment are analyzed, P is greater than 0.05, the score difference value accords with normal distribution, two matched samples are selected for t test, P is less than 0.01, the difference has statistical significance, and the Chinese medicine can improve the Chinese medicine symptoms on the whole.
Table 4 comparison before and after the syndrome differentiation.
1.6.5. And (6) safety observation.
No adverse reaction of children patients in clinical application.
2 typical cases.
Patient 1: zhangqi, male, age 5, chief complaints: crowding eyebrow, blinking, making abnormal voice in throat more than 2 months, aggravating for 10 days. The current medical history: the infant is diagnosed as the pediatric multiple tic disorder through the clinic examination of the clinic, wherein the pediatric multiple tic disorder is diagnosed by the physical and chemical examination related to the clinical examination, which is caused by 2 months ago, eyebrow crowding, blinking and abnormal voice in the throat after the cold, which are not regarded by parents, and the symptoms are aggravated before 10 days, and the symptoms such as grinning, shrugging, finger movement, attention deficit and the like are appeared. The current symptoms are as follows: frequent eyebrow crowding, blinking, grinning and throat sounding, occasional shoulder shrugging, finger movement, correct reception, insomnia, normal stool, 1 time a day, yellow urine. A red tongue with a yellow and greasy coating and a slippery and rapid pulse. And (3) diagnosis: the infant multiple tourette syndrome belongs to the syndrome of liver wind with phlegm according to syndrome differentiation of traditional Chinese medicine, and has the following treatment principles: pacify liver, stop wind, invigorate spleen, resolve phlegm and induce resuscitation. Applying the stop plaster for external application. The application parts are periphery of bilateral eyes, Tiantu acupoint and Shenque acupoint; the preparation is administered 2 times a day for 1 hr, and 4 weeks is 1 course of treatment. The treatment course is 1. The second treatment course is followed by the patch 1. The three pre-treatment symptoms are obviously improved, and 1 course of treatment is continued. After the medicine is stopped, the disease is followed for 2 months without relapse, and the disease belongs to clinical recovery.
Patient 2: wangzhi, male, 6 years old, chief complaints: the eyebrow is squeezed, the eye is blinked, and the mouth is grinned for 3 months, and the weight is increased for 1 week. The current medical history: the infant suffers from no obvious inducement of eyebrow squeezing, winking and puckering before 3 months, parents do not pay attention to the eyebrow squeezing, winking and puckering, the symptoms are aggravated and the attention is not focused before 1 week, and the infant is diagnosed in outpatient service of our hospital and subjected to related physicochemical examination to be diagnosed as the infantile multiple tic syndrome. The current symptoms are as follows: frequent eyebrow crowding, blinking, grinning, correct reception, insomnia at night, normal stool, 1 time a day, yellow urine. A red tongue with a yellow and greasy coating and a slippery and rapid pulse. And (3) diagnosis: the infant multiple tourette syndrome belongs to the syndrome of liver wind with phlegm according to syndrome differentiation of traditional Chinese medicine, and has the following treatment principles: pacify liver, stop wind, invigorate spleen, resolve phlegm and induce resuscitation. Applying the stop plaster for external application. The applied parts are around eyes, orbicularis oris muscle and Shenque acupoint; the preparation is administered 2 times a day for 1 hr, and 4 weeks is 1 course of treatment. The treatment course is 1. The second treatment course is followed by the patch 1. The three diagnostic methods are stopped taking the medicine when the symptom disappears. After the medicine is stopped, the disease is followed for 2 months without relapse, and the disease belongs to clinical recovery.
Patient 3: wangzhi, male, 12 years old, chief complaints: wink, rise shoulder for 3 years, and aggravate for 2 weeks. The current medical history: the infant is diagnosed as the 'pediatric tourette syndrome' by examining related physicochemical examination after seeing the infant in the outpatient clinic 2 weeks later, wherein the infant suffers from no obvious cause of blinking, has occasional shoulder shrugging and is not regarded by parents, and the symptoms are aggravated and cause of dreaminess at night before 3 weeks. The current symptoms are as follows: frequent eyebrow crowding, shoulder shrugging, frequent reception, dreaminess, normal stool, 1 time a day, yellow urine. A red tongue with a yellow and greasy coating and a slippery and rapid pulse. And (3) diagnosis: the infant multiple tourette syndrome belongs to the syndrome of liver wind with phlegm according to syndrome differentiation of traditional Chinese medicine, and has the following treatment principles: pacify liver, stop wind, invigorate spleen, resolve phlegm and induce resuscitation. Applying the stop plaster for external application. The application parts are around eyes, Dazhui acupoint and Shenque acupoint; the preparation is administered 2 times a day for 1 hr, and 4 weeks is 1 course of treatment. The treatment course is 1. The second treatment is improved, the twitch amplitude and frequency are obviously reduced compared with the previous treatment, the patch is used for 1 time every day, and 4 weeks are 1 course of treatment. The three diagnostic methods are stopped taking the medicine when the symptom disappears. After the medicine is stopped, the disease is followed for 2 months without relapse, and the disease belongs to clinical recovery.
Claims (7)
1. A traditional Chinese medicine composition for external use for treating children tic disorder is characterized by comprising the following raw materials in parts by weight: 6-12 parts of radix bupleuri, 6-12 parts of rhizoma acori graminei, 6-12 parts of polygala tenuifolia and 3-5 parts of scorpion; 6-15 parts of white paeony root, 6-15 parts of radix curcumae, 4-8 parts of albizia julibrissin, 4-8 parts of poria cocos, 3-5 parts of stiff silkworm, 6-9 parts of uncaria, 9-12 parts of feather cockscomb seed, 9-12 parts of fructus viticis, 3-5 parts of magnolia flower, 9-12 parts of radix puerariae, 9-12 parts of mulberry twig, 3-5 parts of earthworm and 3-5 parts of borneol.
2. The external traditional Chinese medicine composition for treating children tic disorder as claimed in claim 1, is composed of the following raw materials by weight: 6 parts of radix bupleuri, 6 parts of rhizoma acori graminei, 6 parts of polygala tenuifolia and 3 parts of scorpion; 6 parts of white paeony root, 15 parts of turmeric root-tuber, 8 parts of albizia julibrissin, 8 parts of poria cocos, 5 parts of stiff silkworm, 6 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 3 parts of biond magnolia flower, 12 parts of radix puerariae, 12 parts of mulberry twig, 5 parts of earthworm and 3 parts of borneol.
3. The external traditional Chinese medicine composition for treating children tic disorder as claimed in claim 1, is composed of the following raw materials by weight: 10 parts of radix bupleuri, 10 parts of rhizoma acori graminei, 10 parts of polygala tenuifolia and 3 parts of scorpion; 9 parts of white paeony root, 9 parts of radix curcumae, 8 parts of albizia julibrissin, 8 parts of poria cocos, 3 parts of stiff silkworm, 9 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 5 parts of biond magnolia flower, 9 parts of radix puerariae, 9 parts of mulberry twig, 3 parts of earthworm and 3 parts of borneol.
4. The external traditional Chinese medicine composition for treating children tic disorder as claimed in claim 1, is composed of the following raw materials by weight: 9 parts of radix bupleuri, 9 parts of rhizoma acori graminei, 9 parts of polygala tenuifolia and 4 parts of scorpion; 8 parts of white paeony root, 8 parts of radix curcumae, 8 parts of albizia julibrissin, 8 parts of poria cocos, 4 parts of stiff silkworm, 6 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 4 parts of biond magnolia flower, 9 parts of radix puerariae, 9 parts of mulberry twig, 4 parts of earthworm and 4 parts of borneol.
5. The external traditional Chinese medicine composition for treating children tic disorder as claimed in claim 1, is composed of the following raw materials by weight: 12 parts of radix bupleuri, 12 parts of rhizoma acori graminei, 12 parts of polygala tenuifolia and 5 parts of scorpion; 15 parts of white paeony root, 15 parts of radix curcumae, 8 parts of albizia julibrissin, 8 parts of poria cocos, 5 parts of stiff silkworm, 9 parts of uncaria, 12 parts of feather cockscomb seed, 12 parts of fructus viticis, 5 parts of biond magnolia flower, 12 parts of radix puerariae, 12 parts of mulberry twig, 5 parts of earthworm and 5 parts of borneol.
6. The external traditional Chinese medicine composition for treating children tic disorder as claimed in claim 1, is composed of the following raw materials by weight: 11 parts of radix bupleuri, 11 parts of rhizoma acori graminei, 11 parts of polygala tenuifolia and 3 parts of scorpion; 10 parts of white paeony root, 10 parts of radix curcumae, 6 parts of albizia julibrissin, 6 parts of poria cocos, 5 parts of stiff silkworm, 7 parts of uncaria, 9 parts of feather cockscomb seed, 9 parts of fructus viticis, 4 parts of biond magnolia flower, 11 parts of radix puerariae, 11 parts of mulberry twig, 4 parts of earthworm and 3 parts of borneol.
7. The preparation method of the external traditional Chinese medicine composition for treating children's tic disorders according to any one of claims 1 to 6, which comprises the following steps: extracting the raw materials with 60-80% ethanol under reflux for 2-3 times, each for 2-3 hr, distilling the extractive solutions under reduced pressure respectively to recover ethanol, extracting and concentrating to relative density of 1.5-1.8, and vacuum drying to obtain extract powder; grinding Borneolum Syntheticum, adding into the above dry extract powder, and mixing; adding appropriate amount of glycerol into the mixture, and making into ointment with thickness of 0.5-0.7cm and diameter of 2-3cm to obtain topical Chinese medicinal composition.
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