CN113286885A - 用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法 - Google Patents

用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法 Download PDF

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CN113286885A
CN113286885A CN201980073271.0A CN201980073271A CN113286885A CN 113286885 A CN113286885 A CN 113286885A CN 201980073271 A CN201980073271 A CN 201980073271A CN 113286885 A CN113286885 A CN 113286885A
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compound
patient
administration
plasma
death
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A·列索戈尔
邵青
T·索伦
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Novartis AG
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CN201980073271.0A 2018-11-09 2019-11-08 用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法 Pending CN113286885A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862758323P 2018-11-09 2018-11-09
US62/758,323 2018-11-09
US201962874459P 2019-07-15 2019-07-15
US62/874,459 2019-07-15
PCT/IB2019/059632 WO2020095274A1 (en) 2018-11-09 2019-11-08 Method for reducing the risk of a cardiovascular event with conjugated antisense compounds targeting apo(a)

Publications (1)

Publication Number Publication Date
CN113286885A true CN113286885A (zh) 2021-08-20

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CN201980073271.0A Pending CN113286885A (zh) 2018-11-09 2019-11-08 用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法

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US (2) US20210395737A1 (https=)
EP (1) EP3877523A1 (https=)
JP (3) JP2022512911A (https=)
KR (2) KR20260037169A (https=)
CN (1) CN113286885A (https=)
AU (3) AU2019377275A1 (https=)
CA (1) CA3111382A1 (https=)
IL (1) IL281147A (https=)
WO (1) WO2020095274A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso
MX2021008661A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599706A (en) 1994-09-23 1997-02-04 Stinchcomb; Dan T. Ribozymes targeted to apo(a) mRNA
US7227014B2 (en) 2001-08-07 2007-06-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein (a) expression
US7259150B2 (en) 2001-08-07 2007-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein (a) expression
WO2003014397A1 (en) 2001-08-09 2003-02-20 Biomedlab Corporation Probe for detection of enteric virus detection kit and method for enteric virus with the same
EP3822352A3 (en) 2012-05-24 2021-11-03 Ionis Pharmaceuticals, Inc. Methods and compositions for modulating apolipoprotein(a) expression
DK2992098T3 (da) 2013-05-01 2019-06-17 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
US9382540B2 (en) * 2014-05-01 2016-07-05 Isis Pharmaceuticals, Inc Compositions and methods for modulating angiopoietin-like 3 expression
KR20250078597A (ko) 2015-11-06 2025-06-02 아이오니스 파마수티컬즈, 인코포레이티드 아포리포프로테인 (a) 발현 조정
PL4119569T3 (pl) * 2015-11-06 2024-11-18 Ionis Pharmaceuticals, Inc. Sprzężone związki antysensowne do zastosowania w terapii

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Publication number Publication date
US20210395737A1 (en) 2021-12-23
JP2022512911A (ja) 2022-02-07
KR20210091703A (ko) 2021-07-22
WO2020095274A1 (en) 2020-05-14
AU2019377275A1 (en) 2021-03-25
EP3877523A1 (en) 2021-09-15
JP2026021335A (ja) 2026-02-10
US20260049310A1 (en) 2026-02-19
KR20260037169A (ko) 2026-03-17
JP2024081645A (ja) 2024-06-18
CA3111382A1 (en) 2020-05-14
AU2025267467A1 (en) 2025-12-04
AU2023210550A1 (en) 2023-08-24
IL281147A (en) 2021-04-29

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