CN113318060A - Essence containing embryo extract and production process thereof - Google Patents
Essence containing embryo extract and production process thereof Download PDFInfo
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- CN113318060A CN113318060A CN202110643549.2A CN202110643549A CN113318060A CN 113318060 A CN113318060 A CN 113318060A CN 202110643549 A CN202110643549 A CN 202110643549A CN 113318060 A CN113318060 A CN 113318060A
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- embryo extract
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- 239000000284 extract Substances 0.000 title claims abstract description 69
- 210000001161 mammalian embryo Anatomy 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 10
- 238000000605 extraction Methods 0.000 title description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000011345 viscous material Substances 0.000 claims abstract description 12
- 102000004190 Enzymes Human genes 0.000 claims abstract description 11
- 108090000790 Enzymes Proteins 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 11
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 210000002826 placenta Anatomy 0.000 claims abstract description 8
- 238000004140 cleaning Methods 0.000 claims abstract description 7
- 235000011837 pasties Nutrition 0.000 claims abstract description 6
- 238000011049 filling Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 37
- 239000000243 solution Substances 0.000 claims description 36
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 239000008367 deionised water Substances 0.000 claims description 19
- 229910021641 deionized water Inorganic materials 0.000 claims description 19
- 239000011259 mixed solution Substances 0.000 claims description 18
- 239000000341 volatile oil Substances 0.000 claims description 15
- 239000003974 emollient agent Substances 0.000 claims description 12
- 239000003995 emulsifying agent Substances 0.000 claims description 12
- 239000003906 humectant Substances 0.000 claims description 12
- 239000002562 thickening agent Substances 0.000 claims description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 11
- -1 polydimethylsiloxane Polymers 0.000 claims description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 10
- 229940088598 enzyme Drugs 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 229920002674 hyaluronan Polymers 0.000 claims description 10
- 229960003160 hyaluronic acid Drugs 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- 102000005600 Cathepsins Human genes 0.000 claims description 6
- 108010084457 Cathepsins Proteins 0.000 claims description 6
- 239000004367 Lipase Substances 0.000 claims description 6
- 102000004882 Lipase Human genes 0.000 claims description 6
- 108090001060 Lipase Proteins 0.000 claims description 6
- 102000057297 Pepsin A Human genes 0.000 claims description 6
- 108090000284 Pepsin A Proteins 0.000 claims description 6
- 102000004142 Trypsin Human genes 0.000 claims description 6
- 108090000631 Trypsin Proteins 0.000 claims description 6
- 239000003205 fragrance Substances 0.000 claims description 6
- 235000019421 lipase Nutrition 0.000 claims description 6
- 229940111202 pepsin Drugs 0.000 claims description 6
- 239000012588 trypsin Substances 0.000 claims description 6
- 241000218628 Ginkgo Species 0.000 claims description 5
- 235000011201 Ginkgo Nutrition 0.000 claims description 5
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 5
- 239000007853 buffer solution Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000012752 auxiliary agent Substances 0.000 claims description 3
- 230000003796 beauty Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 230000008439 repair process Effects 0.000 abstract description 4
- 238000000338 in vitro Methods 0.000 abstract description 3
- 239000012466 permeate Substances 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 3
- 102000008186 Collagen Human genes 0.000 abstract description 2
- 108010035532 Collagen Proteins 0.000 abstract description 2
- 229920001436 collagen Polymers 0.000 abstract description 2
- 239000003102 growth factor Substances 0.000 abstract description 2
- 229920001184 polypeptide Polymers 0.000 abstract description 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 14
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 9
- 239000009429 Ginkgo biloba extract Substances 0.000 description 8
- 229940068052 ginkgo biloba extract Drugs 0.000 description 8
- 235000020686 ginkgo biloba extract Nutrition 0.000 description 8
- 230000001804 emulsifying effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 238000007792 addition Methods 0.000 description 4
- 239000008223 sterile water Substances 0.000 description 4
- 230000037303 wrinkles Effects 0.000 description 4
- 241001494479 Pecora Species 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 230000010355 oscillation Effects 0.000 description 3
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- 239000002994 raw material Substances 0.000 description 3
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 description 3
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241000220317 Rosa Species 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 229940100463 hexyl laurate Drugs 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 244000166675 Cymbopogon nardus Species 0.000 description 1
- 235000018791 Cymbopogon nardus Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- DJNTZVRUYMHBTD-UHFFFAOYSA-N Octyl octanoate Chemical compound CCCCCCCCOC(=O)CCCCCCC DJNTZVRUYMHBTD-UHFFFAOYSA-N 0.000 description 1
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 206010048245 Yellow skin Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 150000007946 flavonol Chemical class 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940075495 isopropyl palmitate Drugs 0.000 description 1
- 229940100556 laureth-23 Drugs 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Reproductive Health (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses essence containing an embryo extract and a production process thereof, belongs to the technical field of cosmetic processing, and solves the technical problem that nutritional ingredients of the existing beauty and skin care products usually only stay on the surface of skin and cannot permeate into the deep layer of the skin for repair. The essence containing embryo extract comprises an extract component, a filling component and an auxiliary component, and the components are mixed to prepare the essence; the invention discloses a method for preparing embryo extract, which comprises the following steps: cleaning fresh placenta hominis in vitro, mincing, filtering, centrifuging to obtain extract X, performing enzymolysis on the extract X with compound enzyme, centrifuging to obtain extract Y, extracting pasty viscous substance from the extract Y with ethanol, and dissolving the pasty viscous substance in propylene glycol to obtain embryo extract containing a large amount of collagen, polypeptide, various growth factors and active protein, which is easy to be absorbed by human skin, and can be deeply repaired to achieve the effects of tendering skin and improving skin.
Description
Technical Field
The invention belongs to the technical field of cosmetic processing, and particularly relates to essence containing an embryo extract and a production process thereof.
Background
Aging of the human body is a necessary rule for the growth of life, and the change of the skin is the most obvious. Skin aging refers to the rough surface and appearance of wrinkles. With the improvement of living standard, more and more people begin to pay attention to how to keep skin healthy, and the requirement is higher and higher. In the current skin care and beauty industry, the traditional beauty treatment can not meet the requirements, and the beauty cosmetics containing various natural extraction components are prosperous. Although the existing beauty cosmetics are full of precious Linglan, the nutrient components of the existing beauty skin care products are usually only remained on the surface of the skin and cannot permeate into the deep layer of the skin for repair, and the effect is difficult to last.
Disclosure of Invention
The invention aims to provide essence containing embryo extracts and a production process thereof.
The technical problems to be solved by the invention are as follows: the existing beauty and skin care products have the technical problem that nutrient components usually only stay on the surface of skin and cannot permeate into the deep layer of the skin for repair.
The purpose of the invention can be realized by the following technical scheme:
the essence containing the embryo extract comprises the following components in percentage by mass:
the components of the extract are as follows: embryo extract 17.5-21.5 wt%, and semen Ginkgo extract 4.3-5.1 wt%
Filling components: 6.4 to 8.8 weight percent of glycerin, 2.1 to 2.5 weight percent of polydimethylsiloxane, 9.2 to 11.5 weight percent of hyaluronic acid and the balance of deionized water
Auxiliary agent components: 3.1 to 3.8 weight percent of humectant, 4.1 to 5.5 weight percent of emollient, 2.7 to 3.3 weight percent of emulsifier, 7.3 to 8.6 weight percent of thickener and 0.11 to 0.13 weight percent of fragrance essential oil;
the embryo extract is prepared by the following steps:
step A1: cleaning fresh in-vitro placenta with sterile water, mincing, filtering with coarse filter screen, adding cell buffer solution into filtrate to obtain mixed solution, placing the mixed solution into a centrifuge, controlling the temperature at 5-7 deg.C and the rotation speed at 7500-8000r/min, centrifuging for 30-35min, and collecting supernatant to obtain extract X;
step A2: adding triethanolamine into the extracting solution X to adjust the pH value of the extracting solution X to 7-8, adding a compound enzyme agent into the extracting solution X, controlling the enzymolysis temperature to 35-42 ℃ and carrying out enzymolysis for 5-7h, carrying out centrifugal treatment on the mixed solution after enzymolysis again at the rotation speed of 11000 and 12000r/min for 10-15min, and taking the supernatant to obtain an extracting solution Y;
step A3: heating the extractive solution Y in water bath to 35-38 deg.C, adding 30% ethanol dropwise under shaking, filtering to obtain pasty viscous substance, and dissolving the pasty viscous substance in propylene glycol to obtain embryo extractive solution.
Further, the humectant is one or more of butanediol, polyethylene glycol, propylene glycol, hexanediol, xylitol, polypropylene glycol, sorbitol, panthenol, pyrrolidone carboxylic acid, and sodium lactate.
Further, the emollient is one or more of myristyl myristate, octyl caprylate, oleyl oleate, hexyl laurate, isopropyl palmitate and dimethicone.
Further, the emulsifier is one or more of polyglycerol-3 distearate, polyoxyethylene (20) sorbitan monolaurate, cetearyl glucoside and laureth-23.
Further, the thickening agent is one or more of xanthan gum, PEG-200 glyceryl stearate, cellulose gum, amine myristate oxide, and cetyl palmitate.
Further, the fragrance essential oil is one or more of rose essential oil, lavender essential oil, lily essential oil, grape seed essential oil and citronella essential oil.
Further, in the step a2, the compound enzyme agent includes trypsin, lipase, pepsin, and cathepsin, and the dosage mass ratio of trypsin, lipase, pepsin, and cathepsin is 1: 0.22-0.27:0.75-0.78:0.14-0.17:0.67-0.71.
A production process of essence containing embryo extract specifically comprises the following steps:
step S1: adding one third of the total amount of deionized water and an emulsifier into a vacuum emulsification pot, controlling the emulsification temperature to be 45-50 ℃, the stirring speed to be 800r/min, heating and stirring for 30-40min, cooling to be 35-40 ℃, adding a humectant, an emollient, a thickener and aromatic essential oil, controlling the stirring speed to be 300-400r/min, stirring for 2-3h, and cooling to room temperature to prepare a premixed solution 1;
step S2: taking one third of the total amount of the deionized water, glycerol, polydimethylsiloxane and hyaluronic acid, controlling the stirring speed at 150-;
step S3: taking the premixed solution 1, the premixed solution 2, the embryo extracting solution and the ginkgo biloba extract, controlling the stirring speed at 210-.
The invention has the beneficial effects that:
the invention prepares the embryo extract, the fresh placenta of animal is cleaned, minced, filtered, enzymolyzed, make macromolecule in the placenta decompose, contain a large amount of collagen, polypeptide, many growth factors and active protein in the embryo extract, help the skin absorption of the human body, go deep to repair in the skin, achieve the effects of tendering skin and improving complexion; the flavone component contained in the ginkgo biloba extract can prevent the formation and deposition of pigment in the dermis, thereby achieving the effects of whitening the skin and preventing and treating pigment plaques. The microelements such as manganese and mother-of-pearl in the ginkgo extract can remove oxygen free radicals and inhibit the growth of melanin, and the flavonoid glycoside and the flavonol in the ginkgo extract can remove the free radicals, protect dermal cells, improve blood circulation and prevent the cells from being oxidized to generate wrinkles. In addition, through reasonable design of the auxiliary agent component and the filling component, the essence containing the embryo extract prepared by the invention has fine texture, uniform milky white color and viscosity of 4.7-5.5cP, is easy to apply and has good stability.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the examples:
the humectant is butanediol;
the emollient is hexyl laurate;
the emulsifier is polyglycerol-3 distearate;
the thickening agent is xanthan gum;
the fragrant essential oil is rose essential oil;
example 1
An embryo extract prepared by the steps of:
step A1: cleaning fresh isolated sheep placenta with sterile water, mincing, filtering with 500 mesh filter screen, adding acetic acid-sodium acetate cell buffer solution into the filtrate to obtain mixed solution, placing the mixed solution into a centrifuge, controlling the temperature at 5 deg.C and the rotation speed at 7500r/min, centrifuging for 30min, and collecting supernatant to obtain extractive solution X;
step A2: adding triethanolamine into the extract X to adjust the pH value of the extract X to 7, taking trypsin, lipase, pepsin and cathepsin according to the dosage-mass ratio of 1:0.22:0.75:0.14:0.67 to prepare a compound enzyme, adding the compound enzyme into the extract X, controlling the enzymolysis temperature to be 35 ℃, carrying out enzymolysis for 5 hours, carrying out centrifugal treatment on the mixed solution after the enzymolysis again, controlling the rotation speed to be 11000r/min, carrying out centrifugal treatment for 10min, and taking the supernatant to prepare an extract Y;
step A3: heating the extracting solution Y in a water bath to 35 ℃, dropwise adding 30% ethanol under the oscillation condition, filtering to obtain paste viscous substance, and mixing the paste viscous substance with propylene glycol according to the weight ratio of 5 mL: 20mL of the extract was mixed and dissolved by stirring to obtain an embryo extract.
Example 2
An embryo extract prepared by the steps of:
step A1: cleaning fresh in-vitro sheep placenta with sterile water, cleaning, mincing, filtering with 500 mesh filter screen, adding acetic acid-sodium acetate cell buffer solution into the filtrate to obtain mixed solution, placing the mixed solution into a centrifuge, controlling the temperature at 6 deg.C and the rotation speed at 7500r/min, centrifuging for 35min, and collecting supernatant to obtain extractive solution X;
step A2: adding triethanolamine into the extract X to adjust the pH value of the extract X to 7, taking trypsin, lipase, pepsin and cathepsin according to the mass ratio of 1:0.25:0.76:0.16:0.7 to prepare a compound enzyme, adding the compound enzyme into the extract X, controlling the enzymolysis temperature to be 40 ℃, carrying out enzymolysis for 5 hours, carrying out centrifugal treatment on the mixed solution after enzymolysis again, controlling the rotating speed to be 11000r/min, carrying out centrifugal treatment for 12min, and taking the supernatant to prepare an extract Y;
step A3: heating the extracting solution Y in a water bath to 36 ℃, dropwise adding 30% ethanol under the oscillation condition, filtering to obtain paste viscous substance, and mixing the paste viscous substance with propylene glycol according to the weight ratio of 5 mL: 20mL of the extract was mixed and dissolved by stirring to obtain an embryo extract.
Example 3
An embryo extract prepared by the steps of:
step A1: cleaning fresh isolated sheep placenta with sterile water, mincing, filtering with 500 mesh filter screen, adding acetic acid-sodium acetate cell buffer solution into the filtrate to obtain mixed solution, placing the mixed solution into a centrifuge, controlling the temperature at 7 deg.C and the rotation speed at 8000r/min, centrifuging for 35min, and collecting supernatant to obtain extractive solution X;
step A2: adding triethanolamine into the extract X to adjust the pH value of the extract X to 8, taking trypsin, lipase, pepsin and cathepsin according to the mass ratio of 1:0.27:0.78:0.17:0.71 to prepare a compound enzyme agent, adding the compound enzyme agent into the extract X, controlling the enzymolysis temperature to be 42 ℃, carrying out enzymolysis for 5 hours, carrying out centrifugal treatment on the mixed solution after enzymolysis again, controlling the rotation speed to be 12000r/min, carrying out centrifugal treatment for 15min, and taking the supernatant to prepare an extract Y;
step A3: heating the extracting solution Y in a water bath to 38 ℃, dropwise adding 30% ethanol under the oscillation condition, filtering to obtain paste viscous substance, and mixing the paste viscous substance with propylene glycol according to the weight ratio of 5 mL: 20mL of the extract was mixed and dissolved by stirring to obtain an embryo extract.
Example 4
A production process of essence containing embryo extract specifically comprises the following steps:
step S1: adding one third of deionized water and an emulsifier into a vacuum emulsifying pot, controlling the emulsifying temperature to be 45 ℃, stirring at the speed of 700r/min, heating and stirring for 30min, cooling to 35 ℃, adding a humectant, an emollient, a thickener and an essence oil, controlling the stirring speed to be 300r/min, stirring for 2h, and cooling to room temperature to obtain a premix 1;
step S2: taking one third of the total amount of the deionized water, glycerol, polydimethylsiloxane and hyaluronic acid, controlling the stirring speed at 150r/min at room temperature, and stirring for 5 hours to prepare a premixed solution 2;
step S3: taking the premixed solution 1, the premixed solution 2 and the embryo extract and the ginkgo biloba extract prepared in the embodiment 1, controlling the stirring speed to be 210r/min at room temperature, adding the rest deionized water in the stirring process, and after the addition is finished, carrying out vacuum defoaming treatment on the mixed solution to prepare essence;
wherein the mass percent of each raw material is as follows: 17.5 wt% of embryo extract, 4.3 wt% of ginkgo biloba extract, 6.4 wt% of glycerol, 2.1 wt% of polydimethylsiloxane, 9.2 wt% of hyaluronic acid, 3.1 wt% of humectant, 4.1 wt% of emollient, 2.7 wt% of emulsifier, 7.3 wt% of thickener, 0.11 wt% of fragrance essential oil and the balance of deionized water.
Example 5
A production process of essence containing embryo extract specifically comprises the following steps:
step S1: adding one third of deionized water and an emulsifier into a vacuum emulsifying pot, controlling the emulsifying temperature to be 48 ℃, stirring at the speed of 750r/min, heating and stirring for 35min, cooling to 38 ℃, adding a humectant, an emollient, a thickener and an essence oil, controlling the stirring speed to be 350r/min, stirring for 2.5h, and cooling to room temperature to obtain a premix 1;
step S2: taking one third of the total amount of the deionized water, glycerol, polydimethylsiloxane and hyaluronic acid, controlling the stirring speed at 160r/min at room temperature, and stirring for 6 hours to prepare a premixed solution 2;
step S3: taking the premixed solution 1, the premixed solution 2 and the embryo extract and the ginkgo biloba extract prepared in the embodiment 2, controlling the stirring speed at 230r/min at room temperature, adding the rest deionized water in the stirring process, and after the addition is finished, carrying out vacuum defoaming treatment on the mixed solution to prepare essence;
wherein the mass percent of each raw material is as follows: 18.3 wt% of embryo extract, 4.7 wt% of ginkgo biloba extract, 7.9 wt% of glycerol, 2.3 wt% of polydimethylsiloxane, 10.1 wt% of hyaluronic acid, 3.5 wt% of humectant, 4.7 wt% of emollient, 3.1 wt% of emulsifier, 8.1 wt% of thickener, 0.12 wt% of fragrance essential oil and the balance of deionized water.
Example 6
A production process of essence containing embryo extract specifically comprises the following steps:
step S1: adding one third of deionized water and an emulsifier into a vacuum emulsifying pot, controlling the emulsifying temperature to be 50 ℃, stirring at the speed of 800r/min, heating and stirring for 40min, cooling to 40 ℃, adding a humectant, an emollient, a thickener and an essence oil, controlling the stirring speed to be 400r/min, stirring for 3h, and cooling to room temperature to obtain a premixed solution 1;
step S2: taking one third of the total amount of the deionized water, glycerol, polydimethylsiloxane and hyaluronic acid, controlling the stirring speed at 180r/min at room temperature, and stirring for 7 hours to prepare a premixed solution 2;
step S3: taking the premixed solution 1, the premixed solution 2 and the embryo extract and the ginkgo biloba extract prepared in the embodiment 3, controlling the stirring speed to be 250r/min at room temperature, adding the rest deionized water in the stirring process, and after the addition is finished, carrying out vacuum defoaming treatment on the mixed solution to prepare essence;
wherein the mass percent of each raw material is as follows: 21.5 wt% of embryo extract, 5.1 wt% of ginkgo biloba extract, 8.8 wt% of glycerol, 2.5 wt% of polydimethylsiloxane, 11.5 wt% of hyaluronic acid, 3.8 wt% of humectant, 5.5 wt% of emollient, 3.3 wt% of emulsifier, 8.6 wt% of thickener, 0.13 wt% of fragrance essential oil and the balance of deionized water.
The essence containing the embryo extracts prepared in examples 4 to 6 were subjected to a performance test;
sensory testing: the color and the texture of the essence are observed visually at room temperature under the condition of direct sunlight, the smearing test is carried out, and the obtained results are shown in table 1;
and (3) centrifugal test: respectively putting 10mL of samples into centrifugal test tubes, centrifuging at the rotating speed of 4000r/min for 20min, and observing whether the layering phenomenon exists or not, wherein the obtained result is shown in a table 1;
and (3) viscosity testing: examples 4 to 6 were tested for viscosity according to GB/T10247-2008 and the results are shown in Table 1;
TABLE 1
As can be seen from Table 1, the essence containing the embryo extract prepared by the invention has the advantages of fine texture, uniform milky color, viscosity of about 4.7-5.5cP, easiness in smearing, good stability, and no layering phenomenon after being centrifuged for 20min at the rotating speed of 4000 r/min.
Skin care performance test:
selecting 50 test objects, and selecting the following requirements: age 35-40 years, dark yellow skin, healthy women, daily morning and evening with example 5 skin care using the criteria: the using amount is 1mL, the left face is evenly smeared, the use is insisted on for 30 days, the using effect is scored, the full score is 100, the average score is taken, and the specific formula is as shown in Table 2:
TABLE 2
| Fade black score | Yellow score of dispelling | Score for removing fine wrinkles | Moisture score |
| 87 | 92 | 82 | 91 |
As shown in Table 2, the essence containing the embryo extract has good effects of moisturizing, removing fine wrinkles, removing yellow and fading black.
The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.
Claims (3)
1. The essence containing the embryo extract is characterized by comprising the following components in percentage by mass:
the components of the extract are as follows: 17.5-21.5 wt% of embryo extract and 4.3-5.1 wt% of ginkgo extract;
filling components: 6.4 to 8.8 weight percent of glycerin, 2.1 to 2.5 weight percent of polydimethylsiloxane, 9.2 to 11.5 weight percent of hyaluronic acid and the balance of deionized water;
auxiliary agent components: 3.1 to 3.8 weight percent of humectant, 4.1 to 5.5 weight percent of emollient, 2.7 to 3.3 weight percent of emulsifier, 7.3 to 8.6 weight percent of thickener and 0.11 to 0.13 weight percent of fragrance essential oil;
the embryo extract is prepared by the following steps:
step A1: taking fresh isolated placenta, cleaning, mincing, filtering, adding cell buffer solution into filtrate, centrifuging the mixed solution, and taking supernatant to obtain extract X;
step A2: taking the extracting solution X, adjusting the pH value of the extracting solution X to 7-8, adding a compound enzyme agent, controlling the enzymolysis temperature to 35-42 ℃, carrying out enzymolysis for 5-7h, centrifuging the mixed solution after enzymolysis, and taking supernatant to obtain extracting solution Y;
step A3: heating the extractive solution Y to 35-38 deg.C, adding 30% ethanol dropwise under shaking, filtering to obtain pasty viscous substance, and dissolving the pasty viscous substance in propylene glycol to obtain embryo extractive solution.
2. The essence containing embryo extract according to claim 1, wherein in step A2, the compound enzyme comprises trypsin, lipase, pepsin and cathepsin, and the ratio of dosage to mass is 1: 0.22-0.27:0.75-0.78:0.14-0.17:0.67-0.71.
3. A production process of essence containing embryo extract is characterized by comprising the following steps:
step S1: heating and stirring one third of the total amount of deionized water and an emulsifier, cooling, adding a humectant, an emollient, a thickener and an aroma essential oil, continuing heating and stirring, reacting, and cooling to room temperature to obtain a premixed solution 1;
step S2: taking one third of the total amount of deionized water, glycerol, polydimethylsiloxane and hyaluronic acid, and stirring at room temperature to prepare a premixed solution 2;
step S3: taking the premixed solution 1, the premixed solution 2, the embryo extract and the ginkgo extract, adding the rest deionized water during stirring at room temperature, and carrying out vacuum defoaming treatment on the mixed solution to obtain the essence containing the embryo extract.
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