CN113316564A - 一种稠合三环氘代衍生物及其组合物和应用 - Google Patents

一种稠合三环氘代衍生物及其组合物和应用 Download PDF

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Publication number
CN113316564A
CN113316564A CN201980064626.XA CN201980064626A CN113316564A CN 113316564 A CN113316564 A CN 113316564A CN 201980064626 A CN201980064626 A CN 201980064626A CN 113316564 A CN113316564 A CN 113316564A
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China
Prior art keywords
pharmaceutically acceptable
stereoisomer
acceptable salt
prodrug
solvate
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CN201980064626.XA
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CN113316564B (zh
Inventor
李瑶
王文晶
石宗军
张国彪
徐波
任磊
张晨
严庞科
郑伟
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Sichuan Haisco Pharmaceutical Co Ltd
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Sichuan Haisco Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings

Abstract

本发明涉及一种稠合三环氘代衍生物及其组合物和应用，具体说涉及通式(I)所示稠合三环氘代衍生物或其立体异构体、溶剂化物、代谢产物、药学上可接受的盐、共晶或者前药及含有该衍生物或其立体异构体、溶剂化物、代谢产物、药学上可接受的盐、共晶或者前药的药物组合物，以及其作为治疗和/或预防疼痛的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201980064626.XA 2019-01-30 2019-12-25 一种稠合三环氘代衍生物及其组合物和应用 Active CN113316564B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910084098 2019-01-30
CN2019100840986 2019-01-30
PCT/CN2019/128254 WO2020155953A1 (zh) 2019-01-30 2019-12-25 一种稠合三环氘代衍生物及其组合物和应用

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CN113316564A true CN113316564A (zh) 2021-08-27
CN113316564B CN113316564B (zh) 2023-06-09

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CN (1) CN113316564B (zh)
TW (1) TWI738162B (zh)
WO (1) WO2020155953A1 (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720219A (zh) * 2001-04-19 2006-01-11 沃纳-兰伯特公司 稠合二环或三环氨基酸
WO2017114225A1 (zh) * 2015-12-31 2017-07-06 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用
CN106928080A (zh) * 2015-12-31 2017-07-07 四川海思科制药有限公司 稠合环γ‑氨基酸衍生物及其制备方法和在医药上的应用
WO2018050046A1 (zh) * 2016-09-14 2018-03-22 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720219A (zh) * 2001-04-19 2006-01-11 沃纳-兰伯特公司 稠合二环或三环氨基酸
WO2017114225A1 (zh) * 2015-12-31 2017-07-06 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用
CN106928080A (zh) * 2015-12-31 2017-07-07 四川海思科制药有限公司 稠合环γ‑氨基酸衍生物及其制备方法和在医药上的应用
WO2018050046A1 (zh) * 2016-09-14 2018-03-22 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用

Also Published As

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TWI738162B (zh) 2021-09-01
WO2020155953A1 (zh) 2020-08-06
TW202028172A (zh) 2020-08-01
CN113316564B (zh) 2023-06-09

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