CN113244325A - 一种活血化瘀搽剂及其制备方法 - Google Patents
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Abstract
本发明公开了一种活血化瘀搽剂及其制备方法,所述活血化瘀搽剂包括以下重量份的原料:三七54‑65;红花18‑22;血竭9‑11;自然铜40‑50;地黄90‑110;栅木叶13‑16;盾叶秋海棠90‑110;生草乌0.9‑1.1;天南星0.45‑0.55;雪上一枝蒿0.9‑1.1;马钱子0.9‑1.1;草澄茄110‑130;松叶110‑130。本发明中的所述活血化瘀搽剂,具有活血化瘀、消肿止痛和舒筋活络的功效,其药液能够渗透到皮肤肌理,进而提升治疗效果,可用于急、慢闭合性软组织损伤所导致的血瘀症,尤其是对于局部肿胀、疼和功能障碍等症状的治疗效果更好。
Description
技术领域
本发明属于植物药剂技术领域,尤其是涉及一种活血化瘀搽剂及其制备方法。
背景技术
活血化瘀,是用具有消散作用的、或能攻逐体内瘀血的药物治疗瘀血病证的方法。一般的活血化瘀药物有通畅血脉、消散瘀滞、调经止痛的作用。适用范围很广,如瘀阻于心所致的胸闷心痛、口唇青紫。瘀阻于肺所致的胸痛咳血、瘀阻于肝所致的胁痛痞块、瘀阻于胞宫所致的小腹疼、月经不调、痛经等;瘀阻于肢体所致的局部肿痛青紫;瘀阻于脉络所致的半身不遂等均可治疗。
但是现有的活血化瘀搽剂在使用时,配方的功效较差,需要使用较长时间,使用起来操作难度大,且渗透皮肤内层效果差,不利于身上的肿结瘀堵的排化。因此需要一种新型的活血化瘀搽剂来解决这些问题。
发明内容
有鉴于此,本发明旨在提出一种活血化瘀搽剂及其制备方法,以解决背景技术中提到的问题。
为达到上述目的,本发明提供了一种活血化瘀搽剂,所述活血化瘀搽剂包括以下重量份的原料:
优选地,所述活血化瘀搽剂包括以下重量份的原料:
优选地,所述活血化瘀搽剂包括以下重量份的原料:
优选地,所述马钱子和穿山甲均需要经过砂烫处理,乙醇为70%乙醇。
一种活血化瘀搽剂制备方法,所述活血化瘀搽剂为上述所述的活血化瘀搽剂,包括如下步骤:
S1、对所述活血化瘀搽剂的制备设备进行清洗、净化和消毒处理,同时清洗活血化瘀搽剂的制备原料;
S2、按制备原料的重量比选取三七、自然铜、地黄、盾叶秋海棠、生草乌、天南星、雪上一枝蒿、马钱子、穿山甲和全蝎,将所选取的制备原料放入自动切片机中并切成薄片,制得薄片料;
S3、按制备原料的重量比选取红花、血竭、栅木叶、草澄茄和松叶并放入粉碎机中进行粉碎,制得粉碎料;
S4、将所述步骤S2制得的薄片料和所述步骤S3制得的粉碎料一起加入原料比例的乙醇中进行混合,然后再将原料比例的樟脑、冰片和薄荷脑加入到乙醇混合液中,恒温密封浸泡15-20天,得到浸泡液;
S5、对所述步骤S4中制得的浸泡液进行过滤,将滤渣过滤掉以获取滤液,然后对所获取的滤液进行加压浓缩,并对加压浓缩后的浓缩液进行蒸馏提纯,直至所述浓缩液中的乙醇含量达到35%-40%,最后将其搅拌均匀后再次过滤,得到二次滤液;
S6、对所述步骤S5中得到的二次滤液进行高压蒸汽灭菌,冷却分装,从而得到活血化瘀搽剂。
优选地,所述步骤S4中的浸泡保存温度为20℃-26℃。
与现有技术比较,本发明中所述活血化瘀搽剂由三七、红花、血竭、自然铜、地黄、栅木叶、盾叶秋海棠、生草乌、天南星、雪上一枝蒿、马钱子、草澄茄、松叶、穿山甲、全蝎、樟脑、冰片、薄荷脑和乙醇制成,其中,所述薄荷脑可作用于使用者的皮肤或粘膜,具有清凉止痒作用,提高使用者的舒适性;地黄有强心利尿、解热消炎、促进血液凝固和降低血糖的作用,进一步增强使用效果;生草乌有祛风除湿功效,用于风寒湿痹,关节疼痛,心腹冷痛,寒疝作痛,麻醉止痛;血竭用于跌打损伤,治疗心腹瘀痛、外伤出血、疮疡不敛有奇效,进而大大增强了所述活血化瘀搽剂的使用功能和效果质量。本发明通过上述原料制成活血化瘀搽剂,具有活血化瘀、消肿止痛和舒筋活络的功效,其药液能够渗透到皮肤肌理,进而提升治疗效果,可用于急、慢闭合性软组织损伤所导致的血瘀症,尤其是对于局部肿胀、疼和功能障碍等症状的治疗效果更好。
附图说明
图1示出了本发明中一种活血化瘀搽剂制备方法的流程图。
具体实施方式
为了使本技术领域的人员更好地理解本发明的技术方案,下面结合附图和实施例对本发明作进一步的详细说明,以下实施例中,所用试剂,如无特殊说明,均为常规生化试剂;所述实验方法,如无特殊说明,均为常规方法。
一、活血化瘀搽剂的制备
实施例1
一种活血化瘀搽剂的制备,包括以下步骤:
S1、对所述活血化瘀搽剂的制备设备进行清洗、净化和消毒处理,同时按以下重量比选取原料,并将所选取的原料进行清洗,其中所述活血化瘀搽剂原料的重量比为:三七54-65;红花18-22;血竭9-11;自然铜40-50;地黄90-110;栅木叶13-16;盾叶秋海棠90-110;生草乌0.9-1.1;天南星0.45-0.55;雪上一枝蒿0.9-1.1;马钱子0.9-1.1;草澄茄110-130;松叶110-130,穿山甲13-16;全蝎1.3-1.6;樟脑4.5-5.5;冰片18-22;薄荷脑9-11;70%乙醇130-160;
S2、将步骤S1中所选取的三七、自然铜、地黄、盾叶秋海棠、生草乌、天南星、雪上一枝蒿、马钱子、穿山甲和全蝎放入自动切片机中并切成薄片,制得薄片料;
S3、将步骤S1中所选取的红花、血竭、栅木叶、草澄茄和松叶并放入粉碎机中进行粉碎,制得粉碎料;
S4、将所述步骤S2制得的薄片料和所述步骤S3制得的粉碎料一起加入70%乙醇中进行混合,然后再加入步骤S1中所选取的的樟脑、冰片和薄荷脑,最后恒温密封浸泡15-20天,恒温温度为20℃,进而得到浸泡液;
S5、对所述步骤S4中制得的浸泡液进行过滤以获取滤液,然后将所获取的滤液进行加压浓缩,并对加压浓缩后的浓缩液进行蒸馏提纯,直至所述浓缩液中的乙醇含量达到35%-40%后搅拌均匀并再次过滤,得到二次滤液;
S6、对所述步骤S5中得到的二次滤液进行高压蒸汽灭菌并冷却分装,从而得到活血化瘀搽剂。
实施例2
一种活血化瘀搽剂的制备,包括以下步骤:
S1、对所述活血化瘀搽剂的制备设备进行清洗、净化和消毒处理,同时按以下重量比选取原料,并将所选取的原料进行清洗,其中所述活血化瘀搽剂原料的重量比为:三七54-60;红花18-20;血竭9-10;自然铜40-46;地黄90-102;栅木叶13-15;盾叶秋海棠90-102;生草乌0.9-1.0;天南星0.45-0.50;雪上一枝蒿0.9-1.0;马钱子0.9-1.1;草澄茄110-120;松叶110-122,穿山甲13-15;全蝎1.5-1.5;樟脑4.5-5.2;冰片18-20;薄荷脑9-10;70%乙醇130-150;
S2、将步骤S1中所选取的三七、自然铜、地黄、盾叶秋海棠、生草乌、天南星、雪上一枝蒿、马钱子、穿山甲和全蝎放入自动切片机中并切成薄片,制得薄片料;
S3、将步骤S1中所选取的红花、血竭、栅木叶、草澄茄和松叶并放入粉碎机中进行粉碎,制得粉碎料;
S4、将所述步骤S2制得的薄片料和所述步骤S3制得的粉碎料一起加入70%乙醇中进行混合,然后再加入步骤S1中所选取的的樟脑、冰片和薄荷脑,最后恒温密封浸泡15-20天,恒温温度为24℃,进而得到浸泡液;
S5、对所述步骤S4中制得的浸泡液进行过滤以获取滤液,然后将所获取的滤液进行加压浓缩,并对加压浓缩后的浓缩液进行蒸馏提纯,直至所述浓缩液中的乙醇含量达到35%-40%后搅拌均匀并再次过滤,得到二次滤液;
S6、对所述步骤S5中得到的二次滤液进行高压蒸汽灭菌并冷却分装,从而得到活血化瘀搽剂。
实施例3
一种活血化瘀搽剂的制备,包括以下步骤:
S1、对所述活血化瘀搽剂的制备设备进行清洗、净化和消毒处理,同时按以下重量比选取原料,并将所选取的原料进行清洗,其中所述活血化瘀搽剂原料的重量比为:三七58-65;红花20-22;血竭10-11;自然铜44-50;地黄98-110;栅木叶14-16;盾叶秋海棠100-110;生草乌0.98-1.1;天南星0.50-0.55;雪上一枝蒿1.0-1.1;马钱子0.98-1.1;草澄茄115-130;松叶118-130,穿山甲14-16;全蝎1.4-1.6;樟脑4.9-5.5;冰片20-22;薄荷脑9.8-11;70%乙醇140-160;
S2、将步骤S1中所选取的三七、自然铜、地黄、盾叶秋海棠、生草乌、天南星、雪上一枝蒿、马钱子、穿山甲和全蝎放入自动切片机中并切成薄片,制得薄片料;
S3、将步骤S1中所选取的红花、血竭、栅木叶、草澄茄和松叶并放入粉碎机中进行粉碎,制得粉碎料;
S4、将所述步骤S2制得的薄片料和所述步骤S3制得的粉碎料一起加入70%乙醇中进行混合,然后再加入步骤S1中所选取的的樟脑、冰片和薄荷脑,最后恒温密封浸泡15-20天,恒温温度为26℃,进而得到浸泡液;
S5、对所述步骤S4中制得的浸泡液进行过滤以获取滤液,然后将所获取的滤液进行加压浓缩,并对加压浓缩后的浓缩液进行蒸馏提纯,直至所述浓缩液中的乙醇含量达到35%-40%后搅拌均匀并再次过滤,得到二次滤液;
S6、对所述步骤S5中得到的二次滤液进行高压蒸汽灭菌并冷却分装,从而得到活血化瘀搽剂。
二、药效学试验
1、对小鼠耳廓微循环的影响
取小鼠,随机分为空白对照组(80%乙醇)、阳性对照组(云南白药酊)、实施例组(实施例2样品),每组10只。各鼠腹腔注射戊巴比妥钠25mg/kg,麻醉后用眼科剪修剪耳廓毛,将小鼠固定好,平展耳廓及涂少许香柏油于表面,置于显微镜载物台上,用40~100倍镜观察给药前小鼠耳廓微循环,记录各鼠耳廓细动脉(A)、细静脉(V)的口径、毛细血管开放量。然后于左耳两面外涂给予相应的受试药液0.1ml,给药30分钟后,再测量耳廓细动脉(A)、细静脉(V)的口径、毛细血管开放量(即网点数)。结果表明,实施例组能使小鼠耳廓细动脉(A)、细静脉(V)血管口径明显增大,耳廓毛细血管开放数量增多,见表1。
表1对小鼠耳廓微循环的影响
2、对角叉菜胶致小鼠足肿胀的影响
取小鼠,每只小鼠右后足趾部皮下注射0.5%角叉菜胶混悬液40μl致炎。致炎后将小鼠随机分组,随机分为空白对照组(80%乙醇)、阳性对照组(云南白药酊)、实施例组(实施例2样品),每组10只。分组后小鼠开始给药,于右后足趾部涂抹给予相应的受试药物0.2ml,连续给药3天,每天1次,于末次给药4小时后,处死小鼠,取后双足等同部位,精确称重,以左右足重量差作为肿胀度。结果表明,实施例组对巴豆油性炎症有明显的抑制作用,见表2。
表2对角叉菜胶致小鼠足趾炎症的影响
组别 | 肿胀度(mg) |
空白对照组 | 69.2±23.4 |
阳性对照组 | 49.1±12.1 |
实施例组 | 46.8±12.8 |
3、镇痛试验
取小鼠,随机分为空白对照组(80%乙醇)、阳性对照组(云南白药酊)、实施例组(实施例2样品),每组10只。用药前用热板法测定各小鼠的痛阈值。各小鼠两后肢涂抹给予相应的受试药物各0.2ml,药后20分钟再用热板法分别测定各鼠的痛阈值。结果表明,实施例组具有明显的镇痛作用。
表3镇痛试验
组别 | 药前痛阈(秒) | 药后痛阈(秒) |
空白对照组 | 26.6±5.5 | 28.3±3.4 |
阳性对照组 | 27.6±5.3 | 37.1±6.3 |
实施例组 | 28.7±6.7 | 38.8±5.8 |
三、临床应用试验
1、病例选择
选择急、慢闭合性软组织损伤所导致的血瘀症患者,或局部肿胀、疼痛和功能障碍患者。
2、治疗方案
方案一:
将患处用温水洗净擦干,用消毒棉球或棉签沾上实施例1中所得到的活血化瘀搽剂涂擦患处并轻轻按摩至发热,每日3次;
方案二:
将患处用温水洗净擦干,用消毒棉球或棉签沾上实施例2中所得到的活血化瘀搽剂涂擦患处并轻轻按摩至发热,每日3次;
方案三:
将患处用温水洗净擦干,用消毒棉球或棉签沾上实施例3中所得到的活血化瘀搽剂涂擦患处并轻轻按摩至发热,每日3次。
3、临床疗效
临床试验结果表明:采用本发明中的活血化瘀搽剂治疗上述病例,治愈率72%以上,疗效显著,对正常或破损皮肤均未见有刺激性反应,也没有皮肤过敏性反应,使用安全。
4、典型病例
(1)陈某,女,38岁,因跌伤致右腕关节肿痛、活动受限,诊断为急性闭合软组织损伤,经当地卫生院医生手法复位固定后回家,自用草药(具体不详)外敷10余天,未见好转而来诊,右腕关节肿胀、压痛,皮温稍高,各指节活动受限。采用方案二中的活血化瘀搽剂外敷治疗,10天后,肿胀、疼痛消失,指关节无压痛、活动正常,痊愈。
(2)李某,男,55岁,1年前因参加马拉松赛事致膝关节韧带扭伤疼痛,活动受限。采用方案一中的活血化瘀搽剂外擦治疗,15天后疼痛消失,腰部活动正常,痊愈。
(3)孙某,女,45岁,因打篮球致右脚小腿肌腱拉伤,小腿疼痛疼痛,活动受限。采用方案三种的活血化瘀搽剂外擦治疗,10天后疼痛消失,活动正常,痊愈。
(4)赵某,男,35岁,2年前因颈、右肩部疼痛,活动受限,诊断为颈椎4-6节骨质增生。采用方案二外敷治疗,7天后疼痛消失,至今未见有不适。
(5)向某,男,63岁,3年前因双下肢疼痛10天,到当地医院就诊,诊断为小腿静脉血栓,住院治疗20余天,未见好转;后自己试用了国内生产的多种外用消肿止痛药,病情均未见好转。1年前来诊,诊断为双膝关节至足背浅表静脉曲张、肿胀、压痛,皮下有瘀斑,皮温稍高,关节活动受限,采用方案二中的活血化瘀搽剂外敷治疗,3天后疼痛逐渐好转,后继续用方案二中的活血化瘀搽剂外敷或外擦治疗,30天后,疼痛、肿胀消失,痊愈,至今未见有不适。
以上对本发明所提供的一种活血化瘀搽剂及其制备方法进行了详细介绍。本文中应用了具体个例对本发明的原理及实施方式进行了阐述,以上实施例的说明只是用于帮助理解本发明的核心思想。应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以对本发明进行若干改进和修饰,这些改进和修饰也落入本发明权利要求的保护范围内。
Claims (6)
4.如权利要求1-3任一项所述的活血化瘀搽剂,其特征在于,所述马钱子和穿山甲均需要经过砂烫处理,乙醇为70%乙醇。
5.一种活血化瘀搽剂制备方法,所述活血化瘀搽剂为权利要求4所述的活血化瘀搽剂,其特征在于,包括如下步骤:
S1、对所述活血化瘀搽剂的制备设备进行清洗、净化和消毒处理,同时清洗活血化瘀搽剂的制备原料;
S2、按制备原料的重量比选取三七、自然铜、地黄、盾叶秋海棠、生草乌、天南星、雪上一枝蒿、马钱子、穿山甲和全蝎,将所选取的制备原料放入自动切片机中并切成薄片,制得薄片料;
S3、按制备原料的重量比选取红花、血竭、栅木叶、草澄茄和松叶并放入粉碎机中进行粉碎,制得粉碎料;
S4、将所述步骤S2制得的薄片料和所述步骤S3制得的粉碎料一起加入原料比例的乙醇中进行混合,然后再将原料比例的樟脑、冰片和薄荷脑加入到乙醇混合液中,恒温密封浸泡15-20天,得到浸泡液;
S5、对所述步骤S4中制得的浸泡液进行过滤,将滤渣过滤掉以获取滤液,然后对所获取的滤液进行加压浓缩,并对加压浓缩后的浓缩液进行蒸馏提纯,直至所述浓缩液中的乙醇含量达到35%-40%,最后将其搅拌均匀后再次过滤,得到二次滤液;
S6、对所述步骤S5中得到的二次滤液进行高压蒸汽灭菌,冷却分装,从而得到活血化瘀搽剂。
6.如权利要求5所述的活血化瘀搽剂制备方法,其特征在于,所述步骤S4中恒温密封浸泡的保存温度为20℃-26℃。
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