CN113244122B - Two-component essence cream - Google Patents
Two-component essence cream Download PDFInfo
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- CN113244122B CN113244122B CN202110279532.3A CN202110279532A CN113244122B CN 113244122 B CN113244122 B CN 113244122B CN 202110279532 A CN202110279532 A CN 202110279532A CN 113244122 B CN113244122 B CN 113244122B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A61K8/88—Polyamides
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- A61Q19/00—Preparations for care of the skin
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- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
- C08F220/606—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen and containing other heteroatoms
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- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
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Abstract
The invention discloses a two-component essence cream. The composition is divided into A, B components, wherein the A component is aqueous solution of active ingredient, and the B component is oily solution of active ingredient. Wherein the active component in the component A is a water-soluble polymer, which is prepared by polymerizing a plurality of active monomers through free radicals, and also comprises ceramide, pantothenic acid and beta-glucose, and the rest component is ultrapure water. Wherein the component B comprises oil-soluble active polymer, anti-sensitive active peptide, alcohol substance, thickener and emulsifier. Can be mixed and used in any proportion, so that the user can balance the requirements on moisture retention and oil-free, and the brand of the cosmetics do not need to be replaced due to season change.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to a two-component essence cream.
Background
Female consumers are taken as target customer groups or marketing objects to become the consensus of merchants, so that the female consumers play more and more important roles in economic life in the world at present, the marketing strategies meeting the maximum benefits can be made in time for enterprises by researching female consumption behaviors, and guidance is provided for the merchants to develop the economic strength. The female consumption behavior is not only simple purchasing activity, but also complex behavior formed by the comprehensive action of various factors under a certain historical culture background. The female cosmetic consumer market, especially the urban female cosmetic consumer market, is a broad market with great potential.
The cosmetic industry in China is popular in the 80 th century and is rapidly developed in the 90 th century. In particular, since 1997, the average annual sales of the cosmetics industry has increased by more than 10%, the average annual profit margin has also increased by more than 10%, and some years have even reached 20%. China has two-bit increase in the global sales ranking of cosmetics in 2006, surpasses France and Germany, and has become the third global cosmetic market at present.
Nowadays, young women prefer to do DIY by themselves and can grasp their skin by themselves. At present, no product can meet the requirements of the brand, and brand parties can quit products with different brands to deal with different season conditions, but bottle cans and bottles are more and more.
Disclosure of Invention
In order to solve the problems, the invention discloses a two-component essence cream which is divided into A, B components, wherein the A component is an aqueous solution of active ingredients, and the B component is an oily solution of the active ingredients.
As a further scheme of the two-component essence cream, the component A specifically comprises the following components: 0.1-3% of water-soluble active polymer, 0.05-3% of ceramide, 0.1-3% of pantothenic acid, 0.1-5% of beta-glucose and the balance of ultrapure water.
As a further scheme of the two-component essence cream, all raw materials in the component A are pharmaceutical grade, and meet the use standard of cosmetic raw materials.
As a further scheme of the two-component essence cream, the component B specifically comprises the following components: 5-10% of oil-soluble active polymer, 5-10% of anti-allergic active peptide, 80-95% of alcohol substance, 1-5% of thickening agent and 1-5% of emulsifier.
As a further scheme of the two-component essence cream, the structure of the water-soluble active polymer in the component A is as follows:
as a further scheme of the two-component essence facial cream, the preparation method of the water-soluble active polymer structure in the component A comprises the following steps:
(1) adding a certain amount of pharmaceutical grade salicylic acid and a certain amount of pharmaceutical grade glycidyl methacrylate into a reactor, and continuously reacting until the epoxy group is completely reacted to obtain an intermediate A;
(2) adding a certain amount of the intermediate A, a certain amount of medical grade acryloyl dimethyl ammonium taurate, a certain amount of medical grade vinyl pyrrolidone and a certain amount of pretreated azobisisobutyronitrile into ethyl acetate, and uniformly stirring;
(3) dropwise adding the liquid obtained in the step (2) into a reactor at the temperature of 60-80 ℃, carrying out free radical polymerization, and carrying out heat preservation reaction after dropwise adding is finished;
(4) the polymer solution was passed through an electronic grade silica gel column. (ii) a
(5) Slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring;
(6) filtering to obtain precipitate particles, and repeating the step (5) for more than three times.
As a further scheme of the preparation method of the water-soluble active polymer structure in the component A, the addition ratio of the medical salicylic acid to the medical glycidyl methacrylate in the step (1) of the preparation method is a molar ratio, and the ratio of the medical salicylic acid to the medical glycidyl methacrylate is 1.05:1-1.2: 1.
Specifically, in step (1), it is necessary to ensure that the epoxy group in the pharmaceutical-grade glycidyl methacrylate is completely reacted.
As a further scheme of the preparation method of the water-soluble active polymer structure in the component A, the intermediate A, the medical-grade acryloyl dimethyl ammonium taurate and the medical-grade vinyl pyrrolidone in the step (2) of the preparation method account for 10-25% of the content of the intermediate A, 30-50% of the content of the medical-grade acryloyl dimethyl ammonium taurate and 30-50% of the content of the medical-grade vinyl pyrrolidone.
As a further scheme of the preparation method of the water-soluble active polymer structure in the component A, the pretreatment method of the azobisisobutyronitrile in the step (2) of the preparation method is to recrystallize by using medical grade ethanol for 2-3 times.
Specifically, the pretreatment method comprises the steps of adding 20g of azobisisobutyronitrile into 100g of ethanol, stirring at 60 ℃ until the azobisisobutyronitrile is completely dissolved, reducing the temperature of the system to 10 ℃, filtering to obtain azobisisobutyronitrile crystals, and repeating for 2-3 times to obtain the azobisisobutyronitrile required to be pretreated.
As a further scheme of the preparation method of the water-soluble active polymer structure in the component A, the electronic-grade silica gel column in the step (4) of the preparation method is a Merck 200-mesh silica gel column, and metal ions and small-molecule polymers in the system can be removed through the silica gel column.
As a further embodiment of the process for preparing a water-soluble living polymer structure in component A of the present invention, the amount of ethanol used in step (5) of the above-mentioned preparation process is 10 to 20 times that of the polymer solution.
As a further scheme of the two-component essence facial cream, the molecular weight Mw of the water-soluble active polymer in the component A is 50000-100000.
As a further scheme of the two-component essence cream, the structure of the oil-soluble active polymer in the component B is as follows:
as the structure of the oil-soluble active polymer in the component B, x in the structural formula is 10-18.
As the structure of the oil-soluble active polymer in the component B of the invention, R in the structural formula can be one or more of the following structures:
the preparation method of the oil-soluble active polymer structure in the component B comprises the following steps:
(1) adding a certain amount of long-chain alkane acid and a certain amount of glutamic acid into a reactor, and completely reacting at a certain temperature;
(2) adding the selected R group and a certain amount of solvent dipropylene glycol methyl ether into a system, and reacting under the catalysis of methanesulfonic acid until the reaction is complete;
(3) removing the catalyst by water washing;
(4) passing the polymer solution through an electronic grade silica gel column;
(5) slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring;
(6) filtering to obtain precipitate particles, and repeating the step (5) for more than three times.
As a further scheme of the preparation method of the oil-soluble active polymer structure in the component B, the addition amount of the long-chain alkane acid and the glutamic acid in the step (1) of the preparation method is 1:1.5-1:2 in a molar ratio.
As a further scheme of the preparation method of the oil-soluble active polymer structure in the component B, the adding proportion of the solvent dipropylene glycol methyl ether in the step (2) of the preparation method is 50 percent of the total mass.
As a further scheme of the preparation method of the oil-soluble active polymer structure in the component B, the water washing method in the step (3) of the preparation method is to use ultrapure water with the total mass of 1-1.5 times to mix and stir, then carry out liquid separation, separate off the water layer after the liquid separation is finished, and repeat the process for 3-4 times.
As a further scheme of the preparation method of the oil-soluble active polymer structure in the component B, in the step (4), the electronic-grade silica gel column is a Merck 200-mesh silica gel column, and metal ions and small-molecule polymers in the system can be removed through the silica gel column.
As a further embodiment of the process for preparing an oil-soluble living polymer structure in component B of the present invention, the amount of ethanol used in step (5) of the above-mentioned preparation process is 10 to 20 times the amount of the polymer solution.
As a further scheme of the two-component essence facial cream, the molecular weight Mw of the oil-soluble active polymer in the component B is 10000-50000.
As a further scheme of the two-component essence cream, the anti-allergy active peptide in the component B is one or more of acetyl tetrapeptide, acetyl dipeptide, acetyl hexapeptide and palmitoyl tripeptide.
As a further scheme of the two-component essence cream, the alcohol substance in the component B is one or a mixture of more of ethanol, diethylene glycol, 1, 3-propylene glycol, glycerol, butanediol, 1, 2-pentanediol, 1, 2-hexanediol and polyethylene glycol.
As a further scheme of the two-component essence cream, the thickening agent in the component B is carbomer, xanthan gum, cellulose and modified substances thereof, and starch modified phosphate.
As a further scheme of the two-component essence cream, the emulsifier in the component B is one or a mixture of more of monolaurate sorbitan ester, polyoxyethylene monolaurate sorbitan ester, monopalmitate sorbitan ester, polyoxyethylene monopalmitate sorbitan ester, glyceryl stearate, sucrose polystearate, polyglycerol distearate and coco glucoside.
As a further scheme of the using method of the two-component essence cream, the two-component essence cream can be self-prepared by a user according to the current weather condition and the self condition.
The technical scheme provided by the invention has the beneficial effects that:
the two active ingredients are added, so that basic problems of skin (such as sensitivity, dryness and acne) can be treated, skin water energy can be continuously provided for 120 hours, skin hydration is stimulated, and the active polymer can enhance the skin full-effect barrier and form the triple defense effect.
Meets the higher pursuit (such as fineness, whitening and aging resistance) of the user to the skin texture, and has faster starting speed and continuous and stable performance. The unique double-locked peptide bond can greatly enhance the bioavailability of the active substance, thereby meeting the target requirement.
The dual-component essence cream can balance the requirements of 'moisture retention' and 'oil-free' for users, and the brand of cosmetics do not need to be replaced due to season change.
Detailed description of the invention
The present invention will be further described below by way of specific examples.
In the following examples, those whose operations are not subject to the conditions indicated, are carried out according to the conventional conditions or conditions recommended by the manufacturer. The raw materials used in the scheme of the invention are purchased from Chinese medicine reagents and an Allantin reagent.
Synthesis example 1
Adding 20g of azobisisobutyronitrile into a conical flask containing 100g of ethanol, connecting a spherical condenser pipe on the conical flask, starting normal-temperature condensed water circulation, stirring the mixture in the conical flask at 60 ℃ by using a magnetic stirrer until the azobisisobutyronitrile is completely dissolved, removing a heat source, reducing the temperature of the system to 10 ℃, and filtering the mixture by using double-layer filter paper to obtain the azobisisobutyronitrile crystal.
Repeating for 2-3 times to obtain the azodiisobutyronitrile which needs to be pretreated.
Synthesis example 2
Adding 138g of pharmaceutical-grade salicylic acid and 142g of pharmaceutical-grade glycidyl methacrylate into a reactor, and continuously reacting at 50 ℃ until the epoxy group is completely reacted to obtain an intermediate A1;
20g of intermediate A1, 45g of pharmaceutical grade ammonium acryloyldimethyltaurate, 35g of pharmaceutical grade vinylpyrrolidone and 0.3g of pretreated azobisisobutyronitrile were added to 100g of ethyl acetate and stirred uniformly. Dropwise adding the liquid into a reactor, carrying out free radical polymerization at 70 ℃, and preserving heat at 70 ℃ for reaction for 2 hours after dropwise adding;
the column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring;
filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the water-soluble active polymer 1 in the component A.
Synthesis example 3
Adding 149g of pharmaceutical grade salicylic acid and 142g of pharmaceutical grade glycidyl methacrylate into a reactor, and continuously reacting at 50 ℃ until the epoxy group is completely reacted to obtain an intermediate A2;
15g of intermediate A2, 45g of pharmaceutical grade ammonium acryloyldimethyl taurate, 40g of pharmaceutical grade vinylpyrrolidone and 0.5g of pretreated azobisisobutyronitrile were added to 100g of ethyl acetate and stirred uniformly. Dropwise adding the liquid into a reactor, carrying out free radical polymerization at 70 ℃, and preserving heat at 70 ℃ for reaction for 2 hours after dropwise adding;
the column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring;
filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the water-soluble active polymer 2 in the component A.
Synthesis example 4
Adding 170g of pharmaceutical-grade salicylic acid and 142g of pharmaceutical-grade glycidyl methacrylate into a reactor, and continuously reacting at 50 ℃ until the epoxy group is completely reacted to obtain an intermediate A3;
25g of intermediate A3, 35g of pharmaceutical grade ammonium acryloyldimethyl taurate, 40g of pharmaceutical grade vinylpyrrolidone and 1g of pretreated azobisisobutyronitrile are added to 100g of ethyl acetate and stirred uniformly. Dropwise adding the liquid into a reactor, carrying out free radical polymerization at 70 ℃, and preserving heat at 70 ℃ for reaction for 2 hours after dropwise adding;
the column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring;
filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the water-soluble active polymer 3 in the component A.
Synthesis example 5
Adding 156g of pharmaceutical grade salicylic acid and 142g of pharmaceutical grade glycidyl methacrylate into a reactor, and continuously reacting at 50 ℃ until the epoxy group is completely reacted to obtain an intermediate A4;
10g of intermediate A4, 50g of pharmaceutical grade ammonium acryloyldimethyl taurate, 40g of pharmaceutical grade vinylpyrrolidone and 0.7g of pretreated azobisisobutyronitrile are added to 100g of ethyl acetate and stirred uniformly. Dropwise adding the liquid into a reactor, carrying out free radical polymerization at 70 ℃, and preserving heat at 70 ℃ for reaction for 2 hours after dropwise adding;
the column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring;
filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the water-soluble active polymer 4 in the component A.
Synthesis example 6
Adding 165g of pharmaceutical-grade salicylic acid and 142g of pharmaceutical-grade glycidyl methacrylate into a reactor, and continuously reacting at 50 ℃ until the epoxy group is completely reacted to obtain an intermediate A5;
25g of intermediate A5, 50g of pharmaceutical grade ammonium acryloyldimethyl taurate, 25g of pharmaceutical grade vinylpyrrolidone and 1.5g of pretreated azobisisobutyronitrile were added to 100g of ethyl acetate and stirred uniformly. Dropwise adding the liquid into a reactor, carrying out free radical polymerization at 70 ℃, and preserving heat at 70 ℃ for reaction for 2 hours after dropwise adding;
the column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring;
filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the water-soluble active polymer 5 in the component A.
Synthesis example 7
Adding 1 mol of myristic acid and 1.5 mol of glutamic acid into a reactor, and completely reacting at 50 ℃;
adding 0.5 mol of R1 group and 200g of solvent dipropylene glycol methyl ether into a system, adding 0.5g of methanesulfonic acid as a catalyst, and reacting at 80 ℃ until the reaction is complete;
adding 300g of ultrapure water into the system, mixing and stirring, then carrying out liquid separation, separating out a water layer after the liquid separation is finished, and repeating the process for 3-4 times.
The column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring; filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the oil-soluble active polymer 1 in the component B.
Synthesis example 8
1 mol of hexadecanoic acid and 1.7 mol of glutamic acid are added into a reactor and completely reacted at 50 ℃;
adding 0.7 mol of R2 group and 200g of solvent dipropylene glycol methyl ether into a system, adding 0.5g of methanesulfonic acid as a catalyst, and reacting at 80 ℃ until the reaction is complete;
adding 300g of ultrapure water into the system, mixing and stirring, then carrying out liquid separation, separating out a water layer after the liquid separation is finished, and repeating the process for 3-4 times.
The column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring; filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the oil-soluble active polymer 2 in the component B.
Synthesis example 9
1 mol of octadecanoic acid and 2 mol of glutamic acid are added into a reactor and completely reacted at 50 ℃;
adding 1 mol of R3 group and 200g of solvent dipropylene glycol methyl ether into a system, adding 0.5g of methanesulfonic acid as a catalyst, and reacting at 80 ℃ until the reaction is complete;
adding 300g of ultrapure water into the system, mixing and stirring, then carrying out liquid separation, separating out a water layer after the liquid separation is finished, and repeating the process for 3-4 times.
The column was packed with 50g of merck 200 mesh silica gel and the resulting polymer solution was subjected to column chromatography;
slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring; filtering to obtain precipitate particles, and repeatedly treating with pharmaceutical grade ethanol for more than three times. Finally obtaining the oil-soluble active polymer 3 in the component B.
Example 1:
3g of water-soluble living polymer 1, 0.5g of ceramide, 1g of pantothenic acid, 4g of. beta. -glucose and 91.5g of ultrapure water were charged into a reactor and stirred uniformly at 5 ℃ to obtain component A.
Adding 7g of oil-soluble active polymer 1, 5g of anti-allergic active peptide acetyl tetrapeptide, 2g of palmitoyl tripeptide, 40g of 1, 2-pentanediol, 40g of glycerol, 3g of thickening agent carbomer and 3g of emulsifier polyoxyethylene monolaurate sorbitan ester into a reactor, and uniformly stirring at 5 ℃ to obtain a component B.
Example 2:
2g of water-soluble living polymer 2, 1.5g of ceramide, 2g of pantothenic acid, 5g of. beta. -glucose and 88.5g of ultrapure water were charged into a reactor, and stirred uniformly at 5 ℃ to obtain component A.
7g of oil-soluble active polymer 2, 3g of anti-allergy active peptide acetyl dipeptide, 5g of palmitoyl tripeptide, 34g of 1, 2-pentanediol, 10g of diethylene glycol, 15g of ethanol, 20g of glycerol, 3g of thickener cellulose and a modified substance thereof and 3g of emulsifier coco glucoside are added into a reactor and stirred uniformly at 5 ℃ to obtain a component B.
Example 3:
1.5g of water-soluble living polymer 3, 1.5g of water-soluble living polymer 4, 2g of ceramide, 2.5g of pantothenic acid, 3g of. beta. -glucose and 89.5g of ultrapure water were charged into a reactor, and stirred uniformly at 5 ℃ to obtain component A.
Adding 10g of oil-soluble active polymer 3, 5g of anti-allergy active peptide acetyl tetrapeptide, 3g of acetyl hexapeptide, 20g of 1, 2-hexanediol, 10g of ethanol 36g of 1, 3-propylene glycol, 3g of thickener carbomer and 3g of emulsifier coco glucoside into a reactor, and uniformly stirring at 5 ℃ to obtain a component B.
Example 4:
3g of water-soluble living polymer 5, 0.5g of ceramide, 2g of pantothenic acid, 2g of. beta. -glucose and 92.5g of ultrapure water were charged into a reactor, and stirred uniformly at 5 ℃ to obtain component A.
10g of oil-soluble active polymer 1, 5g of anti-allergy active peptide acetyl tetrapeptide, 5g of palmitoyl tripeptide, 25g of 1, 2-pentanediol, 10g of polyethylene glycol 200, 5g of ethanol, 40g of glycerol, 3g of thickener xanthan gum and 3g of emulsifier sucrose polystearate are added into a reactor and stirred uniformly at 5 ℃ to obtain a component B.
The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
The human skin closed patch test was performed according to the human skin patch test specified in the technical standards for cosmetic safety (2015 edition).
The patch tester with the test substance is applied to the skin of the back of the subject for 24 hours. When the test substance is a cosmetic product, the control well is a blank control (containing no substance), and when the test substance is a diluted cosmetic, the diluent of the cosmetic is used in the control well. And respectively grading the skin according to the skin reaction grading standard of the skin closed patch test 30min (after the indentation disappears), 24h and 48h after the test object patch tester is removed. The number of test persons was 20, women aged 18-50 years.
Test examples 1-4, the A, B components each account for 50%.
In the test results, grade 0 is no reaction, grade 1 is reddish suspected allergy, grade 2 is obvious erythema, and grade 3 is herpes.
| Number of people at level 0 | Number of people at level 1 | Number of people at level 2 | Number of people in class 3 | |
| Example 1 | 20 | 0 | 0 | 0 |
| Example 2 | 20 | 0 | 0 | 0 |
| Example 3 | 20 | 0 | 0 | 0 |
| Example 4 | 20 | 0 | 0 | 0 |
| Control 1 | 20 | 0 | 0 | 0 |
| Control 2 | 20 | 0 | 0 | 0 |
| Control 3 | 20 | 0 | 0 | 0 |
| Control 4 | 20 | 0 | 0 | 0 |
As can be seen from the above table, the present invention is not allergenic at all.
The invention relates to a dual-component essence cream, which can balance the requirements of 'moisture retention' and 'oil-free' for users, and does not need to change the brand and brand of cosmetics due to season change.
Claims (3)
1. The two-component essence cream is characterized in that: the component is A, B, wherein the component A is aqueous solution of active ingredients, the component B is oily solution of the active ingredients,
the component A specifically comprises: 0.1-3% of water-soluble active polymer, 0.05-3% of ceramide, 0.1-3% of pantothenic acid, 0.1-5% of beta-glucose and the balance of ultrapure water,
the component B specifically comprises: 5-10% of oil-soluble active polymer, 5-10% of anti-allergic active peptide, 80-95% of alcohol substance, 1-5% of thickening agent and 1-5% of emulsifier,
the structure of the water-soluble active polymer in the A component is as follows:
the molecular weight Mw of the water-soluble active polymer in the component A is 50000-100000,
the structure of the oil-soluble active polymer in the component B is shown as follows:
in the structural formula, x is 10-18, and in the structural formula, R is one or more of the following structures:
the anti-allergic active peptide in the component B is one or more of acetyl tetrapeptide, acetyl dipeptide, acetyl hexapeptide and palmitoyl tripeptide,
the alcohol substance in the component B is one or a mixture of ethanol, diethylene glycol, 1, 3-propylene glycol, glycerol, butanediol, 1, 2-pentanediol, 1, 2-hexanediol and polyethylene glycol,
the thickening agent in the component B is carbomer, xanthan gum, cellulose and modified substances thereof or starch modified phosphate ester,
the emulsifier in the component B is one or a mixture of more of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, sorbitan monopalmitate, polyoxyethylene sorbitan monopalmitate, glyceryl stearate, sucrose polystearate, polyglycerol distearate and coco glucoside.
2. The method for preparing the two-component essence cream as claimed in claim 1, wherein the method comprises the following steps: the preparation method of the water-soluble active polymer structure in the component A comprises the following steps: (1) adding a certain amount of pharmaceutical grade salicylic acid and a certain amount of pharmaceutical grade glycidyl methacrylate into a reactor, and continuously reacting until the epoxy group is completely reacted to obtain an intermediate A; (2) adding a certain amount of the intermediate A, a certain amount of medical grade acryloyl dimethyl ammonium taurate, a certain amount of medical grade vinyl pyrrolidone and a certain amount of pretreated azobisisobutyronitrile into ethyl acetate, and uniformly stirring; (3) dropwise adding the liquid obtained in the step (2) into a reactor at the temperature of 60-80 ℃, carrying out free radical polymerization, and carrying out heat preservation reaction after dropwise adding is finished; (4) passing the polymer solution through an electronic grade silica gel column; (5) slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring; (6) filtering to obtain precipitate particles, and repeating the step (5) for more than three times.
3. The method for preparing the two-component essence cream as claimed in claim 1, wherein the method comprises the following steps: the preparation method of the oil-soluble active polymer structure in the component B comprises the following steps: (1) adding a certain amount of long-chain alkane acid and a certain amount of glutamic acid into a reactor, and completely reacting at a certain temperature; (2) adding the selected R group and a certain amount of solvent dipropylene glycol methyl ether into a system, and reacting under the catalysis of methanesulfonic acid until the reaction is complete; (3) removing the catalyst by water washing; (4) passing the polymer solution through an electronic grade silica gel column; (5) slowly dripping the polymer solution passing through the silica gel column into the pharmaceutical grade ethanol solution, and generating granular precipitate along with stirring; (6) filtering to obtain precipitate particles, and repeating the step (5) for more than three times.
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| WO2009079889A1 (en) * | 2007-12-21 | 2009-07-02 | Changzhou Zhongke Laifang Power Science & Technology Co., Ltd. | Non-woven fabric reinforced microporous polymer membrane, manufacturing method and use thereof |
| CN110227052A (en) * | 2019-06-19 | 2019-09-13 | 杭州悦萱堂化妆品有限公司 | Face cream and preparation method thereof is repaired in a kind of moisturizing |
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| WO2009079889A1 (en) * | 2007-12-21 | 2009-07-02 | Changzhou Zhongke Laifang Power Science & Technology Co., Ltd. | Non-woven fabric reinforced microporous polymer membrane, manufacturing method and use thereof |
| CN110227052A (en) * | 2019-06-19 | 2019-09-13 | 杭州悦萱堂化妆品有限公司 | Face cream and preparation method thereof is repaired in a kind of moisturizing |
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