CN113244147B

CN113244147B - Compound sterilizing wet tissue and preparation method thereof

Info

Publication number: CN113244147B
Application number: CN202110387027.0A
Authority: CN
Inventors: 翟勤勇
Original assignee: Suzhou Anhou Medical Technology Co ltd
Current assignee: Suzhou Anhou Medical Technology Co ltd
Priority date: 2021-04-12
Filing date: 2021-04-12
Publication date: 2022-03-15
Anticipated expiration: 2041-04-12
Also published as: CN113244147A

Abstract

The invention discloses a compound sterilization wet tissue and a preparation method thereof, wherein ethanol, benzalkonium chloride and polyhexamethylene guanidine are added in the process of preparing the sterilization wet tissue, and the ethanol can denature bacterial cell protein by destroying bacterial cell walls, hinder metabolism and cause bacterial inactivation; benzalkonium chloride is a cationic surfactant, quaternary ammonium cations generated by hydrolysis adsorb bacteria with electronegativity on the surface, the permeability of cell membranes is changed, cytoplasm is lost, metabolism is prevented, and therefore the bacteria are inactivated; polyhexamethylene guanidine is a cationic polymer, which changes the permeability of cell membranes by dissolving lipid, and prevents the normal progress of the metabolic activity of bacteria to lose activity. The three components have good compatibility with each other, form disinfectant after compounding, and the disinfectant wet tissue prepared by taking the composite non-woven fabric as a carrier is a disinfectant wet tissue which gives consideration to cleaning and disinfection of human bodies and cleaning and disinfection of object surfaces, and realizes the function of dual purposes.

Description

Compound sterilizing wet tissue and preparation method thereof

Technical Field

The invention relates to the technical field of disinfection wet tissues, in particular to a compound sterilization disinfection wet tissue and a preparation method thereof.

Background

In the environment of people living at present, bacteria are everywhere, bacteria can be stained on the skin or clothes inadvertently, the bacteria can permeate through the skin or enter the body of people through the oral cavity and wounds, uncomfortable conditions such as belly pulling can be caused if the conditions are light, pathological changes, infection and the like can be caused if the conditions are serious, and therefore people need to be disinfected at any time.

The wet tissue can play a role in cleaning and sterilizing, can be carried at any time, is very beneficial to sterilizing at any time, and along with the social progress, the sterilizing wet tissue on the market cannot meet the requirements of people on rapidness, high efficiency and compounding.

The invention provides a compound sterilizing wet tissue and a preparation method thereof to solve the problems.

Disclosure of Invention

The invention aims to provide a compound sterilizing wet tissue and a preparation method thereof, and aims to solve the problems in the background technology.

In order to solve the technical problems, the invention provides the following technical scheme:

the compound sterilizing wet tissue is mainly prepared from compound non-woven fabrics, and disinfectant is soaked on the surfaces of the non-woven fabrics.

Furthermore, the composite non-woven fabric comprises a spunlace non-woven fabric and a melt-blown non-woven fabric, and the composite non-woven fabric is prepared by hot-pressing and compounding the spunlace non-woven fabric and the melt-blown non-woven fabric.

Furthermore, the spunlace non-woven fabric is mainly prepared from viscose fibers and polyester fibers.

Further, the melt-blown non-woven fabric is polypropylene.

Further, the disinfectant comprises the following raw materials: 55-65 parts of purified water, 3-5 parts of ethanol, 4-7 parts of an active agent, 3-4 parts of a humectant, 2-4 parts of an aromatic, 1-3 parts of an aloe extract and 0.4-0.6 part of citric acid.

Further, the active agent comprises, by weight, 1-2 parts of benzalkonium chloride, 2-3 parts of phosphomolybdotungstic heteropoly acid and 1-2 parts of polyhexamethylene guanidine;

further, the humectant comprises 1-1.5 parts by weight of glycerol and 2-2.5 parts by weight of butanediol;

further, the aromatic comprises, by weight, 1-2 parts of peppermint oil and 1-2 parts of essence.

Further, the phosphomolybdic tungstic heteropoly acid is mainly prepared from disodium hydrogen phosphate, sodium molybdate and sodium tungstate.

A preparation method of a compound sterilizing wet tissue comprises the following steps:

s1: preparing phosphomolybdotungstic heteropoly acid by using disodium hydrogen phosphate, sodium molybdate and sodium tungstate;

s2: mixing 1/2 amounts of purified water with ethanol, benzalkonium chloride, polyhexamethylene guanidine, and phosphomolybdic tungstic heteropoly acid to obtain solution A;

s3: mixing 1/2 amount of purified water with glycerol, butanediol, oleum Menthae Dementholatum, essence, Aloe extractive solution, and citric acid to obtain solution B;

s4: mixing the solution A and the solution B to prepare a disinfectant;

s5: carrying out hot-pressing compounding on the spunlace non-woven fabric and the melt-blown non-woven fabric to form a composite non-woven fabric;

s6: and cutting, folding, adding liquid and packaging the composite non-woven fabric to obtain the disinfectant wet tissue.

Further, the step S1:

putting disodium hydrogen phosphate into deionized water, stirring uniformly, heating in a water bath, adding concentrated sulfuric acid, adjusting pH, stirring uniformly, adding sodium molybdate, stirring uniformly, cooling to room temperature, adding sodium tungstate, stirring uniformly, standing for a period of time, dropwise adding diethyl ether while stirring, continuing for a period of time, separating liquid, and drying for a period of time to obtain phosphomolybdotungstic heteropoly acid;

the S2:

mixing ethanol with 1/2% purified water, adding phosphomolybdotungstic heteropoly acid, benzalkonium chloride and polyhexamethylene guanidine, heating in water bath, stirring, and ultrasonically dispersing for a period of time to obtain solution A;

the S3:

mixing the remaining 1/2 amounts of purified water with glycerol, butanediol, oleum Menthae Dementholatum, essence, Aloe extract, and citric acid, water bathing, stirring, and ultrasonically dispersing for a while to obtain solution B;

the S4:

mixing the solution A and the solution B, heating in a water bath, and uniformly stirring to obtain a disinfectant;

the S5:

mixing viscose fibers and polyester fibers, and carrying out spunlace to obtain spunlace non-woven fabrics;

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

hot-pressing, compounding and bonding the spunlace non-woven fabric and the melt-blown non-woven fabric into a composite non-woven fabric;

the S6:

and cutting the composite non-woven fabric on a machine table, folding, immersing in disinfectant, soaking for 5 hours, taking out, and packaging to obtain the disinfectant wet tissue.

Further, the step S1:

placing disodium hydrogen phosphate into deionized water, mechanically stirring for 20-30 min, heating in a water bath to 40 ℃, adding concentrated sulfuric acid, adjusting the pH to 1.5, mechanically stirring for 10-15 min, adding sodium molybdate, mechanically stirring for 20-30 min, cooling to room temperature, adding sodium tungstate, mechanically stirring for 20-30 min, standing for 2h, dropwise adding diethyl ether while stirring, keeping for 2min, separating liquid, placing the lower-layer liquid into an oven, and drying at 40 ℃ for 3h to obtain phosphomolybdotungstic heteropoly acid;

the S2:

mixing ethanol with 1/2% purified water, adding phosphomolybdotungstic heteropoly acid, benzalkonium chloride and polyhexamethylene guanidine, heating to 30 ℃ in a water bath, mechanically stirring for 20-30 min, and ultrasonically dispersing for 10-15 min to obtain a solution A;

the S3:

mixing the remaining 1/2 amounts of purified water with glycerol, butanediol, peppermint oil, essence, aloe extract and citric acid, heating to 55 ℃ in a water bath, mechanically stirring for 5-10 min, and ultrasonically dispersing for 3-5 min to obtain a solution B;

the S4:

mixing the solution A and the solution B, heating the mixture to 40 ℃ in a water bath, and mechanically stirring the mixture for 15-25 min to prepare a disinfectant;

the S5:

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

the S6:

Compared with the prior art, the invention has the following beneficial effects:

the invention discloses a compound sterilizing wet tissue and a preparation method thereof. In the process of preparing the disinfectant wet tissue, benzalkonium chloride and polyhexamethylene guanidine are added to realize the disinfection and sterilization effect of composite sterilization, the benzalkonium chloride is a cationic active agent, quaternary ammonium cationic groups generated by hydrolysis can adsorb bacteria with electronegativity on the surface, and internal ion loss is caused by changing the permeability of cell membranes, so that the bacterial metabolism is prevented, and the bacteria are inactivated; the hexamethylguanidine is also a cationic polymer, can change the permeability of cell membranes by dissolving lipid, can prevent the normal progress of the metabolic activity of bacteria and lose the activity, has good stability and broad-spectrum and continuous antibacterial function, and can form a membrane outside the bacteria to prevent the respiration of the bacteria, cause oxygen deficiency and further inactivate; benzalkonium chloride and polyhexamethylene guanidine are cationic surfactants, have good compatibility, and can improve the disinfection and sterilization performance of the disinfection wet tissue;

meanwhile, the phosphomolybdotungstic heteropoly acid is added for compounding, the terminal oxygen in heteropoly acid anions has a coordination effect with the nitrogen ions in benzalkonium chloride and polyhexamethylene guanidine, and because the radius of the nitrogen ions is larger than that of hydrogen ions, the chemical bonds between heteropoly acid anions are weakened by the volume effect of cations, so that the coordination effect between the terminal oxygen and the nitrogen ions is formed, a microsphere structure is formed, the antibacterial area is increased, and the antibacterial performance of the disinfectant wet tissue is improved;

meanwhile, when the polyhexamethylene guanidine is compounded with an anion system, a polyelectrolyte compound can be generated, the polyelectrolyte compound is low in stability and easy to coagulate to form precipitates, and quaternary ammonium groups in benzalkonium chloride and anions in phosphomolybdic tungsten heteropoly acid can form heteropoly acid quaternary ammonium salts, so that the stability of the polyelectrolyte compound can be improved, the collision among the polyelectrolyte compounds can be reduced, the coagulation can be avoided, the molecules of the polyelectrolyte compound can be contracted, the volume is reduced, and the turbidity is reduced;

the disinfectant wet tissue prepared by the invention has good antibacterial performance, and good practicability and production value.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

S1：

placing disodium hydrogen phosphate in deionized water, mechanically stirring for 20min, heating in a water bath to 40 ℃, adding concentrated sulfuric acid, adjusting the pH to 1.5, mechanically stirring for 10min, adding sodium molybdate, mechanically stirring for 20min, cooling to room temperature, adding sodium tungstate, mechanically stirring for 20min, standing for 2h, dropwise adding diethyl ether while stirring, continuing for 2min, separating liquid, placing the lower-layer liquid in an oven, and drying at 40 ℃ for 3h to obtain phosphomolybdotungstic heteropoly acid;

S2：

mixing 3 parts of ethanol and 27.5 parts of purified water, adding 2 parts of phosphomolybdotungstic heteropoly acid, 1 part of benzalkonium chloride and 1 part of polyhexamethylene guanidine, heating to 30 ℃ in a water bath, mechanically stirring for 20min, and ultrasonically dispersing for 10min to obtain a solution A;

S3：

mixing the rest 27.5 parts of purified water with 1 part of glycerol, 2 parts of butanediol, 1 part of peppermint oil, 1 part of essence, 1 part of aloe extract and 0.4 part of citric acid, heating in water bath to 55 ℃, mechanically stirring for 5min, and ultrasonically dispersing for 3min to obtain a solution B;

S4：

mixing the solution A and the solution B, heating to 40 ℃ in a water bath, and mechanically stirring for 15min to obtain a disinfectant;

S5：

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

S6：

Example 2

S1：

placing disodium hydrogen phosphate in deionized water, mechanically stirring for 23min, heating in a water bath to 40 ℃, adding concentrated sulfuric acid, adjusting the pH to 1.5, mechanically stirring for 12min, adding sodium molybdate, mechanically stirring for 23min, cooling to room temperature, adding sodium tungstate, mechanically stirring for 23min, standing for 2h, dropwise adding diethyl ether while stirring, continuing for 2min, separating liquid, placing the lower-layer liquid in an oven, and drying at 40 ℃ for 3h to obtain phosphomolybdotungstic heteropoly acid;

S2：

mixing 4 parts of ethanol and 30 parts of purified water, adding 2.5 parts of phosphomolybdotungstic heteropoly acid, 1.5 parts of benzalkonium chloride and 1.5 parts of polyhexamethylene guanidine, heating to 30 ℃ in a water bath, mechanically stirring for 23min, and ultrasonically dispersing for 12min to obtain a solution A;

S3：

mixing the rest 30 parts of purified water with 1.3 parts of glycerol, 2.3 parts of butanediol, 1.5 parts of peppermint oil, 1.5 parts of essence, 2 parts of aloe extract and 0.5 part of citric acid, heating in water bath to 55 ℃, mechanically stirring for 7min, and ultrasonically dispersing for 4min to obtain solution B;

S4：

mixing the solution A and the solution B, heating to 40 ℃ in a water bath, and mechanically stirring for 18min to obtain a disinfectant;

S5：

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

S6：

Example 3

S1：

placing disodium hydrogen phosphate in deionized water, mechanically stirring for 27min, heating in a water bath to 40 ℃, adding concentrated sulfuric acid, adjusting the pH to 1.5, mechanically stirring for 14min, adding sodium molybdate, mechanically stirring for 27min, cooling to room temperature, adding sodium tungstate, mechanically stirring for 27min, standing for 2h, dropwise adding diethyl ether while stirring, continuing for 2min, separating liquid, placing the lower-layer liquid in an oven, and drying at 40 ℃ for 3h to obtain phosphomolybdotungstic heteropoly acid;

S2：

mixing 4 parts of ethanol and 30 parts of purified water, adding 2.5 parts of phosphomolybdotungstic heteropoly acid, 1.5 parts of benzalkonium chloride and 1.5 parts of polyhexamethylene guanidine, heating to 30 ℃ in a water bath, mechanically stirring for 27min, and ultrasonically dispersing for 14min to obtain a solution A;

S3：

mixing the rest 30 parts of purified water with 1.3 parts of glycerol, 2.3 parts of butanediol, 1.5 parts of peppermint oil, 1.5 parts of essence, 2 parts of aloe extract and 0.5 part of citric acid, heating in water bath to 55 ℃, mechanically stirring for 9min, and ultrasonically dispersing for 4min to obtain solution B;

S4：

mixing the solution A and the solution B, heating to 40 ℃ in a water bath, and mechanically stirring for 22min to obtain a disinfectant;

S5：

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

S6：

Example 4

S1：

placing disodium hydrogen phosphate in deionized water, mechanically stirring for 30min, heating in a water bath to 40 ℃, adding concentrated sulfuric acid, adjusting the pH to 1.5, mechanically stirring for 15min, adding sodium molybdate, mechanically stirring for 30min, cooling to room temperature, adding sodium tungstate, mechanically stirring for 30min, standing for 2h, dropwise adding diethyl ether while stirring, continuing for 2min, separating liquid, placing the lower-layer liquid in an oven, and drying at 40 ℃ for 3h to obtain phosphomolybdotungstic heteropoly acid;

S2：

mixing 5 parts of ethanol and 32.5 parts of purified water, adding 3 parts of phosphomolybdotungstic heteropoly acid, 2 parts of benzalkonium chloride and 2 parts of polyhexamethylene guanidine, heating to 30 ℃ in a water bath, mechanically stirring for 30min, and ultrasonically dispersing for 15min to obtain a solution A;

S3：

mixing the rest 32.5 parts of purified water with 1.5 parts of glycerol, 2.5 parts of butanediol, 2 parts of peppermint oil, 2 parts of essence, 3 parts of aloe extract and 0.6 part of citric acid, heating in water bath to 55 ℃, mechanically stirring for 10min, and ultrasonically dispersing for 5min to obtain solution B;

S4：

mixing the solution A and the solution B, heating to 40 ℃ in a water bath, and mechanically stirring for 25min to obtain a disinfectant;

S5：

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

S6：

Comparative example 1

S1：

mixing 5 parts of ethanol and 32.5 parts of purified water, adding 2 parts of benzalkonium chloride and 2 parts of polyhexamethylene guanidine, heating to 30 ℃ in a water bath, mechanically stirring for 30min, and ultrasonically dispersing for 15min to obtain a solution A;

S2：

S3：

S4：

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

S5：

Comparative example 2

S1：

S2：

mixing 5 parts of ethanol and 32.5 parts of purified water, adding 3 parts of phosphomolybdotungstic heteropoly acid and 2 parts of benzalkonium chloride, heating in a water bath to 30 ℃, mechanically stirring for 30min, and ultrasonically dispersing for 15min to obtain a solution A;

S3：

S4：

S5：

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

S6：

Comparative example 3

S1：

S2：

mixing 5 parts of ethanol and 32.5 parts of purified water, adding 3 parts of phosphomolybdotungstic heteropoly acid, heating to 30 ℃ in a water bath, mechanically stirring for 30min, and ultrasonically dispersing for 15min to obtain a solution A;

S3：

S4：

S5：

melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric;

S6：

Experiment of

The disinfectant in examples 1 to 4 and comparative examples 1 to 3 is used as an experimental sample, and the sample is subjected to a suspension quantitative sterilization experiment on escherichia coli, staphylococcus aureus and candida albicans respectively to detect the sterilization rate.

Experimental data

Data analysis

As can be seen from the data, in examples 1 to 4, the sterilization performance of example 4 was the best;

compared with example 4, the comparative example 1 lacks phosphomolybdic tungstic heteropoly acid, can not form a coordination effect by using terminal oxygen in anions and nitrogen ions, can not form microspheres, and has reduced antibacterial performance;

compared with example 4, in comparative example 2, the polyhexamethylene guanidine is absent, a cationic active agent is absent, and the antibacterial performance is reduced;

compared with example 4, the benzalkonium chloride and polyhexamethylene guanidine are absent in comparative example 3, and the antibacterial performance is the worst;

in conclusion, the disinfectant wet tissue prepared by the invention has good antibacterial performance, and good practicability and production value.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The compound sterilizing wet tissue is characterized in that: the disinfection wet tissue is mainly made of composite non-woven fabrics, and disinfectant is soaked on the surfaces of the non-woven fabrics;

the disinfectant comprises the following raw materials: 55-65 parts of purified water, 3-5 parts of ethanol, 4-7 parts of an active agent, 3-4 parts of a humectant, 2-4 parts of an aromatic, 1-3 parts of an aloe extract and 0.4-0.6 part of citric acid by weight;

the active agent comprises, by weight, 1-2 parts of benzalkonium chloride, 2-3 parts of phosphomolybdotungstic heteropoly acid and 1-2 parts of polyhexamethylene guanidine; the humectant comprises 1-1.5 parts by weight of glycerol and 2-2.5 parts by weight of butanediol; the aromatic comprises, by weight, 1-2 parts of peppermint oil and 1-2 parts of essence.

2. The compound sterilizing wet wipe as set forth in claim 1, wherein: the composite non-woven fabric comprises a spunlace non-woven fabric and a melt-blown non-woven fabric, and the composite non-woven fabric is prepared by hot-pressing and compounding the spunlace non-woven fabric and the melt-blown non-woven fabric.

3. The compound sterilizing wet wipe as set forth in claim 2, wherein: the spunlace non-woven fabric is mainly prepared from viscose fibers and polyester fibers.

4. The compound sterilizing wet wipe as set forth in claim 2, wherein: the melt-blown non-woven fabric is polypropylene.

5. The compound sterilizing wet wipe as set forth in claim 1, wherein: the phosphomolybdic tungstic heteropoly acid is mainly prepared from disodium hydrogen phosphate, sodium molybdate and sodium tungstate.

6. The method for preparing the compound sterilizing wet tissue as claimed in claim 1, wherein the method comprises the following steps: the preparation method of the disinfectant wet tissue comprises the following steps: the method comprises the following steps:

s4: mixing the solution A and the solution B to prepare a disinfectant;

7. The method for preparing a compound sterilizing wet wipe as claimed in claim 6, wherein the method comprises the following steps:

the S1: putting disodium hydrogen phosphate into deionized water, stirring uniformly, heating in a water bath, adding concentrated sulfuric acid, adjusting pH, stirring uniformly, adding sodium molybdate, stirring uniformly, cooling to room temperature, adding sodium tungstate, stirring uniformly, standing for a period of time, dropwise adding diethyl ether while stirring, continuing for a period of time, separating liquid, and drying for a period of time to obtain phosphomolybdotungstic heteropoly acid;

the S2: mixing ethanol with 1/2% purified water, adding phosphomolybdotungstic heteropoly acid, benzalkonium chloride and polyhexamethylene guanidine, heating in water bath, stirring, and ultrasonically dispersing for a period of time to obtain solution A;

the S3: mixing the remaining 1/2 amounts of purified water with glycerol, butanediol, oleum Menthae Dementholatum, essence, Aloe extract, and citric acid, water bathing, stirring, and ultrasonically dispersing for a while to obtain solution B;

the S4: mixing the solution A and the solution B, heating in a water bath, and uniformly stirring to obtain a disinfectant;

the S5: mixing viscose fibers and polyester fibers, and carrying out spunlace to obtain spunlace non-woven fabrics; melt-blowing polypropylene fiber to prepare melt-blown non-woven fabric; hot-pressing, compounding and bonding the spunlace non-woven fabric and the melt-blown non-woven fabric into a composite non-woven fabric;

the S6: and cutting the composite non-woven fabric on a machine table, folding, immersing in disinfectant, soaking for 5 hours, taking out, and packaging to obtain the disinfectant wet tissue.

8. The method for preparing a compound sterilizing wet wipe as claimed in claim 7, wherein the method comprises the following steps:

the S1: placing disodium hydrogen phosphate into deionized water, mechanically stirring for 20-30 min, heating in a water bath to 40 ℃, adding concentrated sulfuric acid, adjusting the pH to 1.5, mechanically stirring for 10-15 min, adding sodium molybdate, mechanically stirring for 20-30 min, cooling to room temperature, adding sodium tungstate, mechanically stirring for 20-30 min, standing for 2h, dropwise adding diethyl ether while stirring, keeping for 2min, separating liquid, placing the lower-layer liquid into an oven, and drying at 40 ℃ for 3h to obtain phosphomolybdotungstic heteropoly acid;

the S2: mixing ethanol with 1/2% purified water, adding phosphomolybdotungstic heteropoly acid, benzalkonium chloride and polyhexamethylene guanidine, heating to 30 ℃ in a water bath, mechanically stirring for 20-30 min, and ultrasonically dispersing for 10-15 min to obtain a solution A;

the S3: mixing the remaining 1/2 amounts of purified water with glycerol, butanediol, peppermint oil, essence, aloe extract and citric acid, heating to 55 ℃ in a water bath, mechanically stirring for 5-10 min, and ultrasonically dispersing for 3-5 min to obtain a solution B;

the S4: mixing the solution A and the solution B, heating the mixture to 40 ℃ in a water bath, and mechanically stirring the mixture for 15-25 min to prepare a disinfectant;

the S6: and cutting the composite non-woven fabric on a machine table, folding, immersing in disinfectant, and packaging after immersion to obtain the disinfectant wet tissue.