CN113273640A - Feed additive and preparation method thereof - Google Patents
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- CN113273640A CN113273640A CN202110439317.5A CN202110439317A CN113273640A CN 113273640 A CN113273640 A CN 113273640A CN 202110439317 A CN202110439317 A CN 202110439317A CN 113273640 A CN113273640 A CN 113273640A
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- 239000003674 animal food additive Substances 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 235000003434 Sesamum indicum Nutrition 0.000 claims abstract description 37
- 235000010678 Paulownia tomentosa Nutrition 0.000 claims abstract description 36
- 244000153888 Tung Species 0.000 claims abstract description 36
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 241000207961 Sesamum Species 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 34
- 238000009835 boiling Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 229920000858 Cyclodextrin Polymers 0.000 claims description 6
- 239000001116 FEMA 4028 Substances 0.000 claims description 6
- 229920002774 Maltodextrin Polymers 0.000 claims description 6
- 239000005913 Maltodextrin Substances 0.000 claims description 6
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 6
- 229960004853 betadex Drugs 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229940035034 maltodextrin Drugs 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 239000004576 sand Substances 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 17
- 239000003242 anti bacterial agent Substances 0.000 abstract description 12
- 229940088710 antibiotic agent Drugs 0.000 abstract description 12
- 241000411851 herbal medicine Species 0.000 abstract description 7
- 238000009395 breeding Methods 0.000 abstract description 6
- 230000001488 breeding effect Effects 0.000 abstract description 6
- 241000196324 Embryophyta Species 0.000 abstract description 5
- 235000016709 nutrition Nutrition 0.000 abstract description 5
- 230000035764 nutrition Effects 0.000 abstract description 5
- 244000000231 Sesamum indicum Species 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 description 20
- 241000588724 Escherichia coli Species 0.000 description 11
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 230000003115 biocidal effect Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000036541 health Effects 0.000 description 6
- 244000144972 livestock Species 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000006142 Luria-Bertani Agar Substances 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000006996 mental state Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 235000020927 12-h fasting Nutrition 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 235000013613 poultry product Nutrition 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Physiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Health & Medical Sciences (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses a feed additive which is characterized by comprising the following raw materials in parts by weight: 200 parts of tung leaves and 1500 parts of sesame, and the feed additive provided by the invention uses natural plant Chinese herbal medicines to replace antibiotics, so that the antibiotic-free ecological breeding of the feed is realized, and meanwhile, the feed additive has the function of increasing nutrition, small side effect and easily obtained raw materials. The invention also provides a preparation method of the feed additive, and a finished product prepared by the preparation method has the same effect as the feed additive provided by the invention.
Description
Technical Field
The invention relates to the technical field of feeds, and particularly relates to a feed additive and a preparation method thereof.
Background
In recent years, green, safe and pollution-free livestock and poultry products are more and more favored by consumers. The antibiotic additive has positive effects on reducing feed conversion ratio, accelerating growth of livestock and poultry, production and breeding. However, the abuse of antibiotics can lead to the generation of drug-resistant bacteria, which threatens human health and public environment. Since 2006, the european union has completely banned the introduction of antibiotics into the feed additive line, and the document 194 th ministry of agricultural and rural areas of the people's republic of china states that, from 7 and 1 of 2020, except for Chinese herbal medicines, the production of commercial feeds containing growth-promoting drugs is stopped, and thus no antibiotic feed additives are developed.
However, no antibiotic substitute product can completely substitute antibiotics at present. In the production of non-resistant grains, the addition of certain feed additives can only relieve or partially replace antibiotics to a certain extent. Therefore, the search for antibiotic substitutes, especially natural antibiotic substitutes, to develop safe and efficient antibiotic-free feeds is particularly urgent and urgent. The search for new natural substitute additives suitable for livestock and poultry feeds is the greatest demand at home and abroad, particularly in Europe and China. Therefore, the invention provides a new resource and a new idea for the feed additive and the application thereof based on the technical problems and the feed for replacing natural feed or new natural antibiotics.
Disclosure of Invention
The invention provides a feed additive, which uses natural plant Chinese herbal medicines to replace antibiotics, realizes antibiotic-free ecological breeding of the feed, and has the effects of increasing nutrition, small side effect and easily obtained raw materials.
The invention also provides a preparation method of the feed additive, and a finished product prepared by the preparation method has the same effect as the feed additive provided by the invention.
The feed additive is characterized by comprising the following raw materials in parts by weight:
200 portions of tung leaf and 800 portions of tung leaf;
300 portions of sesame and 1500 portions of sesame.
The feed additive preferably comprises the following raw materials in parts by weight:
500 portions and 800 portions of tung leaves;
1000 portions of sesame and 1500 portions of sesame.
Preferably, the tung leaf and sesame are pulverized for use in the feed additive.
The feed additive preferably further comprises a preparation auxiliary material, wherein the preparation auxiliary material is one of beta-cyclodextrin and maltodextrin.
The preparation method of the feed additive is characterized by comprising the following steps:
a. weighing 800 parts of 200-fold sand of tung leaves and 1500 parts of 300-fold sand of sesame seeds;
b. crushing the tung leaves and the sesame, and soaking in water for 1-3 h to obtain a mixture;
c. heating the mixture obtained in the step b to boiling, boiling for 40-50 minutes, extracting under reflux for 2-3 times, extracting for 45 minutes-2 hours each time, combining the extracting solutions, and filtering to obtain a filtrate.
The preparation method of the feed additive preferably further comprises the following steps: concentrating the filtrate, spray drying, adding adjuvants, and mixing.
In the preparation method of the feed additive, the water adding amount in the step b is preferably 8-12 times of the sum of the parts by weight of the tung leaves and the sesame.
In the preparation method of the feed additive, preferably, the preparation auxiliary material is one of beta-cyclodextrin and maltodextrin.
The invention has the beneficial effects that: the feed additive provided by the invention uses Chinese herbal medicines in natural plants to replace antibiotics, realizes antibiotic-free ecological breeding of the feed, and has the function of increasing nutrition. In addition, the feed additive has small side effect and no drug resistance, the tolerance of livestock can be well shown, the raw materials are wide and natural, and compared with common feed additives, the feed additive is easy to popularize on a large scale and can play a good role in promoting resource utilization.
The invention also provides a preparation method of the feed additive, and a finished product prepared by the preparation method has the same effect as the feed additive provided by the invention.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments.
All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The embodiment of the invention provides a feed additive, which comprises the following raw materials in parts by weight:
200 portions of tung leaf and 800 portions of tung leaf;
300 portions of sesame and 1500 portions of sesame.
In the prior art, no antibiotic substitute product can completely replace antibiotics. In the production of non-resistant grains, the addition of certain feed additives can only relieve or partially replace antibiotics to a certain extent.
The feed additive provided by the invention uses natural plant Chinese herbal medicines to replace antibiotics, realizes antibiotic-free ecological breeding of the feed, and has the function of increasing nutrition. The invention uses Chinese herbal medicine as green feed additive, has the characteristics of pure nature, multifunction and the like, and compared with the traditional feed additive, the green feed additive mainly has the following characteristics: (1) the side effect is small, the drug resistance is avoided, and the livestock has good tolerance degree; (2) the raw materials are wide in source and natural, and compared with common feed additives, the feed additive is easy to popularize on a large scale, and can play a good role in promoting resource utilization.
The feed additive provided by the embodiment of the invention comprises the following raw materials in parts by weight as a preferred scheme:
500 portions and 800 portions of tung leaves;
1000 portions of sesame and 1500 portions of sesame.
Among them, tung leaf and sesame are preferably used after being pulverized.
Preferably, the pharmaceutical composition further comprises a preparation auxiliary material, wherein the preparation auxiliary material is one of beta-cyclodextrin and maltodextrin.
The embodiment of the invention also provides a preparation method of the feed additive, which comprises the following steps:
a. weighing 800 parts of 200-fold sand of tung leaves and 1500 parts of 300-fold sand of sesame seeds;
b. crushing the tung leaves and the sesame, and soaking in water for 1-3 h to obtain a mixture;
c. heating the mixture obtained in the step b to boiling, boiling for 40-50 minutes, extracting under reflux for 2-3 times, extracting for 45 minutes-2 hours each time, combining the extracting solutions, and filtering to obtain a filtrate.
The preparation method of the feed additive preferably further comprises the following steps: concentrating the filtrate, spray drying, adding adjuvants, and mixing.
In the preparation method of the feed additive, the water adding amount in the step b is preferably 8-12 times of the sum of the parts by weight of the tung leaves and the sesame.
In the preparation method of the feed additive, preferably, the preparation auxiliary material is one of beta-cyclodextrin and maltodextrin.
According to the preparation method of the feed additive, natural plant Chinese herbal medicines are used for replacing antibiotics, so that the antibiotic-free ecological breeding of the feed can be realized, and the effect of increasing nutrition is achieved. In addition, the finished product has small side effect and no drug resistance, the livestock can well express the tolerance degree, the raw materials for preparation are wide and natural, the large-scale popularization is easy, and the method can play a good role in promoting the resource utilization.
Specific examples are provided below.
Example 1
A feed additive comprises the following raw materials in parts by weight:
200 parts of tung leaves;
300 parts of sesame.
The preparation method comprises the following steps:
a. weighing 200 parts of tung leaves and 300 parts of sesame;
b. pulverizing folium Tung and semen Sesami, and soaking in water for 1 hr to obtain mixture;
c. heating the mixture obtained in the step b to boiling, boiling for 40 minutes, extracting for 2 times under reflux, extracting for 45 minutes each time, combining the extracting solutions, filtering to obtain filtrate, concentrating the filtrate, and spray drying.
Example 2
A feed additive comprises the following raw materials in parts by weight:
500 parts of tung leaves;
1000 parts of sesame.
The preparation method comprises the following steps:
a. weighing 500 parts of tung leaves and 1000 parts of sesame;
b. pulverizing folium Tung and semen Sesami, and soaking in water for 2 hr to obtain mixture;
c. heating the mixture obtained in the step b to boiling, boiling for 45 minutes, extracting for 2 times under reflux, extracting for 1 hour each time, combining the extracting solutions, filtering to obtain filtrate, concentrating the filtrate, and spray drying.
Example 3
A feed additive comprises the following raw materials in parts by weight:
800 parts of tung leaves;
1500 parts of sesame.
The preparation method comprises the following steps:
a. weighing 800 parts of tung leaves and 1500 parts of sesame;
b. crushing the tung leaves and the sesame, and soaking in water for 3 hours to obtain a mixture;
c. heating the mixture obtained in the step b to boiling, boiling for 50 minutes, extracting for 3 times under reflux, extracting for 2 hours each time, combining the extracting solutions, filtering to obtain filtrate, concentrating the filtrate, and spray drying.
Example 4
In vitro experiments
(1) Preparing experimental bacteria: culturing Escherichia coli, preparing bacterial suspension with sterilized normal saline, diluting Escherichia coli bacterial suspension with PBS solution to 1 × 106cfu/mL。
(2) Preparing bacteriostatic experiment sample solution (related dosage is shown in table 1), wherein a composition high-dose group, a composition medium-dose group and a composition low-dose group are prepared by using the preparation method of the therapeutic feed additive provided by the invention, and the weight parts of the used raw materials, namely tung leaves and sesame, are all 1: 1.
(3) preparation of antibacterial tablets
Bacteriostatic tablets for experimental groups: taking sterile dry filter paper sheets, respectively dropwise adding 20 mu L of different bacteriostatic test sample solutions to each filter paper sheet, then flatly placing the filter paper sheets in a clean sterile plate, and drying for later use.
Control bacteriostatic tablets: taking sterile dry filter paper sheets, respectively dripping different distilled water of 20 mu L into each filter paper sheet, then flatly placing the filter paper sheets in a clean sterile plate, and drying for later use.
(4) Inoculating experimental bacteria: and (3) sucking the escherichia coli bacterial suspension by using a sterile pipette, uniformly smearing the escherichia coli bacterial suspension on the surface of an LB agar culture medium flat plate, and covering the flat plate.
And (3) taking the antibacterial tablets by using sterile forceps, sticking the antibacterial tablets on the surfaces of the LB agar medium plates, slightly pressing the antibacterial tablets by using the sterile forceps after sticking the antibacterial tablets, enabling the antibacterial tablets to be tightly attached to the surfaces of the LB agar medium plates, covering the plates, and sticking 1 antibacterial tablet on each LB agar medium plate.
After the patch is placed, the patch is cultured in a constant temperature box at 37 ℃ for 17 h.
(5) The diameter of the zone (including the patch) was measured with a vernier caliper and recorded. The measurement was repeated 3 times. (wherein if the diameter of the inhibition zone is larger than 7mm, the product has an inhibition effect, if the diameter of the inhibition zone is not larger than 7mm, the product has no inhibition effect.)
TABLE 1 inhibition zone for inhibiting Escherichia coli of each sample
As a result:
except sesame residues, the composition high-dose group, the composition medium-dose group, the composition low-dose group, the tung leaves and the intestines and stomach health have inhibition effects on escherichia coli in different degrees, wherein the inhibition effect on the escherichia coli by the composition is obviously and positively correlated with the dose of the composition, and the inhibition effects on the escherichia coli by the high-dose and the medium-dose of the composition are better than that of the tung leaves, the sesame and the intestines and stomach health.
Example 5
In vivo experiments
(1) Experimental animals: half of the mouse, male and female, 20 +/-2 g of body mass, room temperature (22 +/-2) DEG C, natural rhythm illumination, free feeding and drinking water, standard feed feeding, after adapting to 1 week, carrying out formal experiments, fasting for 12h before the experiments, and free water feeding.
(2) Preparing antibiotic drugs (related doses are shown in table 2), wherein a composition high dose group, a composition medium dose group and a composition low dose group are feed additives provided by the invention or prepared by the method provided by the invention, and the weight parts of the raw materials of tung leaves and sesame are 1: 1, after preparation, three doses of the composition suspension were formulated with 0.9% normal saline, 2g/ml, 4g/ml and 6g/ml, respectively.
(3) The experimental mice were randomly divided into a normal group, a model group, a composition high dose group, a composition medium dose group, a composition low dose group, a tung leaf group, a sesame group, and a gastrointestinal health group.
The administration was continued for 14 days, 1 time a day, and distilled water was given to the normal group and the model group.
(4) After the last administration for 30min, normal group was injected with normal saline, and the other groups of mice were injected with Escherichia coli liquid (concentration of 4.0 × 10)8cfu/mL), 0.2mL per 10g body weight per injection.
(5) And (3) observing the diarrhea condition: and (3) observing and recording the mental state, activity and hair condition of the mouse after injecting the escherichia coli liquid into the abdominal cavity of the mouse, and lasting for 8 hours. The filter paper is replaced once for each time of loose stool, the diameters of the feces are measured and recorded (3 times), the times of the loose stools, the times of the total feces and the average diameter of the loose stools of each group of mice are recorded, and the loose stool rate, the diarrhea index and the diarrhea rate are calculated.
The stool dilution rate is the number of stool dilutions/total stool dilution of each mouse; the stool dilution grade represents the degree of stool dilution of each mouse, and is graded by the diameter of the stool-contaminated filter paper, and is divided into 4 grades: the average stool dilution grade is 1 grade less than 1cm, 2 grade more than or equal to 1 to 2cm, 3 grade more than or equal to 2 to 3cm, 4 grade more than 3cm, and the average stool dilution grade is the total times of all stool dilution grades and/or stool dilution; diarrhea index is the loose stool rate x average loose stool grade; diarrhea rate is the number of mice with diarrhea per group/total number of mice per group x 100%.
TABLE 2 Escherichia coli diarrhea in various groups of mice
Note: p < 0.05, compared to the model group; Δ P < 0.05 vs. WEICHANG, "-" indicates no diarrhea.
As a result: the normal group animals had good mobility and no loose stools. The mice in the model group have obvious diarrhea, the activity is obviously weakened, the arch back and hair are not glossy, and the drinking water amount is obviously reduced. The overall state of mice in each administration group is better than that of a model group, and is worse than that of a normal group, the time for the first diarrhea of each administration group is delayed to different degrees, and the mental state, hair and activity of animals in the composition high-dose group are obviously better than those of other administration groups.
Compared with a model control group, each administration group and the gastrointestinal health can obviously reduce the loose stool rate (P is less than 0.05), the diarrhea index (P is less than 0.05) and the diarrhea rate, wherein the improvement degree of each dosage group of the composition, especially the high dosage group of the composition, is obviously better and better than that of the gastrointestinal health group (P is less than 0.05) and each group.
The feed additive and the preparation method thereof provided by the invention are described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (8)
1. The feed additive is characterized by comprising the following raw materials in parts by weight:
200 portions of tung leaf and 800 portions of tung leaf;
300 portions of sesame and 1500 portions of sesame.
2. The feed additive according to claim 1, which comprises the following raw materials in parts by weight:
500 portions and 800 portions of tung leaves;
1000 portions of sesame and 1500 portions of sesame.
3. The feed additive according to any one of claims 1 to 2, wherein the tung leaves and sesame are pulverized and used.
4. A feed additive according to any one of claims 1 to 3 further comprising a formulation aid, wherein the formulation aid is one of β -cyclodextrin and maltodextrin.
5. A process for the preparation of a feed additive according to any one of claims 1 to 4, characterized in that it comprises the following steps:
a. weighing 800 parts of 200-fold sand of tung leaves and 1500 parts of 300-fold sand of sesame seeds;
b. crushing the tung leaves and the sesame, and soaking in water for 1-3 h to obtain a mixture;
c. heating the mixture obtained in the step b to boiling, boiling for 40-50 minutes, extracting under reflux for 2-3 times, extracting for 45 minutes-2 hours each time, combining the extracting solutions, and filtering to obtain a filtrate.
6. The method for preparing a feed additive according to claim 5, further comprising the steps of: concentrating the filtrate, spray drying, adding adjuvants, and mixing.
7. The method for preparing feed additive according to claim 5, wherein the amount of water added in step b is 8-12 times of the sum of the parts by weight of the tung leaves and the sesame.
8. The method for preparing a feed additive according to claim 6, wherein the formulation auxiliary material is one of beta-cyclodextrin and maltodextrin.
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2021
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