CN113262269A

CN113262269A - Flos puerariae alcohol effect dispelling pellet and preparation method thereof

Info

Publication number: CN113262269A
Application number: CN202010093438.4A
Authority: CN
Inventors: 姚津华
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-02-14
Filing date: 2020-02-14
Publication date: 2021-08-17

Abstract

The invention discloses a preparation method of a pueraria flower alcohol-relieving pill, which comprises the following steps: A. drying the raw materials of the alcohol-effect-dispelling pill, grinding the dried raw materials into powder, sieving the powder by a 80-mesh sieve, and taking fine powder; B. decocting part of the raw materials and the rest coarse powder, and concentrating; C. preparing 1.5 times of honey as the medicinal powder; D. refining Mel, boiling with strong fire, decocting with slow fire, and evaporating water until Mel is in the form of fisheye bubble; E. sieving Mel with 80 mesh sieve, filtering to remove impurities, adding concentrated medicinal liquid into Mel, adding the medicinal powder, stirring, and making into medicinal paste; F. the medicine paste is manually rubbed into small honeyed pills, dried and packaged, and the sobering-up pill is prepared by using the kudzu root, the flower of kudzuvine and the hovenia dulcis thumb as main components. In addition, the wild ginseng is added in the invention, so that the drunkenness can be effectively prevented, the drunkenness can be quickly relieved after drunkenness, and the effects of protecting the liver and the stomach can be achieved.

Description

Flos puerariae alcohol effect dispelling pellet and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a kudzuvine flower alcohol effect dispelling pill and a preparation method thereof.

Background

Wine is an indispensable part of Chinese culture. The shadow of wine can not be obtained in the course of the year, relatives and friends and social communication. People can enjoy the happy speech with wine; for swertia pseudochinensis, the wine is used for helping fun; people are healthy and healthy with wine, and people are worried about … … wine with wine, so that the wine becomes an indispensable thing in daily life. However, the drinking brings about not only positive aspects, but frequent drinking or excessive alcohol intake can easily induce stomach and liver related diseases, and seriously endanger the health of people.

In general, excessive alcohol intake is the fastest and most direct reaction to symptoms such as headache, dizziness, mental confusion and vomiting, and people pay the most attention to eliminating the adverse reactions when drinking alcohol, so that medicines such as sedatives and hormones are taken to make people feel comfortable. In fact, the substances are all used for tranquilizing and numbing through paralysis the nervous system so as to achieve the effect of making the drunk people clear the surface, but after the drug effect, the drunk feeling is reproduced, the body is weak, the energy is not concentrated, and more importantly, the alcohol in the body still exists and continues to have the effect of damaging the human body.

In recent years, many anti-hangover health foods, beverages and pharmaceutical products have been marketed, such as pueraria hovenia dulcis soft capsules, pueraria lobata dark plum sugar, and various oral liquids. However, various sobering-up products are available in the market, and different formulations and different manufacturing processes have different efficacies, and most products have the defects of multiple indications, wide treatment range, undefined curative effect, weak pertinence and the like. The pueraria lobata health promotion soup originated in the original Li Donghou (theory of spleen and stomach), the pueraria lobata powder recorded in the book of Ru Men's relatives of Jintiao Zhang, the test case of using hovenia dulcis to relieve alcoholism ever by famous physicians of Jinyuan, and the drunkenness relieving of hovenia dulcis recorded in the book of compendium of materia medica. Modern researches generally combine one or two of hovenia dulcis thunb, pueraria lobata and pueraria lobata or other Chinese herbal medicines to obtain an anti-hangover composition, but no research on anti-hangover effects of 3 formulas of pueraria lobata, pueraria lobata and hovenia dulcis thunb is found in the market at present. The kudzuvine root, the kudzuvine flower and the hovenia dulcis thunb are all traditional Chinese herbal medicines for relieving alcoholism.

Disclosure of Invention

The invention aims to provide a pueraria flower alcohol effect relieving pellet and a preparation method thereof, which aim to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

the pueraria flower alcohol-relieving pill comprises the following components in percentage by mass: 10-30% of kudzuvine flower, 10-30% of hovenia dulcis thunb, 5-15% of radix puerariae lobatae, 5-10% of white poria, 5-15% of medlar, 2-5% of prepared schisandra chinensis, 5-10% of wild ginseng, 5-10% of Chinese yam, 2-5% of radix ophiopogonis, 0.5-1% of Xinhui dried orange peel and 0.5-1% of rose.

As a further scheme of the invention: comprises the following components in percentage by mass: 20% of pueraria flower, 20% of hovenia dulcis thunb, 10% of radix puerariae powder, 8% of white poria, 13% of wolfberry fruit, 4.5% of schisandra chinensis, 10% of wild ginseng, 10% of Chinese yam, 3% of radix ophiopogonis, 1% of Xinhui dried orange peel and 0.5% of rose.

As a further scheme of the invention: comprises the following components in percentage by mass: 20% of pueraria flower, 20% of hovenia dulcis thunb, 10% of radix puerariae powder, 8% of white poria, 13% of wolfberry fruit, 4.5% of schisandra chinensis, 10% of ginseng under forest, 10% of Chinese yam, 3% of radix ophiopogonis, 1% of Xinhui dried orange peel and 0.5% of rose.

A preparation method of a kudzuvine flower alcohol-relieving pill comprises the following steps:

A. drying the raw materials of the alcohol-effect-dispelling pill, grinding the dried raw materials into powder, sieving the powder by a 80-mesh sieve, and taking fine powder;

B. decocting part of the raw materials and the rest coarse powder, and concentrating;

C. preparing 1.5 times of honey as the medicinal powder;

D. refining Mel, boiling with strong fire, decocting with slow fire, and evaporating water until Mel is in the form of fisheye bubble;

E. sieving Mel with 80 mesh sieve, filtering to remove impurities, adding concentrated medicinal liquid into Mel, adding the medicinal powder, stirring, and making into medicinal paste;

F. manually kneading the medicinal paste into small honeyed pills, drying and packaging.

As a further scheme of the invention: the mass of the small honeyed pill is 0.5 +/-0.1 g.

As a further scheme of the invention: the honey is pure date honey.

As a further scheme of the invention: the raw material in the step A needs to be cleaned and disinfected.

Compared with the prior art, the invention has the beneficial effects that: 1. the formula is safe, and all raw materials are selected from medicinal and edible materials; 2. the flos puerariae alcohol effect dispelling pill prepared by the method can be taken before drinking, can act within 30 minutes, obviously reduces symptoms such as dizziness, headache and nausea and the like during drinking of a user, and partially causes the phenomenon that the drinking amount of the user is increased; 3. the pill can be taken within 30 minutes during drinking to relieve headache, dizziness, nausea, vomiting and other symptoms, and relieve stomach ache and gastrectasia; 4. after drunk, the wine is taken more quickly and shortens the time compared with the conventional sobering-up, and can effectively relieve the phenomena of dizziness, headache and stomach discomfort; 5. the formula is firstly determined to take the basic effects of sobering up, relieving vomit and relieving restlessness by the kudzuvine flower, the kudzuvine root and the Japanese raisin tree seed; the white poria, the wild ginseng and the Chinese yam are added to play roles of promoting diuresis, strengthening spleen and stomach, soothing nerves, accelerating alcohol metabolism, protecting spleen and stomach, calming mind, and relieving symptoms such as dizziness, headache and vomiting; a great amount of medlar is added to play a role in protecting the liver; the addition of the prepared schisandra chinensis and the radix ophiopogonis can relieve the symptoms of thirst, dysphoria, irritability and the like; the added Xinhui dried orange peel and rose flower have the effects of promoting the circulation of qi and soothing the liver, strengthening the effect and playing the role of a catalyst.

Drawings

Fig. 1 is a diagram of a process for alleviating hangover in a human body.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the embodiment of the invention, the pueraria flower alcohol-relieving pill comprises the following components in percentage by mass: 10-30% of kudzuvine flower, 10-30% of hovenia dulcis thunb, 5-15% of radix puerariae lobatae, 5-10% of white poria, 5-15% of medlar, 2-5% of prepared schisandra chinensis, 5-10% of wild ginseng, 5-10% of Chinese yam, 2-5% of radix ophiopogonis, 0.5-1% of Xinhui dried orange peel and 0.5-1% of rose.

Wherein: and (3) kudzuvine flower: spleen and stomach meridians entered; relieving hangover and invigorating spleen. Can be used for treating excessive drinking, headache, dizziness, polydipsia, chest and diaphragm distention, acid regurgitation, etc. and stomach qi injury.

Weaving the raisin tree seeds: entering the stomach channel; relieving alcoholism, quenching thirst, relieving restlessness, stopping vomiting, and facilitating urination and defecation; it is often used for alcoholic intoxication, polydipsia, emesis, and defecation.

Radix puerariae powder: entering stomach meridian; relieving fever and restlessness, promoting the production of body fluid and quenching thirst; can be used for treating dysphoria with smothery sensation, thirst, alcoholic intoxication, pharyngitis, sore, and furuncle.

White poria: spleen, lung and kidney meridians entered; excrete dampness and induce diuresis, invigorate spleen and stomach, calm heart and induce tranquilization.

Wolfberry fruit: entering liver and kidney meridians; nourishing liver and kidney, replenishing vital essence and improving eyesight.

Preparing the schisandra chinensis: it enters lung, heart and kidney meridians; astringe to arrest discharge, benefit qi and promote the production of body fluid, tonify kidney and calm heart.

Wild ginseng: the heart, lung, spleen and kidney meridians are entered; tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote fluid production, and induce tranquilization. The wild ginseng with more than 16 years is selected, so that the effect is more prominent.

Chinese yam rhizome: spleen, lung and kidney meridians entered; to replenish qi, nourish yin, tonify spleen and lung, tonify kidney and secure essence.

Radix ophiopogonis: entering lung, heart and stomach meridians; tonify qi, nourish yin and moisten lung, nourish stomach and promote fluid production, clear heart and relieve restlessness.

Xinhui dried orange peel: entering lung and spleen meridians; has the functions of regulating qi, lowering adverse flow of qi, regulating the middle warmer, stimulating appetite, eliminating dampness and phlegm. The finely selected dried orange peel with 5 years old, the simultaneous tonics and purgatives for tonifying, and the simultaneous purgatives for purging, play the role of a catalyst in the whole formula, and have more prominent effect

And (3) rose: entering lung, spleen and stomach meridians; to soothe the liver, relieve depression, activate blood and dissipate blood stasis.

Kudzu root is the dry root of Pueraria lobata Ohwi of Leguminosae, recorded in pharmacopoeia of the people's republic of China (2015 edition), is sweet, pungent and cool in taste, and has the effects of relieving muscles and fever, promoting fluid production to quench thirst, clearing and activating the channels and collaterals, and relieving alcoholism. The compendium of materia Medica also records: the kudzu root is mainly used for relieving alcoholism and dispelling dysphoria with smothery sensation. The main active ingredient of the composition is pueraria isoflavone compound which can reduce blood viscosity through removing free radicals and resisting lipid peroxidation.

Flos Puerariae Lobatae is dried flower of Pueraria lobata or Pueraria thomsonii of Leguminosae, and is recorded in Shen nong Ben Cao Jing for relieving hangover, activating spleen, treating alcoholic intoxication, fever, polydipsia, anorexia, vomiting, hematemesis, and enteropathogenic wind, and promoting ethanol metabolism by inhibiting lipid peroxidation.

The semen Hoveniae is dried mature fruit and seed with flesh fruit stem of Rhamnaceae plant, has sweet and sour taste, mild property, enters spleen channel, and has effects of inducing diuresis, relieving swelling, and relieving alcoholism. Li Shizhen (compendium of materia Medica) records that the branches and leaves of Li Shizhen can stop vomiting, relieve alcoholism and repel parasites poison. Modern researches show that the hovenia dulcis thunb contains a large amount of glucose, organic acid, peroxidase and the like, can expand the blood volume of a human body, eliminate excessive free radicals generated in the body after drinking, inhibit lipid peroxidation, further reduce the concentration of ethanol in blood, and has the effects of sobering up and soothing the nerves. The existing research shows that the hovenia dulcis thunb, the kudzuvine root and the kudzuvine flower can promote blood circulation and accelerate the excretion of ethanol, so that the effects of promoting the elimination of the ethanol and reducing the concentration of the ethanol in blood are achieved, and the blood circulation and the excretion of the ethanol can be promoted through the ways of eliminating free radicals and resisting lipid peroxidation. Penyawen and the like take kudzuvine root and hovenia dulcis thunb as main raw materials to develop a compound beverage with the function of relieving alcoholism, wherein the ratio of the kudzuvine root to the hovenia dulcis thunb is 1: 2. The influence of different proportions of the pueraria flower and the hovenia dulcis on alcoholic liver injury rats is researched, the pueraria flower and the hovenia dulcis are combined into (1:1), (1:2) and (2:1)3 groups, and experimental results show that the optimal ratio of the pueraria flower to the hovenia dulcis is 1: 1. According to the literature, the compatibility of the pueraria flower, the pueraria root and the hovenia dulcis thunb is designed, wherein the ratio of the pueraria flower to the pueraria root to the hovenia dulcis thunb is (2: 1: 2). By adopting the proportion, the white poria, the medlar, the fried rhizoma atractylodis and the like are added, so that the pueraria flower alcohol-dispelling pill has a good alcohol-dispelling effect, and can effectively protect the liver and stomach of a drinker.

Example 1: comprises the following components in percentage by mass: 20% of pueraria flower, 20% of hovenia dulcis thunb, 10% of radix puerariae powder, 8% of white poria, 13% of wolfberry fruit, 4.5% of schisandra chinensis, 10% of wild ginseng, 10% of Chinese yam, 3% of radix ophiopogonis, 1% of Xinhui dried orange peel and 0.5% of rose.

Example 2: comprises the following components in percentage by mass: 20% of pueraria flower, 20% of hovenia dulcis thunb, 10% of radix puerariae powder, 8% of white poria, 13% of wolfberry fruit, 4.5% of schisandra chinensis, 10% of ginseng under forest, 10% of Chinese yam, 3% of radix ophiopogonis, 1% of Xinhui dried orange peel and 0.5% of rose.

A. drying the above components, grinding, sieving with 80 mesh sieve, collecting fine powder, and sterilizing;

C. preparing 1.5 times of honey (pure date honey with mild property is recommended);

F. manually twisting the medicinal mud into small honeyed pills of 0.5g, drying and packaging.

The specific implementation mode is as follows:

first, the pueraria flower anti-hangover pill of the present invention is further described below with reference to specific examples, but the scope of protection and the scope of application of the present invention are not limited.

The formula proportioning optimization process of the invention is as follows:

experiment 4 is the final confirmed formula, the ratio of the raw materials of the alcohol-relieving pill has the best effect, and experiment 5 is based on the previous experiment, the preparation process is changed from small honeyed pills to concentrated small honeyed pills, so that the viscosity of the pure honeyed pills is reduced.

The method for preparing the concentrated small honeyed pill comprises the following steps:

1. drying the above components, grinding, sieving with 80 mesh sieve, collecting fine powder, and sterilizing;

2. decocting part of the raw materials and the rest coarse powder, and concentrating;

3. preparing 1.5 times of honey (pure date honey with mild property is recommended);

4. refining honey, boiling with strong fire, decocting with slow fire, and evaporating water;

5. sieving Mel with 80 mesh sieve, filtering to remove impurities, adding concentrated medicinal liquid into Mel, adding the medicinal powder, stirring, and making into medicinal paste;

6. and (3) manually rubbing the medicinal mud into small honey pills of 0.5g, drying and packaging to obtain the pueraria flower alcohol-effect-dispelling pill.

Experiments 1-4 are different in the increase and decrease of the components of the formula and the adjustment of the proportion, and experiment 5 is different from experiments 1-4 in the improvement of the process, and the small honeyed pills are changed into thick and small honeyed pills, so that the finished products are dry and are not easy to adhere.

The increase and decrease of the components and the adjustment of the proportion ensure that the sobering-up speed of the kudzuvine flower sobering-up pill is accelerated, the gastrointestinal reaction is reduced to almost no, the dizziness and headache reaction is obviously relieved, and 20 percent of tested individuals have the reaction of increasing the alcohol capacity. The improved process makes the product easy to dry and easy to store, and the pellet with the same formulation has high effective matter concentration.

Disintegration test:

pure water disintegration experiment: the alcohol effect relieving pill is placed in purified water, the pill begins to disintegrate within 15 minutes, and disintegrates 70% within 30 minutes, so the best effect is achieved when the pueraria flower alcohol effect relieving pill is taken 20-30 minutes before drinking.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. The pueraria flower alcohol-relieving pellet is characterized by comprising the following components in percentage by mass: 10-30% of kudzuvine flower, 10-30% of hovenia dulcis thunb, 5-15% of radix puerariae lobatae, 5-10% of white poria, 5-15% of medlar, 2-5% of prepared schisandra chinensis, 5-10% of wild ginseng, 5-10% of Chinese yam, 2-5% of radix ophiopogonis, 0.5-1% of Xinhui dried orange peel and 0.5-1% of rose.

2. The pueraria flower anti-alcoholism pill as claimed in claim 1, which is characterized by comprising the following components in percentage by mass: 20% of pueraria flower, 20% of hovenia dulcis thunb, 10% of radix puerariae powder, 8% of white poria, 13% of wolfberry fruit, 4.5% of schisandra chinensis, 10% of wild ginseng, 10% of Chinese yam, 3% of radix ophiopogonis, 1% of Xinhui dried orange peel and 0.5% of rose.

3. The pueraria flower anti-alcoholism pill as claimed in claim 1, which is characterized by comprising the following components in percentage by mass: 20% of pueraria flower, 20% of hovenia dulcis thunb, 10% of radix puerariae powder, 8% of white poria, 13% of wolfberry fruit, 4.5% of schisandra chinensis, 10% of ginseng under forest, 10% of Chinese yam, 3% of radix ophiopogonis, 1% of Xinhui dried orange peel and 0.5% of rose.

4. A preparation method of a pueraria flower alcohol effect-relieving pill is characterized by comprising the following steps:

C. preparing 1.5 times of honey as the medicinal powder;

5. The preparation method of the pueraria flower anti-alcoholism pill according to claim 4, wherein the mass of the small honeyed pill is 0.5 +/-0.1 g.

6. The preparation method of the pueraria flower anti-alcoholism pill as claimed in claim 4, wherein the honey is pure jujube honey.

7. The method for preparing a pueraria flower anti-alcoholism pill according to claim 4, wherein the raw materials in the step A need to be cleaned and sterilized.