CN113317428B - Calcium, iron and zinc solid preparation and preparation method thereof - Google Patents

Calcium, iron and zinc solid preparation and preparation method thereof Download PDF

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CN113317428B
CN113317428B CN202110668190.4A CN202110668190A CN113317428B CN 113317428 B CN113317428 B CN 113317428B CN 202110668190 A CN202110668190 A CN 202110668190A CN 113317428 B CN113317428 B CN 113317428B
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calcium
zinc
iron
parts
source
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CN113317428A (en
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秦和平
张风洁
刘宁
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Haiersi Zhengzhou Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/42—Preservation of non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3562—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to a calcium-iron-zinc solid preparation and a preparation method thereof. The calcium iron zinc solid preparation comprises the following raw and auxiliary materials in parts by weight: 1-50 parts of maltodextrin, 1-30 parts of cyclodextrin, 1-35 parts of fruit powder, 0.05-10 parts of iron source, 0.001-8 parts of zinc source, 1-30 parts of calcium source, 1-30 parts of xylitol, 1-20 parts of white granulated sugar, 0.01-4.0 parts of stevioside, 0.1-2 parts of vitamin C and 0.1-5 parts of citric acid; the iron source is ferrous glycinate and/or ferric aspartate; the zinc source is zinc glycinate and/or zinc aspartate; the calcium source is calcium aspartate and/or calcium glycinate. The calcium-iron-zinc solid preparation has better bioavailability and good palatability.

Description

Calcium, iron and zinc solid preparation and preparation method thereof
Technical Field
The invention relates to the technical field of pharmaceutical preparations, in particular to a calcium-iron-zinc solid preparation and a preparation method thereof.
Background
The calcium, iron and zinc are important constituent elements of human body, and have special nutritive value and special physiological function. The calcium-iron-zinc deficiency is a series of diseases caused by the deficiency of calcium, iron and zinc, and is particularly suitable for special people such as the old, infants, pregnant women and the like. Has become a serious social health problem worldwide. Calcium deficiency is mainly manifested in children's hypoevolutism, abnormal cartilage structure, and bone calcification disorder, and rickets (bone deformation, tooth dysplasia, etc.) appear. The lack of calcium in pregnant women can cause the slow development of fetuses and influence the growth after birth, which causes children to be easy to have convulsion, X-shaped legs and O-shaped legs, and also causes pregnant women to have gestational hypertension and postpartum osteoporosis. The effect on the elderly is osteoporosis. Iron deficiency can cause hemoglobin reduction, reduce the immunity of a human body and also cause a series of chronic diseases, zinc is an important trace element of the human body, and the deficiency can cause low immunity, reduced learning ability and anorexia to cause serious consequences.
According to the evaluation of the dietary calcium intake condition of Chinese residents in 2000-2007, the average daily calcium intake of Chinese residents is less than 50% of the proper intake, and according to the investigation and statistics of the current situation of nutrition and health of Chinese residents in 2004, the prevalence rate of anemia is 15.2% on average, and nutritional iron-deficiency anemia of infants, pregnant women and old people is more serious. The intake of zinc is 53.3 percent and 45.3 percent of the average demand of Chinese urban residents and rural residents.
At present, the calcium, iron and zinc products on the market are more, mainly oral liquid, tablets and granules, and are compatible with inorganic calcium, calcium gluconate, iron and zinc, so that the product has low absorptivity and low bioavailability, and the absorption mechanisms have mutual competition. Data research shows that calcium has absorption inhibition effect on the absorption of iron and zinc in general.
Most of the calcium, iron and zinc products on the market have single process and are not processed, and the adopted iron supplements are compounds with iron fishy smell and severe gastrointestinal reaction, so that the calcium, iron, zinc and calcium compounds are not easy to accept for pregnant women in pregnancy reaction period and infants with more delicate taste. The gastrointestinal function of the old is further degraded due to the degradation of the body, and the preparation with strong gastrointestinal reaction is not suitable. People who lack calcium, iron and zinc are particularly important to the three groups, so that the people can be provided with products with ideal taste and effect by adopting a relatively advanced process and proper compatibility.
Therefore, the research and development of the calcium, iron and zinc supplementing granules which can mask the bad taste of iron fishy smell and the like, are easy to absorb and are easy to accept by users, can be prepared into reinforced solid beverages and health-care foods, have good palatability and small irritation to the gastrointestinal tract, are suitable for pregnant women, infants and the old, and are social requirements.
Disclosure of Invention
In view of the above, the invention provides a calcium-iron-zinc solid preparation and a preparation method thereof. The calcium, iron and zinc solid preparation has good bioavailability and palatability.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a calcium-iron-zinc solid preparation, which comprises the following raw and auxiliary materials in parts by weight:
1-50 parts of maltodextrin, 1-30 parts of cyclodextrin, 1-35 parts of fruit powder, 0.05-10 parts of iron source, 0.001-8 parts of zinc source, 1-30 parts of calcium source, 1-30 parts of xylitol, 1-20 parts of white granulated sugar, 0.01-4.0 parts of stevioside, 0.1-2 parts of vitamin C and 0.1-5 parts of citric acid;
the iron source is ferrous glycinate and/or ferric aspartate;
the zinc source is zinc glycinate and/or zinc aspartate;
the calcium source is calcium aspartate and/or calcium glycinate.
The invention relates to a particle supplement for people with calcium, iron and zinc deficiency in the field of food and health-care food, which can safely and effectively supplement three elements of calcium, iron and zinc. The research shows that calcium can competitively inhibit the absorption of iron and zinc, the amino acid chelate is used as a calcium-iron-zinc donor, and the cyclodextrin inclusion technology is adopted, so that the absorption of the amino acid chelate can be obviously improved, the cyclodextrin inclusion compound has the effect of mutually promoting the absorption, and the symptom of calcium-iron-zinc deficiency can be quickly improved. The product has good solubility and tastes sour, sweet and delicious.
The invention mainly solves the problem of larger iron fishy smell of calcium, iron and zinc supplementing particles, the three nutrient elements necessary for human bodies, namely calcium, iron and zinc, can be mutually promoted to be absorbed, and each nutrient element has good absorption and high utilization rate, particularly the absorption of calcium, and has better bioavailability and better palatability under the condition of no vitamin D.
Preferably, the calcium, iron and zinc solid preparation comprises the following raw and auxiliary materials in parts by weight:
40-50 parts of maltodextrin, 10-20 parts of cyclodextrin, 10-20 parts of fruit powder, 0.1-1 part of iron source, 0.01-0.1 part of zinc source, 5-15 parts of calcium source, 5-15 parts of xylitol, 1-10 parts of white granulated sugar, 0.1-1 part of stevioside, 0.1-2 parts of vitamin C and 0.1-2 parts of citric acid.
In the specific embodiment provided by the invention, the calcium-iron-zinc solid preparation comprises the following raw and auxiliary materials in parts by weight:
45 parts of maltodextrin, 15 parts of cyclodextrin, 17 parts of fruit powder, 0.12 part of iron source, 0.065 part of zinc source, 10 parts of calcium source, 8 parts of xylitol, 3.6 parts of white granulated sugar, 0.215 part of stevioside, 1 parts of vitamin C and 1 part of citric acid.
Preferably, the cyclodextrin is one or more of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.
Preferably, the DE value of the maltodextrin is 15-20.
Preferably, the fruit powder is selected from, but not limited to, sweet orange powder, mango powder, cherry powder.
The invention also provides a preparation method of the calcium-iron-zinc solid preparation, which comprises the following steps:
mixing cyclodextrin with iron source, zinc source and calcium source, and grinding to obtain cyclodextrin calcium iron zinc clathrate;
mixing cyclodextrin calcium-iron-zinc clathrate, maltodextrin, fruit powder, xylitol, white sugar, stevioside, vitamin C, and citric acid, adding adhesive, granulating, and drying to water content below 2%.
Preferably, the time for polishing is 2 to 10 hours.
Preferably, the binder is selected from, but not limited to, water, ethanol solution, sodium carboxymethyl cellulose slurry, starch slurry.
Preferably, the drying is boiling drying and/or oven drying.
The invention provides a calcium-iron-zinc solid preparation and a preparation method thereof. The calcium iron zinc solid preparation comprises the following raw and auxiliary materials in parts by weight: 1-50 parts of maltodextrin, 1-30 parts of cyclodextrin, 1-35 parts of fruit powder, 0.05-10 parts of iron source, 0.001-8 parts of zinc source, 1-30 parts of calcium source, 1-30 parts of xylitol, 1-20 parts of white granulated sugar, 0.01-4.0 parts of stevioside, 0.1-2 parts of vitamin C and 0.1-5 parts of citric acid; the iron source is ferrous glycinate and/or ferric aspartate; the zinc source is zinc glycinate and/or zinc aspartate; the calcium source is calcium aspartate and/or calcium glycinate. The invention has the technical effects that:
the calcium, iron and zinc are synergistically supplemented by taking ferrous glycinate, zinc glycinate and calcium aspartate as raw materials, the effect is good compared with other calcium, iron and zinc preparations, the index is improved quickly, and the increase is obvious.
In the formula of the calcium-iron-zinc granules, cyclodextrin inclusion technology and amino acid chelated calcium-iron-zinc, fruit powder and other raw materials are adopted, so that the calcium-iron-zinc granules have the advantages of solubility, comfortable mouthfeel, no competitive absorption of the three components, no influence on respective absorption, good absorption and small iron fishy smell. And has the effect of promoting absorption mutually.
The method adopts a grinding method to include the molecules of zinc ferrous glycinate, ferrous glycinate and calcium aspartate into the cavity of the cyclodextrin, thereby avoiding the exposure of calcium, iron and zinc ions, avoiding the damage of the calcium, iron and zinc ions by phytic acid substances in food and the action of gastric acid, protecting the emission of iron fishy smell of ferrous ions in the process of taking, and simultaneously protecting the contact of the ferrous ions and oxygen in the air, so that the ferrous ions are not easily oxidized into ferric ions to lose the effect.
Detailed Description
The invention discloses a calcium-iron-zinc solid preparation and a preparation method thereof, and a person skilled in the art can realize the preparation by properly improving process parameters by referring to the content. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The raw materials or auxiliary materials used in the invention can be purchased from the market.
The invention is further illustrated by the following examples:
example 1
The formula of the calcium, iron and zinc granules in the embodiment comprises the following components in parts by weight:
45 parts of maltodextrin (DE value of 20), 15 parts of beta-cyclodextrin, 17 parts of sweet orange powder, 0.12 part of ferrous glycinate, 0.065 part of zinc glycinate, 10 parts of calcium aspartate, 8 parts of xylitol, 3.6 parts of white granulated sugar, 0.215 part of stevioside, 1 part of vitamin C and 1 part of citric acid.
The preparation method comprises the following steps:
mixing cyclodextrin with ferrous glycinate, zinc glycinate and calcium aspartate, and grinding to obtain cyclodextrin calcium iron zinc clathrate;
mixing cyclodextrin calcium-iron-zinc clathrate, maltodextrin, fruit powder, xylitol, white sugar, stevioside, vitamin C and citric acid, spraying appropriate amount of binder (4 parts of 50% alcohol), boiling, drying for 1 hr, oven drying at 60 deg.C for 90 min until water content is below 2%, and discharging to obtain granule.
Comparative example 1
The formula of the calcium iron zinc granule of the comparative example comprises the following components in parts by weight:
45 parts of maltodextrin, 15 parts of beta-cyclodextrin, 17 parts of fruit powder, 0.2 part of ferrous gluconate, 0.065 part of zinc glycinate, 10 parts of calcium aspartate, 8 parts of xylitol, 3.6 parts of white granulated sugar, 0.215 part of stevioside, 1 part of vitamin C and 1 part of citric acid.
Mixing cyclodextrin with ferrous gluconate, zinc glycinate and calcium aspartate, and grinding to obtain cyclodextrin ferrous gluconate, zinc glycinate and calcium aspartate clathrate;
mixing cyclodextrin ferrous gluconate, zinc glycinate, calcium aspartate clathrate and other components, spraying appropriate amount of binder (4 parts of 50% alcohol), boiling, drying for 1 hr, oven drying at 60 deg.C for 90 min until water content is below 2%, and discharging to obtain granule.
Comparative example 2
The formula of the calcium iron zinc granule of the comparative example comprises the following components in parts by weight:
45 parts of maltodextrin, 15 parts of beta-cyclodextrin, 17 parts of fruit powder, 0.12 part of ferrous glycinate, 0.15 part of zinc gluconate, 10 parts of calcium aspartate, 8 parts of xylitol, 3.6 parts of white granulated sugar, 0.215 part of stevioside, 1 part of vitamin C and 1 part of citric acid.
Mixing cyclodextrin with ferrous glycinate, zinc gluconate and calcium aspartate, and grinding to obtain cyclodextrin ferrous glycinate, zinc gluconate and calcium aspartate clathrate;
mixing cyclodextrin ferrous glycinate, zinc gluconate, calcium aspartate clathrate and other components, spraying appropriate amount of binder (4 parts of 50% alcohol), boiling, drying for 1 hr, oven drying at 60 deg.C for 90 min until water content is below 2%, and discharging to obtain granule.
Comparative example 3
The formula of the calcium iron zinc granule of the comparative example comprises the following components in parts by weight:
45 parts of maltodextrin, 15 parts of beta-cyclodextrin, 17 parts of fruit powder, 0.12 part of ferrous glycinate, 0.065 part of zinc glycinate, 13.7 parts of calcium gluconate, 8 parts of xylitol, 3.6 parts of white granulated sugar, 0.215 part of stevioside, 1 part of vitamin C and 1 part of citric acid.
Mixing cyclodextrin with ferrous glycinate, zinc glycinate and calcium gluconate, and grinding to obtain cyclodextrin ferrous glycinate, zinc glycinate and calcium gluconate clathrate;
mixing cyclodextrin ferrous glycinate, zinc glycinate, calcium gluconate clathrate and the rest components, spraying appropriate amount of binder (4 parts of 50% alcohol), boiling, drying for 1 hr, oven drying at 60 deg.C for 90 min until water content is below 2%, and discharging to obtain granule.
Comparative example 4
The formula of the calcium iron zinc granule of the comparative example comprises the following components in parts by weight:
45 parts of maltodextrin, 15 parts of beta-cyclodextrin, 17 parts of fruit powder, 0.2 part of ferrous gluconate, 0.15 part of zinc gluconate, 13.7 parts of calcium gluconate, 8 parts of xylitol, 3.6 parts of white granulated sugar, 0.215 part of stevioside, 1 part of vitamin C and 1 part of citric acid.
Mixing cyclodextrin with ferrous gluconate, zinc gluconate and calcium gluconate, and grinding to obtain cyclodextrin inclusion compound containing ferrous gluconate, zinc gluconate and calcium gluconate;
mixing cyclodextrin ferrous gluconate, zinc gluconate, calcium gluconate clathrate and other components, spraying appropriate amount of binder (4 parts of 50% alcohol), boiling, drying for 1 hr, oven drying at 60 deg.C for 90 min until water content is below 2%, and discharging to obtain granule.
Verification example
100 children with serum iron, serum calcium and serum zinc lower than normal values are selected as testees. The test population was divided into five groups of 20 persons each: the control group is the population taking the calcium-iron-zinc fortified solid beverage prepared by using ferrous gluconate to replace ferrous glycinate in the comparative example 1; the control group is the group taking the fortified solid beverage prepared by replacing zinc glycinate with zinc gluconate in comparative example 2; the control three groups are the population taking the calcium-iron-zinc fortified solid beverage prepared by using the calcium gluconate to replace the calcium aspartate in the comparative example 3; the four groups of control groups are the groups taking the fortified solid beverage prepared by using ferrous gluconate, zinc gluconate and calcium gluconate to replace ferrous glycinate, zinc glycinate and calcium aspartate in the comparative example 4; the group of subjects who took the calcium-iron-zinc fortified solid beverage prepared in example 1. Each group was taken three times a day, one bag each time, 15g each bag, 5mL venous blood was extracted from the abdomen of 30 days, 60 days and 90 days, serum calcium, iron and zinc were measured once each with atomic absorption spectrophotometer, all data were averaged and the results are shown in table 1:
TABLE 1
(unit: serum calcium mmol/L, serum zinc. mu. mol/L, serum iron. mu.g/dl)
Figure BDA0003117774040000071
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (7)

1. The calcium-iron-zinc solid preparation is characterized by comprising the following raw materials in parts by weight:
45 parts of maltodextrin, 15 parts of cyclodextrin, 17 parts of fruit powder, 0.12 part of iron source, 0.065 part of zinc source, 10 parts of calcium source, 8 parts of xylitol, 3.6 parts of white granulated sugar, 0.215 part of stevioside, 1 part of vitamin C and 1 part of citric acid;
the iron source is ferrous glycinate;
the zinc source is zinc glycinate;
the calcium source is calcium aspartate;
the preparation method of the calcium-iron-zinc solid preparation comprises the following steps:
mixing cyclodextrin with iron source, zinc source and calcium source, and grinding to obtain cyclodextrin calcium iron zinc clathrate;
mixing cyclodextrin calcium-iron-zinc clathrate, maltodextrin, fruit powder, xylitol, white sugar, stevioside, vitamin C, and citric acid, adding adhesive, granulating, and drying to water content below 2%.
2. The solid preparation of calcium, iron and zinc as claimed in claim 1, wherein the cyclodextrin is one or more of α -cyclodextrin, β -cyclodextrin and γ -cyclodextrin.
3. The calcium-iron-zinc solid preparation according to claim 1, wherein the DE value of maltodextrin is 15 to 20.
4. The calcium-iron-zinc solid preparation according to any one of claims 1 to 3, wherein the fruit powder is selected from but not limited to sweet orange powder, mango powder and cherry powder.
5. The solid preparation of calcium, iron and zinc according to claim 1, wherein the time for grinding is 2 to 10 hours.
6. The solid preparation of calcium, iron and zinc as claimed in claim 1, wherein the binder is selected from the group consisting of water, ethanol solution, sodium carboxymethyl cellulose slurry, starch slurry.
7. The solid preparation of calcium, iron and zinc according to claim 1, wherein the drying is boiling drying and/or oven drying.
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