CN103690559A - Formulation form of supplement calcium, magnesium, iron, zinc and iodine, and oral liquid preparation method of formulation - Google Patents
Formulation form of supplement calcium, magnesium, iron, zinc and iodine, and oral liquid preparation method of formulation Download PDFInfo
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- CN103690559A CN103690559A CN201410002887.8A CN201410002887A CN103690559A CN 103690559 A CN103690559 A CN 103690559A CN 201410002887 A CN201410002887 A CN 201410002887A CN 103690559 A CN103690559 A CN 103690559A
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Abstract
The invention provides a formulation of supplement calcium, magnesium, iron and zinc, which can be prepared into granules, oral liquid, injection, tablets, capsules, soft capsules and trace mineral additives. The invention also provides a preparation method and production process of the supplement calcium, magnesium, iron and zinc oral liquid, and in particular relates to a formulation comprising 50 to 2,000mg of soluble calcium (a calcium agent calcium gluconate and calcium lactate), 10 to 700mg of soluble magnesium (a magnesium agent magnesium chloride and magnesium gluconate), 1 to 30mg of soluble ferrum (a ferrum agent ferrous gluconate and ferrous lactate), and 1 to 25mg of soluble zinc (a zinc agent zinc gluconate and zinc lactate). The formulation is prepared for treating a plurality of common diseases of Chinese people caused by calcium, ferrum, magnesium and zinc deficiency and obviously improves the physical quality of Chinese people. The preparation has the effects of building a body and preventing and treating diseases while drinking as water.
Description
Technical field
The present invention relates to a kind of preparation type of supplement Ca, Mg and Fe zinc and wherein oral liquor and production technology thereof, relate in particular to a kind of with 50～2000 milligrams of calcium (calcium preparation: calcium gluconate, calcium lactate, calcium hydrogen phosphate, activated calcium, biological calcium carbonate, calcium acetate, L-Aspartic acid calcium, calcium carbonate, calcium citrate, calcium cirate malate, calcium glycine, l threonic acid, superfine fresh bone meal); 10～700 milligrams, magnesium (magnesia mixture: magnesium chloride, magnesium gluconate, magnesium sulfate, magnesium oxide); 1～30 milligram of ferrum (chalybeate: Ferrous gluconate, ferric ammonium citrate, ferric citrate, ferrous fumarate, ferrous lactate, ferric phrophosphate, ferrous succinate, ferrous sulfate, protohemin, electrolytic iron, iron porphyrin, reduced iron); 1～25 milligram, zinc (zinc agent: zinc gluconate, zinc acetate, zinc chloride, zinc citrate, zinc glycinate, zinc lactate, zinc sulfate, zinc oxide); Can make electuary, tablet, injection, capsule, soft capsule, oral liquid, trace mineral supplement.Wherein to need pure water or deionized water and mineral water be raw material, oral liquid and production technology thereof for oral liquid preparation.
Background technology
Trace element is considered to be related to human health and a long-lived frontier full of hope, has caused the generally attention of domestic and international nutrition circle and medical circle.China urban and rural residents trace element deficiency ubiquity.Although the content of trace element in human body is few, closely bound up with people's existence and health, people's life is played to vital effect.Taking the photograph deficiency, imbalance or lacking of they all can cause to some extent the abnormal of Human Physiology or disease occurs.Human body is that trace element accounts for 1% by various elementary composition organisms, and the effect in life process can not be underestimated in vivo.Do not have these must trace element, the activity of enzyme will reduce or completely lose, and the synthetic and metabolism of hormone, protein, vitamin also obstacle will occur, and human life's process is just difficult to proceed.Child's numerous disease is relevant with trace element, reduced or too much all likely caused disease, and in trace element family, calcium, magnesium, ferrum, zinc enjoys attention.The trace element that in actual life, human body more easily lacks mainly contains zinc, ferrum, calcium, magnesium etc.The important biochemical functions of zinc is in recent years especially for people payes attention to.If child's zinc deficiency, will cause growth retardation, hypogeusia, inappetence is anorexia and occur pica even, and wound is difficult for healing, sends out well skin ulcer and stomatocace etc., and can there is sexual maturation disorder in older child.During man's zinc deficiency, occur that sexual impotence and seminal fluid reduce.Old people's zinc deficiency can cause crystalline lens regression sclerosis in eyeball, forms the cataract generation oral ulcer of becoming reconciled.Ferrum is the important element that forms hemoglobin, participates in the transportation of oxygen and carbon dioxide.Ferrum is again the constituent of the peroxidase of cytochrome system, in breathing and biological oxidation process, plays an important role.The under-supply iron deficiency anemia (being again low pigment anemia or minicell anemia) that causes of ferrum element.Calcium is mainly present in body with inorganic salt form, forms the main part of skeleton and tooth.Become the content of calcium in human body to be about 700～1400 grams, but only have few part to be present in body fluid as ion.Calcium participates in muscle contraction, emiocytosis and coagulation process, can reduce nervimuscular irritability.If but infant-growth period, gestation period and senectitude, particularly Ca supply are not enough, can produce larger harm: child's calcium deficiency affect sclerotin growth, easily suffers from rickets; Can there is tetany in anemia of pregnant woman's calcium deficiency; Old people's calcium deficiency can cause numb limbs and tense tendons, lumbago and skelalgia even because osteoporosis causes spontaneous fracture.Magnesium ion can maintain contraction and the diastole balance of blood vessel.Magnesium deficiency can cause hypertension and atherosclerosis.Be prone to anemia of pregnant woman's magnesium deficiency edema, albuminuria, cholesterol such as increase at the eclamposia symptom, cause Placenta Hominis to reduce for water, and fetal growth is slow, and severe patient can lethal tire.According to the element balance theory of medicine of human body, various trace elements zinc, ferrum, calcium, the magnesium useful to human body are rich in screening, and the multiple difficult and complicated illness that trace element is for want of caused has significant curative effect.The present invention has overcome that present market sale is replenished the calcium, iron supplement, zinc supplement are single a kind of trace element that supplements, and causes other trace element deficiencies, and trace element is unbalanced at human body, and expensive, is difficult to universal popular.The various diseases that this invention causes in order to solve the general calcium deficiency magnesium deficiency of Chinese iron deficiency zinc deficiency, obviously improves Chinese sons and daughters's body constitution.Through test for many years, checking, evident in efficacy repeatedly.Generally reflection, convenient, inexpensive, strengthening body, prevents and cures diseases.It is fast, effective that the present invention absorbs, and indication scope is wide, and taking convenience has no side effect.Summary of the invention
One of the object of the invention is to provide a kind of preparation of supplement Ca, Mg and Fe zinc, can make electuary, oral liquid, tablet, injection, capsule, soft capsule, oral liquid, trace mineral supplement; Another object of the present invention is to provide a kind of supplement Ca, Mg and Fe zinc oral liquor production technology.Relate in particular to a kind of with 50～2000 milligrams of calcium (calcium preparation: calcium gluconate, calcium lactate, activated calcium, calcium acetate, L-Aspartic acid calcium, calcium citrate, calcium cirate malate, calcium glycine, l threonic acid); 10～700 milligrams, magnesium (magnesia mixture: magnesium chloride, magnesium gluconate, magnesium sulfate); 1～30 milligram of (chalybeate: Ferrous gluconate, ferric ammonium citrate, ferric citrate, ferrous fumarate, ferrous lactate, ferric phrophosphate, ferrous succinate, ferrous sulfate, protohemin, electrolytic iron, iron porphyrin of ferrum.1～25 milligram, zinc (zinc agent: zinc gluconate, zinc acetate, zinc chloride, zinc citrate, zinc glycinate, zinc lactate, zinc sulfate, zinc oxide).
Every 10～1000 milliliters of the oral liquid formulations of supplement Ca, Mg and Fe zinc of the present invention, 50～2000 milligrams of middle solubility calciums (calcium preparation: calcium gluconate, calcium lactate, calcium hydrogen phosphate, activated calcium, calcium acetate, L-Aspartic acid calcium, calcium citrate, calcium cirate malate, calcium glycine, l threonic acid); 10～700 milligrams of soluble magnesiums (magnesia mixture: magnesium chloride, magnesium gluconate, magnesium sulfate); 1～30 milligram of soluble iron (chalybeate: Ferrous gluconate, ferric ammonium citrate, ferric citrate, ferrous fumarate, ferrous lactate, ferric phrophosphate, ferrous succinate, ferrous sulfate, protohemin, electrolytic iron, iron porphyrin); 1～25 milligram of soluble Zn (zinc agent: zinc gluconate, zinc acetate, zinc chloride, zinc citrate, zinc glycinate, zinc lactate, zinc sulfate); All the other are pure water or deionized water and mineral water.
The oral liquid formulations production technology of supplement Ca, Mg and Fe zinc of the present invention comprises the steps: that preparation method of the present invention is: in Agitation Tank, add pure water or deionized water and mineral water to be heated to boiling, by formula dosage, pour solubility calcium preparation into, continue heated and stirred, after the solubility calcium preparation that makes to add fully dissolves, add successively solubility chalybeate, soluble Zn agent, soluble magnesium, continuation heating, stir, mix, be cooled to after 90 ℃, then add pure water or deionized water and mineral water, water is to total amount, be cooled to 30 ℃, enter cascade filtration, fill, sterilizing; Fill; Sealing: sterilization: ultraviolet radiation, check; Packing.
Claims (4)
1. one of the object of the invention is to provide a kind of preparation of supplement Ca, Mg and Fe zinc, can make electuary, oral liquid, tablet, injection, capsule, soft capsule, oral liquid, trace mineral supplement; Another object of the present invention is to provide a kind of supplement Ca, Mg and Fe zinc oral liquor production technology.
2. relate in particular to a kind of with 50～2000 milligrams of calcium (calcium preparation: calcium gluconate, calcium lactate, activated calcium, calcium acetate, L-Aspartic acid calcium, calcium citrate, calcium cirate malate, calcium glycine, l threonic acid); 10～700 milligrams, magnesium (magnesia mixture: magnesium chloride, magnesium gluconate, magnesium sulfate); 1～30 milligram of ferrum (chalybeate: Ferrous gluconate, ferric ammonium citrate, ferric citrate, ferrous fumarate, ferrous lactate, ferric phrophosphate, ferrous succinate, ferrous sulfate, protohemin, electrolytic iron, iron porphyrin); 1～25 milligram, zinc (zinc agent: zinc gluconate, zinc acetate, zinc chloride, zinc citrate, zinc glycinate, zinc lactate, zinc sulfate, zinc oxide).
3. the oral liquid formulations of supplement Ca, Mg and Fe zinc of the present invention is every 10～1000 milliliters, 50～2000 milligrams of middle solubility calciums (calcium preparation: calcium gluconate, calcium lactate, calcium hydrogen phosphate, activated calcium, calcium acetate, L-Aspartic acid calcium, calcium citrate, calcium cirate malate, calcium glycine, l threonic acid); 10～700 milligrams of soluble magnesiums (magnesia mixture: magnesium chloride, magnesium gluconate, magnesium sulfate); 1～30 milligram of soluble iron (chalybeate: Ferrous gluconate, ferric ammonium citrate, ferric citrate, ferrous fumarate, ferrous lactate, ferric phrophosphate, ferrous succinate, ferrous sulfate, protohemin, electrolytic iron, iron porphyrin); 1～25 milligram of soluble Zn (zinc agent: zinc gluconate, zinc acetate, zinc chloride, zinc citrate, zinc glycinate, zinc lactate, zinc sulfate); All the other are pure water or deionized water and mineral water.
4. the oral liquid formulations production technology of supplement Ca, Mg and Fe zinc of the present invention comprises the steps: that preparation method of the present invention is: in Agitation Tank, add pure water or deionized water and mineral water to be heated to boiling, by formula dosage, pour solubility calcium preparation into, continue heated and stirred, after the solubility calcium preparation that makes to add fully dissolves, add successively solubility chalybeate, soluble Zn agent, soluble magnesium, continuation heating, stir, mix, be cooled to after 90 ℃, then add pure water or deionized water and mineral water, water is to total amount, be cooled to 30 ℃, enter cascade filtration, fill, sterilizing; Fill; Sealing: sterilization: ultraviolet radiation, check; Packing.
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| CN201410002887.8A CN103690559A (en) | 2014-01-05 | 2014-01-05 | Formulation form of supplement calcium, magnesium, iron, zinc and iodine, and oral liquid preparation method of formulation |
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| CN201410002887.8A CN103690559A (en) | 2014-01-05 | 2014-01-05 | Formulation form of supplement calcium, magnesium, iron, zinc and iodine, and oral liquid preparation method of formulation |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103876153A (en) * | 2014-04-16 | 2014-06-25 | 罗英明 | Health-care lobed kudzuvine root oral liquid and preparation method thereof |
| CN104546818A (en) * | 2015-02-04 | 2015-04-29 | 澳诺（中国）制药有限公司 | Pharmaceutical composition with calcium supplement and zinc supplement effects and preparation of pharmaceutical composition |
| CN104886555A (en) * | 2015-05-04 | 2015-09-09 | 上海鸿儒科技发展有限公司 | Food preparation for supplementing micronutrients including iron, zinc and calcium |
| CN105077280A (en) * | 2015-09-01 | 2015-11-25 | 张伟 | Liquid preparation for supplementing zinc and preparation method thereof |
| CN105595346A (en) * | 2015-09-01 | 2016-05-25 | 张伟 | Liquid preparation for calcium supplementation and preparation method thereof |
| CN109588611A (en) * | 2018-11-20 | 2019-04-09 | 东莞市欣荣天丽科技实业有限公司 | A kind of edible oxygen absorber composition and deoxidant packing body |
| CN110301648A (en) * | 2019-07-24 | 2019-10-08 | 杭州海王生物工程有限公司 | A kind of minerals class drops and preparation method thereof |
| CN111663151A (en) * | 2020-04-24 | 2020-09-15 | 广西科学院 | Process for preparing high-purity calcium glycinate by electrochemical-complexation reaction technology |
| CN113317428A (en) * | 2021-06-16 | 2021-08-31 | 海而思（郑州）科技有限公司 | Calcium, iron and zinc solid preparation and preparation method thereof |
-
2014
- 2014-01-05 CN CN201410002887.8A patent/CN103690559A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103876153A (en) * | 2014-04-16 | 2014-06-25 | 罗英明 | Health-care lobed kudzuvine root oral liquid and preparation method thereof |
| CN104546818A (en) * | 2015-02-04 | 2015-04-29 | 澳诺（中国）制药有限公司 | Pharmaceutical composition with calcium supplement and zinc supplement effects and preparation of pharmaceutical composition |
| CN104886555A (en) * | 2015-05-04 | 2015-09-09 | 上海鸿儒科技发展有限公司 | Food preparation for supplementing micronutrients including iron, zinc and calcium |
| CN105077280A (en) * | 2015-09-01 | 2015-11-25 | 张伟 | Liquid preparation for supplementing zinc and preparation method thereof |
| CN105595346A (en) * | 2015-09-01 | 2016-05-25 | 张伟 | Liquid preparation for calcium supplementation and preparation method thereof |
| CN109588611A (en) * | 2018-11-20 | 2019-04-09 | 东莞市欣荣天丽科技实业有限公司 | A kind of edible oxygen absorber composition and deoxidant packing body |
| CN110301648A (en) * | 2019-07-24 | 2019-10-08 | 杭州海王生物工程有限公司 | A kind of minerals class drops and preparation method thereof |
| CN111663151A (en) * | 2020-04-24 | 2020-09-15 | 广西科学院 | Process for preparing high-purity calcium glycinate by electrochemical-complexation reaction technology |
| CN113317428A (en) * | 2021-06-16 | 2021-08-31 | 海而思（郑州）科技有限公司 | Calcium, iron and zinc solid preparation and preparation method thereof |
| CN113317428B (en) * | 2021-06-16 | 2022-08-09 | 海而思（郑州）科技有限公司 | Calcium, iron and zinc solid preparation and preparation method thereof |
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