CN111387217A - Preparation method of disinfectant - Google Patents
Preparation method of disinfectant Download PDFInfo
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- CN111387217A CN111387217A CN202010221999.8A CN202010221999A CN111387217A CN 111387217 A CN111387217 A CN 111387217A CN 202010221999 A CN202010221999 A CN 202010221999A CN 111387217 A CN111387217 A CN 111387217A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
Abstract
The invention relates to the technical field of disinfectant preparation, in particular to a preparation method of a disinfectant. The method comprises the following steps: adding N-alkyl propylamine glycine and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8. The N-alkyl propylamine glycine amphoteric surfactant is used as a main raw material, the product quality and stability are improved through a reliable and stable formula adjustment mode, the prepared disinfectant is clear in appearance and good in stability, and meanwhile, the sterilization and bacteriostasis effects of the N-alkyl propylamine glycine can be optimal.
Description
Technical Field
The invention relates to the technical field of disinfectant preparation, in particular to a preparation method of a disinfectant.
Background
The disinfectant is used for killing pathogenic microorganisms on a transmission medium, so that the requirement of harmlessness is met, the pathogenic microorganisms are killed out of a human body, the transmission path of infectious diseases is cut off, and the purpose of controlling the infectious diseases is achieved. The disinfectant can be divided into a sterilizing agent, a high-efficiency disinfectant, a middle-efficiency disinfectant and a low-efficiency disinfectant according to the action level. The sterilizing agent can kill all microorganisms to meet the sterilizing requirement, and comprises formaldehyde, glutaraldehyde, ethylene oxide, peracetic acid, hydrogen peroxide, chlorine dioxide, chlorine, copper sulfate, quicklime, ethanol and the like. The high-efficiency disinfectant can kill all bacteria propagules (including mycobacteria), viruses, fungi, spores thereof and the like, has a certain killing effect on bacterial spores, meets the requirement of high-level disinfection, and comprises chlorine-containing disinfectant, ozone, methyl hydantoin compounds, double-chain quaternary ammonium salt and the like. The intermediate disinfectant can only kill microbes such as mycobacteria, fungi, viruses, bacterial propagules and the like, meets the disinfection requirement and comprises iodine-containing disinfectant, alcohol disinfectant, phenol disinfectant and the like. The low-efficiency disinfectant can only kill bacteria propagules and lipophilic viruses to meet the requirements of the disinfectant, and comprises quaternary ammonium salt disinfectants such as benzalkonium bromide and the like, biguanide disinfectants such as chlorhexidine (chlorhexidine) and the like, metal ion disinfectants such as mercury, silver, copper and the like and Chinese herbal medicine disinfectants.
N-alkyl propylamine glycine is an amphoteric surfactant, has excellent bactericidal and bacteriostatic properties, has the best effect at the pH value of 6-9.5, and is further preferably 7.5-8.5, so when the disinfectant taking the N-alkyl propylamine glycine amphoteric surfactant as a main raw material is produced, the pH value is frequently required to be adjusted. The pH of N-alkyl propylamino glycine is usually adjusted by an alkali solution, however, when the pH is more than 8, turbidity easily occurs, white floc is generated, and precipitate is generated. In order to eliminate the precipitation, the pH value is reduced by adding conventional acidic substances, but the pH value of the solution is adjusted by general acid-base equilibrium, so that the instability of the system is easily caused, turbidity is generated, and the precipitation phase separation is carried out. In the actual production process, the pH fluctuation is influenced by the feeding process, the raw material batch and the like. The pH fluctuation is easy to generate turbidity and precipitation phenomena. Aiming at the problems, the invention aims to provide a preparation method of the disinfectant, which takes an N-alkyl propylamine glycine amphoteric surfactant as a main raw material, improves the quality and stability of products through a reliable and stable formula adjustment mode, reduces the risk of unqualified products in large batches in production, and solves the problem that the whole batch of products need to be scrapped due to the generation of white precipitates; meanwhile, the sterilization and bacteriostasis effects of the product can reach the best.
Disclosure of Invention
When the disinfectant taking the N-alkyl propylamine glycine amphoteric surfactant as the main raw material is produced, in order to enable the N-alkyl propylamine glycine to play a good sterilization and bacteriostasis effect, the pH value of the mixture is adjusted by sodium hydroxide. However, when the pH of the mixture is adjusted to a value higher than 8 by adding sodium hydroxide, turbidity and precipitation are liable to occur. In order to eliminate the precipitation, an acid is usually added to the system to adjust the pH, however, the mixture cannot be adjusted to a clear and transparent state by adding a common acid, and 1 ton or 2 tons of the product are discarded in production. In order to solve the problems, the invention can eliminate the precipitate by adding the disodium ethylene diamine tetraacetate to adjust the pH value to 7.5-8, so that the mixture becomes clear, the product quality and the stability are improved, the risk of unqualified products in large batches in production is reduced, and the problem that the whole batch of products needs to be scrapped due to the generation of white precipitate is solved.
The specific invention content is as follows:
in a first aspect of the invention, there is provided a method of preparing a disinfectant, comprising the steps of: adding N-alkyl propylamine glycine and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
As a preferable technical scheme, the method comprises the following steps: adding N-alkyl propylamine glycine, an alcohol compound, a humectant and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
As a preferable technical scheme, the method comprises the following steps: adding N-alkyl propylamine glycine, an antibacterial agent, a bacteriostatic agent, an alcohol compound, a humectant and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
As a preferable technical solution, the metal in the metal hydroxide is an alkali metal.
In a preferred embodiment, the alkali metal is at least one selected from sodium, potassium, and lithium.
In a preferred embodiment, the auxiliary agent is at least one selected from disodium ethylenediamine tetraacetic acid, tetrasodium glutamate diacetate, and trisodium methylglycine diacetate.
In a preferred embodiment, the modifier is at least one selected from the group consisting of citric acid, succinic acid, cresylic acid, dodecylbenzenesulfonic acid, phosphoric acid, salicylic acid, sorbic acid, sulfamic acid, acetic acid, benzoic acid, boric acid, capric acid, caproic acid, cyanuric acid, dihydroacetic acid, dimethylaminosulfonic acid, propionic acid, malonic acid, polyacrylic acid, 2-ethyl-caproic acid, fumaric acid, alanine, glutamic acid, glycine, isopropylaminosulfonic acid, naphthenic acid, oxalic acid, phosphoric acid, valeric acid, benzenesulfonic acid, xylenesulfonic acid, sulfonic acid, maleic acid, acetic acid, adipic acid, lactic acid, butyric acid, succinic acid, gluconic acid, malic acid, tartaric acid, glycolic acid, ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate, and iminodiacetic acid.
In a preferred embodiment, the alcohol compound is at least one selected from ethanol, ethylene glycol, cyclohexanol, and isopropanol.
In a preferred embodiment, the humectant is at least one selected from the group consisting of 1, 2-propanediol, 1, 3-propanediol, triethylene glycol, glycerin, and butylene glycol.
As a preferred technical solution, the plant bacteriostatic agent is at least one selected from the group consisting of a folium Ilicis Purpureae extract, a begonia extract, an ivy extract, a nettle extract, a senecio scandens extract, a honeysuckle flower extract, a patchouli extract, a cinnamon extract, an Usnea barbata extract, and a gentian flower extract.
Has the advantages that: the invention provides a preparation method of a disinfectant, which takes N-alkyl propylamine glycine amphoteric surfactant as a main raw material, improves the product quality and stability by a reliable and stable formula adjustment mode, and the prepared disinfectant has clear appearance and good stability, and simultaneously, the sterilization and bacteriostasis effects of the N-alkyl propylamine glycine can reach the best.
Detailed Description
The technical features in the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, but the scope of protection of the present invention is not limited thereto.
"preferred", "more preferred", and the like, in the present invention, refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
In a first aspect of the invention, there is provided a method of preparing a disinfectant, comprising the steps of: adding N-alkyl propylamine glycine and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
In a preferred embodiment, the method comprises the following steps: adding N-alkyl propylamine glycine, an alcohol compound, a humectant and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
In a preferred embodiment, the method comprises the following steps: adding N-alkyl propylamine glycine, an antibacterial agent, a bacteriostatic agent, an alcohol compound, a humectant and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
N-alkyl propylamino glycine
The N-alkyl propylamine glycine is an amphoteric surfactant, is safe to human bodies and environment, has no stimulation to skin, high efficiency, no toxicity, cleanness, wetting, no corrosiveness and easy biodegradability, has excellent sterilization and bacteriostasis performance, and also has good sterilization efficiency at low temperature. When the pH value of the N-alkyl propylamine glycine is 6-9.5, the sterilization and bacteriostasis effects are optimal.
The N-alkyl propylamino glycine is purchased from Shanghai Special chemical (Shanghai) Co., Ltd and has the model of REWOCID WK 30.
Antibacterial agent
In a preferred embodiment, the antimicrobial agent is a quaternary ammonium salt antimicrobial agent.
In a preferred embodiment, the quaternary ammonium salt based antibacterial agent is selected from at least one of benzalkonium chloride, benzalkonium bromide, benzalkonium chloride, dodecyltrimethyl ammonium chloride, dodecyldimethylbenzyl ammonium bromide, didecyldimethyl ammonium chloride, and alkyldimethylbenzyl ammonium chloride.
In a preferred embodiment, the quaternary ammonium based antibacterial agent is benzalkonium chloride.
Bacteriostatic agent
In a preferred embodiment, the bacteriostatic agent is a plant bacteriostatic agent.
In a preferred embodiment, the plant bacteriostatic agent is selected from at least one of folium Ilicis Purpureae extract, begonia extract, caulis Hederae sinensis extract, herba Urticae Cannabinae extract, herba Senecionis Scandentis extract, flos Lonicerae extract, herba Agastaches extract, cortex Cinnamomi extract, Usnea barbata extract, and flos Gentianae extract.
In a more preferred embodiment, the plant bacteriostatic agent is a mixture of patchouli extract, cinnamon extract, usnea barbata extract, gentian flower extract.
The plant bacteriostatic agent is purchased from Shanghai Gayu Biotech limited company, and has the following types: a plant bacteriostatic agent YDH.
Alcohol compounds
In a preferred embodiment, the alcohol compound is at least one selected from ethanol, ethylene glycol, cyclohexanol, and isopropanol.
In a more preferred embodiment, the alcohol compound is ethanol.
Moisture-retaining agent
The moisturizer is a cosmetic raw material with the functions of moisturizing and repairing sebum membranes, and the raw material has a special molecular structure, can adsorb and retain moisture, and maintains the skin barrier function while maintaining the skin hydration.
In a preferred embodiment, the humectant is selected from at least one of 1, 2-propanediol, 1, 3-propanediol, triethylene glycol, glycerol, butylene glycol.
In a more preferred embodiment, the humectant is 1, 2-propylene glycol.
Metal hydroxides
In a preferred embodiment, the metal of the metal hydroxide is an alkali metal.
In a preferred embodiment, the alkali metal is selected from at least one of sodium, potassium, lithium.
In a more preferred embodiment, the metal oxide is sodium hydroxide.
In order to enable the N-alkyl propylamine glycine to exert a good sterilization and bacteriostasis effect, the pH value of the mixture is adjusted through sodium hydroxide. However, the applicants have unexpectedly found that when the pH of the mixture is adjusted to a value greater than 8 by the addition of sodium hydroxide, turbidity tends to occur and even a white precipitate tends to occur.
Conditioning agents
In a preferred embodiment, the modulator is selected from at least one of citric acid, succinic acid, cresylic acid, dodecylbenzenesulfonic acid, phosphoric acid, salicylic acid, sorbic acid, sulfamic acid, acetic acid, benzoic acid, boric acid, capric acid, caproic acid, cyanuric acid, dihydroacetic acid, dimethylaminesulfonic acid, propionic acid, malonic acid, polyacrylic acid, 2-ethyl-caproic acid, fumaric acid, alanine, glutamic acid, glycine, isopropylaminosulfonic acid, naphthenic acid, oxalic acid, phosphoric acid, valeric acid, benzenesulfonic acid, xylenesulfonic acid, sulfonic acid, maleic acid, acetic acid, adipic acid, lactic acid, butyric acid, succinic acid, gluconic acid, malic acid, tartaric acid, glycolic acid, ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate, iminodiacetic acid.
In a preferred embodiment, the modulator is disodium edetate.
In order to eliminate the precipitation, an acid is usually added to the system to adjust the pH, however, the applicants have found that the mixture cannot be adjusted to a clear and transparent state by adding a common acid such as citric acid or the like. The acid needs to be added permanently to a pH below about 4.0. However, if the alkali is added continuously, the pH value is more than 11, the white floccule can be dissolved, the turbidity is removed, and the clarification is recovered, so that the sterilization and bacteriostasis effects of the N-alkyl propylamine glycine can not be achieved, and the clear state of the system can not be maintained.
In the research and development process, the applicant unexpectedly finds that the precipitate can be eliminated by adding disodium ethylene diamine tetraacetate to adjust the pH value to 7.5-8, so that the mixture becomes clear, the sterilization and bacteriostasis effects of the N-alkyl propylamine glycine can reach the best, the prepared disinfectant has excellent high and low temperature stability, and the phenomena of layering, discoloration, precipitation and the like can not occur when the disinfectant is stored for 3 months at the temperature of-8 ℃, room temperature and 50 ℃.
In addition, the applicant finds that when tetrasodium glutamate diacetate is used as an auxiliary agent, sodium hydroxide is added to adjust the pH value of the mixture to be more than 8, turbidity and precipitation phenomena occur, and the mixture can still be clarified by further adding disodium ethylene diamine tetraacetate to adjust the pH value to be 7.5-8; when the trisodium methylglycinediacetate is used as an auxiliary agent, sodium hydroxide is added to adjust the pH value of the mixture to be more than 8, turbidity and precipitation phenomena occur, and more white precipitates are generated by further adding disodium ethylenediamine tetraacetic acid to adjust the pH value to be 7.5-8.
Hereinafter, the present invention will be described in more detail by way of examples, but it should be understood that these examples are merely illustrative and not restrictive. In addition, all the raw materials are commercially available if not particularly limited.
Examples
Example 1
Embodiment 1 of the present invention provides a method for preparing a disinfectant, including the steps of: adding 1 weight part of N-alkyl propylamine glycine, 0.5 weight part of benzalkonium chloride, 0.5 weight part of plant bacteriostatic agent YDH, 0.1 weight part of disodium ethylene diamine tetraacetate, 2 weight parts of ethanol and 2 weight parts of 1, 2-propylene glycol into 93.9 weight parts of water, mixing, adding sodium hydroxide, and adjusting the pH value of the mixture to 8.5.
Example 2
Embodiment 2 of the present invention provides a method for preparing a disinfectant, comprising the steps of: adding 1 weight part of N-alkyl propylamine glycine, 0.5 weight part of benzalkonium chloride, 0.5 weight part of plant bacteriostatic agent YDH, 0.1 weight part of disodium ethylene diamine tetraacetate, 2 weight parts of ethanol and 2 weight parts of 1, 2-propylene glycol into 93.9 weight parts of water, mixing, adding sodium hydroxide, adjusting the pH value of the mixture to 8.5, and then adding disodium ethylene diamine tetraacetate to adjust the pH value to 8.
Example 3
Embodiment 3 of the present invention provides a method for preparing a disinfectant, comprising the steps of: adding 1 weight part of N-alkyl propylamine glycine, 0.5 weight part of benzalkonium chloride, 0.5 weight part of plant bacteriostatic agent YDH, 0.1 weight part of disodium ethylene diamine tetraacetate, 2 weight parts of ethanol and 2 weight parts of 1, 2-propylene glycol into 93.9 weight parts of water, mixing, adding sodium hydroxide, adjusting the pH value of the mixture to 8.5, and then adding citric acid to adjust the pH value to 8.
Example 4
Embodiment 4 of the present invention provides a method for preparing a disinfectant, comprising the steps of: adding 1 weight part of N-alkyl propylamine glycine, 0.5 weight part of benzalkonium chloride, 0.5 weight part of plant bacteriostatic agent YDH, 0.4 weight part of tetrasodium glutamate diacetate, 2 weight parts of ethanol and 2 weight parts of 1, 2-propylene glycol into 93.9 weight parts of water, mixing, adding sodium hydroxide, and adjusting the pH value of the mixture to 8.5.
Example 5
Embodiment 5 of the present invention provides a method for preparing a disinfectant, comprising the steps of: adding 1 weight part of N-alkyl propylamine glycine, 0.5 weight part of benzalkonium chloride, 0.5 weight part of plant bacteriostatic agent YDH, 0.4 weight part of tetrasodium glutamate diacetate, 2 weight parts of ethanol and 2 weight parts of 1, 2-propylene glycol into 93.9 weight parts of water, mixing, adding sodium hydroxide, adjusting the pH value of the mixture to 8.5, and then adding disodium ethylene diamine tetraacetate to adjust the pH value to 8.
Example 6
Embodiment 6 of the present invention provides a method for preparing a disinfectant, comprising the steps of: adding 1 weight part of N-alkyl propylamine glycine, 0.5 weight part of benzalkonium chloride, 0.5 weight part of plant bacteriostatic agent YDH, 0.4 weight part of trisodium methylglycinediacetate, 2 weight parts of ethanol and 2 weight parts of 1, 2-propylene glycol into 93.9 weight parts of water, mixing, adding sodium hydroxide, and adjusting the pH value of the mixture to 8.5.
Example 7
Embodiment 7 of the present invention provides a method for preparing a disinfectant, comprising the steps of: adding 1 weight part of N-alkyl propylamine glycine, 0.5 weight part of benzalkonium chloride, 0.5 weight part of plant bacteriostatic agent YDH, 0.4 weight part of trisodium methylglycinediacetate, 2 weight parts of ethanol and 2 weight parts of 1, 2-propylene glycol into 93.9 weight parts of water, mixing, adding sodium hydroxide, adjusting the pH value of the mixture to 8.5, and then adding disodium ethylenediamine tetraacetic acid to adjust the pH value to 8.
Performance evaluation
1. Appearance evaluation
The disinfectants were prepared by the preparation methods of the disinfectants described in examples 1 to 7, respectively, and the stability of the appearance of the disinfectants prepared was observed, and the evaluation criteria were as follows: good-clear; poor turbidity with precipitation.
2. High and Low temperature stability
The disinfectants prepared by the preparation method of the disinfectants described in the examples 1 to 7 are respectively filled in 100ml transparent plastic bottles and are respectively placed in the environment of-8 ℃, room temperature and 50 ℃ for continuous observation for 3 months. And (4) judging the standard: good-no phenomena such as layering, color change, precipitation and the like; poor-delamination or discoloration or precipitation phenomena.
The results are shown in Table 1.
TABLE 1 appearance and high and Low temperature stability test results
According to experimental results, the disinfectant prepared by the preparation method disclosed by the invention is clear in appearance and good in stability, and can not be layered, discolored, precipitated and the like after being stored for 3 months at the temperature of-8 ℃, room temperature and 50 ℃; meanwhile, the N-alkyl propylamine glycine has the best sterilization and bacteriostasis effects.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. The use of some numerical ranges in the claims also includes sub-ranges within their range, and variations in these ranges are also to be construed as being covered by the appended claims where possible.
Claims (10)
1. The preparation method of the disinfectant is characterized by comprising the following steps: adding N-alkyl propylamine glycine and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
2. A method of preparing a disinfectant as claimed in claim 1, comprising the steps of: adding N-alkyl propylamine glycine, an alcohol compound, a humectant and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
3. A method of preparing a disinfectant as claimed in claim 2, comprising the steps of: adding N-alkyl propylamine glycine, an antibacterial agent, a bacteriostatic agent, an alcohol compound, a humectant and an auxiliary agent into water, mixing, adding a metal hydroxide, adjusting the pH value of the mixture to be more than 8, and then adding an adjusting agent to adjust the pH value to 7.5-8.
4. A process for the preparation of a disinfectant as claimed in any of claims 1 to 3, wherein the metal of said metal hydroxide is an alkali metal.
5. The method for producing disinfectant according to claim 4, wherein said alkali metal is at least one selected from the group consisting of sodium, potassium, and lithium.
6. A process for the preparation of a disinfectant as claimed in any of claims 1 to 3, wherein said adjuvant is selected from at least one of disodium edetate, tetrasodium glutamate diacetate, trisodium methylglycine diacetate.
7. A method of producing a disinfectant as set forth in any of claims 1-3, wherein said modifier is selected from at least one of citric acid, succinic acid, cresylic acid, dodecylbenzenesulfonic acid, phosphoric acid, salicylic acid, sorbic acid, sulfamic acid, acetic acid, benzoic acid, boric acid, capric acid, caproic acid, cyanuric acid, dihydroacetic acid, dimethylaminesulfonic acid, propionic acid, malonic acid, polyacrylic acid, 2-ethyl-hexanoic acid, fumaric acid, alanine, glutamic acid, glycine, isopropylaminosulfonic acid, naphthenic acid, oxalic acid, phosphoric acid, valeric acid, benzenesulfonic acid, xylenesulfonic acid, sulfonic acid, maleic acid, acetic acid, adipic acid, lactic acid, butyric acid, succinic acid, gluconic acid, malic acid, tartaric acid, glycolic acid, ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate, iminodiacetic acid.
8. The method for producing a disinfectant according to claim 2 or 3, wherein said alcohol compound is at least one selected from the group consisting of ethanol, ethylene glycol, cyclohexanol, and isopropyl alcohol.
9. The method for preparing a disinfectant according to claim 2 or 3, wherein said humectant is at least one selected from the group consisting of 1, 2-propanediol, 1, 3-propanediol, triethylene glycol, glycerin, and butanediol.
10. The method of claim 3, wherein the plant bacteriostatic agent is at least one selected from the group consisting of a folium Ilicis Purpureae extract, a begonia extract, an ivy extract, a nettle extract, a senecio extract, a honeysuckle flower extract, a patchouli extract, a cinnamon extract, an Usnea barbata extract, and a gentian flower extract.
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| CN112251300A (en) * | 2020-10-26 | 2021-01-22 | 深圳全棉时代科技有限公司 | Cleaning composition and cleaning wet tissue and application thereof |
| CN113545363A (en) * | 2021-07-23 | 2021-10-26 | 广东环凯生物技术有限公司 | Double-component chlorine dioxide disinfectant and preparation method and use method thereof |
| CN114306096A (en) * | 2021-12-30 | 2022-04-12 | 福建恒安集团有限公司 | Anti-influenza virus wet tissue and preparation method thereof |
| CN115109665A (en) * | 2022-07-29 | 2022-09-27 | 成都汉德尔新材料有限公司 | Safe and environment-friendly disinfection and sterilization laundry detergent and preparation method thereof |
-
2020
- 2020-03-26 CN CN202010221999.8A patent/CN111387217A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112251300A (en) * | 2020-10-26 | 2021-01-22 | 深圳全棉时代科技有限公司 | Cleaning composition and cleaning wet tissue and application thereof |
| CN112251300B (en) * | 2020-10-26 | 2021-11-23 | 深圳全棉时代科技有限公司 | Cleaning composition and cleaning wet tissue and application thereof |
| CN113545363A (en) * | 2021-07-23 | 2021-10-26 | 广东环凯生物技术有限公司 | Double-component chlorine dioxide disinfectant and preparation method and use method thereof |
| CN114306096A (en) * | 2021-12-30 | 2022-04-12 | 福建恒安集团有限公司 | Anti-influenza virus wet tissue and preparation method thereof |
| CN114306096B (en) * | 2021-12-30 | 2023-08-15 | 福建恒安集团有限公司 | Influenza virus resistant wet tissue and preparation method thereof |
| CN115109665A (en) * | 2022-07-29 | 2022-09-27 | 成都汉德尔新材料有限公司 | Safe and environment-friendly disinfection and sterilization laundry detergent and preparation method thereof |
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