CN113331424A - Composition for promoting regeneration of injured articular cartilage tissue - Google Patents
Composition for promoting regeneration of injured articular cartilage tissue Download PDFInfo
- Publication number
- CN113331424A CN113331424A CN202110565729.3A CN202110565729A CN113331424A CN 113331424 A CN113331424 A CN 113331424A CN 202110565729 A CN202110565729 A CN 202110565729A CN 113331424 A CN113331424 A CN 113331424A
- Authority
- CN
- China
- Prior art keywords
- parts
- composition
- regeneration
- collagen
- cartilage tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 230000008929 regeneration Effects 0.000 title claims abstract description 30
- 238000011069 regeneration method Methods 0.000 title claims abstract description 30
- 210000001188 articular cartilage Anatomy 0.000 title claims abstract description 21
- 230000001737 promoting effect Effects 0.000 title claims abstract description 18
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims abstract description 18
- 102000008186 Collagen Human genes 0.000 claims abstract description 18
- 108010035532 Collagen Proteins 0.000 claims abstract description 18
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920001436 collagen Polymers 0.000 claims abstract description 18
- 229960002442 glucosamine Drugs 0.000 claims abstract description 18
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000654 additive Substances 0.000 claims abstract description 16
- 239000011575 calcium Substances 0.000 claims abstract description 16
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 16
- 235000013373 food additive Nutrition 0.000 claims abstract description 14
- 239000002778 food additive Substances 0.000 claims abstract description 14
- 229920002567 Chondroitin Polymers 0.000 claims abstract description 12
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims abstract description 12
- 229920001184 polypeptide Polymers 0.000 claims abstract description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 12
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 10
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 10
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 10
- 229920001661 Chitosan Polymers 0.000 claims abstract description 9
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 9
- 235000019733 Fish meal Nutrition 0.000 claims abstract description 7
- 239000004467 fishmeal Substances 0.000 claims abstract description 7
- -1 arthrokinin Chemical compound 0.000 claims abstract description 4
- 102000000503 Collagen Type II Human genes 0.000 claims description 19
- 108010041390 Collagen Type II Proteins 0.000 claims description 19
- 230000004048 modification Effects 0.000 claims description 19
- 238000012986 modification Methods 0.000 claims description 19
- 229960005069 calcium Drugs 0.000 claims description 14
- 230000003078 antioxidant effect Effects 0.000 claims description 13
- 239000003963 antioxidant agent Substances 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 11
- 235000003599 food sweetener Nutrition 0.000 claims description 11
- 229920000159 gelatin Polymers 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000019322 gelatine Nutrition 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- 239000003765 sweetening agent Substances 0.000 claims description 11
- 239000000834 fixative Substances 0.000 claims description 10
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 7
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 7
- 230000000996 additive effect Effects 0.000 claims description 7
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 7
- 239000000796 flavoring agent Substances 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 235000013355 food flavoring agent Nutrition 0.000 claims description 6
- 239000000049 pigment Substances 0.000 claims description 6
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 6
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 6
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 6
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 claims description 5
- MTDHILKWIRSIHB-UHFFFAOYSA-N (5-azaniumyl-3,4,6-trihydroxyoxan-2-yl)methyl sulfate Chemical compound NC1C(O)OC(COS(O)(=O)=O)C(O)C1O MTDHILKWIRSIHB-UHFFFAOYSA-N 0.000 claims description 5
- 229960001911 glucosamine hydrochloride Drugs 0.000 claims description 5
- 229960002849 glucosamine sulfate Drugs 0.000 claims description 5
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 3
- 230000010933 acylation Effects 0.000 claims description 3
- 238000005917 acylation reaction Methods 0.000 claims description 3
- 230000029936 alkylation Effects 0.000 claims description 3
- 238000005804 alkylation reaction Methods 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 3
- 239000001527 calcium lactate Substances 0.000 claims description 3
- 229960002401 calcium lactate Drugs 0.000 claims description 3
- 235000011086 calcium lactate Nutrition 0.000 claims description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 239000004571 lime Substances 0.000 claims description 3
- 230000011987 methylation Effects 0.000 claims description 3
- 238000007069 methylation reaction Methods 0.000 claims description 3
- 230000003472 neutralizing effect Effects 0.000 claims description 3
- 235000010333 potassium nitrate Nutrition 0.000 claims description 3
- 239000004323 potassium nitrate Substances 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 235000010344 sodium nitrate Nutrition 0.000 claims description 3
- 239000004317 sodium nitrate Substances 0.000 claims description 3
- 235000010288 sodium nitrite Nutrition 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 229960001295 tocopherol Drugs 0.000 claims description 3
- 229930003799 tocopherol Natural products 0.000 claims description 3
- 235000010384 tocopherol Nutrition 0.000 claims description 3
- 239000011732 tocopherol Substances 0.000 claims description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 3
- 239000004263 Guaiac resin Substances 0.000 claims 1
- 229920000932 Gum guaicum Polymers 0.000 claims 1
- 235000019278 guaiac resin Nutrition 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 abstract description 31
- 238000011084 recovery Methods 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 8
- 102000004169 proteins and genes Human genes 0.000 abstract description 8
- 108090000623 proteins and genes Proteins 0.000 abstract description 8
- 235000021075 protein intake Nutrition 0.000 abstract description 7
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 description 13
- 210000001503 joint Anatomy 0.000 description 9
- 230000008439 repair process Effects 0.000 description 7
- 206010023232 Joint swelling Diseases 0.000 description 4
- 201000008482 osteoarthritis Diseases 0.000 description 4
- 241000251468 Actinopterygii Species 0.000 description 3
- 208000032170 Congenital Abnormalities Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 241000147041 Guaiacum officinale Species 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 210000003321 cartilage cell Anatomy 0.000 description 2
- 210000001612 chondrocyte Anatomy 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 229940091561 guaiac Drugs 0.000 description 2
- 210000002478 hand joint Anatomy 0.000 description 2
- 210000003035 hyaline cartilage Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000008407 joint function Effects 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000001179 synovial fluid Anatomy 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 206010023215 Joint effusion Diseases 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000001162 elastic cartilage Anatomy 0.000 description 1
- 210000000968 fibrocartilage Anatomy 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 235000020803 food preference Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 210000005065 subchondral bone plate Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a composition for promoting regeneration of injured articular cartilage tissues, which comprises the following components: glucosamine, collagen, fish meal, chondroitin, arthrokinin, calcium additives, polypeptide, trehalose, chitosan and food additives, wherein the components are prepared from the following components in parts by weight: 15-35 parts of glucosamine, 6-30 parts of collagen, 10-18 parts of fish meal, 3-6 parts of chondroitin, 4-8 parts of articular active, 8-12 parts of calcium additives, 8-15 parts of polypeptide, 6-30 parts of trehalose, 5-20 parts of chitosan and 5-8 parts of food additives; the composition provided by the invention can improve the protein intake of a patient, simultaneously improve the regeneration speed of the cartilage tissue, is beneficial to the recovery of the patient, and solves the problems that the protein utilization rate is low and the regeneration speed of the cartilage tissue is slow, the recovery of the patient is not facilitated and the treatment process and efficiency are influenced because the patient takes too little protein in the existing method of treating the bone joint by only taking the collagen.
Description
Technical Field
The invention relates to the technical field of health care products, in particular to a composition for promoting regeneration of injured articular cartilage tissues.
Background
Cartilage is composed of cartilage tissue and its surrounding perichondrium, and cartilage tissue is composed of chondrocytes, matrix and fibers. Cartilage is classified into hyaline cartilage, elastic cartilage and fibrocartilage according to the fiber components contained in cartilage tissue, and hyaline cartilage is widely distributed and has a typical structure. Osteoarthritis is a common osteoarticular disease, a degenerative disease, and is a degenerative disease, which is degenerative injury of articular cartilage, reactive hyperplasia of articular margin and subchondral bone, caused by many factors such as aging, obesity, strain, trauma, congenital abnormality of joints, and joint deformity. The clinical manifestations are slowly developing joint pain, tenderness, stiffness, joint swelling, limited mobility and joint deformity.
At present, a common treatment method for osteoarthritis is to eat collagen, but only the mode of eating collagen is adopted for treatment, so that the utilization rate of protein is low, the protein intake of a patient is too small, the regeneration speed of cartilage tissues is slow, the rehabilitation of the patient is not facilitated, and the treatment process and efficiency are influenced.
Disclosure of Invention
The invention aims to provide a composition for promoting regeneration of damaged articular cartilage tissues, which can improve the protein intake of a patient, improve the regeneration speed of the cartilage tissues, facilitate the recovery of the patient, accelerate the treatment process of the patient and solve the problems that the protein utilization rate is low, the regeneration speed of the cartilage tissues is slow and the recovery of the patient is not facilitated because the bone joints are treated only by adopting a mode of eating collagen at present.
In order to achieve the purpose, the invention provides the following technical scheme: a composition for promoting regeneration of damaged articular cartilage tissue, comprising the following components: glucosamine, collagen, fish meal, chondroitin, arthrokinin, calcium additives, polypeptide, trehalose, chitosan and food additives, wherein the components are prepared from the following components in parts by weight: 15-35 parts of glucosamine, 6-30 parts of collagen, 10-18 parts of fish meal, 3-6 parts of chondroitin, 4-8 parts of articular active, 8-12 parts of calcium additives, 8-15 parts of polypeptide, 6-30 parts of trehalose, 5-20 parts of chitosan and 5-8 parts of food additives.
Preferably, the collagen is composed of non-denatured type II collagen and hydrolyzed type II collagen, and the ratio of the non-denatured type II collagen to the hydrolyzed type II collagen is 1: 1.2.
preferably, the polypeptide also comprises a modification product, and the modification product is formed by methylation modification, alkylation modification, PEG modification and acylation modification.
Preferably, the glucosamine is glucosamine sulfate or glucosamine hydrochloride.
Preferably, the food additive comprises an antioxidant, a sweetener, a flavoring agent, a toning agent and a color fixative, and the ratio of the antioxidant, the sweetener, the flavoring agent, the toning agent and the color fixative is 1: 2.5: 1.3: 2.2: 1.3.
preferably, the antioxidant is guaiac or a tocopherol mixture, and the sweetener is made of any one of stevioside, sucrose, fructose or honey.
Preferably, the toner is made of plant pigment or animal pigment, and the color fixative is any one of potassium nitrate, sodium nitrate or sodium nitrite.
Preferably, the calcium additive is a drug containing calcium carbonate, calcium sulfate or calcium lactate.
Preferably, the chondroitin is chondroitin sulfate, the composition further comprises edible gelatin, and the edible gelatin accounts for 3-5 parts.
Preferably, the edible gelatin is prepared by fully soaking animal bones, skins and the like with lime emulsion, and neutralizing and decocting the soaked animal bones, skins and the like with hydrochloric acid.
Compared with the prior art, the invention has the following beneficial effects:
1. the composition provided by the invention can improve the protein intake of a patient, simultaneously improve the regeneration speed of cartilage tissues, is beneficial to the recovery of the patient, and accelerate the treatment process of the patient, and solves the problems that the protein utilization rate is low and the regeneration speed of the cartilage tissues is slow, the recovery of the patient is not facilitated and the treatment process and efficiency are influenced because the protein intake of the patient is too little because the bone joints are treated only by adopting a collagen eating mode at present;
2. through the addition of non-denatured type II collagen and hydrolyzed type II collagen, the type II collagen of cartilage tissue can be effectively supplemented, the regeneration of the cartilage tissue is promoted, glucosamine is designed to be any one of glucosamine sulfate or glucosamine hydrochloride, wherein the main effect of the glucosamine is to repair the cartilage of joints, promote the generation of joint synovial fluid, effectively reduce the friction of joint surfaces, relieve the pain and swelling of the joints and restore the gaps of the joints. The mechanism of glucosamine for repairing cartilage surface is to stimulate cartilage cells to synthesize cartilage matrix, repair damaged cartilage, enhance the repair ability of articular cartilage, and effectively improve the repair efficiency of cartilage tissue. The composition is easier to be absorbed by patients and is more widely used;
3. the antioxidant can improve the inoxidizability of the composition by adding an antioxidant, the composition is not easy to deteriorate, the storage time of the composition is prolonged, the taste of the composition is sweet by adding a sweetening agent and is more easily accepted by patients, the food toner is an additive which mainly colors foods, the foods have pleasant color and luster, the food has important significance for increasing the food palatability and stimulating the appetite and is more easily accepted by the patients by adding a color fixative, the foods can generate color or improve the food color and the color of the surface of the composition is not easy to fade by adding a calcium additive, the content of calcium in the composition can be improved, the cartilage assembly regeneration is facilitated, and the pain of the osteoarthritis patients can be reduced by adding chondroitin sulfate, the composition has the advantages that joint functions are improved, joint swelling and effusion are reduced, gap narrowing of knee joints and hand joint parts is prevented, the chondroitin sulfate can improve the cartilage assembling, regenerating and repairing efficiency of the composition through adding of the chondroitin sulfate, the gelatin is eaten through eating strong protective colloid, the emulsifying power is strong, protein can be coagulated due to the action of gastric acid after entering the stomach, and accordingly food digestion is facilitated, the composition can be fully digested and absorbed by patients, and the rehabilitation of the patients is facilitated.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A composition for promoting regeneration of damaged articular cartilage tissue, comprising the following components: glucosamine, collagen, fish meal, chondroitin, arthrokinin, calcium additives, polypeptide, trehalose, chitosan and food additives, wherein the components are prepared from the following components in parts by weight: 15 parts of glucosamine, 6 parts of collagen, 10 parts of fish powder, 3 parts of chondroitin, 4 parts of arthrokinin, 8 parts of calcium additives, 8 parts of polypeptide, 6 parts of trehalose, 50 parts of chitosan and 5 parts of food additives, and by adding the glucosamine, the collagen, the fish powder, the chondroitin, the arthrokinin, the calcium additives, the polypeptide, the trehalose, the chitosan and the food additives, the composition can improve the protein intake of a patient, simultaneously improve the regeneration speed of cartilage tissues, is beneficial to the recovery of the patient and accelerate the treatment process of the patient, solves the problems that the bone joints are treated only by eating the collagen at present, the protein utilization rate is low easily caused, the protein intake of the patient is too small, the regeneration speed of the cartilage tissues is slow, the recovery of the patient is not beneficial, and the treatment process and the treatment efficiency are influenced, and the trehalose is a typical stress metabolite, the biological molecular structure can be effectively protected from being damaged, so that the life process and biological characteristics of a living body are maintained, cartilage assembly and repair are facilitated, meanwhile, the fish meat powder is rich in a large amount of protein, recovery of a patient is facilitated, joint vitamine can increase bone density, multiple vitamins and trace elements are supplemented, articular cartilage of an articular damaged protective layer is repaired, joint movement vigor is comprehensively improved, and recovery efficiency of the patient is facilitated to be improved.
In this example, the collagen was composed of non-denatured type II collagen and hydrolyzed type II collagen, and the ratio of the non-denatured type II collagen to the hydrolyzed type II collagen was 1: 1.2 type II collagen is mainly produced by chondrocytes and is present in many tissues such as bones, joints, tendons, etc., and addition of non-denatured type II collagen and hydrolyzed type II collagen enables type II collagen in cartilage tissues to be effectively supplemented, thereby promoting regeneration of cartilage tissues.
In this embodiment, the polypeptide further comprises a modification product, and the modification product is formed by methylation modification, alkylation modification, PEG modification, and acylation modification.
In this embodiment, glucosamine is any one of glucosamine sulfate and glucosamine hydrochloride, and glucosamine is any one of glucosamine sulfate and glucosamine hydrochloride by design, wherein the main effects of glucosamine are to repair cartilage of joints, promote generation of joint synovial fluid, effectively reduce friction of joint surfaces, alleviate joint pain and swelling, and recover joint gaps. The mechanism of repairing the cartilage surface by the glucosamine is to stimulate cartilage cells to synthesize a matrix of the cartilage, repair damaged cartilage, enhance the self-repairing capacity of articular cartilage and effectively improve the efficiency of the composition for repairing cartilage tissues.
In this embodiment, the food additive includes an antioxidant, a sweetener, a flavoring agent, a toning agent, and a color fixative, and the ratio of the antioxidant, the sweetener, the flavoring agent, the toning agent, and the color fixative is 1: 2.5: 1.3: 2.2: 1.3, by the addition of food additives, food additives are non-nutritive substances which are consciously added to food, generally in small amounts, to improve the appearance, flavour, texture or storage properties of the food. The composition is more easily absorbed by the patient and more widely used.
In the embodiment, the antioxidant is guaiac or a tocopherol mixture, the sweetener is made of any one of stevioside, sucrose, fructose or honey, the antioxidant property of the composition can be improved by adding the antioxidant, the composition is less prone to deterioration, the preservation time of the composition is prolonged, and the taste of the composition becomes sweet and is more easily accepted by patients by adding the sweetener.
In this embodiment, the toner is made of a plant pigment or an animal pigment, the color fixative is any one of potassium nitrate, sodium nitrate or sodium nitrite, the food toner is an additive mainly used for coloring food by adding the toner, so that the food has pleasant color, which is significant for increasing food preference and stimulating appetite, and the composition is more easily accepted by patients.
In this embodiment, the calcium additive is a drug containing calcium carbonate, calcium sulfate or calcium lactate, and by adding the calcium additive, the content of calcium in the composition can be increased, and cartilage assembly and regeneration can be facilitated.
In the embodiment, the chondroitin is chondroitin sulfate, the composition further comprises edible gelatin in 3 parts, and the chondroitin sulfate can reduce pain of osteoarthritis patients, improve joint functions, reduce joint swelling and hydrops and prevent gaps between knee joints and hand joints from being narrow.
In the embodiment, the edible gelatin is prepared by fully soaking animal bones, skins and the like in lime emulsion and neutralizing and decocting the gelatin by hydrochloric acid, and the edible gelatin is a powerful protective colloid with strong emulsifying power and can be coagulated by gastric acid after entering the stomach, so that the composition is favorable for food digestion, can be fully digested and absorbed by patients and is favorable for the recovery of the patients.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A composition for promoting regeneration of damaged articular cartilage tissue, comprising: comprises the following components: glucosamine, collagen, fish meal, chondroitin, arthrokinin, calcium additives, polypeptide, trehalose, chitosan and food additives, wherein the components are prepared from the following components in parts by weight: 15-35 parts of glucosamine, 6-30 parts of collagen, 10-18 parts of fish meal, 3-6 parts of chondroitin, 4-8 parts of articular active, 8-12 parts of calcium additives, 8-15 parts of polypeptide, 6-30 parts of trehalose, 5-20 parts of chitosan and 5-8 parts of food additives.
2. The composition for promoting the regeneration of damaged articular cartilage tissue according to claim 1, wherein: the collagen is composed of non-denatured type II collagen and hydrolyzed type II collagen, and the ratio of the non-denatured type II collagen to the hydrolyzed type II collagen is 1: 1.2.
3. the composition for promoting the regeneration of damaged articular cartilage tissue according to claim 1, wherein: the polypeptide also comprises a modification product, and the modification product is formed by methylation modification, alkylation modification, PEG modification and acylation modification.
4. The composition for promoting the regeneration of damaged articular cartilage tissue according to claim 1, wherein: the glucosamine is any one of glucosamine sulfate or glucosamine hydrochloride.
5. The composition for promoting the regeneration of damaged articular cartilage tissue according to claim 1, wherein: the food additive comprises an antioxidant, a sweetening agent, a flavoring agent, a toning agent and a color fixative, wherein the ratio of the antioxidant to the sweetening agent to the flavoring agent to the toning agent to the color fixative is 1: 2.5: 1.3: 2.2: 1.3.
6. the composition for promoting the regeneration of damaged articular cartilage tissue according to claim 5, wherein: the antioxidant is guaiac resin or tocopherol mixture, and the sweetener is made of any one of stevioside, sucrose, fructose or honey.
7. The composition for promoting the regeneration of damaged articular cartilage tissue according to claim 5, wherein: the toner is made of plant pigment or animal pigment, and the color fixative is any one of potassium nitrate, sodium nitrate or sodium nitrite.
8. The composition for promoting the regeneration of damaged articular cartilage tissue according to claim 1, wherein: the calcium additive is a medicine containing calcium carbonate, calcium sulfate or calcium lactate.
9. The composition for promoting the regeneration of damaged articular cartilage tissue according to claim 1, wherein: the chondroitin is chondroitin sulfate, the composition also comprises edible gelatin, and the part of the edible gelatin is 3-5 parts.
10. The composition for promoting the regeneration of damaged articular cartilage tissue according to claim 9, wherein: the edible gelatin is prepared by soaking animal bone and skin with lime emulsion, and neutralizing with hydrochloric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110565729.3A CN113331424A (en) | 2021-05-24 | 2021-05-24 | Composition for promoting regeneration of injured articular cartilage tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110565729.3A CN113331424A (en) | 2021-05-24 | 2021-05-24 | Composition for promoting regeneration of injured articular cartilage tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113331424A true CN113331424A (en) | 2021-09-03 |
Family
ID=77471084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110565729.3A Pending CN113331424A (en) | 2021-05-24 | 2021-05-24 | Composition for promoting regeneration of injured articular cartilage tissue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113331424A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023215454A1 (en) * | 2022-05-06 | 2023-11-09 | Ageless Sciences, Inc. | Chondroitin- and collagen peptide-based methods for slowing down aging and extending lifespan |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178933A (en) * | 2011-04-20 | 2011-09-14 | 威海康博尔生物药业有限公司 | Preparation for preventing and treating osteoporosis and osteoarthrosis |
| CN107865343A (en) * | 2017-11-19 | 2018-04-03 | 山东千屋央厨海洋科技有限公司 | A kind of preparation method of the sleeve-fish protein peptide of repairing articular cartilage damage |
| CN111320682A (en) * | 2020-02-27 | 2020-06-23 | 广州领晟医疗科技有限公司 | Application of polypeptide in preparation of medicine for promoting cartilage repair and/or treating osteoarthritis |
-
2021
- 2021-05-24 CN CN202110565729.3A patent/CN113331424A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178933A (en) * | 2011-04-20 | 2011-09-14 | 威海康博尔生物药业有限公司 | Preparation for preventing and treating osteoporosis and osteoarthrosis |
| CN107865343A (en) * | 2017-11-19 | 2018-04-03 | 山东千屋央厨海洋科技有限公司 | A kind of preparation method of the sleeve-fish protein peptide of repairing articular cartilage damage |
| CN111320682A (en) * | 2020-02-27 | 2020-06-23 | 广州领晟医疗科技有限公司 | Application of polypeptide in preparation of medicine for promoting cartilage repair and/or treating osteoarthritis |
Non-Patent Citations (2)
| Title |
|---|
| 崔晓丽: "《药食搭配宜忌一本全》", 30 April 2014, 广东科技出版社 * |
| 张石革: "《常见病家庭用药手册》", 31 January 2018, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023215454A1 (en) * | 2022-05-06 | 2023-11-09 | Ageless Sciences, Inc. | Chondroitin- and collagen peptide-based methods for slowing down aging and extending lifespan |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8703174B2 (en) | Joint preserving nutritional vitamin, mineral and herbal pet supplement | |
| WO2004012665A2 (en) | Composition and methods for the treatment of musculoskeletal disorders and collagen and elastin deficiencies | |
| Munir et al. | Dietary prebiotics and probiotics influence the growth performance, feed utilisation, and body indices of snakehead (Channa striata) fingerlings | |
| US20120004157A1 (en) | Hydroxyproline compositions and uses thereof | |
| MX2008010904A (en) | Animal food composition comprising nut shell. | |
| WO1989011799A2 (en) | Improvements in and relating to protein products | |
| MXPA99002169A (en) | Concentration of glycosaminoglycans and precursors thereto in food products. | |
| CN107439824A (en) | The preparation method that a kind of dog cat is starched with semi-fluid shape proteolysis meat | |
| CN110771741A (en) | Composition, preparation method and application thereof in preparation of joint care medicines, health-care products and foods | |
| CN111938037A (en) | Dog food for promoting muscle growth and improving joint health and preparation method thereof | |
| CN113331424A (en) | Composition for promoting regeneration of injured articular cartilage tissue | |
| JP2003048850A (en) | Therapeutic agent of arthropathy, and functional food | |
| CN1633895A (en) | Cellulose sausage and its production method | |
| US20080312149A1 (en) | Health Food and Pharmaceutical Composition for Amelioration of Disease Induced by Metabolic Disorder in Cartilage | |
| CN105941319A (en) | A forced moulting method for laying hens | |
| US7754256B2 (en) | Nutritional composition | |
| Ananda et al. | Profil organ dalam broiler dengan penambahan probiotik effective microorganism-4 (em-4) dalam air minum | |
| Guilford | New ideas for the dietary management of gastrointestinal tract disease | |
| US20100316732A1 (en) | Beverage compositions for the promotion of joint health in companion animals | |
| CN110692939A (en) | Meat tenderizer and use method thereof | |
| BRPI0721851A2 (en) | feed composition, methods for improving the quality of feces and / or the frequency of evacuation of a puppy, method for treating a puppy, kit for changing the quality of feces of a puppy, and use of metabolizable anions and metabolizable cations. | |
| CN108741054A (en) | A kind of sport nutrition for protecting Bones and joints | |
| JP2002281910A (en) | Bread and premix of bread for dog | |
| KR20180105108A (en) | Food composition using nuclotide extracts | |
| JP2011223965A (en) | Foodstuff compound containing collagen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210903 |